JP6640229B2 - 補体活性の変調剤 - Google Patents

補体活性の変調剤 Download PDF

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Publication number
JP6640229B2
JP6640229B2 JP2017539419A JP2017539419A JP6640229B2 JP 6640229 B2 JP6640229 B2 JP 6640229B2 JP 2017539419 A JP2017539419 A JP 2017539419A JP 2017539419 A JP2017539419 A JP 2017539419A JP 6640229 B2 JP6640229 B2 JP 6640229B2
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Japan
Prior art keywords
polypeptide
acid
polypeptides
composition
complement
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JP2017539419A
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English (en)
Japanese (ja)
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JP2018509388A (ja
JP2018509388A5 (enExample
Inventor
デニス ホアーティ、ミシェル
デニス ホアーティ、ミシェル
アショク ダムナスカー、ケットキ
アショク ダムナスカー、ケットキ
エルバーム、ダニエル
ジョセフソン、クリストファー
クロニン ラーソン、ケリー
クロニン ラーソン、ケリー
マー、ジョン
エゼキエル ニムス、ネイサン
エゼキエル ニムス、ネイサン
リカルド、アロンソ
セイブ、キャスリーン
タン、グォ−クィン
エイ． トレコ、ダグラス
エイ． トレコ、ダグラス
ワン、ジャオリン
イー、ピン
チェン、ホン
ジャクリーン パールムッター、サラ
ジャクリーン パールムッター、サラ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Inc
Original Assignee
Ra Pharmaceuticals Inc
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Publication date
Priority claimed from PCT/US2015/035473 external-priority patent/WO2015191951A2/en
Application filed by Ra Pharmaceuticals Inc filed Critical Ra Pharmaceuticals Inc
Publication of JP2018509388A publication Critical patent/JP2018509388A/ja
Publication of JP2018509388A5 publication Critical patent/JP2018509388A5/ja
Priority to JP2019233666A priority Critical patent/JP6915034B2/ja
Application granted granted Critical
Publication of JP6640229B2 publication Critical patent/JP6640229B2/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Amplifiers (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
JP2017539419A 2015-01-28 2016-01-28 補体活性の変調剤 Active JP6640229B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2019233666A JP6915034B2 (ja) 2015-01-28 2019-12-25 補体活性の変調剤

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562108772P 2015-01-28 2015-01-28
US62/108,772 2015-01-28
USPCT/US2015/035473 2015-06-12
PCT/US2015/035473 WO2015191951A2 (en) 2014-06-12 2015-06-12 Modulation of complement activity
US201562185298P 2015-06-26 2015-06-26
US62/185,298 2015-06-26
PCT/US2016/015412 WO2016123371A1 (en) 2015-01-28 2016-01-28 Modulators of complement activity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019233666A Division JP6915034B2 (ja) 2015-01-28 2019-12-25 補体活性の変調剤

Publications (3)

Publication Number Publication Date
JP2018509388A JP2018509388A (ja) 2018-04-05
JP2018509388A5 JP2018509388A5 (enExample) 2019-03-07
JP6640229B2 true JP6640229B2 (ja) 2020-02-05

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
JP2017539419A Active JP6640229B2 (ja) 2015-01-28 2016-01-28 補体活性の変調剤
JP2019233666A Active JP6915034B2 (ja) 2015-01-28 2019-12-25 補体活性の変調剤

Family Applications After (1)

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Country Status (14)

Country Link
US (6) US9937222B2 (enExample)
EP (2) EP3988110A1 (enExample)
JP (2) JP6640229B2 (enExample)
CY (1) CY1124761T1 (enExample)
ES (1) ES2900998T3 (enExample)
HR (1) HRP20211824T1 (enExample)
HU (1) HUE056613T2 (enExample)
LT (1) LT3250230T (enExample)
PL (1) PL3250230T3 (enExample)
PT (1) PT3250230T (enExample)
RS (1) RS62630B9 (enExample)
SI (1) SI3250230T1 (enExample)
SM (1) SMT202100688T1 (enExample)
WO (1) WO2016123371A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2895029T3 (es) 2014-06-12 2022-02-17 Ra Pharmaceuticals Inc Modulación de actividad del complemento
HUE056613T2 (hu) 2015-01-28 2022-02-28 Ra Pharmaceuticals Inc Komplementaktivitás modulátorai
ES2941640T3 (es) * 2015-12-16 2023-05-24 Ra Pharmaceuticals Inc Moduladores de la actividad del complemento
EP3551210A1 (en) * 2016-12-07 2019-10-16 RA Pharmaceuticals, Inc. Modulators of complement activity
JP7153669B2 (ja) * 2017-04-21 2022-10-14 ヴォリューション イミュノ ファーマシューティカルズ エスエイ 瘢痕性眼炎症障害の治療のためのコバーシン
DK3612208T5 (da) 2017-04-21 2024-09-02 Volution Immuno Pharmaceuticals Sa Coversin til behandlingen af autoimmune sygdomme med blisterdannelse
SG11202103972SA (en) 2018-10-22 2021-05-28 Ra Pharmaceuticals Inc Neurological disease treatment with zilucoplan
EP3980047B1 (en) 2019-06-04 2024-02-14 RA Pharmaceuticals, Inc. Inflammatory disease treatment with complement inhibitors
JP6773930B1 (ja) 2019-08-09 2020-10-21 住友化学株式会社 液晶ポリエステル樹脂成形体、液晶ポリエステル樹脂ペレット、及び液晶ポリエステル樹脂ペレットの製造方法
WO2021050885A1 (en) 2019-09-12 2021-03-18 Ra Pharmaceuticals, Inc. Neurological disease treatment with complement inhibitors
WO2022177635A2 (en) * 2021-02-22 2022-08-25 Ra Pharmaceuticals, Inc. Compositions and methods for microbial disease treatment

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