JP6545684B2 - エアロゾル移送装置およびエアロゾル移送装置の作動方法 - Google Patents
エアロゾル移送装置およびエアロゾル移送装置の作動方法 Download PDFInfo
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- JP6545684B2 JP6545684B2 JP2016539970A JP2016539970A JP6545684B2 JP 6545684 B2 JP6545684 B2 JP 6545684B2 JP 2016539970 A JP2016539970 A JP 2016539970A JP 2016539970 A JP2016539970 A JP 2016539970A JP 6545684 B2 JP6545684 B2 JP 6545684B2
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Description
膜が振動器により振動する場合、これは能動膜である。
シプロフロキサシン、ガチフロキサシン、ノルフロキサシン、オフロキサシン、レボフロキサシン、ペフロキサシン、ロメフロキサシン、フレロキサシン、ガレノキサシン、クリナフロキサシン、シタフロキサシン、プルリフロキサシン、オラムフロキサシン、カドロフロキサシン(caderofloxacin)、ゲミフロキサシン、バロフロキサシン、トロバフロキサシンおよびモキシフロキサシンを含むジャイレース阻害剤またはフルオロキノン類(fluroquinolones);
プレクタシン、ダルババシン、ダプトマイシン、オリタバンシン、ラモプラニン、ダルババシン、テラバンシン、バシトラシン、チロトリシン、ネオマイシン、カナマイシン、ムピロシン、パロモマイシン、ポリミクシンBおよびコリスチンを含むポリペプチド類;
アンホテリシンB、ナタマイシン、ナイスタチン、フルシトシンを含むポリエン類;
抗生物質、例えばアクラルビシン(alcarubicine)、ブレオマイシン、ダクチノマイシン、ダウノルビシン、ドキソルビシン、エピルビシン、イダルビシン、マイトマイシン、プリカマイシン;
検出器は、2曲線間の差を決定するように構成されている演算処理装置等、例えばCPUを含んでいてもよい。
一実施形態においては、検出器は、膜と接触するおよび/または流体リザーバー内の流体の存在を、振動周波数の関数としてまたは振動周波数に対して依存する少なくとも1つの電気パラメータの検出値の曲線のフーリエ変換に基づいて検出するように構成されている。フーリエ変換によると、振動周波数の関数は時間に対して依存する新たな関数、すなわち、引数が時間の関数に変換され、その逆も成立する。
本発明の方法は、本発明の装置に関して既に詳細に上記した有利な効果を提供する。特に、この方法は、膜に接触するおよび/または流体リザーバー内の流体の存在を確実および効率的に検出することを可能とする。
ポドフィロトキシン(podophyllotoxine)、ビダラビン、トロマンタジン、ジドブジンおよびアンチトリプシン(a−antitrypsin)等のウィルス抑止剤、および/または、コルチコトロピン(corticotro−pine)、テトラコサクチド、コリオゴナドトロピン(choriogonandotropine)、ウロフォリトロピン(urofolitropine)、ウロゴナドドロピン(urogonadotropine)、サオマトロピン(saomatotropine)、メテルゴリン、デスモプレシン(desmopressine)、オキシトシン、アルギプレシン(argipressine)、オルニプレシン(or−nipressine)、リュープロレリン(leuproreline)、トリプトレリン(triptoreline)、ゴナドレリン(gonadoreline)、ブセレリン(busereline)、ナファレリン(nafareline)、ゴセレリン(goselerine)、ソマトスタチン(somatostatine)、副甲状腺ホルモン類(parathyroide gland hormones)、ジヒドロタキステロール(Dihydrotachysterole)、カルシトニン(calcitonine)、クロドロン酸(clodron acid)、エチドロン酸、甲状腺治療、アナボリック類、アンドロゲン類、エトロゲン類(etrogens)、ゲスターゲン類および抗エストロゲン剤類からなる群、および/または、ニムスチン、メルファンァン(melphanlane)、カルマスティン、ロムスチン、シクロフォスフォサミン(cyclophosphosphamide)、イホスファミド、トロホスファミド、クロラムブチル、ブスルファン(busulfane)、トレオスルファン(treosulfane)、プレドニスチン(prednismustine)、チオテパ、シタラビン、フルオロウラシル、メルカプトプリン、チオグアニン、ビンブラスチン、ビンクリスチン、ビンデシン、アルカルビシン(alcarubicine)、ブレオマイシン(bleomycine)、ダクチノマイシン(dactinomycine)、ダウノルビシン(daunorubicine)、ドキソルビシン(doxorubicine)、エピルビシン(epirubicine)、イダルビシン(idarubicine)、マイトマイシン(mitomycine)、プリカマイシン(plicamycine)、カルボプラチン(carboplatinum)、cis−プラチン、チタノセンジクロライド アムサクリン、ダカルバジン、エストラムスティン(estramustine)、エトポシド、ヒドロキシカルバミド、ミトキサントロン(mitoxanthrone)、プロカルバジンおよびテミポシド(temiposide)からなる群、および/または、プロキシバルバール、リスリド、メチルセルギド、ジヒドロエルゴタミン、エルゴタミン、クロニジン、ピゾテフィン(pizotifene)、ベンゾジアゼピン類、バルビツル酸塩、シクロピロン類、イミダゾールピリジン類、アービツレート類(arbiturates)、フェニトイン、プリミドン、メスクシミド、エトスクシミド、スルチアム、カルバマゼピン(carbamezepin)、バルプロ酸、ビガバトリン(vigabatrine)、レボドーパ、カルビドパ、ベンセラジド、セレギリン、ブロモクリプチン、アマンタジン、チアプリド、チエチルペラジン、ブロモペリド(bromopride)、ドンペリドン、グラニセトロン(granisetrone)、オンダンセトロン(ondasetrone)、トロピセトロン(tropisetrone)、ピリドキシン、モルヒネ、コデイン、ヒドロモルフォン、メサドン、フェンピプラミド、フェンタニル、ピリトラミド、ペンタゾシン、ブプレノルフィン、ナルブフィン(nalbuphine)、チリジン(tilidine)、N−メチル化バルビツル酸塩、チオバルビツレート、ケタミン、エトミデート、プロポフォール、ベンゾジアゼピン類、ドロペリドール、ハロペリドール、アルフェンタニル(alfentanyl)、スフェンタニル(sulfentanyl)、腫瘍壊死因子アルファおよび非ステロイド系抗炎症性薬からなる群、および/または、インシュリン、スルホニル尿素誘導体類、ビグアニド類(biguanids)、グリチゾール類(glitizols)、グルカゴン、ジアゾキシド(diazoxid)、インターロキシン類(interleukines)、インターフェロン類(interferones)、腫瘍壊死因子(TN F)およびコロニー刺激因子からなる群、および/または、プロテイン類、ペプチド類、ヘパリン(heparine)、ヘパリン類似物質、ウロキナーゼ類、ストレプトキナーゼ類、ATPアーゼ、プロスタサイクリン、性的興奮剤および遺伝子からなる群から選択されてもよい。
図1は、本発明の現在のところ好ましい実施形態における、エアロゾル移送装置Aの縦方向に切断された概略断面図を示す。
例えば、第1の参照長さの値は、膜1に接する流体3が存在する場合に得られてもよく、第2の参照長さの値は、膜1に接する流体3が存在しない場合に得られてもよい。また、検出された電圧値の曲線の長さをこれらの参照長さの値の両方と比較してもよい。
図7(a)は、30〜55kHzの周波数範囲における振動周波数に依存する振動器7の電圧の2つの測定された曲線を示し、一方の曲線は膜1と接する流体3が存在する場合に、他方の曲線は膜1と接する流体3が存在しない場合に得られた。振動器7の測定された電圧は、図7(a)のY軸方向(縦座標)にf(n)として与えられ、図7(a)のX軸方向(横座標)に与えられるパラメータnは整数である。図7(a)に示される曲線は、高周波数のバックグラウンドノイズを除去するために、ローパスフィルタに付した。
Claims (19)
- エアロゾル移送装置にてエアロゾルを発生させるためのエアロゾル発生機であって、膜(1)と、流体を振動させ、および前記膜(1)により前記流体をエアロゾル化するように構成されている振動器(7)とを含むエアロゾル発生機、
エアロゾル化される流体(3)を貯留するための流体リザーバー(2)であって、前記膜(1)と流体連通して配置される流体リザーバー(2)、
複数の異なる振動周波数において前記振動器(7)を逐次的に作動するように構成されているコントローラ(10)、
前記複数の異なる振動周波数のそれぞれについて、前記振動器(7)の少なくとも1つの電気パラメータを検出するように構成されているセンサー(13)、ならびに
少なくとも1つの電気パラメータの検出値の、該電気パラメータに対応する振動周波数への依存性に基づいて、前記膜(1)に接触するおよび/または前記流体リザーバー(2)内の流体(3)の存在を検出するように構成されている検出器(13a)を含み、
前記検出器(13a)は、前記振動周波数の関数としての少なくとも1つの電気パラメータの検出値の曲線の傾きの数値に基づいて、および/または、前記振動周波数の関数としての少なくとも1つの電気パラメータの検出値の曲線の長さに基づいて、前記膜(1)と接触するおよび/または前記流体リザーバー(2)内の流体(3)の存在を検出するように構成されている、エアロゾル移送装置(A)。 - 前記検出器(13a)は、前記振動周波数の関数としての少なくとも1つの電気パラメータの検出値の曲線と参照曲線との相互相関関数に基づいて、前記膜(1)と接触するおよび/または前記流体リザーバー(2)内の前記流体(3)の存在を検出するように構成されている、請求項1に記載のエアロゾル移送装置(A)。
- 前記検出器(13a)は、1検出サイクルにおいて得られる前記振動周波数の関数としての少なくとも1つの電気パラメータの検出値の曲線を、別の検出サイクルにおいて得られる前記振動周波数の関数としての少なくとも1つの電気パラメータの検出値の曲線から減じることによって得られる差に基づいて、前記膜(1)と接触するおよび/または前記流体リザーバー(2)内の前記流体(3)の存在を検出するように構成されている、請求項1または2に記載のエアロゾル移送装置(A)。
- 前記検出器(13a)は、前記振動周波数の関数としての少なくとも1つの電気パラメータの検出値の曲線下の面積に基づいて前記膜(1)に接触するおよび/または前記流体リザーバー(2)内の前記流体(3)の存在を検出するように構成されている、請求項1〜3のいずれかに記載のエアロゾル移送装置(A)。
- 前記検出器(13a)は、前記振動周波数の関数としての少なくとも1つの電気パラメータの検出値の曲線のフーリエ変換に基づいて前記膜(1)に接触するおよび/または前記流体リザーバー(2)内の前記流体(3)の存在を検出するように構成されている、請求項1〜4のいずれかに記載のエアロゾル移送装置(A)。
- 前記少なくとも1つの電気パラメータは、電圧および/または電流および/または電力および/または電流の位相シフトおよび/または電圧の位相シフトである、請求項1〜5のいずれかに記載のエアロゾル移送装置(A)。
- 前記コントローラ(10)は、前記膜(1)と接触するおよび/または前記流体リザーバー(2)内の前記流体(3)の不存在が前記検出器(13a)によって検出された場合に前記振動器(7)を停止するように構成されている、請求項1〜6のいずれかに記載のエアロゾル移送装置(A)。
- 前記コントローラ(10)は、40以上の前記異なる振動周波数において前記振動器(7)を逐次的に作動させるように構成されている、請求項1〜7のいずれかに記載のエアロゾル移送装置(A)。
- 前記コントローラ(10)は、前記複数の異なる振動周波数のうち、1つの振動周波数からその次の振動周波数へと20ms以下の時間範囲内で前記振動器(7)を切り替えるように構成されている、請求項1〜8のいずれかに記載のエアロゾル移送装置(A)。
- 前記コントローラ(10)は、30〜60kHzおよび/または90〜170kHzおよび/または350〜600kHzの範囲の複数の異なる振動周波数において前記振動器(7)を逐次的に作動させるように構成されている、請求項1〜9のいずれかに記載のエアロゾル移送装置(A)。
- 前記コントローラ(10)は、1つの振動周波数とその次の振動周波数との相違が、前記1つの振動周波数に対して3%以下であるように、前記複数の異なる振動周波数において前記振動器(7)を逐次的に作動させるように構成されている、請求項1〜10のいずれかに記載のエアロゾル移送装置(A)。
- 前記コントローラ(10)は、前記複数の異なる振動周波数のうち、1つの振動周波数とその次の振動周波数の相違が振動周波数の関数であるように前記振動器(7)を前記複数の異なる振動周波数において逐次的に作動させるように構成されている、請求項1〜11のいずれかに記載のエアロゾル移送装置(A)。
- 前記膜(1)は、外力によって振動しない膜であり、前記振動器(7)は、流体供給システムおよび/またはエアロゾル移送装置(A)の後方にある膜を振動させるように構成されている、請求項1〜12のいずれかに記載のエアロゾル移送装置(A)。
- 前記膜(1)は、前記振動器(7)によって振動する膜であり、前記振動器(7)は、前記膜(1)を振動させるように構成されている、請求項1〜12のいずれかに記載のエアロゾル移送装置(A)。
- エアロゾル移送装置(A)を作動させる方法であり、
前記エアロゾル移送装置(A)は、
前記エアロゾル移送装置にてエアロゾルを発生させるためのエアロゾル発生機であって、膜(1)と、流体を振動させ、および前記膜(1)により前記流体をエアロゾル化するように構成されている振動器(7)とを含む前記エアロゾル発生機、および
エアロゾル化するための前記流体(3)を貯留するための流体リザーバー(2)であって、前記膜(1)と流体連通して配置される前記流体リザーバー(2)、を含み、
前記方法は、
複数の異なる振動周波数において前記振動器(7)を逐次的に作動させる工程、
複数の異なる振動周波数のそれぞれに対して、前記振動器(7)の少なくとも1つの電気パラメータを検出する工程、
少なくとも1つの電気パラメータの検出値の、該電気パラメータに対応する振動周波数への依存性に基づいて、前記膜(1)と接するおよび/または前記流体リザーバー(2)内の前記流体(3)の存在を検出する工程を含む、エアロゾル移送装置(A)の作動方法であり、
前記膜(1)と接するおよび/または前記流体リザーバー(2)内の前記流体(3)の存在は、前記振動周波数の関数としての少なくとも1つの電気パラメータの検出値の曲線の傾きの数値に基づいて、および/または、前記振動周波数の関数としての少なくとも1つの電気パラメータの検出値の曲線の長さに基づいて、検出される、エアロゾル移送装置(A)の作動方法。 - 前記膜(1)は、外力によって振動しない膜であり、前記振動器(7)は、流体供給システムおよび/またはエアロゾル移送装置(A)の後方にある膜を振動させるように構成されている、請求項15に記載のエアロゾル移送装置(A)の作動方法。
- 前記膜(1)は、前記振動器(7)によって振動する膜であり、前記振動器(7)は、前記膜(1)を振動させるように構成されている、請求項15に記載のエアロゾル移送装置(A)の作動方法。
- エアロゾル化するための前記流体(3)は、1以上の活性成分を含み、前記1以上の活性成分は、抗てんかん薬、抗けいれん薬、鎮吐薬、免疫調整薬、鎮痛剤、抗リュウマチ薬、抗がん剤、粘液溶解薬、睡眠補助、抗カビ性、抗真菌、プロテインまたはペプチド、ヘパランおよび遺伝子からなる群、および/または、抗糖尿病薬、インスリンおよびホルモンからなる群、および/または、副腎皮質ホルモン、ロイコトリエン拮抗剤、ブラジキニン拮抗剤、クロモン、抗ヒスタミン剤および抗体からなる群、および/または、アミノグリコシド、セファロスポリン、マクロライド、コノロン、ニトロイミダゾール、グリコペプチド、ポリエン系抗生物質、ベータラクタム、テトラサイクリン、キノロン、スルホンアミド、およびアゾール誘導体からなる群、および/または、ベンゾジアゼピン、バルビツルおよびスクシンイミドからなる群、および/または、アルファトリプシン、エリスロポエチン、インターフェロン類、キナーゼ類、エラスターゼ類、ペプチド類およびプロテイン類からなる群、および/または、サルブタモール、レブアルブテロール、フォルモテロール、フェノテロール、サルメテロール、バンブテロール、ブロカテロール、クレンブテロール、テルブタリン、ツロブテロール、エピネフリン、イソプレナリン、およびヘキソプレナリンからなる群、および/または、チオトロピウム、オキシトロピウム、イプラトロピウムおよびグリコピロレートからなる群、および/または、アセチルシステイン、アンブロキソール、炭素システイン、チロキサポール、ジパルミトイルホスファチジクロリン、組み換え型界面活性剤タンパク質類およびデオキシリボヌクレアーゼからなる群、および/または、界面活性剤からなる群、および/または、クロモグリケート、ネドクロミル、ベクロメタゾン、ベタメタゾン、ブデソニド、シクレソニド、フルニソリド、フルチカゾン、イコメタゾン、モメタゾン、ロフレポニド、トリアムシノロン、ブラジキニン、プロスタグランジン、ロイコトリエンおよび血小板活性化因子の拮抗薬からなる群、および/または、アモキシシリン、ピペラシリン、クラブラン酸、スルバクタム、セファクロル、セファゼドン、セフロキシム、セフォキシチン、セフォジジム、セフスロジン、セフポドキシム、セフィキシム、コリスチン、イミペネム、シラスタチン、アズトレオナム、ストレプトマイシン、ネオマイシン、パロモマイシン、カナマイシン、ゲンタマイシン、アミカシン、トブラマイシン、スペクチノマイシン、ドキシサイクリン、ミノサイクリン、エリスロマイシン、クラリスロマイシン、ロキシスロマイシン、アジスロマイシン、ジョサマイシン、スピラマイシン、シプロフロキサン、オフロキサシン、レボフロキサシン、ペフロキサシン、ロメフロキサシン、フレロキサシン、クリナフロキサシン、シタフロキサシン、ゲミフロキサシン、バロフロキサシン、トロバフロキサシン、モキシフロキサシン、メトロニダゾール、チニダゾール、クロラムフェニコール、リンコマイシン、クリンダマイシン、ホスホマイシン、バンコマイシンおよびテイコプラニンからなる群、および/または、リファンピシン、イソニアジド、サイクロセリン、テリジドンおよびアンサマイシンからなる群、および/または、クロトリマゾール、オキシコナゾール、ミコナゾール、ケトコナゾール、イトラコナゾール、フルコナゾール、アムホテリシンB、ナタマイシン、ナイスタチン、フルシトシンおよびペンタミジンからなる群、および/または、ジメプラノール−4−アセテートアミドベンゾエート、チモペンチン、干渉剤、フェルグラスチン、インターロイキン、アザチオプリンおよびシクロスポリンからなる群;ウィルス抑止剤、および/または、コルチコトロピン、テトラコサクチド、コリオゴナドトロピン、ウロフォリトロピン、ウロゴナドドロピン、サオマトロピン、メテルゴリン、デスモプレシン、オキシトシン、アルギプレシン、オルニプレシン、リュープロレリン、トリプトレリン、ゴナドレリン、ブセレリン、ナファレリン、ゴセレリン、ソマトスタチン、副甲状腺ホルモン類、ジヒドロタキステロール、カルシトニン、クロドロン酸、エチドロン酸、甲状腺治療、アナボリック類、アンドロゲン類、エトロゲン類、ゲスターゲン類および抗エストロゲン剤類からなる群、および/または、ニムスチン、メルファンァン、カルマスティン、ロムスチン、シクロフォスフォサミン、イホスファミド、トロホスファミド、クロラムブチル、ブスルファン、トレオスルファン、プレドニスチン、チオテパ、シタラビン、フルオロウラシル、メルカプトプリン、チオグアニン、ビンブラスチン、ビンクリスチン、ビンデシン、アルカルビシン、ブレオマイシン、ダクチノマイシン、ダウノルビシン、ドキソルビシン、エピルビシン、イダルビシン、マイトマイシン、プリカマイシン、カルボプラチン、cis−プラチン、チタノセンジクロライド アムサクリン、ダカルバジン、エストラムスティン、エトポシド、ヒドロキシカルバミド、ミトキサントロン、プロカルバジンおよびテミポシドからなる群、および/または、プロキシバルバール、リスリド、メチルセルギド、ジヒドロエルゴタミン、エルゴタミン、クロニジン、ピゾテフィン、ベンゾジアゼピン類、バルビツル酸塩、シクロピロン類、イミダゾールピリジン類、アービツレート類、フェニトイン、プリミドン、メスクシミド、エトスクシミド、スルチアム、カルバマゼピン、バルプロ酸、ビガバトリン、レボドーパ、カルビドパ、ベンセラジド、セレギリン、ブロモクリプチン、アマンタジン、チアプリド、チエチルペラジン、ブロモペリド、ドンペリドン、グラニセトロン、オンダンセトロン、トロピセトロン、ピリドキシン、モルヒネ、コデイン、ヒドロモルフォン、メサドン、フェンピプラミド、フェンタニル、ピリトラミド、ペンタゾシン、ブプレノルフィン、ナルブフィン、チリジン、N−メチル化バルビツル酸塩、チオバルビツレート、ケタミン、エトミデート、プロポフォール、ベンゾジアゼピン類、ドロペリドール、ハロペリドール、アルフェンタニル、スフェンタニル、腫瘍壊死因子アルファおよび非ステロイド系抗炎症性薬からなる群、および/または、インシュリン、スルホニル尿素誘導体類、ビグアニド類、グリチゾール類、グルカゴン、ジアゾキシド、インターロキシン類、インターフェロン類、腫瘍壊死因子(TN F)およびコロニー刺激因子からなる群、および/または、プロテイン類、ペプチド類、ヘパリン、ヘパリン類似物質、ウロキナーゼ類、ストレプトキナーゼ類、ATPアーゼ、プロスタサイクリン、性的興奮剤および遺伝子からなる群から選択される、請求項1〜14のいずれかに記載のエアロゾル移送装置(A)。
- エアロゾル化するための前記流体(3)は、1以上の活性成分を含み、前記1以上の活性成分は、抗てんかん薬、抗けいれん薬、鎮吐薬、免疫調整薬、鎮痛剤、抗リュウマチ薬、抗がん剤、粘液溶解薬、睡眠補助、抗カビ性、抗真菌、プロテインまたはペプチド、ヘパランおよび遺伝子からなる群、および/または、抗糖尿病薬、インスリンおよびホルモンからなる群、および/または、副腎皮質ホルモン、ロイコトリエン拮抗剤、ブラジキニン拮抗剤、クロモン、抗ヒスタミン剤および抗体からなる群、および/または、アミノグリコシド、セファロスポリン、マクロライド、コノロン、ニトロイミダゾール、グリコペプチド、ポリエン系抗生物質、ベータラクタム、テトラサイクリン、キノロン、スルホンアミド、およびアゾール誘導体からなる群、および/または、ベンゾジアゼピン、バルビツルおよびスクシンイミドからなる群、および/または、アルファトリプシン、エリスロポエチン、インターフェロン類、キナーゼ類、エラスターゼ類、ペプチド類およびプロテイン類からなる群、および/または、サルブタモール、レブアルブテロール、フォルモテロール、フェノテロール、サルメテロール、バンブテロール、ブロカテロール、クレンブテロール、テルブタリン、ツロブテロール、エピネフリン、イソプレナリン、およびヘキソプレナリンからなる群、および/または、チオトロピウム、オキシトロピウム、イプラトロピウムおよびグリコピロレートからなる群、および/または、アセチルシステイン、アンブロキソール、炭素システイン、チロキサポール、ジパルミトイルホスファチジクロリン、組み換え型界面活性剤タンパク質類およびデオキシリボヌクレアーゼからなる群、および/または、界面活性剤からなる群、および/または、クロモグリケート、ネドクロミル、ベクロメタゾン、ベタメタゾン、ブデソニド、シクレソニド、フルニソリド、フルチカゾン、イコメタゾン、モメタゾン、ロフレポニド、トリアムシノロン、ブラジキニン、プロスタグランジン、ロイコトリエンおよび血小板活性化因子の拮抗薬からなる群、および/または、アモキシシリン、ピペラシリン、クラブラン酸、スルバクタム、セファクロル、セファゼドン、セフロキシム、セフォキシチン、セフォジジム、セフスロジン、セフポドキシム、セフィキシム、コリスチン、イミペネム、シラスタチン、アズトレオナム、ストレプトマイシン、ネオマイシン、パロモマイシン、カナマイシン、ゲンタマイシン、アミカシン、トブラマイシン、スペクチノマイシン、ドキシサイクリン、ミノサイクリン、エリスロマイシン、クラリスロマイシン、ロキシスロマイシン、アジスロマイシン、ジョサマイシン、スピラマイシン、シプロフロキサン、オフロキサシン、レボフロキサシン、ペフロキサシン、ロメフロキサシン、フレロキサシン、クリナフロキサシン、シタフロキサシン、ゲミフロキサシン、バロフロキサシン、トロバフロキサシン、モキシフロキサシン、メトロニダゾール、チニダゾール、クロラムフェニコール、リンコマイシン、クリンダマイシン、ホスホマイシン、バンコマイシンおよびテイコプラニンからなる群、および/または、リファンピシン、イソニアジド、サイクロセリン、テリジドンおよびアンサマイシンからなる群、および/または、クロトリマゾール、オキシコナゾール、ミコナゾール、ケトコナゾール、イトラコナゾール、フルコナゾール、アムホテリシンB、ナタマイシン、ナイスタチン、フルシトシンおよびペンタミジンからなる群、および/または、ジメプラノール−4−アセテートアミドベンゾエート、チモペンチン、干渉剤、フェルグラスチン、インターロイキン、アザチオプリンおよびシクロスポリンからなる群;ウィルス抑止剤、および/または、コルチコトロピン、テトラコサクチド、コリオゴナドトロピン、ウロフォリトロピン、ウロゴナドドロピン、サオマトロピン、メテルゴリン、デスモプレシン、オキシトシン、アルギプレシン、オルニプレシン、リュープロレリン、トリプトレリン、ゴナドレリン、ブセレリン、ナファレリン、ゴセレリン、ソマトスタチン、副甲状腺ホルモン類、ジヒドロタキステロール、カルシトニン、クロドロン酸、エチドロン酸、甲状腺治療、アナボリック類、アンドロゲン類、エトロゲン類、ゲスターゲン類および抗エストロゲン剤類からなる群、および/または、ニムスチン、メルファンァン、カルマスティン、ロムスチン、シクロフォスフォサミン、イホスファミド、トロホスファミド、クロラムブチル、ブスルファン、トレオスルファン、プレドニスチン、チオテパ、シタラビン、フルオロウラシル、メルカプトプリン、チオグアニン、ビンブラスチン、ビンクリスチン、ビンデシン、アルカルビシン、ブレオマイシン、ダクチノマイシン、ダウノルビシン、ドキソルビシン、エピルビシン、イダルビシン、マイトマイシン、プリカマイシン、カルボプラチン、cis−プラチン、チタノセンジクロライド アムサクリン、ダカルバジン、エストラムスティン、エトポシド、ヒドロキシカルバミド、ミトキサントロン、プロカルバジンおよびテミポシドからなる群、および/または、プロキシバルバール、リスリド、メチルセルギド、ジヒドロエルゴタミン、エルゴタミン、クロニジン、ピゾテフィン、ベンゾジアゼピン類、バルビツル酸塩、シクロピロン類、イミダゾールピリジン類、アービツレート類、フェニトイン、プリミドン、メスクシミド、エトスクシミド、スルチアム、カルバマゼピン、バルプロ酸、ビガバトリン、レボドーパ、カルビドパ、ベンセラジド、セレギリン、ブロモクリプチン、アマンタジン、チアプリド、チエチルペラジン、ブロモペリド、ドンペリドン、グラニセトロン、オンダンセトロン、トロピセトロン、ピリドキシン、モルヒネ、コデイン、ヒドロモルフォン、メサドン、フェンピプラミド、フェンタニル、ピリトラミド、ペンタゾシン、ブプレノルフィン、ナルブフィン、チリジン、N−メチル化バルビツル酸塩、チオバルビツレート、ケタミン、エトミデート、プロポフォール、ベンゾジアゼピン類、ドロペリドール、ハロペリドール、アルフェンタニル、スフェンタニル、腫瘍壊死因子アルファおよび非ステロイド系抗炎症性薬からなる群、および/または、インシュリン、スルホニル尿素誘導体類、ビグアニド類、グリチゾール類、グルカゴン、ジアゾキシド、インターロキシン類、インターフェロン類、腫瘍壊死因子(TN F)およびコロニー刺激因子からなる群、および/または、プロテイン類、ペプチド類、ヘパリン、ヘパリン類似物質、ウロキナーゼ類、ストレプトキナーゼ類、ATPアーゼ、プロスタサイクリン、性的興奮剤および遺伝子からなる群から選択される、請求項15〜17のいずれかに記載のエアロゾル移送装置(A)の作動方法。
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