JP2016533775A5 - - Google Patents
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- JP2016533775A5 JP2016533775A5 JP2016518431A JP2016518431A JP2016533775A5 JP 2016533775 A5 JP2016533775 A5 JP 2016533775A5 JP 2016518431 A JP2016518431 A JP 2016518431A JP 2016518431 A JP2016518431 A JP 2016518431A JP 2016533775 A5 JP2016533775 A5 JP 2016533775A5
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- Prior art keywords
- paste
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- 229920001661 Chitosan Polymers 0.000 claims description 34
- 239000000203 mixture Substances 0.000 claims description 24
- 229910019142 PO4 Inorganic materials 0.000 claims description 13
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 13
- 239000010452 phosphate Substances 0.000 claims description 13
- 239000000243 solution Substances 0.000 claims description 12
- 206010052428 Wound Diseases 0.000 claims description 9
- 208000027418 Wounds and injury Diseases 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000000314 lubricant Substances 0.000 claims description 6
- 239000000080 wetting agent Substances 0.000 claims description 6
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims description 3
- 239000002953 phosphate buffered saline Substances 0.000 claims description 3
- XYZZKVRWGOWVGO-UHFFFAOYSA-N Glycerol-phosphate Chemical compound OP(O)(O)=O.OCC(O)CO XYZZKVRWGOWVGO-UHFFFAOYSA-N 0.000 claims description 2
- 230000003013 cytotoxicity Effects 0.000 claims description 2
- 231100000135 cytotoxicity Toxicity 0.000 claims description 2
- 231100000065 noncytotoxic Toxicity 0.000 claims description 2
- 230000002020 noncytotoxic effect Effects 0.000 claims description 2
- 150000003841 chloride salts Chemical class 0.000 claims 1
- 150000001860 citric acid derivatives Chemical class 0.000 claims 1
- 150000002306 glutamic acid derivatives Chemical class 0.000 claims 1
- 150000003893 lactate salts Chemical class 0.000 claims 1
- 150000002823 nitrates Chemical class 0.000 claims 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 description 19
- 239000003638 chemical reducing agent Substances 0.000 description 8
- 229920002807 Thiomer Polymers 0.000 description 5
- 125000003396 thiol group Chemical class [H]S* 0.000 description 5
- 238000012377 drug delivery Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 238000012382 advanced drug delivery Methods 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 238000009509 drug development Methods 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- -1 glutamate salts Chemical class 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000003232 mucoadhesive effect Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 239000005060 rubber Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- OMDQUFIYNPYJFM-XKDAHURESA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-[[(2r,3s,4r,5s,6r)-4,5,6-trihydroxy-3-[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 229920000926 Galactomannan Polymers 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 208000031737 Tissue Adhesions Diseases 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229940023476 agar Drugs 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000001733 carboxylic acid esters Chemical class 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 239000000599 controlled substance Substances 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/061,993 US9192692B2 (en) | 2013-10-24 | 2013-10-24 | Chitosan stenting paste |
| US14/061,993 | 2013-10-24 | ||
| US14/319,901 US9192574B2 (en) | 2013-10-24 | 2014-06-30 | Chitosan paste wound dressing |
| US14/319,901 | 2014-06-30 | ||
| PCT/US2014/062041 WO2015061612A1 (en) | 2013-10-24 | 2014-10-23 | Chitosan paste wound dressing |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016533775A JP2016533775A (ja) | 2016-11-04 |
| JP2016533775A5 true JP2016533775A5 (enExample) | 2018-09-20 |
| JP6491647B2 JP6491647B2 (ja) | 2019-03-27 |
Family
ID=51862592
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016518431A Active JP6491647B2 (ja) | 2013-10-24 | 2014-10-23 | キトサンペースト創傷手当て材 |
| JP2016522114A Active JP6397491B2 (ja) | 2013-10-24 | 2014-10-23 | キトサンステント材ペースト |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016522114A Active JP6397491B2 (ja) | 2013-10-24 | 2014-10-23 | キトサンステント材ペースト |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9192574B2 (enExample) |
| EP (2) | EP3060266B1 (enExample) |
| JP (2) | JP6491647B2 (enExample) |
| AU (2) | AU2014340006B2 (enExample) |
| CA (2) | CA2926401C (enExample) |
| ES (2) | ES2765348T3 (enExample) |
| WO (2) | WO2015061612A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8932560B2 (en) | 2007-09-04 | 2015-01-13 | University of Maryland, College Parke | Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells |
| EP2498820B1 (en) | 2009-11-13 | 2019-01-09 | University of Maryland, College Park | Advanced functional biocompatible foam used as a hemostatic agent for compressible and non-compressible acute wounds |
| WO2014160136A1 (en) | 2013-03-13 | 2014-10-02 | University Of Maryland, Office Of Technology Commercialization | Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells |
| CN105142399B (zh) | 2013-03-14 | 2018-06-12 | 金珂生物医疗公司 | 生物相容的和生物可吸收的衍生的壳聚糖组合物 |
| WO2017032897A1 (en) | 2015-08-27 | 2017-03-02 | Alimentary Health Limited | Use of bifidobacterium longum and an exopolysaccharide produced thereby |
| US10576099B2 (en) | 2016-10-21 | 2020-03-03 | Covidien Lp | Injectable scaffold for treatment of intracranial aneurysms and related technology |
| US10925997B2 (en) * | 2016-10-26 | 2021-02-23 | Biointelligence Systems S.L. | Bone bioactive composition and uses thereof |
| US20220135750A1 (en) * | 2019-02-08 | 2022-05-05 | Chitogel Limited | Surgical hydrogel |
| US11541490B2 (en) | 2019-11-04 | 2023-01-03 | Covidien Lp | Aneurysm treatment device |
| WO2022198208A1 (en) | 2021-03-16 | 2022-09-22 | Covidien Lp | Injectable biopolymer compositions and associated systems and methods |
| EP4084580A1 (en) * | 2021-04-30 | 2022-11-02 | Koninklijke Philips N.V. | A light output system and design method |
| KR102852787B1 (ko) * | 2021-12-28 | 2025-08-28 | 단국대학교 천안캠퍼스 산학협력단 | 신규한 화합물을 포함하는 생리 식염수 |
| EP4572811A1 (en) * | 2022-11-10 | 2025-06-25 | Hemostasis LLC | Dressing formulations |
| CN116059430B (zh) * | 2022-12-16 | 2025-09-23 | 无锡学院 | 一种可降解伤口敷料及其制备方法 |
Family Cites Families (61)
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|---|---|---|---|---|
| US4394373A (en) | 1981-04-06 | 1983-07-19 | Malette William Graham | Method of achieving hemostasis |
| US4532134A (en) | 1981-04-06 | 1985-07-30 | Malette William Graham | Method of achieving hemostasis, inhibiting fibroplasia, and promoting tissue regeneration in a tissue wound |
| US4452785A (en) | 1982-11-08 | 1984-06-05 | Malette William Graham | Method for the therapeutic occlusion |
| CA1202904A (en) | 1983-11-21 | 1986-04-08 | Brian G. Sparkes | Chitosan based wound dressing materials |
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| JPH0735281B2 (ja) | 1988-02-16 | 1995-04-19 | 学校法人松本歯科大学 | 硬化性組成物 |
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-
2014
- 2014-06-30 US US14/319,901 patent/US9192574B2/en active Active
- 2014-10-23 ES ES14793730T patent/ES2765348T3/es active Active
- 2014-10-23 ES ES14793731T patent/ES2755137T3/es active Active
- 2014-10-23 WO PCT/US2014/062041 patent/WO2015061612A1/en not_active Ceased
- 2014-10-23 EP EP14793731.2A patent/EP3060266B1/en active Active
- 2014-10-23 JP JP2016518431A patent/JP6491647B2/ja active Active
- 2014-10-23 AU AU2014340006A patent/AU2014340006B2/en active Active
- 2014-10-23 CA CA2926401A patent/CA2926401C/en not_active Expired - Fee Related
- 2014-10-23 AU AU2014340012A patent/AU2014340012B2/en active Active
- 2014-10-23 JP JP2016522114A patent/JP6397491B2/ja active Active
- 2014-10-23 EP EP14793730.4A patent/EP3060265B1/en active Active
- 2014-10-23 CA CA2927357A patent/CA2927357A1/en not_active Abandoned
- 2014-10-23 WO PCT/US2014/062029 patent/WO2015061606A1/en not_active Ceased
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