JP6639236B2 - 混合モードクロマトグラフィー膜 - Google Patents

混合モードクロマトグラフィー膜 Download PDF

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JP6639236B2
JP6639236B2 JP2015559296A JP2015559296A JP6639236B2 JP 6639236 B2 JP6639236 B2 JP 6639236B2 JP 2015559296 A JP2015559296 A JP 2015559296A JP 2015559296 A JP2015559296 A JP 2015559296A JP 6639236 B2 JP6639236 B2 JP 6639236B2
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certain embodiments
monomer
methacrylate
present
membrane
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JP2016510005A5 (enExample
JP2016510005A (ja
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ハニーマン，チャールズ，エイチ．
コムコワ，エレナ，エヌ．
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ナトリックス セパレイションズ インコーポレーテッド
ナトリックス セパレイションズ インコーポレーテッド
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3285—Coating or impregnation layers comprising different type of functional groups or interactions, e.g. different ligands in various parts of the sorbent, mixed mode, dual zone, bimodal, multimodal, ionic or hydrophobic, cationic or anionic, hydrophilic or hydrophobic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3847—Multimodal interactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28033—Membrane, sheet, cloth, pad, lamellar or mat
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/291—Gel sorbents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/26—Cation exchangers for chromatographic processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/20—Anion exchangers for chromatographic processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J43/00—Amphoteric ion-exchange, i.e. using ion-exchangers having cationic and anionic groups; Use of material as amphoteric ion-exchangers; Treatment of material for improving their amphoteric ion-exchange properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J47/00—Ion-exchange processes in general; Apparatus therefor
    • B01J47/12—Ion-exchange processes in general; Apparatus therefor characterised by the use of ion-exchange material in the form of ribbons, filaments, fibres or sheets, e.g. membranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
JP2015559296A 2013-02-26 2014-02-26 混合モードクロマトグラフィー膜 Active JP6639236B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361769330P 2013-02-26 2013-02-26
US61/769,330 2013-02-26
PCT/US2014/018635 WO2014134147A1 (en) 2013-02-26 2014-02-26 Mixed-mode chromatography membranes

Related Child Applications (1)

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JP2019137395A Division JP7246277B2 (ja) 2013-02-26 2019-07-26 混合モードクロマトグラフィー膜

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JP2016510005A JP2016510005A (ja) 2016-04-04
JP2016510005A5 JP2016510005A5 (enExample) 2017-03-23
JP6639236B2 true JP6639236B2 (ja) 2020-02-05

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JP2015559296A Active JP6639236B2 (ja) 2013-02-26 2014-02-26 混合モードクロマトグラフィー膜
JP2019137395A Active JP7246277B2 (ja) 2013-02-26 2019-07-26 混合モードクロマトグラフィー膜
JP2021119271A Withdrawn JP2021184987A (ja) 2013-02-26 2021-07-20 混合モードクロマトグラフィー膜

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JP2021119271A Withdrawn JP2021184987A (ja) 2013-02-26 2021-07-20 混合モードクロマトグラフィー膜

Country Status (8)

Country Link
US (2) US20140238935A1 (enExample)
EP (2) EP2961762B1 (enExample)
JP (3) JP6639236B2 (enExample)
KR (1) KR102284079B1 (enExample)
AU (1) AU2014223583B2 (enExample)
CA (1) CA2902180C (enExample)
ES (1) ES2912930T3 (enExample)
WO (1) WO2014134147A1 (enExample)

Cited By (1)

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JP2019206002A (ja) * 2013-02-26 2019-12-05 ナトリックス セパレイションズ インコーポレーテッド 混合モードクロマトグラフィー膜

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US20190217285A1 (en) * 2016-09-09 2019-07-18 Asahi Kasei Medical Co., Ltd. Strong cation exchange chromatographic matrix and method for using same
WO2018048696A1 (en) 2016-09-09 2018-03-15 3M Innovative Properties Company Functionalized copolymers and use thereof
JP2020525445A (ja) * 2017-06-21 2020-08-27 セファロン・インコーポレイテッドＣｅｐｈａｌｏｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ カチオン交換クロマトグラフィーの洗浄緩衝液
JP7018175B2 (ja) * 2017-12-08 2022-02-10 東ソー株式会社 共重合体、基材用表面処理剤および細胞培養基材
US20220267369A1 (en) * 2018-07-25 2022-08-25 Merck Sharp & Dohme Corp. Methods of separating host cell lipases from a production protein in chromatographic processes
US12485364B2 (en) 2018-08-10 2025-12-02 Clemson University Research Foundation Multi-modal ion-exchange membranes for rapid separations
US10737259B2 (en) * 2018-08-31 2020-08-11 Pall Corporation Salt tolerant anion exchange medium
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TWI786468B (zh) * 2019-11-21 2022-12-11 愛爾蘭商默克密理博有限公司 將配體偶合至複合材料的方法
TWI774425B (zh) * 2020-06-17 2022-08-11 美商恩特葛瑞斯股份有限公司 離子交換膜、過濾器及方法
CN111909418B (zh) * 2020-08-17 2021-09-03 吉林大学 一种改性聚酰亚胺气凝胶及其制备方法和应用
CN114618455A (zh) * 2020-12-11 2022-06-14 中国科学院大连化学物理研究所 一种多极性官能团包埋的反相色谱固定相及其制备和应用
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JP2019206002A (ja) * 2013-02-26 2019-12-05 ナトリックス セパレイションズ インコーポレーテッド 混合モードクロマトグラフィー膜
JP2021184987A (ja) * 2013-02-26 2021-12-09 メルク・ミリポア・リミテッド 混合モードクロマトグラフィー膜
JP7246277B2 (ja) 2013-02-26 2023-03-27 メルク・ミリポア・リミテッド 混合モードクロマトグラフィー膜

Also Published As

Publication number Publication date
ES2912930T3 (es) 2022-05-30
EP2961762B1 (en) 2022-04-06
CA2902180A1 (en) 2014-09-04
WO2014134147A1 (en) 2014-09-04
AU2014223583B2 (en) 2019-03-28
AU2014223583A1 (en) 2015-10-15
EP4089101A1 (en) 2022-11-16
KR20150123309A (ko) 2015-11-03
EP2961762A4 (en) 2016-11-02
US11554361B2 (en) 2023-01-17
CA2902180C (en) 2023-08-15
JP2016510005A (ja) 2016-04-04
EP2961762A1 (en) 2016-01-06
KR102284079B1 (ko) 2021-08-02
US20180353939A1 (en) 2018-12-13
JP2021184987A (ja) 2021-12-09
JP2019206002A (ja) 2019-12-05
JP7246277B2 (ja) 2023-03-27
US20140238935A1 (en) 2014-08-28

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