JP6624616B2 - sGC刺激剤 - Google Patents

sGC刺激剤 Download PDF

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JP6624616B2
JP6624616B2 JP2017515199A JP2017515199A JP6624616B2 JP 6624616 B2 JP6624616 B2 JP 6624616B2 JP 2017515199 A JP2017515199 A JP 2017515199A JP 2017515199 A JP2017515199 A JP 2017515199A JP 6624616 B2 JP6624616 B2 JP 6624616B2
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disease
pulmonary
hypertension
disorder
fibrosis
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JP2017528494A (ja
JP2017528494A5 (OSRAM
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クロード バーデン,ティモシー
クロード バーデン,ティモシー
エドワード シェペック,ジェームズ
エドワード シェペック,ジェームズ
ロバート レニー,グレン
ロバート レニー,グレン
アラン レンハウ,ポール
アラン レンハウ,ポール
パール,ニコラス
ナカイ,タカシ
マーメリアン,アラ
ワイホ イ,トーマス
ワイホ イ,トーマス
チョン,ジュン
ジア,ジェームズ
アイヤル,カールティック
アール. イエンガー,ラジェッシュ
アール. イエンガー,ラジェッシュ
ジェイミー イム,ギュン
ジェイミー イム,ギュン
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サイクレリオン・セラピューティクス,インコーポレーテッド
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    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D495/04Ortho-condensed systems

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  • Cardiology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017515199A 2014-09-17 2015-09-16 sGC刺激剤 Expired - Fee Related JP6624616B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462051557P 2014-09-17 2014-09-17
US62/051,557 2014-09-17
US201562204710P 2015-08-13 2015-08-13
US62/204,710 2015-08-13
PCT/US2015/050468 WO2016044447A1 (en) 2014-09-17 2015-09-16 Pyrazole derivatives as sgc stimulators

Publications (3)

Publication Number Publication Date
JP2017528494A JP2017528494A (ja) 2017-09-28
JP2017528494A5 JP2017528494A5 (OSRAM) 2018-10-25
JP6624616B2 true JP6624616B2 (ja) 2019-12-25

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JP2017515199A Expired - Fee Related JP6624616B2 (ja) 2014-09-17 2015-09-16 sGC刺激剤

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US (4) US20170291889A1 (OSRAM)
EP (1) EP3194382B1 (OSRAM)
JP (1) JP6624616B2 (OSRAM)
CN (1) CN107406422B (OSRAM)
AU (2) AU2015317824A1 (OSRAM)
CA (1) CA2959757A1 (OSRAM)
MX (1) MX2017003516A (OSRAM)
WO (1) WO2016044447A1 (OSRAM)

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MX2018007152A (es) 2015-12-14 2018-08-15 Ironwood Pharmaceuticals Inc Uso de estimuladores de guanilato ciclasa soluble (sgc) para el tratamiento de la disfuncion del esfinter gastrointestinal.
CN105859726B (zh) * 2016-05-18 2018-07-13 南京富润凯德生物医药有限公司 一种嘧啶并环中选择性脱卤素的方法
SG10202100168XA (en) * 2016-07-07 2021-02-25 Cyclerion Therapeutics Inc Novel processes for preparation of soluble guanylate cyclase stimulators
JP7112384B2 (ja) * 2016-07-07 2022-08-03 サイクレリオン・セラピューティクス,インコーポレーテッド 可溶性グアニル酸シクラーゼ刺激剤の新規な調製方法
AU2017292818B2 (en) * 2016-07-07 2021-10-21 Cyclerion Therapeutics, Inc. Solid forms of an sGC stimulator
CN110022871A (zh) 2016-10-11 2019-07-16 拜耳制药股份公司 包含sGC刺激物和盐皮质激素受体拮抗剂的组合产品
CN109890379A (zh) 2016-10-11 2019-06-14 拜耳制药股份公司 包含sGC活化剂和盐皮质激素受体拮抗剂的组合产品
EP3554488A2 (en) 2016-12-13 2019-10-23 Cyclerion Therapeutics, Inc. Use of sgc stimulators for the treatment of esophageal motility disorders
WO2019081456A1 (en) 2017-10-24 2019-05-02 Bayer Aktiengesellschaft USE OF SGC ACTIVATORS AND STIMULATORS COMPRISING A BETA2 SUBUNIT
EP3498298A1 (en) 2017-12-15 2019-06-19 Bayer AG The use of sgc stimulators and sgc activators alone or in combination with pde5 inhibitors for the treatment of bone disorders including osteogenesis imperfecta (oi)
EA202091502A1 (ru) * 2017-12-19 2020-11-12 Сайклерион Терапьютикс, Инк. СТИМУЛЯТОРЫ sGC
AU2019206560B2 (en) * 2018-01-10 2023-08-24 Cyclerion Therapeutics, Inc. Novel processes and intermediates for the preparation of soluble guanylate cyclase stimulators
WO2019161534A1 (en) * 2018-02-22 2019-08-29 Ironwood Pharmaceuticals, Inc. Novel processes and intermediates for preparation of soluble guanylate cyclase stimulators
CA3098475A1 (en) 2018-04-30 2019-11-07 Bayer Aktiengesellschaft The use of sgc activators and sgc stimulators for the treatment of cognitive impairment
EA202092680A1 (ru) 2018-05-15 2021-04-13 Байер Акциенгезельшафт 1,3-тиазол-2-ил-замещенные бензамиды для лечения заболеваний, ассоциированных с сенситизацией нервных волокон
EP3574905A1 (en) 2018-05-30 2019-12-04 Adverio Pharma GmbH Method of identifying a subgroup of patients suffering from dcssc which benefits from a treatment with sgc stimulators and sgc activators in a higher degree than a control group
BR112021000358A2 (pt) 2018-07-11 2021-04-06 Cyclerion Therapeutics, Inc. Uso de estimulantes de sgc para o tratamento de distúrbios mitocondriais
EP3911675A1 (en) 2019-01-17 2021-11-24 Bayer Aktiengesellschaft Methods to determine whether a subject is suitable of being treated with an agonist of soluble guanylyl cyclase (sgc)
CN110577467A (zh) * 2019-09-18 2019-12-17 重庆医药高等专科学校 一种3-羟基丙酸的合成方法
CN110498740A (zh) * 2019-09-18 2019-11-26 重庆医药高等专科学校 一种生产3-羟基丙酸的方法
US20230330066A1 (en) * 2019-12-18 2023-10-19 Bioradical Research Institute Corp. Vasodilator and Use Thereof
CN112007027B (zh) * 2020-09-14 2022-07-15 长春金赛药业有限责任公司 含酯基芳香丙酰胺类化合物及其代谢产物在制备治疗心衰药物中的应用
CN112169717B (zh) * 2020-09-30 2022-06-03 深圳大学 一种微胶囊化氯化血红素及其制备方法与应用
US20230372317A1 (en) * 2020-10-27 2023-11-23 Pts Consulting, Llc A liquid injectable composition of donepezil
US20240366596A1 (en) * 2021-07-28 2024-11-07 Cyclerion Therapeutics, Inc. Treatment of hfpef in post-menopausal women with an sgc stimulator
WO2025106494A1 (en) * 2023-11-15 2025-05-22 Yanping Kong Compositions and methods for treating erectile dysfunction and male hypogonadism
WO2025189097A1 (en) * 2024-03-07 2025-09-12 Yale University Artificial intelligence-guided screening of under-recognized cardiomyopathies adapted for point-of-care cardiac ultrasound
DE202024103267U1 (de) 2024-06-18 2024-07-09 Ashutosh Aggarwal Ein System zur Herstellung einer antihypertensiven Formulierung mit verlängerter Freisetzung
CN119185590B (zh) * 2024-11-28 2025-02-25 华润双鹤利民药业(济南)有限公司 羟丙基-β-环糊精在制备维立西呱固体制剂中的应用、固体制剂及制备方法
CN119909007B (zh) * 2025-04-02 2025-06-03 四川大学 一种具有氧化还原活性和电活性的可注射水凝胶及其制备方法与应用

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US20170291889A1 (en) 2017-10-12
US20190031641A1 (en) 2019-01-31
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US20190284168A1 (en) 2019-09-19
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CA2959757A1 (en) 2016-03-24
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