JP6621420B2 - 糖尿病を治療するためのトランスジェニックブタ膵島およびその使用 - Google Patents

糖尿病を治療するためのトランスジェニックブタ膵島およびその使用 Download PDF

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JP6621420B2
JP6621420B2 JP2016561296A JP2016561296A JP6621420B2 JP 6621420 B2 JP6621420 B2 JP 6621420B2 JP 2016561296 A JP2016561296 A JP 2016561296A JP 2016561296 A JP2016561296 A JP 2016561296A JP 6621420 B2 JP6621420 B2 JP 6621420B2
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transgenic
isolated
diabetes
cells
islets
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JP2017519483A5 (enExample
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ジャネッロ，ピエール
ムラド，ニザル
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ウニベルシテ カソリーク デ ルーベン
ウニベルシテ カソリーク デ ルーベン
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2207/00—Modified animals
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    • A—HUMAN NECESSITIES
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    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • A61K2035/128—Immunoprotecting barriers, e.g. jackets, diffusion chambers capsules, e.g. microcapsules
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8527—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases
    • C12N2015/8536—Animal models for genetic diseases

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JP2016561296A 2014-04-11 2015-04-10 糖尿病を治療するためのトランスジェニックブタ膵島およびその使用 Active JP6621420B2 (ja)

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EP14164372 2014-04-11
EP14164372.6 2014-04-11
EP14199910.2 2014-12-22
EP14199910 2014-12-22
PCT/EP2015/057914 WO2015155360A1 (en) 2014-04-11 2015-04-10 Transgenic pig islets and uses thereof for treating diabetes

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JP2019208487A Pending JP2020048565A (ja) 2014-04-11 2019-11-19 糖尿病を治療するためのトランスジェニックブタ膵島およびその使用

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US11160836B2 (en) * 2014-04-11 2021-11-02 Université Catholique de Louvain Transgenic pig islets and uses thereof for treating diabetes
EP3745404B1 (en) * 2019-05-29 2024-04-03 Cell Networks GmbH Method and system for predicting coupling probabilities of g-protein coupled receptors with g-proteins
EP3789765A1 (en) * 2019-09-09 2021-03-10 ETH Zürich A method for evaluating damage of solid tissue
CN115152693A (zh) * 2021-11-22 2022-10-11 兰州大学 一种小鼠2型糖尿病模型的构建及评价方法
CN115569194A (zh) * 2022-10-28 2023-01-06 陕西中鸿科瑞再生医学研究院有限公司 一种具有糖尿病治疗作用的温敏水凝胶、试剂盒、使用方法及其应用
WO2025202874A1 (en) * 2024-03-25 2025-10-02 Crispr Therapeutics Ag Genetically modified cells expressing glp-1 receptor agonist
CN118787658B (zh) * 2024-06-14 2025-01-21 中国农业大学 一种胰高血糖素样肽-1受体特异性核酸适配体在代谢疾病干预中的应用

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UA65549C2 (uk) * 1996-11-05 2004-04-15 Елі Ліллі Енд Компані Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
US7094593B1 (en) * 1998-09-01 2006-08-22 Basf Aktiengesellschaft Method for improving the function of heterologous G protein-coupled receptors
ES2386505T3 (es) 2000-10-17 2012-08-22 Diatranz Otsuka Limited Preparación y xenotrasplante de islotes de cerdo
FR2820057A1 (fr) 2001-01-30 2002-08-02 Ct De Transfert De Technologie Membrane pour chambre d'encapsulation de cellules produisant au moins une substance biologiquement active et organe bio-artificiel comprenant une telle membrane
NZ539491A (en) 2005-04-15 2008-04-30 Living Cell Products Pty Ltd Swine population and uses thereof
EP1940427A4 (en) 2005-10-21 2013-01-02 Living Cell Products Pty Ltd encapsulation
ATE552867T1 (de) 2006-06-16 2012-04-15 Fmc Biopolymer As Alginatbeschichtete collagenmatrix- zellvorrichtung, herstellungsverfahren dafür und verwendungen davon
WO2010032242A1 (en) 2008-09-17 2010-03-25 Beta O2 Technologies Ltd. Optimization of alginate encapsulation of islets for transplantation
JP2013501528A (ja) 2009-08-14 2013-01-17 レビビコア， インコーポレイテッド 糖尿病の処置のためのマルチ・トランスジェニック・ブタ
US20140017678A1 (en) * 2012-06-11 2014-01-16 Nodality, Inc. Pathway characterization of cells
EP2677863A1 (en) * 2011-02-23 2014-01-01 Université Catholique de Louvain Modified pig islets for diabetes treatment
UY34347A (es) * 2011-09-26 2013-04-30 Novartis Ag Proteínas de función dual para tratar trastornos metabólicos
US11160836B2 (en) * 2014-04-11 2021-11-02 Université Catholique de Louvain Transgenic pig islets and uses thereof for treating diabetes

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EP3604498A1 (en) 2020-02-05
DK3129467T3 (da) 2020-02-10
US20170189453A1 (en) 2017-07-06
EP3129467B1 (en) 2019-11-13
ES2769813T3 (es) 2020-06-29
PL3129467T3 (pl) 2020-05-18
WO2015155360A1 (en) 2015-10-15
CN106456674B (zh) 2020-06-30
US20220008480A1 (en) 2022-01-13
JP2020048565A (ja) 2020-04-02
PT3129467T (pt) 2020-02-04
EP3129467A1 (en) 2017-02-15
CA2945240C (en) 2021-08-03
WO2015155360A8 (en) 2019-01-10
CA2945240A1 (en) 2015-10-15
JP2017519483A (ja) 2017-07-20
US11160836B2 (en) 2021-11-02
CN106456674A (zh) 2017-02-22

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