JP6603474B2 - 癌治療 - Google Patents

癌治療 Download PDF

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Publication number
JP6603474B2
JP6603474B2 JP2015087291A JP2015087291A JP6603474B2 JP 6603474 B2 JP6603474 B2 JP 6603474B2 JP 2015087291 A JP2015087291 A JP 2015087291A JP 2015087291 A JP2015087291 A JP 2015087291A JP 6603474 B2 JP6603474 B2 JP 6603474B2
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cells
tumor
axitinib
positive
treatment
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Japanese (ja)
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JP2015210268A (ja
JP2015210268A5 (fr
Inventor
アンドレ マーティニ ジーン―フランソア
クリスト タラツィ ジャマル
アンドリュー ウリアムズ ジェームス
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ファイザー・インク
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Mycology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2015087291A 2014-04-24 2015-04-22 癌治療 Expired - Fee Related JP6603474B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461983951P 2014-04-24 2014-04-24
US61/983,951 2014-04-24

Publications (3)

Publication Number Publication Date
JP2015210268A JP2015210268A (ja) 2015-11-24
JP2015210268A5 JP2015210268A5 (fr) 2018-05-31
JP6603474B2 true JP6603474B2 (ja) 2019-11-06

Family

ID=53398149

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015087291A Expired - Fee Related JP6603474B2 (ja) 2014-04-24 2015-04-22 癌治療

Country Status (24)

Country Link
US (2) US20170184602A1 (fr)
EP (1) EP3134119B1 (fr)
JP (1) JP6603474B2 (fr)
KR (1) KR101943177B1 (fr)
CN (1) CN106233143B (fr)
AR (1) AR100169A1 (fr)
AU (3) AU2015249513A1 (fr)
BR (1) BR112016024143A2 (fr)
CA (1) CA2946362C (fr)
CY (1) CY1120731T1 (fr)
DK (1) DK3134119T3 (fr)
ES (1) ES2691213T3 (fr)
HK (1) HK1231561A1 (fr)
HU (1) HUE040167T2 (fr)
IL (1) IL247859B (fr)
MX (1) MX2016013910A (fr)
PL (1) PL3134119T3 (fr)
PT (1) PT3134119T (fr)
RU (1) RU2651469C1 (fr)
SG (1) SG11201607918TA (fr)
SI (1) SI3134119T1 (fr)
TR (1) TR201815682T4 (fr)
TW (1) TWI568439B (fr)
WO (1) WO2015162532A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6945199B2 (ja) 2017-05-19 2021-10-06 国立大学法人山口大学 アキシチニブの薬物動態判定方法及びアキシチニブの薬物動態に基づくアキシチニブによる治療効果予測方法
JP2021532084A (ja) 2018-07-12 2021-11-25 コーバス・ファーマシューティカルズ・インコーポレイテッド アデノシン経路活性化を有する癌を検出および治療するための方法
CA3106038A1 (fr) * 2018-07-12 2020-01-16 Corvus Pharmaceuticals, Inc. Procedes de detection et de traitement de cancers presentant une activation de la voie de l'adenosine
US10586164B1 (en) 2018-10-15 2020-03-10 AIble Inc. Interface for visualizing and improving model performance
US10936768B2 (en) * 2018-10-15 2021-03-02 Aible, Inc. Interface for visualizing and improving model performance
US20220390456A1 (en) * 2019-10-17 2022-12-08 Board Of Regents, The University Of Texas System Small extracellular vesicle-associated vegf as a predictor for therapeutic responses
WO2023217886A1 (fr) * 2022-05-11 2023-11-16 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Utilisation de la protéine rep bmmf1 en tant que marqueur diagnostique pour le cancer du pancréas et le diabète sucré de type 2
AU2023267942A1 (en) * 2022-05-11 2024-12-19 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Use of bmmf1 rep protein as diagnostic marker for lung cancer
WO2024026407A1 (fr) * 2022-07-28 2024-02-01 The Board Of Regents Of The University Of Oklahoma Biomarqueurs, méthodes de diagnostic, traitements et agents thérapeutiques pour maladies et troubles auto-immuns

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1678327A4 (fr) 2003-10-16 2007-10-10 Genomic Health Inc Systeme d'essai qrt-pcr pour le profilage d'expression genetique
CA2848463A1 (fr) * 2004-04-09 2005-10-27 Genomic Health, Inc. Marqueurs d'expression genique permettant de predire la reponse a la chimiotherapie
US8383357B2 (en) * 2005-03-16 2013-02-26 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors
KR20080073711A (ko) * 2005-10-21 2008-08-11 바이엘 헬스케어 엘엘씨 암의 예측 및 예후 방법, 및 암 치료 모니터링 방법
WO2007067500A2 (fr) * 2005-12-05 2007-06-14 Genomic Health, Inc. Predicteurs de la reponse d'un patient a un traitement avec des inhibiteurs d'egfr
MX2009001070A (es) * 2006-07-28 2009-04-23 Novartis Ag Uso de proteina con actividad inhibidora de melanoma (mia) como un indicador temprano para la respuesta terapeutica en melanoma.
US8338433B2 (en) * 2006-11-22 2012-12-25 University Of Georgia Research Foundation, Inc. Tyrosine kinase inhibitors as anti-kinetoplastid agents
SG177571A1 (en) * 2009-07-08 2012-03-29 Worldwide Innovative Network Method for predicting efficacy of drugs in a patient
EP2478114B1 (fr) * 2009-09-17 2014-12-17 F.Hoffmann-La Roche Ag Méthodes pour le diagnostic du cancer du poumon
US7736861B1 (en) * 2009-10-19 2010-06-15 Aveo Pharmaceuticals, Inc. Tivozanib response prediction
WO2012052757A1 (fr) * 2010-10-20 2012-04-26 Astrazeneca Ab Procédé de sélection de patients selon leur phénotype tumoral
WO2012068487A1 (fr) * 2010-11-18 2012-05-24 Synta Pharmaceuticals Corp. Présélection de patients pour un traitement thérapeutique fondé sur un état hypoxique, avec des agents sensibles à l'oxygène
US9046534B2 (en) * 2011-10-04 2015-06-02 Invivis Pharmaceuticals Inc. Methods and systems for identifying and treating anti-progestin sensitive tumors
WO2013106765A1 (fr) 2012-01-13 2013-07-18 Genentech, Inc. Marqueurs biologiques servant à identifier des patients pour un traitement avec des antagonistes du vegf

Also Published As

Publication number Publication date
IL247859B (en) 2020-07-30
CN106233143B (zh) 2020-01-21
TW201545747A (zh) 2015-12-16
CA2946362A1 (fr) 2015-10-29
PL3134119T3 (pl) 2018-12-31
CN106233143A (zh) 2016-12-14
BR112016024143A2 (pt) 2017-08-15
EP3134119A1 (fr) 2017-03-01
WO2015162532A1 (fr) 2015-10-29
EP3134119B1 (fr) 2018-08-22
CY1120731T1 (el) 2019-12-11
ES2691213T3 (es) 2018-11-26
CA2946362C (fr) 2019-03-12
TWI568439B (zh) 2017-02-01
DK3134119T3 (en) 2018-10-22
AU2015249513A1 (en) 2016-10-06
SI3134119T1 (sl) 2018-11-30
SG11201607918TA (en) 2016-11-29
IL247859A0 (en) 2016-11-30
US20190331687A1 (en) 2019-10-31
HUE040167T2 (hu) 2019-02-28
AR100169A1 (es) 2016-09-14
US20170184602A1 (en) 2017-06-29
KR20160134817A (ko) 2016-11-23
PT3134119T (pt) 2018-11-07
AU2020200237A1 (en) 2020-02-06
JP2015210268A (ja) 2015-11-24
MX2016013910A (es) 2017-01-11
TR201815682T4 (tr) 2018-11-21
AU2018203086A1 (en) 2018-05-24
HK1231561A1 (zh) 2017-12-22
RU2651469C1 (ru) 2018-04-19
KR101943177B1 (ko) 2019-01-28

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