JP6564873B2 - リポソーム組成物およびその製造方法 - Google Patents

リポソーム組成物およびその製造方法 Download PDF

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Publication number
JP6564873B2
JP6564873B2 JP2017548770A JP2017548770A JP6564873B2 JP 6564873 B2 JP6564873 B2 JP 6564873B2 JP 2017548770 A JP2017548770 A JP 2017548770A JP 2017548770 A JP2017548770 A JP 2017548770A JP 6564873 B2 JP6564873 B2 JP 6564873B2
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liposome
lipid
nucleic acid
anticancer agent
acid analog
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JP2017548770A
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Japanese (ja)
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JPWO2017078009A1 (ja
Inventor
貴宏 関口
貴宏 関口
幹永 森
幹永 森
健太郎 沼尻
健太郎 沼尻
弘行 北岡
弘行 北岡
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Fujifilm Corp
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Fujifilm Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2017548770A 2015-11-02 2016-11-01 リポソーム組成物およびその製造方法 Active JP6564873B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2015215767 2015-11-02
JP2015215767 2015-11-02
PCT/JP2016/082417 WO2017078009A1 (fr) 2015-11-02 2016-11-01 Composition liposomale et son procédé de production

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019139019A Division JP6705933B2 (ja) 2015-11-02 2019-07-29 リポソーム組成物およびその製造方法

Publications (2)

Publication Number Publication Date
JPWO2017078009A1 JPWO2017078009A1 (ja) 2018-08-09
JP6564873B2 true JP6564873B2 (ja) 2019-08-21

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ID=58662894

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JP2017548770A Active JP6564873B2 (ja) 2015-11-02 2016-11-01 リポソーム組成物およびその製造方法
JP2019139019A Active JP6705933B2 (ja) 2015-11-02 2019-07-29 リポソーム組成物およびその製造方法

Family Applications After (1)

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JP2019139019A Active JP6705933B2 (ja) 2015-11-02 2019-07-29 リポソーム組成物およびその製造方法

Country Status (5)

Country Link
US (2) US20180243215A1 (fr)
EP (1) EP3372223B1 (fr)
JP (2) JP6564873B2 (fr)
MA (1) MA43184A (fr)
WO (1) WO2017078009A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3138555T (pt) 2014-04-30 2020-12-15 Fujifilm Corp Composição lipossómica e método de produção da mesma
EP4129304A4 (fr) 2020-04-03 2023-06-07 FUJIFILM Corporation Agent antitumoral

Family Cites Families (35)

* Cited by examiner, † Cited by third party
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US2566559A (en) * 1951-09-04 Preparation of agetals
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US5153000A (en) * 1988-11-22 1992-10-06 Kao Corporation Phosphate, liposome comprising the phosphate as membrane constituent, and cosmetic and liposome preparation comprising the liposome
US5049392A (en) * 1989-01-18 1991-09-17 The Liposome Company, Inc. Osmotically dependent vesicles
IS1685B (is) * 1990-12-11 1998-02-24 Bracco International B.V. Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum
US5993850A (en) * 1994-09-13 1999-11-30 Skyepharma Inc. Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances
EP0825852B1 (fr) * 1995-04-18 2004-07-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Procede de chargement de medicaments dans des liposomes et composition
DE19813773A1 (de) 1998-03-27 1999-09-30 Clemens Unger Verfahren zur Herstellung von liposomalen Wirkstoffformulierungen
US6726925B1 (en) * 1998-06-18 2004-04-27 Duke University Temperature-sensitive liposomal formulation
JP2000302685A (ja) * 1999-02-18 2000-10-31 Sankyo Co Ltd 抗腫瘍薬含有リポソーム製剤
US6727475B2 (en) * 2001-07-27 2004-04-27 Eastman Kodak Company Heating control system which minimizes AC power line voltage fluctuations
WO2003083443A2 (fr) * 2002-03-29 2003-10-09 University Of Florida Criblage a base de lipides de medicaments candidats, destine a l'identification de composes actifs
CA2536612A1 (fr) * 2003-04-02 2004-10-14 Celator Pharmaceuticals, Inc. Compositions combinees de camptothecines et de fluoropyrimidines
WO2005021012A1 (fr) * 2003-08-29 2005-03-10 Terumo Kabushiki Kaisha Vecteur de medicament contenant de la gemcitabine
AU2005235455B2 (en) * 2004-04-22 2011-01-20 Celator Pharmaceuticals, Inc. Liposomal formulations of anthracycline agents and cytidine analogs
CN107811971B (zh) * 2004-05-03 2021-10-29 益普生生物制药公司 用于药物输送的脂质体
JP4758915B2 (ja) * 2004-08-06 2011-08-31 バイオスペクトラム，インコーポレイテッド 多重層リポソームおよびその製造方法
US20080213183A1 (en) * 2004-09-20 2008-09-04 Marcel Bally Free or Liposomal Gemcitabine Alone or in Combination with Free or Liposomal Idarubicin
JP5110880B2 (ja) * 2004-11-18 2012-12-26 テルモ株式会社 医薬組成物、製剤および組み合わせ製剤
EP1674081A1 (fr) * 2004-12-23 2006-06-28 KTB Tumorforschungsgesellschaft mbH Préparation de nano-particules à bases lipides en utilisant une centrifuge duale et asymétrique
GB2464430B8 (en) * 2007-07-20 2011-12-21 Rohto Pharma Emulsified composition
WO2009059449A1 (fr) * 2007-11-05 2009-05-14 Celsion Corporation Nouveaux liposomes thermosensibles contenant des agents thérapeutiques
US8079820B2 (en) * 2008-12-18 2011-12-20 General Electric Company Blade module, a modular rotor blade and a method for assembling a modular rotor blade
CA2756811C (fr) * 2009-03-30 2014-09-23 Eisai R&D Management Co., Ltd. Composition liposomique d'eribuline ou un sel pharmacologiquement accepttable de celui-ci
US8215869B2 (en) * 2009-07-27 2012-07-10 Terratech Consulting Ltd. Reinforced soil arch
CA2794473A1 (fr) * 2010-02-03 2011-08-11 National Cancer Center Cellule souche hepatique induite et procede pour la production de celle-ci, et applications de la cellule
PL226015B1 (pl) * 2011-03-03 2017-06-30 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Liposomowy preparat zawierajacy przeciwnowotworowa substancje aktywna, sposob jego wytwarzania i zawierajaca go kompozycja farmaceutyczna
CN106727329B (zh) * 2012-02-17 2020-11-03 效思因公司 热敏纳米颗粒制剂及其制备方法
US20140029493A1 (en) * 2012-07-26 2014-01-30 Sierra Wireless, Inc. Wireless Communication Interworking Function
KR20140120218A (ko) * 2013-04-02 2014-10-13 삼성전자주식회사 혈관신생 유도 물질 전달용 조성물, 및 이를 이용하여 제작된 인공 조직
PT3138555T (pt) * 2014-04-30 2020-12-15 Fujifilm Corp Composição lipossómica e método de produção da mesma
EP3138556B1 (fr) * 2014-04-30 2022-03-02 FUJIFILM Corporation Procédé de production de liposomes
JP6276847B2 (ja) * 2014-04-30 2018-02-07 富士フイルム株式会社 リポソーム組成物及びその製造方法
EP3138557B1 (fr) * 2014-04-30 2023-06-07 FUJIFILM Corporation Composition liposomale et procédé de production associé
JP6316182B2 (ja) * 2014-12-19 2018-04-25 富士フイルム株式会社 リポソームの製造方法及びリポソーム製造装置

Also Published As

Publication number Publication date
JPWO2017078009A1 (ja) 2018-08-09
EP3372223A1 (fr) 2018-09-12
MA43184A (fr) 2021-04-14
WO2017078009A1 (fr) 2017-05-11
US20210128471A1 (en) 2021-05-06
JP6705933B2 (ja) 2020-06-03
JP2019178181A (ja) 2019-10-17
US20180243215A1 (en) 2018-08-30
EP3372223B1 (fr) 2024-04-17
EP3372223A4 (fr) 2018-09-12

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