|
US4271068A
(en)
|
1968-05-10 |
1981-06-02 |
Ciba-Geigy Corporation |
Process for the manufacture of cystine-containing peptides
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4033940A
(en)
|
1975-11-12 |
1977-07-05 |
Armour Pharmaceutical Company |
Cyclization of peptides
|
|
US4216141A
(en)
|
1978-07-19 |
1980-08-05 |
The Salk Institute For Biological Studies |
Method for cyclization of peptides
|
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
|
NZ199722A
(en)
|
1981-02-25 |
1985-12-13 |
Genentech Inc |
Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
|
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
|
US6309669B1
(en)
|
1984-03-16 |
2001-10-30 |
The United States Of America As Represented By The Secretary Of The Army |
Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
|
|
EP0206448B1
(en)
|
1985-06-19 |
1990-11-14 |
Ajinomoto Co., Inc. |
Hemoglobin combined with a poly(alkylene oxide)
|
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
|
US5371109A
(en)
|
1986-07-01 |
1994-12-06 |
Drilletten Ab |
Controlled release composition for a biologically active material dissolved or dispersed in an L2-phase
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
KR0185192B1
(ko)
|
1989-10-05 |
1999-04-01 |
제임스 더블유. 데이비 |
신규의 유전자 및 폴리펩티드의 무세포 합성 및 분리
|
|
US5585353A
(en)
|
1990-02-02 |
1996-12-17 |
The Rockefeller University |
Antibiotic peptides containing D-amino acids
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
US5766897A
(en)
|
1990-06-21 |
1998-06-16 |
Incyte Pharmaceuticals, Inc. |
Cysteine-pegylated proteins
|
|
US5843701A
(en)
|
1990-08-02 |
1998-12-01 |
Nexstar Pharmaceticals, Inc. |
Systematic polypeptide evolution by reverse translation
|
|
US5270170A
(en)
|
1991-10-16 |
1993-12-14 |
Affymax Technologies N.V. |
Peptide library and screening method
|
|
EP0617706B1
(en)
|
1991-11-25 |
2001-10-17 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
|
EP0700522A1
(en)
|
1993-05-28 |
1996-03-13 |
Chiron Corporation |
Method for selection of biologically active peptide sequences
|
|
DK0710243T3
(da)
|
1993-06-29 |
2000-10-16 |
Ferring Bv |
Syntese af cykliske peptider
|
|
US6074642A
(en)
|
1994-05-02 |
2000-06-13 |
Alexion Pharmaceuticals, Inc. |
Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
US5834318A
(en)
|
1995-05-10 |
1998-11-10 |
Bayer Corporation |
Screening of combinatorial peptide libraries for selection of peptide ligand useful in affinity purification of target proteins
|
|
US5912014A
(en)
|
1996-03-15 |
1999-06-15 |
Unigene Laboratories, Inc. |
Oral salmon calcitonin pharmaceutical products
|
|
US6720472B2
(en)
|
1996-07-12 |
2004-04-13 |
University Of Medicine And Dentistry Of New Jersey |
HMGI proteins in cancer and obesity
|
|
US6268343B1
(en)
|
1996-08-30 |
2001-07-31 |
Novo Nordisk A/S |
Derivatives of GLP-1 analogs
|
|
US6348584B1
(en)
|
1996-10-17 |
2002-02-19 |
John Edward Hodgson |
Fibronectin binding protein compounds
|
|
WO1998016636A1
(en)
|
1996-10-17 |
1998-04-23 |
Mitsubishi Chemical Corporation |
Molecule that homologizes genotype and phenotype and utilization thereof
|
|
US5922680A
(en)
|
1996-10-23 |
1999-07-13 |
Ferring, B.V. |
Stabilized composition for oral administration of peptides
|
|
US6261804B1
(en)
|
1997-01-21 |
2001-07-17 |
The General Hospital Corporation |
Selection of proteins using RNA-protein fusions
|
|
CA2278786C
(en)
|
1997-01-21 |
2010-07-20 |
The General Hospital Corporation |
Selection of proteins using rna-protein fusions
|
|
US5990237A
(en)
|
1997-05-21 |
1999-11-23 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
|
|
EP2380906A2
(en)
|
1997-06-12 |
2011-10-26 |
Novartis International Pharmaceutical Ltd. |
Artificial antibody polypeptides
|
|
EP0896001A1
(en)
|
1997-08-08 |
1999-02-10 |
Daicel Chemical Industries, Ltd. |
Method for preparing oxytocin antagoniste derivatives, intermediates for the preparation of oxytocin antagonist derivatives and method for preparing the intermediates
|
|
US6429301B1
(en)
|
1998-04-17 |
2002-08-06 |
Whitehead Institute For Biomedical Research |
Use of a ribozyme to join nucleic acids and peptides
|
|
HUP0103188A2
(hu)
|
1998-08-07 |
2001-12-28 |
Emisphere Technologies, Inc. |
Vegyületek és készítmények hatóanyagok célbajuttatására
|
|
AU1705100A
(en)
|
1998-10-09 |
2000-05-01 |
Musc Foundation For Research Development |
Blocking factor b to treat complement-mediated immune disease
|
|
US6962781B1
(en)
|
2000-05-19 |
2005-11-08 |
Proteonova, Inc. |
In vitro evolution of nucleic acids and encoded polypeptide
|
|
US7244701B2
(en)
|
2000-06-16 |
2007-07-17 |
Zealand Phama A/S |
Diuretic peptide conjugate
|
|
CA2524534C
(en)
|
2003-05-15 |
2012-12-11 |
Sek Chung Fung |
Methods and compositions for the prevention and treatment of sepsis
|
|
CA2579635A1
(en)
*
|
2003-09-10 |
2005-03-17 |
Baxter International Inc. |
Peptides that inhibit complement activation
|
|
CA2537029C
(en)
|
2003-11-26 |
2013-03-12 |
Likan Liang |
Micellar systems useful for delivery of lipophilic or hydrophobic compounds
|
|
US7803931B2
(en)
|
2004-02-12 |
2010-09-28 |
Archemix Corp. |
Aptamer therapeutics useful in the treatment of complement-related disorders
|
|
US20060027059A1
(en)
|
2004-08-09 |
2006-02-09 |
Chih-Ching Hsien |
Extendable handle device
|
|
US20090054623A1
(en)
|
2004-12-17 |
2009-02-26 |
Neose Technologies, Inc. |
Lipo-Conjugation of Peptides
|
|
AU2006206848B2
(en)
|
2005-01-24 |
2012-05-31 |
Pepscan Systems B.V. |
Binding compounds, immunogenic compounds and peptidomimetics
|
|
EP1874289A2
(en)
|
2005-03-29 |
2008-01-09 |
Cardax Pharmaceuticals, Inc. |
Reduction in complement activation and inflammation during tissue injury by carotenoids, carotenoid analogs, or derivatives thereof
|
|
CA2610340C
(en)
|
2005-05-26 |
2016-02-16 |
Vernon Michael Holers |
Inhibition of the alternative complement pathway for treatment of traumatic brain injury, spinal cord injury and related conditions
|
|
CN101217940B
(zh)
|
2005-06-06 |
2013-03-27 |
卡穆鲁斯公司 |
Glp-1类似物制剂
|
|
KR20130137716A
(ko)
|
2005-11-04 |
2013-12-17 |
제넨테크, 인크. |
안질환 치료를 위한 보체 경로 억제제의 용도
|
|
US20090220508A1
(en)
|
2006-03-15 |
2009-09-03 |
Alexion Pharmaceuticals, Inc. |
Treatment Of Paroxysmal Nocturnal Hemoglobinuria Patients By An Inhibitor Of Complement
|
|
EP1876183A1
(en)
|
2006-07-04 |
2008-01-09 |
Technische Universität München |
Minimized small peptides with high affinity for factor VIII and factor VIII-like proteins
|
|
WO2008044928A1
(en)
|
2006-10-10 |
2008-04-17 |
Academisch Ziekenhuis Bij De Universiteit Van Amsterdam |
Complement inhibition for improved nerve regeneration
|
|
US7736860B2
(en)
|
2006-11-09 |
2010-06-15 |
Univeristy Of Massachusetts |
Methods of identifying compounds for the treatment of sterile inflammation
|
|
US20100092493A1
(en)
|
2007-03-06 |
2010-04-15 |
Novo Nordisk A/S |
Modulation of Complement System Activation for Treatment of Bleeding-Related Inflammation
|
|
KR20100015773A
(ko)
|
2007-03-22 |
2010-02-12 |
노파르티스 아게 |
Ｃ５ 항원 및 그의 용도
|
|
US20100015139A1
(en)
|
2008-07-10 |
2010-01-21 |
Rekha Bansal |
METHOD OF INHIBITING COMPLEMENT ACTIVATION WITH FACTOR Ba SPECIFIC ANTIBODIES AND USE THEREOF
|
|
WO2008137236A2
(en)
|
2007-04-30 |
2008-11-13 |
Alcon Research, Ltd. |
Treatment of age-related macular degeneration using inhibitors of complement factor d
|
|
MX2009013082A
(es)
|
2007-06-07 |
2010-01-15 |
Genentech Inc |
Anticuerpos contra c3b y metodos para la prevencion y el tratamiento de trastornos asociados con el complemento.
|
|
WO2009014633A1
(en)
|
2007-07-20 |
2009-01-29 |
Trustees Of The University Of Pennsylvania |
Method of treating acute respiratory distress syndrome
|
|
CA2701470A1
(en)
|
2007-10-02 |
2009-04-09 |
Potentia Pharmaceuticals, Inc. |
Sustained delivery of compstatin analogs from gels
|
|
WO2009067191A2
(en)
|
2007-11-16 |
2009-05-28 |
The General Hospital Corporation |
Methods and compositions for the treatment of hepatitis c virus (hcv) infection
|
|
WO2009121065A2
(en)
|
2008-03-28 |
2009-10-01 |
Apellis Ag |
Modulation and repletion/enhancement of the complement system for treatment of trauma
|
|
US20100093624A1
(en)
|
2008-07-30 |
2010-04-15 |
Cosmix Therapeutics Llc |
Peptide therapeutics that bind vegf and methods of use thereof
|
|
US20110172126A1
(en)
|
2008-09-03 |
2011-07-14 |
Xenome Ltd |
Libraries of peptide conjugates and methods for making them
|
|
EP2894166A1
(en)
|
2008-11-10 |
2015-07-15 |
Alexion Pharmaceuticals, Inc. |
Methods and compositions for treating complement-associated disorders
|
|
JP5911804B2
(ja)
|
2009-10-16 |
2016-04-27 |
オメロス コーポレーション |
Ｍａｓｐ−２依存性の補体活性化を阻害することによって播種性血管内凝固を処置するための方法
|
|
NZ600393A
(en)
|
2009-11-05 |
2014-08-29 |
Alexion Cambridge Corp |
Treatment of paroxysmal nocturnal hemoglobinuria, hemolytic anemias and disease states involving intravascular and extravascular hemolysis
|
|
JP5411366B2
(ja)
|
2009-12-16 |
2014-02-12 |
ノヴォ ノルディスク アー／エス |
二重アシル化ｇｌｐ−１誘導体
|
|
US9172511B2
(en)
|
2009-12-24 |
2015-10-27 |
Samsung Electronics Co., Ltd. |
Apparatus and method of communicating automatic repeat request (ARQ) feedback in a wireless communication network
|
|
US9358266B2
(en)
|
2010-02-25 |
2016-06-07 |
The Trustees Of The University Of Pennsylvania |
Treatment of sepsis using complement inhibitors
|
|
US20110269807A1
(en)
|
2010-04-30 |
2011-11-03 |
Allergan, Inc. |
Novel treatment for age related macular degeneration and ocular ischemic disease associated with complement activation by targeting 5-lipoxygenase
|
|
TW201241008A
(en)
|
2010-10-01 |
2012-10-16 |
Alexion Pharma Inc |
Polypeptides that bind to human complement component C5
|
|
RU2743409C2
(ru)
|
2011-04-08 |
2021-02-18 |
Юниверсити Оф Лестер |
Способы лечения состояний, связанных с masp-2 зависимой активацией комплемента
|
|
WO2012162215A1
(en)
|
2011-05-20 |
2012-11-29 |
The Trustees Of The University Of Pennsylvania |
Promotion of fracture healing using complement inhibitors
|
|
WO2012174055A1
(en)
|
2011-06-13 |
2012-12-20 |
The Trustees Of The University Of Pennsylvania |
Wound healing using complement inhibitors
|
|
CN102321170B
(zh)
|
2011-09-14 |
2013-11-13 |
深圳翰宇药业股份有限公司 |
利拉鲁肽变构体及其缀合物
|
|
WO2013052736A2
(en)
|
2011-10-06 |
2013-04-11 |
The Medicines Company |
Methods of treating or preventing blood loss during surgery using the serine protease inhibitor mdco-2010
|
|
KR102336895B1
(ko)
|
2012-02-20 |
2021-12-08 |
스위디쉬 오르펀 바이오비트럼 에이비 (피유비엘) |
인간 보체 c5에 결합하는 폴리펩티드
|
|
WO2013126606A1
(en)
*
|
2012-02-21 |
2013-08-29 |
Production Sciences, Inc. |
System and method for measuring well flow rate
|
|
US20130246083A1
(en)
|
2012-03-16 |
2013-09-19 |
Alexion Pharmaceuticals, Inc. |
Methods of distributing complement-inhibiting drugs to patients receiving a complement inhibitor
|
|
WO2013172954A1
(en)
|
2012-05-17 |
2013-11-21 |
Ra Pharmaceuticals, Inc |
Peptide and peptidomimetic inhibitors
|
|
US9579360B2
(en)
|
2012-06-20 |
2017-02-28 |
The Trustees Of The University Of Pennsylvania |
Methods of treating or preventing periodontitis and diseases associated with periodontitis
|
|
US20130345257A1
(en)
|
2012-06-26 |
2013-12-26 |
The Regents Of The University Of California |
Composition for lupus nephritis and methods of making and using the same
|
|
US20150330989A1
(en)
|
2012-11-15 |
2015-11-19 |
The Brigham And Women's Hospital, Inc. |
Method and system for diagnosing and treating preeclampsia
|
|
US9700633B2
(en)
|
2013-01-28 |
2017-07-11 |
Jenkem Technology Co., Ltd., Tianjin Branch |
Conjugates of water soluble polymer-amino acid oligopeptide-drug, preparation method and use thereof
|
|
US20140234275A1
(en)
|
2013-02-15 |
2014-08-21 |
Jason Williams |
Method for treating als via the increased production of factor h
|
|
WO2015025312A1
(en)
|
2013-08-21 |
2015-02-26 |
Cannabics Pharmaceuticals Inc |
Compositions for combined immediate and sustained release of cannabinoids, methods of manufacture and use thereof
|
|
MX2016011862A
(es)
|
2014-03-20 |
2016-12-05 |
Inflarx Gmbh |
Inhibidores de c5a para el tratamiento de la neumonia viral.
|
|
MX2016016449A
(es)
*
|
2014-06-12 |
2017-08-24 |
Ra Pharmaceuticals Inc |
Modulacion de la actividad del complemento.
|
|
US20160168237A1
(en)
|
2014-12-12 |
2016-06-16 |
Alexion Pharmaceuticals, Inc. |
Method for treating a complement mediated disorder caused by an infectious agent in a patient
|
|
GB2541835B
(en)
|
2015-01-21 |
2018-09-12 |
Pacira Pharmaceuticals Inc |
Multivesicular liposome formulations of tranexamic acid
|
|
RS62630B9
(sr)
*
|
2015-01-28 |
2022-04-29 |
Ra Pharmaceuticals Inc |
Modulatori aktivnosti komplementa
|
|
WO2017035362A1
(en)
|
2015-08-26 |
2017-03-02 |
Achillion Pharmaceuticals, Inc. |
Use of complement pathway inhibitor compounds to mitigate adoptive t-cell therapy associated adverse immune responses
|
|
LT3685847T
(lt)
|
2015-12-16 |
2023-03-27 |
Ra Pharmaceuticals, Inc. |
Komplemento aktyvumo moduliatoriai
|
|
AU2017370692A1
(en)
|
2016-12-07 |
2019-06-06 |
Ra Pharmaceuticals, Inc. |
Modulators of complement activity
|
|
US10376595B2
(en)
|
2017-04-03 |
2019-08-13 |
Inflarx Gmbh |
Treatment of inflammatory diseases with inhibitors of C5a activity
|
|
EP3682016A4
(en)
|
2017-09-11 |
2021-06-02 |
RA Pharmaceuticals, Inc. |
FORMULATIONS FOR THE ADMINISTRATION OF COMPOUNDS
|
|
US20210000927A1
(en)
|
2017-12-04 |
2021-01-07 |
Ra Pharmaceuticals, Inc. |
Modulators of complement activity
|
|
TW202100179A
(zh)
|
2019-03-08 |
2021-01-01 |
美商Ｒａ製藥公司 |
補體活性之調節劑
|
|
JP7726791B2
(ja)
|
2019-04-24 |
2025-08-20 |
ユーシービー ホールディングス インコーポレイテッド |
補体活性を調節するための組成物及び方法
|