JP6494634B2 - 置換されているアミノピリミジン化合物および使用方法 - Google Patents

置換されているアミノピリミジン化合物および使用方法 Download PDF

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Publication number
JP6494634B2
JP6494634B2 JP2016543960A JP2016543960A JP6494634B2 JP 6494634 B2 JP6494634 B2 JP 6494634B2 JP 2016543960 A JP2016543960 A JP 2016543960A JP 2016543960 A JP2016543960 A JP 2016543960A JP 6494634 B2 JP6494634 B2 JP 6494634B2
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alkylene
heterocyclyl
cycloalkyl
alkyl
membered heteroaryl
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Japanese (ja)
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JP2016534146A5 (OSRAM
JP2016534146A (ja
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ニン・シー
ワン・リアン
ワン・ティンジン
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Sunshine Lake Pharma Co Ltd
Calitor Sciences LLC
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Sunshine Lake Pharma Co Ltd
Calitor Sciences LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pulmonology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
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  • Cardiology (AREA)
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  • Diabetes (AREA)
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  • Hematology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
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  • Dermatology (AREA)
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JP2016543960A 2013-09-22 2014-09-17 置換されているアミノピリミジン化合物および使用方法 Active JP6494634B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361880974P 2013-09-22 2013-09-22
US61/880,974 2013-09-22
US201461983444P 2014-04-23 2014-04-23
US61/983,444 2014-04-23
PCT/US2014/055967 WO2015042078A2 (en) 2013-09-22 2014-09-17 Substituted aminopyrimidine compounds and methods of use

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JP2016534146A JP2016534146A (ja) 2016-11-04
JP2016534146A5 JP2016534146A5 (OSRAM) 2017-07-27
JP6494634B2 true JP6494634B2 (ja) 2019-04-03

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US (4) US9670194B2 (OSRAM)
EP (2) EP3046563B1 (OSRAM)
JP (2) JP6494634B2 (OSRAM)
KR (2) KR20160058889A (OSRAM)
AU (2) AU2014321419B2 (OSRAM)
BR (1) BR112016003229A8 (OSRAM)
CA (2) CA2918938C (OSRAM)
MX (2) MX2016003456A (OSRAM)
MY (2) MY184292A (OSRAM)
RU (2) RU2675105C9 (OSRAM)
SG (2) SG11201600028YA (OSRAM)
WO (3) WO2015042077A1 (OSRAM)

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CA2918938C (en) * 2013-09-22 2021-05-18 Calitor Sciences, Llc Substituted aminopyrimidine compounds and methods of use
BR112016028876A2 (pt) 2014-06-13 2017-08-22 Gilead Sciences Inc composto, composição farmacêutica, método para tratar uma doença ou condição em um ser humano, kit, e, uso de um composto, um sal, isômero ou uma mistura farmaceuticamente aceitável dos mesmos.
JP6454736B2 (ja) 2014-06-13 2019-01-16 ギリアード サイエンシーズ， インコーポレイテッド ホスファチジルイノシトール３−キナーゼ阻害剤
CN106459005A (zh) * 2014-06-13 2017-02-22 吉利德科学公司 磷脂酰肌醇3‑激酶抑制剂
ES2763103T3 (es) 2014-06-13 2020-05-27 Gilead Sciences Inc Inhibidor de la fosfatidilinositol 3-quinasa
US9944639B2 (en) 2014-07-04 2018-04-17 Lupin Limited Quinolizinone derivatives as PI3K inhibitors
CN105924433B (zh) * 2015-02-28 2020-12-22 广东东阳光药业有限公司 取代的氨基嘧啶类化合物及其使用方法和用途
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