JP6599338B2 - Hbv感染および関連症状の治療のための免疫エフェクター細胞表面抗原およびhbv抗原結合性の二重特異性または多重特異性ポリペプチド - Google Patents

Hbv感染および関連症状の治療のための免疫エフェクター細胞表面抗原およびhbv抗原結合性の二重特異性または多重特異性ポリペプチド Download PDF

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JP6599338B2
JP6599338B2 JP2016542337A JP2016542337A JP6599338B2 JP 6599338 B2 JP6599338 B2 JP 6599338B2 JP 2016542337 A JP2016542337 A JP 2016542337A JP 2016542337 A JP2016542337 A JP 2016542337A JP 6599338 B2 JP6599338 B2 JP 6599338B2
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polypeptide
cells
hbv
antigen
bispecific
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ウルリケ プロッツェル
フェリックス ボーネ
フランク モンブルク
ゲルハルト モルデンハウアー
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Deutsches Krebsforschungszentrum DKFZ
Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt GmbH
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JP2016542337A 2013-09-16 2014-09-16 Hbv感染および関連症状の治療のための免疫エフェクター細胞表面抗原およびhbv抗原結合性の二重特異性または多重特異性ポリペプチド Active JP6599338B2 (ja)

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EP13184635.4 2013-09-16
EP13184635 2013-09-16
PCT/EP2014/069675 WO2015036606A1 (en) 2013-09-16 2014-09-16 Bi- or multispecific polypeptides binding immune effector cell surface antigens and hbv antigens for treating hbv infections and associated conditions

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JP2016530889A JP2016530889A (ja) 2016-10-06
JP2016530889A5 JP2016530889A5 (cg-RX-API-DMAC7.html) 2019-04-11
JP6599338B2 true JP6599338B2 (ja) 2019-10-30

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Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2747011C (en) 2008-12-18 2018-06-19 Dana-Farber Cancer Institute, Inc. Nkg2d-fc for immunotherapy
US10059767B2 (en) 2013-09-16 2018-08-28 Helmholtz Zentrum München—Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Means and methods for treating HBV infection and associated conditions
EP3271387B1 (en) * 2015-03-16 2023-12-06 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Trispecific binding molecules for treating hbv infection and associated conditions
CN106349391A (zh) * 2015-07-17 2017-01-25 中国科学院深圳先进技术研究院 Hbv特异性双靶向抗体及其制备方法和应用、含该双靶向抗体表达盒的微环dna及应用
JP7037480B2 (ja) * 2015-11-13 2022-03-16 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド がんの免疫療法のためのnkg2d-ig融合タンパク質
CN105505872B (zh) * 2016-02-16 2019-01-15 广州赛莱拉干细胞科技股份有限公司 一种致敏nk细胞的方法及组合物
CN107129537A (zh) * 2016-02-29 2017-09-05 北京赛诺泰生物科技有限公司 抗乙型肝炎病毒的免疫反应性细胞
WO2018064611A1 (en) * 2016-09-30 2018-04-05 Baylor College Of Medicine Antibody based gene therapy with tissue-directed expression
US11219646B2 (en) * 2016-09-30 2022-01-11 Baylor College Of Medicine Chimeric antigen receptor therapy with reduced cytotoxicity for viral disease
KR20250089564A (ko) 2017-02-08 2025-06-18 드래곤플라이 쎄라퓨틱스, 인크. 천연 킬러 세포의 활성화를 위한 다중-특이적 결합 단백질 및 암 치료에서의 그의 치료적 용도
KR20190120782A (ko) 2017-02-20 2019-10-24 드래곤플라이 쎄라퓨틱스, 인크. Her2, nkg2d 및 cd16에 결합하는 단백질
PE20210375A1 (es) 2018-02-08 2021-03-02 Dragonfly Therapeutics Inc Terapia de combinacion del cancer que incluye proteinas de union multiespecificas que activan a las celulas asesinas naturales
CA3090244A1 (en) 2018-02-08 2019-08-15 Dragonfly Therapeutics, Inc. Antibody variable domains targeting the nkg2d receptor
CN112119093A (zh) 2018-02-20 2020-12-22 蜻蜓治疗公司 结合cd33、nkg2d和cd16的多特异性结合蛋白和使用方法
EA202091888A1 (ru) 2018-08-08 2020-10-23 Драгонфлай Терапьютикс, Инк. Вариабельные домены антител, нацеленные на рецептор nkg2d
CA3108427A1 (en) 2018-08-08 2020-02-13 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use
BR112021002276A2 (pt) 2018-08-08 2021-05-04 Dragonfly Therapeutics, Inc. proteínas de ligação a nkg2d, cd16 e um antígeno associado ao tumor
CN109265559B (zh) * 2018-09-25 2021-12-07 山东兴瑞生物科技有限公司 嵌合抗原受体、其制备方法、利用其修饰的nk细胞及治疗hbv感染的应用
SG11202105948TA (en) * 2018-12-19 2021-07-29 Regeneron Pharma Bispecific anti-muc16 x anti-cd28 antibodies and uses thereof
GB201904328D0 (en) * 2019-03-28 2019-05-15 Immunocore Ltd Specific binding molecules
KR102503349B1 (ko) 2019-05-14 2023-02-23 프로벤션 바이오, 인코포레이티드 제1형 당뇨병을 예방하기 위한 방법 및 조성물
US12157771B2 (en) 2020-05-06 2024-12-03 Dragonfly Therapeutics, Inc. Proteins binding NKG2D, CD16 and CLEC12A
WO2021252917A2 (en) 2020-06-11 2021-12-16 Provention Bio, Inc. Methods and compositions for preventing type 1 diabetes
WO2022081529A1 (en) * 2020-10-12 2022-04-21 Greffex, Inc. Antibody constructs to target t cell responses to sars-cov protein expressing cells, their design and uses
CN112592902B (zh) * 2020-12-16 2022-03-29 熊猫乳品集团股份有限公司 一种生物活性肽aseppvldvkrpflc及其制备方法和应用
WO2022187539A1 (en) 2021-03-03 2022-09-09 Dragonfly Therapeutics, Inc. Methods of treating cancer using multi-specific binding proteins that bind nkg2d, cd16 and a tumor-associated antigen
CN114573705B (zh) * 2022-03-17 2024-05-14 杭州师范大学 特异性启动抗乙型肝炎病毒t细胞免疫的双特异性抗体及其应用
KR20250042205A (ko) * 2022-06-27 2025-03-26 에스씨지 셀 테라피 피티이. 리미티드 HBV 표면 항원 (HBsAg) 및 CD3에 대한 이중 특이적 항체 및 이의 용도

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8928874D0 (en) * 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
EP1311530A4 (en) * 2000-08-03 2004-10-06 Wim-Van Schooten PRODUCTION OF HUMANIZED ANTIBODIES IN TRANSGENIC ANIMALS
CN1294148C (zh) 2001-04-11 2007-01-10 中国科学院遗传与发育生物学研究所 环状单链三特异抗体
FR2844513B1 (fr) * 2002-09-13 2007-08-03 Lab Francais Du Fractionnement Anticorps pour adcc et induisant la production de cytokines.
US7534604B2 (en) * 2004-01-16 2009-05-19 Regeneron Pharmaceuticals, Inc. Fusion polypeptides capable of activating receptors
CN100376599C (zh) 2004-04-01 2008-03-26 北京安波特基因工程技术有限公司 基因工程重组抗cea抗cd3抗cd28线性单链三特异抗体
PT2520590T (pt) * 2007-04-03 2018-11-14 Amgen Res Munich Gmbh Domínio de ligação específico de espécies cruzadas
RS53008B2 (sr) * 2007-04-03 2022-12-30 Amgen Res Munich Gmbh Interspecijski specifičan cd3-epsilon vezujući domen
WO2011057124A1 (en) * 2009-11-06 2011-05-12 Transtarget, Inc. Polyclonal bispecific antibody compositions and method of use
WO2012156430A1 (en) * 2011-05-17 2012-11-22 Trion Research Gmbh Vaccine preparation containing trifunctional antibodies with antigen immunogenicity enhancer properties
EP2524699A1 (en) * 2011-05-17 2012-11-21 Trion Research GmbH Vaccine preparation containing trifunctional antibodies with antigen immunogenicity enhancer properties
EP2797629A4 (en) * 2011-12-28 2015-09-30 Novelmed Therapeutics Inc AGLYCOSYLATED HUMAN ANTIBODY AND FUSION PROTEIN AND USES THEREOF
US10059767B2 (en) 2013-09-16 2018-08-28 Helmholtz Zentrum München—Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Means and methods for treating HBV infection and associated conditions

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JP2016530889A (ja) 2016-10-06
CA2924252A1 (en) 2015-03-19
RU2016114504A3 (cg-RX-API-DMAC7.html) 2018-04-25
US20180362649A1 (en) 2018-12-20
US20160200798A1 (en) 2016-07-14
CN105636982B (zh) 2020-06-23
US10059767B2 (en) 2018-08-28
RU2671089C2 (ru) 2018-10-29
CA2924252C (en) 2022-01-04
CN105636982A (zh) 2016-06-01
CN111606998B (zh) 2024-05-24
EP3046938A1 (en) 2016-07-27
EP3046938B1 (en) 2019-12-04
CN111606998A (zh) 2020-09-01
WO2015036606A1 (en) 2015-03-19

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