JP6649540B2 - 置換されたヘテロアリール化合物および使用方法 - Google Patents
置換されたヘテロアリール化合物および使用方法 Download PDFInfo
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- JP6649540B2 JP6649540B2 JP2017519817A JP2017519817A JP6649540B2 JP 6649540 B2 JP6649540 B2 JP 6649540B2 JP 2017519817 A JP2017519817 A JP 2017519817A JP 2017519817 A JP2017519817 A JP 2017519817A JP 6649540 B2 JP6649540 B2 JP 6649540B2
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- Prior art keywords
- cycloalkyl
- membered heterocyclyl
- alkyl
- compound
- membered heteroaryl
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Landscapes
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| US201462063460P | 2014-10-14 | 2014-10-14 | |
| US62/063,460 | 2014-10-14 | ||
| PCT/US2015/055034 WO2016060963A1 (en) | 2014-10-14 | 2015-10-10 | Substituted heteroaryl compounds and methods of use |
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| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| CN109776522B (zh) * | 2017-10-30 | 2020-12-29 | 广东东阳光药业有限公司 | 取代的杂芳基化合物及其组合物和用途 |
| WO2019099311A1 (en) | 2017-11-19 | 2019-05-23 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use |
| CR20200347A (es) | 2018-02-13 | 2020-09-23 | Gilead Sciences Inc | Inhibidores pd-1/pd-l1 |
| TWI712412B (zh) | 2018-04-19 | 2020-12-11 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
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| WO2020086556A1 (en) | 2018-10-24 | 2020-04-30 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| US12522583B2 (en) | 2018-11-07 | 2026-01-13 | Dana-Farber Cancer Institute, Inc. | Benzimidazole derivatives and aza-benzimidazole derivatives as Janus kinase 2 inhibitors and uses thereof |
| EP3877371A4 (en) | 2018-11-07 | 2022-07-27 | Dana-Farber Cancer Institute, Inc. | IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF |
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| PT3943491T (pt) | 2019-03-19 | 2025-07-28 | Voronoi Inc | Derivado de heteroarilo, método para a produção do mesmo e composição farmacêutica que compreende o mesmo como componente eficaz |
| US12157730B2 (en) | 2019-03-19 | 2024-12-03 | Voronoi Inc. | Heteroaryl derivative, method for producing same, and pharmaceutical composition comprising same as effective component |
| WO2021083185A1 (zh) * | 2019-10-29 | 2021-05-06 | 沈阳中化农药化工研发有限公司 | 含嘧啶的哌啶胺类化合物及其制备方法和用途 |
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| ATE342892T1 (de) * | 1998-08-29 | 2006-11-15 | Astrazeneca Ab | Pyrimidine verbindungen |
| WO2003030909A1 (en) | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer |
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- 2015-10-10 EP EP15851260.8A patent/EP3206691B1/en active Active
- 2015-10-10 JP JP2017519817A patent/JP6649540B2/ja active Active
- 2015-10-10 US US14/880,199 patent/US10059689B2/en active Active
- 2015-10-10 ES ES15851260T patent/ES2699948T3/es active Active
- 2015-10-12 TW TW104133416A patent/TW201617338A/zh unknown
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| WO2016060963A1 (en) | 2016-04-21 |
| EP3206691A4 (en) | 2018-04-11 |
| ES2699948T3 (es) | 2019-02-13 |
| EP3206691A1 (en) | 2017-08-23 |
| US20160229837A1 (en) | 2016-08-11 |
| US10059689B2 (en) | 2018-08-28 |
| TW201617338A (zh) | 2016-05-16 |
| JP2017531000A (ja) | 2017-10-19 |
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