JP6591429B2 - マラリアの治療のための化合物及び方法 - Google Patents

マラリアの治療のための化合物及び方法 Download PDF

Info

Publication number
JP6591429B2
JP6591429B2 JP2016553266A JP2016553266A JP6591429B2 JP 6591429 B2 JP6591429 B2 JP 6591429B2 JP 2016553266 A JP2016553266 A JP 2016553266A JP 2016553266 A JP2016553266 A JP 2016553266A JP 6591429 B2 JP6591429 B2 JP 6591429B2
Authority
JP
Japan
Prior art keywords
compound
malaria
compounds
alkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016553266A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017502080A5 (https=
JP2017502080A (ja
Inventor
イーモン コマー、
イーモン コマー、
ノブタカ カトウ、
ノブタカ カトウ、
クリスティーナ シェレール、
クリスティーナ シェレール、
ジェシカ バスティアン、
ジェシカ バスティアン、
ジェレミー デュバル、
ジェレミー デュバル、
ティモシー ルイス、
ティモシー ルイス、
モルガン セイズ、
モルガン セイズ、
マシュー ライティー、
マシュー ライティー、
ジュン プ、
ジュン プ、
ジェニファー ボードイン、
ジェニファー ボードイン、
バートランド ブレバン、
バートランド ブレバン、
ベニト ムニョス、
ベニト ムニョス、
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Broad Institute Inc
Original Assignee
Broad Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Broad Institute Inc filed Critical Broad Institute Inc
Publication of JP2017502080A publication Critical patent/JP2017502080A/ja
Publication of JP2017502080A5 publication Critical patent/JP2017502080A5/ja
Application granted granted Critical
Publication of JP6591429B2 publication Critical patent/JP6591429B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2016553266A 2013-11-11 2014-11-11 マラリアの治療のための化合物及び方法 Active JP6591429B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361902356P 2013-11-11 2013-11-11
US61/902,356 2013-11-11
PCT/US2014/064962 WO2015070204A1 (en) 2013-11-11 2014-11-11 Compounds and methods for the treatment of malaria

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019169028A Division JP7044392B2 (ja) 2013-11-11 2019-09-18 マラリアの治療のための化合物及び方法

Publications (3)

Publication Number Publication Date
JP2017502080A JP2017502080A (ja) 2017-01-19
JP2017502080A5 JP2017502080A5 (https=) 2017-12-21
JP6591429B2 true JP6591429B2 (ja) 2019-10-16

Family

ID=53042227

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016553266A Active JP6591429B2 (ja) 2013-11-11 2014-11-11 マラリアの治療のための化合物及び方法
JP2019169028A Active JP7044392B2 (ja) 2013-11-11 2019-09-18 マラリアの治療のための化合物及び方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2019169028A Active JP7044392B2 (ja) 2013-11-11 2019-09-18 マラリアの治療のための化合物及び方法

Country Status (4)

Country Link
US (3) US10059711B2 (https=)
EP (1) EP3068387A4 (https=)
JP (2) JP6591429B2 (https=)
WO (1) WO2015070204A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020023504A (ja) * 2013-11-11 2020-02-13 ザ・ブロード・インスティテュート・インコーポレイテッド マラリアの治療のための化合物及び方法

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016172631A2 (en) * 2015-04-24 2016-10-27 President And Fellows Of Harvard College Substrate selective inhibitors of insulin-degrading enzyme (ide) and uses thereof
US11406694B2 (en) 2016-09-16 2022-08-09 Griffith University Vaccine comprising drug and parasite administration
US10064119B2 (en) 2016-12-27 2018-08-28 Google Llc Attenuation device in transmitter system
SG11201908691PA (en) * 2017-03-20 2019-10-30 Broad Inst Inc Compounds and methods for the treatment of parasitic diseases
US12600727B2 (en) 2018-09-18 2026-04-14 Washington University Treatment of infections of toxoplasma gondii and closely related parasites
US12421246B2 (en) 2019-01-09 2025-09-23 Eisai R&D Management Co., Ltd. Method for synthesis of diazabicyclo[6.2.0]decane related compounds
US12414935B2 (en) * 2019-04-23 2025-09-16 Washington University Compounds and methods for the treatment of parasitic diseases
US20230009323A1 (en) * 2019-10-25 2023-01-12 The Broad Institute, Inc. Compounds and methods for the treatment of cryptosporidiosis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3176017A (en) 1963-02-26 1965-03-30 American Home Prod Aroylalkyl derivatives of diazabicyclo-nonanes and-decanes
WO2015070204A1 (en) * 2013-11-11 2015-05-14 The Broad Institute, Inc. Compounds and methods for the treatment of malaria
WO2016172631A2 (en) * 2015-04-24 2016-10-27 President And Fellows Of Harvard College Substrate selective inhibitors of insulin-degrading enzyme (ide) and uses thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020023504A (ja) * 2013-11-11 2020-02-13 ザ・ブロード・インスティテュート・インコーポレイテッド マラリアの治療のための化合物及び方法
JP7044392B2 (ja) 2013-11-11 2022-03-30 ザ・ブロード・インスティテュート・インコーポレイテッド マラリアの治療のための化合物及び方法
US11325913B2 (en) 2013-11-11 2022-05-10 The Broad Institute, Inc. Compounds and methods for the treatment of malaria

Also Published As

Publication number Publication date
JP7044392B2 (ja) 2022-03-30
US11325913B2 (en) 2022-05-10
US10059711B2 (en) 2018-08-28
US10738055B2 (en) 2020-08-11
US20200399276A1 (en) 2020-12-24
JP2017502080A (ja) 2017-01-19
EP3068387A1 (en) 2016-09-21
WO2015070204A1 (en) 2015-05-14
JP2020023504A (ja) 2020-02-13
EP3068387A4 (en) 2017-04-19
US20190055252A1 (en) 2019-02-21
US20160289235A1 (en) 2016-10-06

Similar Documents

Publication Publication Date Title
JP6591429B2 (ja) マラリアの治療のための化合物及び方法
JP2020023504A6 (ja) マラリアの治療のための化合物及び方法
AU2016215431B2 (en) 3-aryl-4-amido-bicyclic (4,5,0) hydroxamic acids as HDAC inhibitors
CN111848615B (zh) 吡啶酮衍生物及包含其的抗流感病毒药物组合物
US11866441B2 (en) Compounds and methods for the treatment of parasitic diseases
CA2803920A1 (en) Derivatives of cycloalkyl- and cycloalkenyl-1,2-dicarboxylic acid compounds having formyl peptide receptor like-1 (fprl-1) agonist or antagonist activity
US9266842B2 (en) Anti-malarial agents
JP2023513373A (ja) Ｐ２ｘ３修飾薬
US9428507B2 (en) Compounds for the treatment of malaria
US20220331299A1 (en) Substituted 2-azabicyclo[3.1.1]heptane and 2-azabicyclo[3.2.1]octane derivatives as orexin receptor antagonists
CN109134481B (zh) 一种取代吡咯色原酮类化合物或其药学上可接受的盐及其制备方法和应用
ES2204171T3 (es) Derivados de furopiridina y su utilizacion terapeutica.
WO2023003862A1 (en) Cxcr4 modulators and uses related thereto
RU2793122C2 (ru) Соединения и способы лечения паразитарных заболеваний
AU2007260298A1 (en) Pyrrolidine compounds as renin inhibitors
CA2653524A1 (en) Pyrrolidine derivatives useful against diseases that depends on activity of renin
HK40015340B (en) Compounds and methods for the treatment of parasitic diseases
HK40015340A (en) Compounds and methods for the treatment of parasitic diseases
BR112019019494B1 (pt) Compostos, composições farmacêuticas e usos para o tratamento de doenças parasitárias
HK1202859B (en) Anti -malarial agents

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20161209

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20171110

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20171110

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20180803

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180904

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20181204

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190129

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190219

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20190517

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190808

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20190820

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20190918

R150 Certificate of patent or registration of utility model

Ref document number: 6591429

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250