JP6588962B2 - 神経疾患を治療するための方法 - Google Patents
神経疾患を治療するための方法 Download PDFInfo
- Publication number
- JP6588962B2 JP6588962B2 JP2017501145A JP2017501145A JP6588962B2 JP 6588962 B2 JP6588962 B2 JP 6588962B2 JP 2017501145 A JP2017501145 A JP 2017501145A JP 2017501145 A JP2017501145 A JP 2017501145A JP 6588962 B2 JP6588962 B2 JP 6588962B2
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- Prior art keywords
- compound
- formula
- acid
- apoe4
- disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/20—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/70—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mental therapies, e.g. psychological therapy or autogenous training
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
- G16H40/20—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- General Engineering & Computer Science (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461968595P | 2014-03-21 | 2014-03-21 | |
| US61/968,595 | 2014-03-21 | ||
| PCT/US2015/022058 WO2015143447A2 (en) | 2014-03-21 | 2015-03-23 | Methods for treating neurological disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019012873A Division JP2019065044A (ja) | 2014-03-21 | 2019-01-29 | 神経疾患を治療するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017511377A JP2017511377A (ja) | 2017-04-20 |
| JP2017511377A5 JP2017511377A5 (enExample) | 2018-03-29 |
| JP6588962B2 true JP6588962B2 (ja) | 2019-10-09 |
Family
ID=54145492
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017501145A Active JP6588962B2 (ja) | 2014-03-21 | 2015-03-23 | 神経疾患を治療するための方法 |
| JP2019012873A Withdrawn JP2019065044A (ja) | 2014-03-21 | 2019-01-29 | 神経疾患を治療するための方法 |
| JP2020066670A Withdrawn JP2020109123A (ja) | 2014-03-21 | 2020-04-02 | 神経疾患を治療するための方法 |
| JP2022131705A Pending JP2022159555A (ja) | 2014-03-21 | 2022-08-22 | 神経疾患を治療するための方法 |
| JP2024205572A Pending JP2025022992A (ja) | 2014-03-21 | 2024-11-26 | 神経疾患を治療するための方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019012873A Withdrawn JP2019065044A (ja) | 2014-03-21 | 2019-01-29 | 神経疾患を治療するための方法 |
| JP2020066670A Withdrawn JP2020109123A (ja) | 2014-03-21 | 2020-04-02 | 神経疾患を治療するための方法 |
| JP2022131705A Pending JP2022159555A (ja) | 2014-03-21 | 2022-08-22 | 神経疾患を治療するための方法 |
| JP2024205572A Pending JP2025022992A (ja) | 2014-03-21 | 2024-11-26 | 神経疾患を治療するための方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US10471029B2 (enExample) |
| EP (2) | EP3119911B1 (enExample) |
| JP (5) | JP6588962B2 (enExample) |
| KR (2) | KR102448386B1 (enExample) |
| CN (1) | CN106170563A (enExample) |
| AU (1) | AU2015230972B2 (enExample) |
| CA (1) | CA2941415A1 (enExample) |
| DK (1) | DK3119911T3 (enExample) |
| ES (1) | ES2960625T3 (enExample) |
| FI (1) | FI3119911T3 (enExample) |
| HR (1) | HRP20231172T1 (enExample) |
| HU (1) | HUE063369T2 (enExample) |
| LT (1) | LT3119911T (enExample) |
| PL (1) | PL3119911T3 (enExample) |
| PT (1) | PT3119911T (enExample) |
| RS (1) | RS64744B1 (enExample) |
| SI (1) | SI3119911T1 (enExample) |
| SM (1) | SMT202300369T1 (enExample) |
| WO (1) | WO2015143447A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD3347002T2 (ro) | 2015-09-10 | 2023-10-31 | Alzheon Inc | Tratamentul bolii Alzheimer într-o populație specifică de pacienți |
| WO2018012596A1 (ja) * | 2016-07-13 | 2018-01-18 | 株式会社マイトス | 水素を有効成分として含む軽度認知障害又は認知症の予防又は治療用組成物 |
| CN108623501B (zh) | 2017-03-21 | 2022-04-19 | 润佳(苏州)医药科技有限公司 | 同位素富集的3-氨基-1-丙磺酸衍生物及其用途 |
| CN110003058B (zh) | 2018-01-04 | 2022-01-25 | 润佳(苏州)医药科技有限公司 | 3-((l-缬氨酰基)氨基)-3,3-二氘-1-丙磺酸晶型、制备方法及用途 |
| CN110668980A (zh) * | 2018-07-03 | 2020-01-10 | 浙江京新药业股份有限公司 | 一种2-取代的高牛磺酸衍生物 |
| WO2020028290A1 (en) * | 2018-08-01 | 2020-02-06 | Alzheon, Inc. | Methods for treating neurodegenerative disorders |
| IL316611A (en) | 2018-08-01 | 2024-12-01 | Alzheon Inc | Sulfopropanoic acid derivatives for treating neurodegenerative disorders |
| CN111170901A (zh) * | 2018-11-13 | 2020-05-19 | 润佳(苏州)医药科技有限公司 | 3-((l-缬氨酰基)氨基)-1-丙磺酸晶型、制备方法及其用途 |
| PH12021553196A1 (en) | 2019-06-17 | 2022-11-07 | Alzheon Inc | Methods for treating neurodegenerative disorders |
| CN116059192B (zh) | 2019-11-13 | 2024-10-29 | 润佳(苏州)医药科技有限公司 | 同位素富集的3-氨基-1-丙磺酸及其衍生物的用途 |
| EP4514335A1 (en) | 2022-04-28 | 2025-03-05 | Alzheon, Inc. | Tramiprosate for treating apoe4-related diseases |
| CN120641092A (zh) | 2022-12-02 | 2025-09-12 | 阿尔泽恩股份有限公司 | 用于用曲米沙特治疗神经变性病症的方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| KR100279898B1 (ko) * | 1992-10-13 | 2001-04-02 | 로버트 엘. 타버 | 알쯔하이머 질환의 검출방법 |
| US20050031651A1 (en) | 2002-12-24 | 2005-02-10 | Francine Gervais | Therapeutic formulations for the treatment of beta-amyloid related diseases |
| US20060079578A1 (en) * | 2003-06-23 | 2006-04-13 | Julie Laurin | Pharmaceutical formulations of amyloid inhibiting compounds |
| US20070010573A1 (en) * | 2003-06-23 | 2007-01-11 | Xianqi Kong | Methods and compositions for treating amyloid-related diseases |
| US20050142191A1 (en) | 2003-06-23 | 2005-06-30 | Neurochem (International) Limited | Pharmaceutical formulations of amyloid inhibiting compounds |
| WO2005060393A2 (en) | 2003-08-11 | 2005-07-07 | California Institute Of Technology | Microfluidic large scale integration |
| CA2666246C (en) | 2006-10-12 | 2013-12-31 | Bellus Health (International) Limited | Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid |
| WO2008061795A2 (en) | 2006-11-24 | 2008-05-29 | Ac Immune Sa | N- (methyl) -1h- pyrazol- 3 -amine, n- (methyl) -pyridin-2-amine and n- (methyl) -thiaz0l-2-amine derivatives for the treatment of diseases associated with amyloid or amyloid-like proteins, like e.g. alzheimer's |
| US20120009125A1 (en) * | 2010-07-06 | 2012-01-12 | Lombard Jay L | Apoe4 and apoj biomarker-based prevention and treatment of dementia |
| US10449177B2 (en) | 2010-08-19 | 2019-10-22 | Buck Institute For Research On Aging | Methods of treating mild cognitive impairment (MCI) and related disorders |
| DK2994160T3 (da) | 2013-05-06 | 2019-08-12 | Baxalta Inc | Behandling af alzheimers sygdom subpopulationer med poolet immunoglobulin g |
| JP6685912B2 (ja) * | 2014-02-08 | 2020-04-22 | ジェネンテック, インコーポレイテッド | アルツハイマー病治療方法 |
| MD3347002T2 (ro) | 2015-09-10 | 2023-10-31 | Alzheon Inc | Tratamentul bolii Alzheimer într-o populație specifică de pacienți |
| US20180250249A1 (en) | 2016-02-02 | 2018-09-06 | Alzheon, Inc. | Methods of treating neurodegenerative disorders in a particular population |
-
2015
- 2015-03-23 CA CA2941415A patent/CA2941415A1/en active Pending
- 2015-03-23 ES ES15764560T patent/ES2960625T3/es active Active
- 2015-03-23 FI FIEP15764560.7T patent/FI3119911T3/fi active
- 2015-03-23 JP JP2017501145A patent/JP6588962B2/ja active Active
- 2015-03-23 PL PL15764560.7T patent/PL3119911T3/pl unknown
- 2015-03-23 HU HUE15764560A patent/HUE063369T2/hu unknown
- 2015-03-23 KR KR1020167027090A patent/KR102448386B1/ko active Active
- 2015-03-23 US US15/127,565 patent/US10471029B2/en active Active
- 2015-03-23 LT LTEPPCT/US2015/022058T patent/LT3119911T/lt unknown
- 2015-03-23 SI SI201531967T patent/SI3119911T1/sl unknown
- 2015-03-23 CN CN201580015086.8A patent/CN106170563A/zh active Pending
- 2015-03-23 DK DK15764560.7T patent/DK3119911T3/da active
- 2015-03-23 WO PCT/US2015/022058 patent/WO2015143447A2/en not_active Ceased
- 2015-03-23 EP EP15764560.7A patent/EP3119911B1/en active Active
- 2015-03-23 SM SM20230369T patent/SMT202300369T1/it unknown
- 2015-03-23 KR KR1020227033161A patent/KR102645633B1/ko active Active
- 2015-03-23 EP EP23189240.7A patent/EP4289820A3/en active Pending
- 2015-03-23 RS RS20230993A patent/RS64744B1/sr unknown
- 2015-03-23 AU AU2015230972A patent/AU2015230972B2/en active Active
- 2015-03-23 PT PT157645607T patent/PT3119911T/pt unknown
- 2015-03-23 HR HRP20231172TT patent/HRP20231172T1/hr unknown
-
2019
- 2019-01-29 JP JP2019012873A patent/JP2019065044A/ja not_active Withdrawn
- 2019-09-13 US US16/570,487 patent/US20200101031A1/en not_active Abandoned
-
2020
- 2020-04-02 JP JP2020066670A patent/JP2020109123A/ja not_active Withdrawn
-
2022
- 2022-07-29 US US17/877,380 patent/US20230087041A1/en active Pending
- 2022-08-22 JP JP2022131705A patent/JP2022159555A/ja active Pending
-
2024
- 2024-11-26 JP JP2024205572A patent/JP2025022992A/ja active Pending
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