JP6655243B2 - 口腔前癌病変の検出方法 - Google Patents

口腔前癌病変の検出方法 Download PDF

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JP6655243B2
JP6655243B2 JP2015172327A JP2015172327A JP6655243B2 JP 6655243 B2 JP6655243 B2 JP 6655243B2 JP 2015172327 A JP2015172327 A JP 2015172327A JP 2015172327 A JP2015172327 A JP 2015172327A JP 6655243 B2 JP6655243 B2 JP 6655243B2
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dna
methylation
gene
genes
promoter region
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JP2017046628A (ja
JP2017046628A5 (https=
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倫史 ▲濱▼田
倫史 ▲濱▼田
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Kagoshima University NUC
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Priority to JP2015172327A priority Critical patent/JP6655243B2/ja
Priority to PCT/JP2016/075667 priority patent/WO2017038939A1/ja
Priority to US15/755,714 priority patent/US20190024181A1/en
Priority to EP16841968.7A priority patent/EP3346014B1/en
Publication of JP2017046628A publication Critical patent/JP2017046628A/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
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  • Genetics & Genomics (AREA)
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  • Biotechnology (AREA)
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  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
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  • Biophysics (AREA)
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  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2015172327A 2015-09-01 2015-09-01 口腔前癌病変の検出方法 Active JP6655243B2 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2015172327A JP6655243B2 (ja) 2015-09-01 2015-09-01 口腔前癌病変の検出方法
PCT/JP2016/075667 WO2017038939A1 (ja) 2015-09-01 2016-09-01 口腔前癌病変の検出方法
US15/755,714 US20190024181A1 (en) 2015-09-01 2016-09-01 Method for detecting oral precancerous lesion
EP16841968.7A EP3346014B1 (en) 2015-09-01 2016-09-01 Method for detecting precancerous oral lesion

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2015172327A JP6655243B2 (ja) 2015-09-01 2015-09-01 口腔前癌病変の検出方法

Publications (3)

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JP2017046628A JP2017046628A (ja) 2017-03-09
JP2017046628A5 JP2017046628A5 (https=) 2018-10-04
JP6655243B2 true JP6655243B2 (ja) 2020-02-26

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JP2015172327A Active JP6655243B2 (ja) 2015-09-01 2015-09-01 口腔前癌病変の検出方法

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US (1) US20190024181A1 (https=)
EP (1) EP3346014B1 (https=)
JP (1) JP6655243B2 (https=)
WO (1) WO2017038939A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113834927A (zh) * 2020-06-08 2021-12-24 南京市口腔医院 预测口腔粘膜癌前病变患者发生癌变的唾液代谢标志物及其应用
WO2022181444A1 (ja) * 2021-02-26 2022-09-01 国立大学法人 鹿児島大学 口腔癌検出キット、試薬の使用、試薬、口腔癌検出装置、情報取得方法及びプログラム
CN113278704A (zh) * 2021-07-22 2021-08-20 北京泱深生物信息技术有限公司 用于口腔鳞癌诊断的标志物及产品
WO2023086382A2 (en) * 2021-11-09 2023-05-19 Mayo Foundation For Medical Education And Research Methods and materials for assessing and treating oral lichen planus
CN119639903B (zh) * 2025-01-17 2025-11-25 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 用于肝内胆管癌的生物标记物、药物及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070066552A1 (en) * 2005-01-21 2007-03-22 Introgen Therapeutics, Inc. Topical administration permitting prolonged exposure of target cells to therapeutic and prophylactic nucleic acids
WO2007133725A1 (en) * 2006-05-12 2007-11-22 University Of Miami Biomarkers for detection and diagnosis of head and neck squamous cell carcinoma
WO2008036333A2 (en) * 2006-09-19 2008-03-27 University Of Miami Hypermethylation of cd44 promoter in head and neck squamous cell carcinoma
WO2010001933A1 (ja) * 2008-07-01 2010-01-07 学校法人日本大学 標的遺伝子特異的ヒストン修飾制御剤
JP4538525B2 (ja) * 2009-01-16 2010-09-08 千絵 宮本 癌関連遺伝子マーカーの検出方法
CN102191312A (zh) * 2010-03-16 2011-09-21 上海交通大学医学院附属第九人民医院 抑癌基因启动子甲基化检测在口腔白斑癌变评估中的应用
AU2012340441A1 (en) * 2011-11-15 2014-05-29 University Of Miami Methods for detecting human papillomavirus and providing prognosis for head and neck squamous cell carcinoma
JP2015526096A (ja) * 2012-08-31 2015-09-10 国防医学院Ｎａｔｉｏｎａｌ Ｄｅｆｅｎｓｅ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ 癌のスクリーニング方法

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Publication number Publication date
JP2017046628A (ja) 2017-03-09
EP3346014A4 (en) 2019-01-16
EP3346014A1 (en) 2018-07-11
US20190024181A1 (en) 2019-01-24
EP3346014B1 (en) 2023-11-08
WO2017038939A1 (ja) 2017-03-09

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