JP6491647B2 - キトサンペースト創傷手当て材 - Google Patents

キトサンペースト創傷手当て材 Download PDF

Info

Publication number
JP6491647B2
JP6491647B2 JP2016518431A JP2016518431A JP6491647B2 JP 6491647 B2 JP6491647 B2 JP 6491647B2 JP 2016518431 A JP2016518431 A JP 2016518431A JP 2016518431 A JP2016518431 A JP 2016518431A JP 6491647 B2 JP6491647 B2 JP 6491647B2
Authority
JP
Japan
Prior art keywords
paste
salt
phosphate
weight
chitosan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016518431A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016533775A (ja
JP2016533775A5 (enExample
Inventor
メディナ，ジェニファー・ゲイツ
シャーマン，イーサン・グレン
Original Assignee
メドトロニック・ゾーメド・インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/061,993 external-priority patent/US9192692B2/en
Application filed by メドトロニック・ゾーメド・インコーポレーテッド filed Critical メドトロニック・ゾーメド・インコーポレーテッド
Publication of JP2016533775A publication Critical patent/JP2016533775A/ja
Publication of JP2016533775A5 publication Critical patent/JP2016533775A5/ja
Application granted granted Critical
Publication of JP6491647B2 publication Critical patent/JP6491647B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0071—Plasticisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Surgery (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polymers & Plastics (AREA)
JP2016518431A 2013-10-24 2014-10-23 キトサンペースト創傷手当て材 Active JP6491647B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US14/061,993 2013-10-24
US14/061,993 US9192692B2 (en) 2013-10-24 2013-10-24 Chitosan stenting paste
US14/319,901 US9192574B2 (en) 2013-10-24 2014-06-30 Chitosan paste wound dressing
US14/319,901 2014-06-30
PCT/US2014/062041 WO2015061612A1 (en) 2013-10-24 2014-10-23 Chitosan paste wound dressing

Publications (3)

Publication Number Publication Date
JP2016533775A JP2016533775A (ja) 2016-11-04
JP2016533775A5 JP2016533775A5 (enExample) 2018-09-20
JP6491647B2 true JP6491647B2 (ja) 2019-03-27

Family

ID=51862592

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016522114A Active JP6397491B2 (ja) 2013-10-24 2014-10-23 キトサンステント材ペースト
JP2016518431A Active JP6491647B2 (ja) 2013-10-24 2014-10-23 キトサンペースト創傷手当て材

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2016522114A Active JP6397491B2 (ja) 2013-10-24 2014-10-23 キトサンステント材ペースト

Country Status (7)

Country Link
US (1) US9192574B2 (enExample)
EP (2) EP3060265B1 (enExample)
JP (2) JP6397491B2 (enExample)
AU (2) AU2014340012B2 (enExample)
CA (2) CA2926401C (enExample)
ES (2) ES2755137T3 (enExample)
WO (2) WO2015061612A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8932560B2 (en) 2007-09-04 2015-01-13 University of Maryland, College Parke Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells
US8668899B2 (en) 2009-11-13 2014-03-11 University Of Maryland, College Park Advanced functional biocompatible foam used as a hemostatic agent for compressible and non-compressible acute wounds
WO2014160136A1 (en) 2013-03-13 2014-10-02 University Of Maryland, Office Of Technology Commercialization Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells
CN105142399B (zh) 2013-03-14 2018-06-12 金珂生物医疗公司 生物相容的和生物可吸收的衍生的壳聚糖组合物
WO2017032897A1 (en) 2015-08-27 2017-03-02 Alimentary Health Limited Use of bifidobacterium longum and an exopolysaccharide produced thereby
US10576099B2 (en) 2016-10-21 2020-03-03 Covidien Lp Injectable scaffold for treatment of intracranial aneurysms and related technology
PL3532111T3 (pl) * 2016-10-26 2021-08-23 Biointelligence Systems S.L. Kompozycja bioaktywna względem kości i jej zastosowania
GB2595144B (en) * 2019-02-08 2023-07-26 Chitogel Ltd Surgical hydrogel
EP4054440B1 (en) 2019-11-04 2024-06-05 Covidien LP Manufacturing method of devices for treatment of intracranial aneurysms
US12364793B2 (en) 2021-03-16 2025-07-22 Covidien Lp Injectable biopolymer compositions and associated systems and methods
EP4084580A1 (en) * 2021-04-30 2022-11-02 Koninklijke Philips N.V. A light output system and design method
KR102852787B1 (ko) * 2021-12-28 2025-08-28 단국대학교 천안캠퍼스 산학협력단 신규한 화합물을 포함하는 생리 식염수
WO2024102389A1 (en) * 2022-11-10 2024-05-16 Hemostasis, Llc Dressing formulations
CN116059430B (zh) * 2022-12-16 2025-09-23 无锡学院 一种可降解伤口敷料及其制备方法

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4532134A (en) 1981-04-06 1985-07-30 Malette William Graham Method of achieving hemostasis, inhibiting fibroplasia, and promoting tissue regeneration in a tissue wound
US4394373A (en) 1981-04-06 1983-07-19 Malette William Graham Method of achieving hemostasis
US4452785A (en) 1982-11-08 1984-06-05 Malette William Graham Method for the therapeutic occlusion
CA1202904A (en) 1983-11-21 1986-04-08 Brian G. Sparkes Chitosan based wound dressing materials
US4659700A (en) 1984-03-02 1987-04-21 Johnson & Johnson Products, Inc. Chitosan-glycerol-water gel
JPH0735281B2 (ja) 1988-02-16 1995-04-19 学校法人松本歯科大学 硬化性組成物
US4956350A (en) 1988-08-18 1990-09-11 Minnesota Mining And Manufacturing Company Wound filling compositions
US5124151A (en) 1990-08-07 1992-06-23 Mediventures Inc. Drug delivery by injection with thermo-irreversible gels
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
US5871985A (en) 1992-09-28 1999-02-16 Brown University Research Foundation Particulate non cross-linked chitosan core matrices for encapsulated cells
GB2276819B (en) 1993-03-23 1996-12-11 Johnson & Johnson Medical Aqueous wound treatment composition comprising a polysaccharide and hexylene glycol
US5531716A (en) 1993-09-29 1996-07-02 Hercules Incorporated Medical devices subject to triggered disintegration
US5622834A (en) 1993-12-01 1997-04-22 Marine Polymer Technologies, Inc. Method of isolating poly-β-1-4-N-acetylglucosamine from microalgal culture
SE9402531L (sv) 1994-07-19 1996-01-20 Medicarb Ab Sårläkningsmedel
GB9421969D0 (en) 1994-10-28 1994-12-21 Innovative Tech Ltd Wound treatment composition
USRE38431E1 (en) 1995-12-01 2004-02-17 The American National Red Cross Methods of production and use of liquid formulations of plasma proteins
US6344077B1 (en) 1997-05-13 2002-02-05 Young-Keun Hong Aqueous cellulose solution and rayon fiber produced from the same
CA2212300A1 (en) 1997-08-04 1999-02-04 Abdellatif Chenite In vitro or in vivo gelfying chitosan and therapeutic uses thereof
US6458375B1 (en) 1998-02-27 2002-10-01 Musculoskeletal Transplant Foundation Malleable paste with allograft bone reinforcement for filling bone defects
DE60003459T2 (de) 1999-12-09 2004-05-06 Biosyntech Canada Inc., Laval Mineral-polymer hybrid-zusammensetzung
DK1294414T3 (da) 2000-06-29 2006-07-24 Biosyntech Canada Inc Præparat og fremgangsmåde til heling og regenerering af brusk og andre væv
EP1190702A1 (en) 2000-09-22 2002-03-27 Ciba SC Holding AG Chitosan emulsion formulation
WO2002040072A2 (en) 2000-11-15 2002-05-23 Bio Syntech Canada Inc. Filler composition for soft tissue augmentation and reconstructive surgery
US20020058704A1 (en) 2000-11-15 2002-05-16 Kimberly-Clark Worldwide, Inc. Multicomponent compositions containing chitosan and methods of preparing same
ATA13842001A (de) 2001-08-31 2002-10-15 Mucobiomer Biotechnologische F Chitosan-thio-alkyl-amidin konjugate und deren kosmetische sowie pharmazeutische verwendung
WO2003042250A1 (en) 2001-11-15 2003-05-22 Biosyntech Canada Inc. Composition and method to homogeneously modify or cross-link chitosan under neutral conditions
JP3947391B2 (ja) 2001-11-28 2007-07-18 独立行政法人 日本原子力研究開発機構 橋かけ構造を有するキチン誘導体及び／又はキトサン誘導体の製造方法
FR2836044A1 (fr) 2002-02-15 2003-08-22 Octaris Composition pour la reparation et la cicatrisation cutanee comprenant exclusivement un vrai hydrogel physique de chitosane
CA2493083C (en) 2002-07-16 2012-11-06 Bio Syntech Canada Inc. Composition for cytocompatible, injectable, self-gelling chitosan solutions for encapsulating and delivering live cells or biologically active factors
GB2393120A (en) 2002-09-18 2004-03-24 Johnson & Johnson Medical Ltd Compositions for wound treatment
JP5102435B2 (ja) 2002-10-08 2012-12-19 株式会社リコム キトサン含有多糖、その製造方法及び用途
JP2006347883A (ja) * 2003-09-08 2006-12-28 Neetec:Kk 糖鎖含有キトサン誘導体及びグリコサミノグリカンを含有する医療用組成物
US7968122B2 (en) 2003-12-10 2011-06-28 Adventrx Pharmaceuticals, Inc. Anti-viral pharmaceutical compositions
US8124120B2 (en) 2003-12-22 2012-02-28 Anika Therapeutics, Inc. Crosslinked hyaluronic acid compositions for tissue augmentation
GB0329918D0 (en) 2003-12-24 2004-01-28 West Pharm Serv Drug Res Ltd Intranasal compositions
GB0403938D0 (en) 2004-02-21 2004-03-24 West Pharm Serv Drug Res Ltd Chitosan containing solution
JP2005281654A (ja) * 2004-03-31 2005-10-13 Rikogaku Shinkokai 温度応答性組成物およびそのヒドロゲル
ITRM20040539A1 (it) 2004-11-02 2005-02-02 Mavi Sud S R L Preparati a base di chitina o suoi derivati per uso cosmetico o medico.
CA2589139A1 (en) 2004-12-20 2006-06-29 Carbgraft Ab Chitosan compositions
US20060287278A1 (en) 2005-06-21 2006-12-21 Zhenze Hu Method for improving water solubility of chitosan
CA2628244A1 (en) 2005-11-04 2007-05-10 Bio Syntech Canada Inc. Gel formation of polyelectrolyte aqueous solutions by thermally induced changes in ionization state
AU2007208332B2 (en) 2006-01-25 2014-02-06 University Of Virginia Patent Foundation Methods for regulating gelation of polysaccharide solutions and uses thereof
CA2643322C (en) 2006-02-24 2015-07-21 Novartis Ag Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions
US7976873B2 (en) 2006-05-10 2011-07-12 Medtronic Xomed, Inc. Extracellular polysaccharide solvating system for treatment of bacterial ear conditions
US20070264296A1 (en) 2006-05-10 2007-11-15 Myntti Matthew F Biofilm extracellular polysachharide solvating system
US7959943B2 (en) 2006-05-10 2011-06-14 Medtronics Xomed, Inc. Solvating system and sealant for medical use in the middle or inner ear
WO2008127287A2 (en) 2006-10-11 2008-10-23 Biolife, L.L.C. Materials and methods for wound treatment
US8153612B2 (en) 2006-12-11 2012-04-10 Chi2Gel Ltd. Injectable chitosan mixtures forming hydrogels
US20100178313A1 (en) 2007-06-13 2010-07-15 Fmc Corporation Implantable Degradable Biopolymer Fiber Devices
WO2009056602A1 (en) 2007-10-30 2009-05-07 Viscogel Ab Chitosan composition
WO2009114535A2 (en) 2008-03-10 2009-09-17 Marfly 2, Lp Bone paste composition
CA2722155C (en) 2008-04-24 2019-07-30 Medtronic, Inc. Cold ionizing radiation sterilization
CA2721938C (en) 2008-04-24 2016-08-09 Medtronic, Inc. Chitosan-containing protective composition
WO2009132226A1 (en) 2008-04-24 2009-10-29 Medtronic, Inc. Thiolated chitosan gel
CA2727432C (en) 2008-06-12 2016-10-11 Medtronic Xomed, Inc. Method for treating chronic wounds with an extracellular polymeric substance solvating system
WO2010033943A1 (en) 2008-09-19 2010-03-25 The Trustees Of The University Of Pennsylvania Biodegradable stent
EP3311823B1 (en) 2009-09-02 2020-11-25 Synedgen, Inc. Methods and compositions for disrupting biofilm utilizing chitosan-derivative compounds
WO2011060545A1 (en) 2009-11-19 2011-05-26 Corporation De L'ecole Polytechnique De Montreal Specific blood:chitosan mixing ratios producing a viscous paste-like implant with good handling properties for tissue repair
WO2011060555A1 (en) 2009-11-19 2011-05-26 Corporation De L'ecole Polytechnique De Montreal Soluble physiological chitosan formulations combined with platelet-rich plasma (prp) for tissue repair
CN102469782A (zh) 2010-06-18 2012-05-23 哈洛资源公司 包含壳聚糖的固态共混物的制剂及方法
US8506972B2 (en) 2010-08-27 2013-08-13 Oligo Medic Inc Highly biocompatible dual thermogelling chitosan/glucosamine salt compositions

Also Published As

Publication number Publication date
WO2015061612A1 (en) 2015-04-30
CA2927357A1 (en) 2015-04-30
US9192574B2 (en) 2015-11-24
CA2926401A1 (en) 2015-04-30
JP2016533775A (ja) 2016-11-04
EP3060265A1 (en) 2016-08-31
AU2014340006B2 (en) 2018-06-28
US20150119358A1 (en) 2015-04-30
CA2926401C (en) 2019-08-20
WO2015061606A1 (en) 2015-04-30
EP3060266A1 (en) 2016-08-31
ES2755137T3 (es) 2020-04-21
JP2016534050A (ja) 2016-11-04
JP6397491B2 (ja) 2018-09-26
ES2765348T3 (es) 2020-06-08
EP3060265B1 (en) 2019-11-27
EP3060266B1 (en) 2019-09-04
AU2014340012B2 (en) 2018-06-28

Similar Documents

Publication Publication Date Title
JP6491647B2 (ja) キトサンペースト創傷手当て材
AU2014340012A1 (en) Chitosan paste wound dressing
US9192692B2 (en) Chitosan stenting paste
AU2014340006A1 (en) Chitosan stenting paste
JP5711113B2 (ja) チオール化キトサンゲル
JP5738753B2 (ja) 再水和可能な多糖粒子およびスポンジ
US12419989B2 (en) Solid solution compositions comprising cannabidiols
KR101004551B1 (ko) 조직유착 방지액 및 조직유착 방지방법
JP2011518838A (ja) キトサンと酸化多糖とに基づく保護用ゲル
Geng et al. Convergent architecting of multifunction-in-one hydrogels as wound dressings for surgical anti-infections
WO2020181015A1 (en) System and method to reduce tissue or organ adhesion
EP4329831A1 (en) Antimicrobial compositions

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160531

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170425

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20180119

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180209

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180509

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180709

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20180809

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20190131

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20190301

R150 Certificate of patent or registration of utility model

Ref document number: 6491647

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250