JP6609247B2 - 検知のための方法及びシステム - Google Patents

検知のための方法及びシステム Download PDF

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Publication number
JP6609247B2
JP6609247B2 JP2016525073A JP2016525073A JP6609247B2 JP 6609247 B2 JP6609247 B2 JP 6609247B2 JP 2016525073 A JP2016525073 A JP 2016525073A JP 2016525073 A JP2016525073 A JP 2016525073A JP 6609247 B2 JP6609247 B2 JP 6609247B2
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Prior art keywords
oxidation
cells
sample
compartment
sensing
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JP2016525073A
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Japanese (ja)
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JP2016535988A (ja
JP2016535988A5 (https=
Inventor
フェルナンド パトルスキー
ル−チャン ション
ヴァディム クリヴィツキー
ヴラディミール ナダッカ
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Ramot at Tel Aviv University Ltd
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Ramot at Tel Aviv University Ltd
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4146—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS involving nanosized elements, e.g. nanotubes, nanowires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3278—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction involving nanosized elements, e.g. nanogaps or nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7057—(Intracellular) signaling and trafficking pathways
    • G01N2800/7066—Metabolic pathways

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Electrochemistry (AREA)
  • Nanotechnology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
JP2016525073A 2013-10-22 2014-10-22 検知のための方法及びシステム Expired - Fee Related JP6609247B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361893977P 2013-10-22 2013-10-22
US61/893,977 2013-10-22
PCT/IL2014/050921 WO2015059704A1 (en) 2013-10-22 2014-10-22 Method and system for sensing

Publications (3)

Publication Number Publication Date
JP2016535988A JP2016535988A (ja) 2016-11-24
JP2016535988A5 JP2016535988A5 (https=) 2017-11-24
JP6609247B2 true JP6609247B2 (ja) 2019-11-20

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Family Applications (1)

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JP2016525073A Expired - Fee Related JP6609247B2 (ja) 2013-10-22 2014-10-22 検知のための方法及びシステム

Country Status (10)

Country Link
US (2) US10274456B2 (https=)
EP (1) EP3060675B1 (https=)
JP (1) JP6609247B2 (https=)
KR (1) KR20160072258A (https=)
CN (1) CN106164286A (https=)
AU (1) AU2014338510A1 (https=)
CA (1) CA2927332A1 (https=)
MX (1) MX2016005273A (https=)
SG (1) SG11201602976XA (https=)
WO (1) WO2015059704A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2927332A1 (en) 2013-10-22 2015-04-30 Ramot At Tel-Aviv University Ltd. Method and system for sensing
CN110038652B (zh) * 2014-09-11 2021-12-07 克忧健康公司 用于检测和量化分析物的系统和方法
US10667750B2 (en) 2015-12-09 2020-06-02 Ramot At Tel-Aviv University Ltd. Method and system for sensing by modified nanostructure
US10940474B2 (en) * 2016-03-21 2021-03-09 University Of South Australia Oxidant sensor
BR112018074349A2 (pt) * 2016-06-10 2019-03-06 Unilever Nv máquina, método para o controle de qualidade de uma formulação de fluído e método para o controle de uma máquina
CN109890286A (zh) * 2016-08-22 2019-06-14 拉莫特特拉维夫大学有限公司 用于皮下传感的方法及系统
CN109863397A (zh) * 2016-08-22 2019-06-07 拉莫特特拉维夫大学有限公司 用于检测生物分析物的方法及系统
WO2018178992A1 (en) 2017-03-29 2018-10-04 Ramot At Tel-Aviv University Ltd. Method and system for separating biomolecules from a mixture containing same
WO2018198008A1 (en) * 2017-04-24 2018-11-01 Abdolahad Mohammad In-situ microbubbles generation for ultrasonic biomedical applications
BR112019026721A2 (pt) 2017-06-15 2020-06-30 Ramot At Tel-Aviv University Ltd. detecção eletroquímica de compostos contendo peróxido
CA3020655C (en) 2017-06-15 2020-06-16 Ramot At Tel-Aviv University Ltd. Electrochemical detection of nitro-containing compounds
US11179077B2 (en) 2017-06-20 2021-11-23 Mohammad Abdolahad Apparatus for in-vivo measuring of H2O2 oxidation
WO2018234896A1 (en) * 2017-06-20 2018-12-27 Abdolahad Mohammad Real-time and label free analyzer for in-vitro and in-vivo detecting the suspicious regions to cancer
US10786188B1 (en) * 2017-06-20 2020-09-29 Mohammad Abdolahad Real-time and label free analyzer for in-vitro and in-vivo detection of cancer
KR102213538B1 (ko) * 2017-08-01 2021-02-08 일루미나, 인코포레이티드 전계 효과 센서
IL272810B2 (en) 2017-08-21 2025-10-01 Savicell Diagnostic Ltd Methods for diagnosing and treating lung cancer
TWI765209B (zh) * 2019-01-18 2022-05-21 國立陽明交通大學 用來偵測全細胞細菌之以場效電晶體為主的生物感測器以及包含生物感測器的生物感測器組
IL289729B2 (en) 2019-07-12 2025-09-01 Qulab Medical Ltd Electrochemical FET sensor
CN111487107B (zh) * 2020-06-07 2022-12-09 黑龙江省农业科学院农产品质量安全研究所 一种用于食品安全检测的样本分级处理装置
TWI852718B (zh) * 2023-08-08 2024-08-11 國立清華大學 多病毒檢測裝置、系統及其使用方法

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DE2214442C3 (de) * 1972-03-24 1981-09-10 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur Überführung von Glucose in Gluconsäure
ATE408140T1 (de) 2000-12-11 2008-09-15 Harvard College Vorrichtung enthaltend nanosensoren zur ekennung eines analyten und verfahren zu ihrer herstellung
WO2004034025A2 (en) 2002-10-10 2004-04-22 Nanosys, Inc. Nano-chem-fet based biosensors
US7416911B2 (en) * 2003-06-24 2008-08-26 California Institute Of Technology Electrochemical method for attaching molecular and biomolecular structures to semiconductor microstructures and nanostructures
JP2009540798A (ja) 2006-03-15 2009-11-26 プレジデント アンド フェロウズ オブ ハーバード カレッジ ナノバイオエレクトロニクス
WO2008030395A1 (en) 2006-09-07 2008-03-13 California Institute Of Technology Apparatus and method for quantitative determination of target molecules
CA2675172A1 (en) 2007-01-12 2008-07-17 Environmental Biotechnology Crc Pty Limited Sample handling device
IL189576A0 (en) 2008-02-18 2008-12-29 Technion Res & Dev Foundation Chemically sensitive field effect transistors for explosive detection
EP2364382A2 (en) 2008-11-04 2011-09-14 Ramot at Tel-Aviv University Ltd. Tubular nanostructures, processes of preparing same and devices made therefrom
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JP5990254B2 (ja) 2011-04-06 2016-09-07 ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッドＲａｍｏｔ Ａｔ Ｔｅｌ Ａｖｉｖ Ｕｎｉｖｅｒｓｉｔｙ Ｌｔｄ． 代謝活性プロフィルのモニタリング方法および分析方法ならびにそれらの診断使用および治療使用
CA2927332A1 (en) 2013-10-22 2015-04-30 Ramot At Tel-Aviv University Ltd. Method and system for sensing
US10667750B2 (en) 2015-12-09 2020-06-02 Ramot At Tel-Aviv University Ltd. Method and system for sensing by modified nanostructure

Also Published As

Publication number Publication date
WO2015059704A1 (en) 2015-04-30
HK1225414B (en) 2017-09-08
CA2927332A1 (en) 2015-04-30
EP3060675A1 (en) 2016-08-31
SG11201602976XA (en) 2016-05-30
US10274456B2 (en) 2019-04-30
US20190234900A1 (en) 2019-08-01
US20160258899A1 (en) 2016-09-08
KR20160072258A (ko) 2016-06-22
JP2016535988A (ja) 2016-11-24
CN106164286A (zh) 2016-11-23
MX2016005273A (es) 2017-01-05
EP3060675B1 (en) 2019-01-30
AU2014338510A1 (en) 2016-06-09

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