JP6619743B2 - 抗体−薬物複合体及び免疫毒素 - Google Patents

抗体−薬物複合体及び免疫毒素

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Publication number
JP6619743B2
JP6619743B2 JP2016550779A JP2016550779A JP6619743B2 JP 6619743 B2 JP6619743 B2 JP 6619743B2 JP 2016550779 A JP2016550779 A JP 2016550779A JP 2016550779 A JP2016550779 A JP 2016550779A JP 6619743 B2 JP6619743 B2 JP 6619743B2
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alkyl
solvate
pharmaceutically acceptable
seq
acceptable salt
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JP2017506630A5 (OSRAM
JP2017506630A (ja
Inventor
コンテルマン，ローランド
ファイゼンマイヤー，クラウス
ファーラー，クリスティーナ
ファーブル，ミリアム
シモン，ラウレアーノ
Original Assignee
オンコマトリックス バイオファーマ，エス．エル．
オンコマトリックス バイオファーマ，エス．エル．
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6871—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting an enzyme
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2497—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing N- glycosyl compounds (3.2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
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    • C12Y302/02—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2) hydrolysing N-glycosyl compounds (3.2.2)
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Botany (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2016550779A 2014-02-06 2015-02-04 抗体−薬物複合体及び免疫毒素 Active JP6619743B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1402006.9 2014-02-06
GB201402006A GB201402006D0 (en) 2014-02-06 2014-02-06 Antibody-drug conjugates and immunotoxins
PCT/EP2015/052341 WO2015118030A2 (en) 2014-02-06 2015-02-04 Antibody-drug conjugates and immunotoxins

Publications (3)

Publication Number Publication Date
JP2017506630A JP2017506630A (ja) 2017-03-09
JP2017506630A5 JP2017506630A5 (OSRAM) 2018-03-15
JP6619743B2 true JP6619743B2 (ja) 2019-12-11

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US (2) US10137202B2 (OSRAM)
EP (1) EP3102244B1 (OSRAM)
JP (1) JP6619743B2 (OSRAM)
KR (1) KR102342935B1 (OSRAM)
CN (1) CN105979971B (OSRAM)
AU (1) AU2015215015B2 (OSRAM)
CA (1) CA2937455C (OSRAM)
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CN105979971B (zh) 2019-10-11
CA2937455A1 (en) 2015-08-13
WO2015118030A3 (en) 2015-10-01
US20170007716A1 (en) 2017-01-12
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SI3102244T1 (sl) 2020-07-31
MX375383B (es) 2025-03-06
CA2937455C (en) 2022-09-13
KR20160113620A (ko) 2016-09-30
MX2016010127A (es) 2017-02-15
CN105979971A (zh) 2016-09-28
PL3102244T3 (pl) 2020-11-02
ES2788864T3 (es) 2020-10-23
EP3102244A2 (en) 2016-12-14
AU2015215015A1 (en) 2016-07-21
BR112016018005A2 (pt) 2018-02-20
US20190105406A1 (en) 2019-04-11
US10137202B2 (en) 2018-11-27
AU2015215015B2 (en) 2019-02-07
PT3102244T (pt) 2020-05-11
KR102342935B1 (ko) 2021-12-24
HUE049291T2 (hu) 2020-09-28

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