JP6637882B2 - 生物学的検知機器 - Google Patents
生物学的検知機器 Download PDFInfo
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- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
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Description
半導体製造プロセスにより形成された集積回路に含まれ、電気特性を検知するように構成されている粒子検知機器;および
流動性物質の流入を抑えるまたは供給するように構成されている流入装置を含み、
粒子検知機器は、流動性物質が流入装置を通って流れる際に、粒子検知機器が流動性物質に含まれる粒子の電気特性を検知する働きをするよう、流入装置に応じて配置されている。
対応する電圧に変換し、変換された電圧を増幅するように構成されてもよい;または
対応する電流に変換し、変換された電流を増幅するように構成されてもよい。
流動性物質を流入装置内に封じ込める工程と、そこを通る流動性物質の流れを供給する工程;
流動性物質が流入装置を通って流れる際に、流動性物質に含まれる粒子の電気特性を検知する工程を含み、粒子の電気特性は、流入装置に応じて配置されている粒子検知機器により検知され、粒子検知機器は、半導体製造プロセスにより形成された集積回路に含まれる。
半導体製造プロセスにより形成された集積回路に含まれる粒子検知機器;および
流動性物質の流入を抑えるまたは供給するように構成されている流入装置を含み、
粒子検知機器は、流動性物質が流入装置を通って流れる際に、粒子検知機器が流動性物質に含まれる粒子の電気特性を検知する働きをするよう、流入装置に応じて配置されている。流動性物質は、液体と気体の少なくとも一つを含むことができる。あるいは、または加えて、粒子は液体担体中に同伴されてもよい。あるいは、または加えて、粒子は液体担体中に分散されてもよい。本発明のさらなる態様のさらなる実施形態は、本発明の前述の態様の一つ以上の特徴を含み得る。
半導体製造プロセスにより形成された集積回路に含まれる検知機器;および
流動性物質の流入を抑えるまたは供給するように構成されている流入装置を含み、
検知機器は、流動性物質が流入装置を通って流れる際に、検知機器が流動性物質を検知する働きをするよう、流入装置に応じて配置されている。流動性物質は、粒子を含むことができる。検知機器は、流動性物質に含まれる粒子を検知するように構成されている粒子検知機器であってもよい。本発明のさらに他の態様のさらなる実施形態は、本発明の前述の態様の一つ以上の特徴を含み得る。
は、テスト中のシステムの推定出力スペクトルであり、mはシーケンスオーダー、Hはアダマール行列、ηは測定されたM系列符号化反応、並びに
および
は、アダマール行列で使用するためにM系列データを正しい順序に変換する符号および復号行列である。一形態において、
および
は、互いに等しい。PCはさらに、高速フーリエ変換(FFT)を復号されたデータに実行する働きをし、これにより、周波数領域のデータを提供する。周波数領域データは、したがって、使用者の解釈のために表示されている。周波数領域データは、検体中の生体細胞の、寸法や組成などに関する特性を提供し、それにより特定の細胞型の性質を決定することができる、または異なる細胞型を区別することができる。PCはまた、使用者に示されている数および密度の情報と共に、流入装置の流速および容積に基づき、検体中に存在する生体細胞を計数し、検体中に存在する細胞の濃度を決定する働きをする。
Claims (19)
- 流動性物質に含まれる生物学的粒子を検知するように構成されている生物学的分析機器であって、
該流動性物質が流れるチャネルを備える流入装置;
半導体製造プロセスにより形成された集積回路に含まれる粒子刺激機器及び粒子検知機器を備える生物学的検知機器であって、
該集積回路は、該チャネルに対して配置され、
該粒子刺激機器は、電場源回路と少なくとも一つの刺激電極対とを備え、該電場源回路は、該少なくとも一つの刺激電極対と電気的に結合され、該少なくとも一つの刺激電極対は、該チャネルの第1側に配置され、
該粒子検知機器は、検知回路と少なくとも一つの検知電極対とを備え、該検知回路は、該少なくとも一つの検知電極対と電気的に結合され、該少なくとも一つの検知電極対は、該チャネルの該第1側に配置され、
該電場源回路は、該少なくとも一つの刺激電極対を介して、該流動性物質に含まれる少なくとも一つの該生物学的粒子に第1の電場を印加し、
該検知回路は、該少なくとも一つの検知電極対を介して、該第1の電場の印加によって発生した、少なくとも一つの該生物学的粒子の第2の電場を検知し、該検知された第2の電場に応じて、対応する出力信号を出力する、該生物学的検知機器;
該流動性物質を該チャネルに流れさせる流れ誘導装置;および
該流れ誘導装置を制御して、該生物学的粒子を含む該流動性物質を該チャネルに流れさせ、該電場源回路を制御して、該流動性物質が該チャネルを流れる際に、該第1の電場を該流動性物質に含まれる該生物学的粒子に印加し、該検知回路を制御して、該電場源回路による該第1の電場の印加の後であって、該流動性物質が該チャネルを流れる際に、少なくとも一つの該生物学的粒子の該第2の電場を検知し、該検知された第2の電場に応じて、該対応する出力信号を出力する、制御機器、を含み、
該電場源回路によって印加される該第1の電場は変動する、該生物学的分析機器。 - 該流動性物質は、少なくとも一つの電気感受性標識を含む、請求項1に記載の生物学的分析機器。
- 該少なくとも一つの刺激電極対及び該少なくとも一つの検知電極対が並んで配置されている、請求項1又は2に記載の生物学的分析機器。
- 刺激電極及び検知電極の少なくとも一つは、100ミクロン、50ミクロン、30ミクロン、20ミクロン、15ミクロン、10ミクロン、5ミクロン、3ミクロンおよび1ミクロンのうちの一つより小さい寸法を有する、請求項3に記載の生物学的分析機器。
- 該粒子検知機器は複数の隔置された検知電極対を備え、各検知電極対は生物学的粒子を検知し、該チャネルは生物学的粒子が通って移動する流路を画定し、該粒子検知機器は、該生物学的粒子が該流路に沿って移動した際に、次に続く検知電極対により該生物学的粒子が検知されるように構成されている、請求項3又は4に記載の生物学的分析機器。
- 該粒子検知機器は検知電極対の配列を含み、該検知電極対の配列は該チャネルを通る該流動性物質の流れの方向と、該流動性物質の流れの方向に直交する方向とに延在する、請求項5に記載の生物学的分析機器。
- 該粒子検知機器は、動電場を検知するように構成されている、請求項1〜6のいずれか一項に記載の生物学的分析機器。
- 該粒子刺激機器は、動電場を該流動性物質に印加する、請求項1〜7のいずれか一項に記載の生物学的分析機器。
- 該少なくとも一つの検知電極対及び該少なくとも一つの刺激電極対の少なくとも一つは該チャネル内の該流動性物質から電気的に分離されている、請求項8に記載の生物学的分析機器。
- 該粒子検知機器は、差動検知のために構成されている、請求項1〜9のいずれか一項に記載の生物学的分析機器。
- 該生物学的検知機器は、該第1の電場と該第2の電場とを比較する、請求項1〜10のいずれか一項に記載の生物学的分析機器。
- 該チャネルを通る該流動性物質の流れの方向に直交する方向に延在する作動素子の配列を更に含み、作動素子の該配列は、該チャネルにおいて生物学的粒子に力を加えるように該チャネルに応じて配置され、作動素子の該配列は、該生物学的検知機器からの該対応する信号に基づいて動作する、請求項1〜11のいずれか一項に記載の生物学的分析機器。
- 該半導体製造プロセスは金属酸化膜半導体プロセスである、請求項1〜12のいずれか一項に記載の生物学的分析機器。
- 該対応する出力信号を受信する分析装置を更に含む、請求項1〜13のいずれか一項に記載の生物学的分析機器。
- 該電場源回路によって印加される該第1の電場は、疑似ランダムノイズ成分を含む、請求項1〜14のいずれか一項に記載の生物学的分析機器。
- 該疑似ランダムノイズ成分はM系列を含む、請求項15に記載の生物学的分析機器。
- 該少なくとも一つの刺激電極対及び該少なくとも一つの検知電極対は、共通の電極を有する、請求項1〜16のいずれか一項に記載の生物学的分析機器。
- 該生物学的検知機器は、該第1の電場の印加するようにアドレス指定される持続的回路を更に備え、該持続的回路は所定の期間にわたってアドレス指定され、該所定の期間よりも長く状態を保持して、該流動性物質に含まれる少なくとも一つの該生物学的粒子に該第1の電場を印加し続ける、請求項1〜17のいずれか一項に記載の生物学的分析機器。
- 流動性物質に含まれる生物学的粒子を検知するための生物学的検知方法であり、
請求項1〜18のいずれか一項に記載の生物学的分析機器を用意する工程;
該流動性物質に該チャネルを流れさせる工程;
該流れ誘導装置を制御して、該生物学的粒子を含む該流動性物質を該チャネルに流れさせる工程と、該電場源回路を制御して、該流動性物質が該チャネルを流れる際に、該第1の電場を該流動性物質に含まれる少なくとも一つの該生物学的粒子に印加する工程と、該検知回路を制御して、該流動性物質が該チャネルを流れる際に、少なくとも一つの該生物学的粒子の該第2の電場を検知し、該検知された第2の電場に応じて、該対応する出力信号を出力する工程、を含み、
該電場源回路によって印加される該第1の電場は変動する、該方法。
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