JP6618892B2 - 細菌バイオフィルムの遺伝的リプログラミング - Google Patents

細菌バイオフィルムの遺伝的リプログラミング Download PDF

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JP6618892B2
JP6618892B2 JP2016510750A JP2016510750A JP6618892B2 JP 6618892 B2 JP6618892 B2 JP 6618892B2 JP 2016510750 A JP2016510750 A JP 2016510750A JP 2016510750 A JP2016510750 A JP 2016510750A JP 6618892 B2 JP6618892 B2 JP 6618892B2
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csga
biofilm
curli
polypeptide
modified
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JP2016526013A5 (OSRAM
JP2016526013A (ja
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ニール サティシュ ジョシ、
ニール サティシュ ジョシ、
ピーター クオック グエン、
ピーター クオック グエン、
ソフィア ボトヤンツキ、
ソフィア ボトヤンツキ、
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Harvard University
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245Escherichia (G)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/20Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Water Treatment By Sorption (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
JP2016510750A 2013-04-23 2014-04-23 細菌バイオフィルムの遺伝的リプログラミング Active JP6618892B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361814908P 2013-04-23 2013-04-23
US61/814,908 2013-04-23
PCT/US2014/035095 WO2014176311A1 (en) 2013-04-23 2014-04-23 Genetic reprogramming of bacterial biofilms

Related Child Applications (1)

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JP2018166085A Division JP2019022491A (ja) 2013-04-23 2018-09-05 細菌バイオフィルムの遺伝的リプログラミング

Publications (3)

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JP2016526013A JP2016526013A (ja) 2016-09-01
JP2016526013A5 JP2016526013A5 (OSRAM) 2017-06-15
JP6618892B2 true JP6618892B2 (ja) 2019-12-11

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JP2016510750A Active JP6618892B2 (ja) 2013-04-23 2014-04-23 細菌バイオフィルムの遺伝的リプログラミング
JP2018166085A Pending JP2019022491A (ja) 2013-04-23 2018-09-05 細菌バイオフィルムの遺伝的リプログラミング

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US (3) US9815871B2 (OSRAM)
EP (1) EP2989122B1 (OSRAM)
JP (2) JP6618892B2 (OSRAM)
WO (1) WO2014176311A1 (OSRAM)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014176311A1 (en) 2013-04-23 2014-10-30 President And Fellows Of Harvard College Genetic reprogramming of bacterial biofilms
US20160326220A1 (en) * 2013-12-24 2016-11-10 Vib Vzw Secretion and functional display of chimeric polypeptides
JP6916524B2 (ja) * 2015-04-06 2021-08-11 プレジデント アンド フェローズ オブ ハーバード カレッジ 機能的タンパク質配列をディスプレイする生合成アミロイドに基づく材料
WO2017087786A1 (en) * 2015-11-19 2017-05-26 President And Fellows Of Harvard College Electrically conductive protein nanofibers and biofilms
US12351805B2 (en) 2015-11-19 2025-07-08 Northeastern University Method of making recombinant silk and silk-amyloid hybrid proteins using bacteria
US11365225B2 (en) 2015-11-19 2022-06-21 President And Fellows Of Harvard College Method of making recombinant silk and silk-amyloid hybrid proteins using bacteria
WO2017201061A1 (en) * 2016-05-16 2017-11-23 President And Fellows Of Harvard College Scalable production of genetically engineered nanofibrous macroscopic materials via filtration
US11098133B2 (en) 2016-05-19 2021-08-24 President And Fellows Of Harvard College Methods of making gels and films using curli nanofibers
WO2018005493A2 (en) * 2016-06-27 2018-01-04 President And Fellows Of Harvard College Regeneratable curli nanofiber-based catalysts for multistep biotransformations
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
CN107446052A (zh) * 2017-06-09 2017-12-08 上海科技大学 多功能复合超分子纳米纤维自组装体系及其应用
JP2020534261A (ja) 2017-09-08 2020-11-26 ザ ユニバーシティ オブ ブリストル 膜へのタンパク質送達
GB201819850D0 (en) 2018-12-05 2019-01-23 Univ Oxford Innovation Ltd Polypeptide and its use in affinity purification
GB201902992D0 (en) 2019-03-06 2019-04-17 Cytoseek Ltd Product and method
CN112646800B (zh) * 2019-10-11 2025-10-17 北京科技大学 制备固定化酶或固定化蛋白质的方法以及固定化酶或固定化蛋白质
CN112625991B (zh) * 2020-12-30 2023-05-05 江苏大学 一种具备石墨烯亲和能力的希瓦氏菌及其构建方法与应用
CN112934180B (zh) * 2021-01-26 2022-07-29 中南大学 甘氨酸衍生物-氧化石墨烯复合材料及其制备方法与应用
EP4525615A2 (en) 2022-05-14 2025-03-26 Novozymes A/S Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections
CN114934044B (zh) * 2022-05-27 2023-11-10 国网电力科学研究院武汉南瑞有限责任公司 一种重组大肠杆菌在养护铅酸蓄电池中的应用
KR102855274B1 (ko) * 2022-12-06 2025-09-08 충남대학교산학협력단 strep-tag 결합물질에 대한 결합능을 가지는 융합단백질을 암호화하는 유전자 구조물 및 이를 함유하는 발현벡터, 재조합 균주 및 항암 조성물

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5762620A (en) 1992-04-02 1998-06-09 Ndm Acquisition Corp. Wound dressing containing a partially dehydrated hydrogel
US6864365B1 (en) * 1999-04-05 2005-03-08 Innovation And Development Corporation, University Of Victoria Bacterial fimbrial system for presentation of heterologous peptide sequences
EP1432729B1 (en) 2001-07-02 2008-11-12 Merrion Research III Limited Peyers's patch and/or m-cell targeting ligands
US20030219402A1 (en) 2002-02-14 2003-11-27 Rutter William J. Chimeric molecules for cleavage in a treated host
NZ543288A (en) 2003-04-30 2009-06-26 Univ Drexel Thermogelling polymer blends for biomaterial applications
WO2006096515A2 (en) 2005-03-04 2006-09-14 Biorexis Pharmaceutical Corporation Modified transferrin fusion proteins
RU2495129C2 (ru) 2007-01-12 2013-10-10 Актогеникс Н.В. ПРОМОТОРЫ Lactococcus И ИХ ПРИМЕНЕНИЕ:
JP2009073766A (ja) 2007-09-21 2009-04-09 Otsuka Pharmaceut Co Ltd 医薬
WO2010111516A2 (en) * 2009-03-25 2010-09-30 Whitehead Institute For Biomedical Research Compositions and methods for inhibiting biofilms
WO2010129033A2 (en) * 2009-04-29 2010-11-11 Calmune Corporation Modified antibodies for passive immunotherapy
US20110108199A1 (en) 2009-11-10 2011-05-12 Tyco Healthcare Group Lp Hemostatic Tapes and Dispensers Therefor
US9493543B2 (en) 2010-02-16 2016-11-15 Novo Nordisk A/S Factor VIII fusion protein
WO2011123591A1 (en) 2010-03-31 2011-10-06 Wayne State University Injectable dendrimer hydrogel nanoparticles
KR20110111594A (ko) 2010-04-05 2011-10-12 서울대학교산학협력단 알파-시뉴클레인 유래 곱슬 아밀로이드 섬유의 제조방법, 이를 이용한 하이드로젤의 제조 방법 및 그 이용 방법
US8741417B2 (en) 2010-04-16 2014-06-03 Korea University Research And Business Foundation Films having switchable reflectivity
EP2624874A4 (en) 2010-10-08 2014-04-02 Univ Texas Anti-adhesive barrier membrane using alginate and hyaluronic acid for biomedical applications
EP2627770B1 (en) 2010-10-15 2017-06-28 Cornell University Compositions and methods for treating endocrine, gastrointestinal or autoimmune disorders
KR20120060442A (ko) 2010-12-02 2012-06-12 가톨릭대학교 산학협력단 위암 진단용 마커로서 tff2의 용도
CA2832443C (en) 2011-04-06 2020-08-25 The Board Of Regents Of The University Of Texas System Modulating bacterial mam polypeptides in pathogenic disease
WO2012166906A1 (en) * 2011-05-31 2012-12-06 Massachusetts Institute Of Technology Cell-directed synthesis of multifunctional nanopatterns and nanomaterials
CN104271588B (zh) 2011-07-08 2017-10-10 安米林药品有限责任公司 具有增强的作用持续时间和降低的免疫原性的工程改造的多肽
EP2739312B1 (en) * 2011-08-03 2017-10-04 Children's Medical Center Corporation A broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza hemagglutinin
WO2013188529A1 (en) 2012-06-15 2013-12-19 Temple University Of The Commonwealth System Of Higher Education Use of isolated bacterial amyloids for treatment of inflammatory disorders or diseases of the epithelium
CN104640561A (zh) 2012-07-23 2015-05-20 酵活有限公司 包含轻链和重链的选择性配对的免疫球蛋白构建体
US20150291991A1 (en) * 2012-11-16 2015-10-15 President And Fellows Of Harvard College Methods and compositions relating to amyloidogenic polypeptides
DK2943511T3 (da) 2013-01-14 2019-10-21 Xencor Inc Nye heterodimeriske proteiner
JP2014156428A (ja) 2013-02-15 2014-08-28 Univ Of Tokyo 抗体結合タンパク質
WO2014139468A1 (en) 2013-03-15 2014-09-18 Admark Healthcare, Llc Fusion protein molecules and method of use
WO2014176311A1 (en) 2013-04-23 2014-10-30 President And Fellows Of Harvard College Genetic reprogramming of bacterial biofilms
MX2016006990A (es) 2013-11-30 2017-05-04 Agency Science Tech & Res Peptidos autoensamblables, peptidomimeticos y conjugados peptidicos como bloques de construccion para la biofabricacion e impresion.
US20160326220A1 (en) * 2013-12-24 2016-11-10 Vib Vzw Secretion and functional display of chimeric polypeptides
US20150342893A1 (en) 2014-05-29 2015-12-03 Sigmoid Pharma Limited Celecoxib formulations useful for treating colorectal cancer
JP6916524B2 (ja) 2015-04-06 2021-08-11 プレジデント アンド フェローズ オブ ハーバード カレッジ 機能的タンパク質配列をディスプレイする生合成アミロイドに基づく材料
US11098133B2 (en) 2016-05-19 2021-08-24 President And Fellows Of Harvard College Methods of making gels and films using curli nanofibers

Also Published As

Publication number Publication date
US20180186840A1 (en) 2018-07-05
US10550160B2 (en) 2020-02-04
EP2989122A1 (en) 2016-03-02
US20200255480A1 (en) 2020-08-13
US11352397B2 (en) 2022-06-07
WO2014176311A1 (en) 2014-10-30
JP2019022491A (ja) 2019-02-14
EP2989122B1 (en) 2019-04-03
US9815871B2 (en) 2017-11-14
US20160185828A1 (en) 2016-06-30
EP2989122A4 (en) 2016-10-26
JP2016526013A (ja) 2016-09-01

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