JP6531042B2 - スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用 - Google Patents

スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用 Download PDF

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JP6531042B2
JP6531042B2 JP2015556099A JP2015556099A JP6531042B2 JP 6531042 B2 JP6531042 B2 JP 6531042B2 JP 2015556099 A JP2015556099 A JP 2015556099A JP 2015556099 A JP2015556099 A JP 2015556099A JP 6531042 B2 JP6531042 B2 JP 6531042B2
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JP2016506959A (ja
JP2016506959A5 (show.php
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サード ロウ，ジョン，エー．，ザ
サード ロウ，ジョン，エー．，ザ
カーン，エム．，アミン
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アプティニックス インコーポレイテッド
アプティニックス インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2015556099A 2013-01-29 2014-01-29 スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用 Active JP6531042B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361757920P 2013-01-29 2013-01-29
US61/757,920 2013-01-29
PCT/US2014/013621 WO2014120784A1 (en) 2013-01-29 2014-01-29 Spiro-lactam nmda receptor modulators and uses thereof

Publications (3)

Publication Number Publication Date
JP2016506959A JP2016506959A (ja) 2016-03-07
JP2016506959A5 JP2016506959A5 (show.php) 2019-03-28
JP6531042B2 true JP6531042B2 (ja) 2019-06-12

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JP2015556099A Active JP6531042B2 (ja) 2013-01-29 2014-01-29 スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用

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Country Link
US (5) US9828384B2 (show.php)
EP (1) EP2951182B1 (show.php)
JP (1) JP6531042B2 (show.php)
KR (1) KR102410989B1 (show.php)
CN (1) CN105408336B (show.php)
AU (1) AU2014212485C1 (show.php)
BR (1) BR112015018089B1 (show.php)
CA (1) CA2898774C (show.php)
CL (1) CL2015002122A1 (show.php)
EA (1) EA032153B1 (show.php)
IL (1) IL240162B (show.php)
MX (1) MX375286B (show.php)
PE (1) PE20151427A1 (show.php)
PH (1) PH12015501596B1 (show.php)
SG (1) SG11201505942YA (show.php)
WO (1) WO2014120784A1 (show.php)

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TWI887245B (zh) * 2019-06-24 2025-06-21 美商諾雷克斯股份有限公司 用於產生二氮雜螺內醯胺化合物之方法及中間物
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MX375286B (es) 2025-03-06
NZ709872A (en) 2020-09-25
CA2898774A1 (en) 2014-08-07
EA032153B1 (ru) 2019-04-30
WO2014120784A1 (en) 2014-08-07
BR112015018089B1 (pt) 2022-09-20
AU2014212485A1 (en) 2015-07-30
CN105408336B (zh) 2018-06-26
KR102410989B1 (ko) 2022-06-17
JP2016506959A (ja) 2016-03-07
MX2015009772A (es) 2016-05-31
IL240162B (en) 2020-08-31
AU2014212485C1 (en) 2018-10-25
PH12015501596A1 (en) 2015-10-19
HK1218418A1 (en) 2017-02-17
EA201591402A1 (ru) 2015-12-30
CL2015002122A1 (es) 2015-12-18
CA2898774C (en) 2021-07-13
KR20150110788A (ko) 2015-10-02
EP2951182A1 (en) 2015-12-09
IL240162A0 (en) 2015-09-24
PE20151427A1 (es) 2015-10-10
US20180215767A1 (en) 2018-08-02
BR112015018089A2 (pt) 2017-07-18
US20150368252A1 (en) 2015-12-24
US20210155632A1 (en) 2021-05-27
EP2951182B1 (en) 2020-03-18
CN105408336A (zh) 2016-03-16
US20180244680A1 (en) 2018-08-30
AU2014212485B2 (en) 2018-04-19
PH12015501596B1 (en) 2023-12-06
SG11201505942YA (en) 2015-08-28
US20180179218A1 (en) 2018-06-28
US9828384B2 (en) 2017-11-28

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