JP6635949B2 - 炎症性および自己免疫性の病気の処置のためのmth1阻害剤 - Google Patents
炎症性および自己免疫性の病気の処置のためのmth1阻害剤 Download PDFInfo
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- JP6635949B2 JP6635949B2 JP2016571095A JP2016571095A JP6635949B2 JP 6635949 B2 JP6635949 B2 JP 6635949B2 JP 2016571095 A JP2016571095 A JP 2016571095A JP 2016571095 A JP2016571095 A JP 2016571095A JP 6635949 B2 JP6635949 B2 JP 6635949B2
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- JKDZFWAOCTVIRR-UHFFFAOYSA-N C=CCNc1cc(Cl)nc(N)n1 Chemical compound C=CCNc1cc(Cl)nc(N)n1 JKDZFWAOCTVIRR-UHFFFAOYSA-N 0.000 description 1
- JZIULQAAQKFJMQ-UHFFFAOYSA-N Cc(c(-c1nc(N)nc(Cl)c1)c1)ccc1Cl Chemical compound Cc(c(-c1nc(N)nc(Cl)c1)c1)ccc1Cl JZIULQAAQKFJMQ-UHFFFAOYSA-N 0.000 description 1
- JOGXEBBCLDMDDA-UHFFFAOYSA-N Cc(c(-c1nc(N)nc(NCCCN)c1)ccc1)c1Cl Chemical compound Cc(c(-c1nc(N)nc(NCCCN)c1)ccc1)c1Cl JOGXEBBCLDMDDA-UHFFFAOYSA-N 0.000 description 1
- QOUAQKOLTZGLCO-UHFFFAOYSA-N Cc(c(-c1nc(N)nc(NCCO)c1)ccc1)c1Cl Chemical compound Cc(c(-c1nc(N)nc(NCCO)c1)ccc1)c1Cl QOUAQKOLTZGLCO-UHFFFAOYSA-N 0.000 description 1
- IBWAUWPRUZNPKW-UHFFFAOYSA-N Cc1c(C)c(-c2nc(N)nc(Cl)c2)ccc1 Chemical compound Cc1c(C)c(-c2nc(N)nc(Cl)c2)ccc1 IBWAUWPRUZNPKW-UHFFFAOYSA-N 0.000 description 1
- VGFWOWKPCVKHIM-UHFFFAOYSA-N NC(COc1cc(B(O)O)ccc1)=O Chemical compound NC(COc1cc(B(O)O)ccc1)=O VGFWOWKPCVKHIM-UHFFFAOYSA-N 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1450681 | 2014-06-04 | ||
| SE1450681-0 | 2014-06-04 | ||
| PCT/SE2015/050654 WO2015187089A1 (en) | 2014-06-04 | 2015-06-04 | Mth1 inhibitors for treatment of inflammatory and autoimmune conditions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017516826A JP2017516826A (ja) | 2017-06-22 |
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| JP2020516672A (ja) | 2017-04-18 | 2020-06-11 | セルジーン クオンティセル リサーチ,インク. | 治療用化合物 |
| KR102626982B1 (ko) | 2017-05-18 | 2024-01-18 | 이도르시아 파마슈티컬스 리미티드 | Pge2 수용체 조절제로서의 피리미딘 유도체 |
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| WO2018210994A1 (en) | 2017-05-18 | 2018-11-22 | Idorsia Pharmaceuticals Ltd | Phenyl derivatives as pge2 receptor modulators |
| CN109467538A (zh) | 2017-09-07 | 2019-03-15 | 和记黄埔医药(上海)有限公司 | 环烯烃取代的杂芳环类化合物及其用途 |
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| WO2019166639A1 (en) | 2018-03-01 | 2019-09-06 | Thomas Helledays Stiftelse För Medicinsk Forskning | Substituted benzodiazoles and use thereof in therapy |
| CN111960970B (zh) * | 2018-08-08 | 2021-08-20 | 中国人民解放军总医院 | 抗肿瘤化合物 |
| AR116635A1 (es) * | 2018-10-15 | 2021-05-26 | Servier Lab | Proceso para la síntesis de derivados de piperazinil-etoxi-bromofenilo y su aplicación en la producción de compuestos que los contienen |
| CN117396474A (zh) * | 2021-03-17 | 2024-01-12 | 武田药品工业株式会社 | 血浆激肽释放酶抑制剂 |
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| WO2014084778A1 (en) * | 2012-11-27 | 2014-06-05 | Thomas Helledays Stiftelse För Medicinsk Forskning | Pyrimidine-2,4-diamine derivatives for treatment of cancer |
| US10064869B2 (en) * | 2014-06-04 | 2018-09-04 | Thomas Helledays Stiftelse For Medicinsk Forskning | MTH1 inhibitors for treatment of inflammatory and autoimmune conditions |
| CN104288170B (zh) | 2014-10-22 | 2018-02-16 | 吉林大学 | 松果菊苷在抗肿瘤药物中的应用 |
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