JP6490660B2 - 活性に基づくプローブの化合物、組成物、および使用方法 - Google Patents

活性に基づくプローブの化合物、組成物、および使用方法 Download PDF

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Publication number
JP6490660B2
JP6490660B2 JP2016503301A JP2016503301A JP6490660B2 JP 6490660 B2 JP6490660 B2 JP 6490660B2 JP 2016503301 A JP2016503301 A JP 2016503301A JP 2016503301 A JP2016503301 A JP 2016503301A JP 6490660 B2 JP6490660 B2 JP 6490660B2
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Prior art keywords
compound
group
compound according
probe
alkyl
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JP2016503301A
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Japanese (ja)
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JP2016518341A5 (https=
JP2016518341A (ja
Inventor
マシュー エス． ボギョー，
マシュー エス． ボギョー，
マルテイン フェルドウス，
マルテイン フェルドウス，
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Leland Stanford Junior University
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Leland Stanford Junior University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Immunology (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Surgery (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Biotechnology (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2016503301A 2013-03-15 2014-03-15 活性に基づくプローブの化合物、組成物、および使用方法 Active JP6490660B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361794296P 2013-03-15 2013-03-15
US61/794,296 2013-03-15
PCT/US2014/029990 WO2014145257A2 (en) 2013-03-15 2014-03-15 Activity-based probe compounds, compositions, and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019034163A Division JP2019081791A (ja) 2013-03-15 2019-02-27 活性に基づくプローブの化合物、組成物、および使用方法

Publications (3)

Publication Number Publication Date
JP2016518341A JP2016518341A (ja) 2016-06-23
JP2016518341A5 JP2016518341A5 (https=) 2017-04-20
JP6490660B2 true JP6490660B2 (ja) 2019-03-27

Family

ID=51538442

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2016503301A Active JP6490660B2 (ja) 2013-03-15 2014-03-15 活性に基づくプローブの化合物、組成物、および使用方法
JP2019034163A Withdrawn JP2019081791A (ja) 2013-03-15 2019-02-27 活性に基づくプローブの化合物、組成物、および使用方法
JP2021005558A Withdrawn JP2021059606A (ja) 2013-03-15 2021-01-18 活性に基づくプローブの化合物、組成物、および使用方法
JP2023060174A Active JP7689753B2 (ja) 2013-03-15 2023-04-03 活性に基づくプローブの化合物、組成物、および使用方法
JP2025084936A Pending JP2025124721A (ja) 2013-03-15 2025-05-21 活性に基づくプローブの化合物、組成物、および使用方法

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2019034163A Withdrawn JP2019081791A (ja) 2013-03-15 2019-02-27 活性に基づくプローブの化合物、組成物、および使用方法
JP2021005558A Withdrawn JP2021059606A (ja) 2013-03-15 2021-01-18 活性に基づくプローブの化合物、組成物、および使用方法
JP2023060174A Active JP7689753B2 (ja) 2013-03-15 2023-04-03 活性に基づくプローブの化合物、組成物、および使用方法
JP2025084936A Pending JP2025124721A (ja) 2013-03-15 2025-05-21 活性に基づくプローブの化合物、組成物、および使用方法

Country Status (7)

Country Link
US (4) US10100037B2 (https=)
EP (2) EP4218829A3 (https=)
JP (5) JP6490660B2 (https=)
KR (1) KR102279618B1 (https=)
CN (2) CN105431546A (https=)
ES (1) ES2938225T3 (https=)
WO (1) WO2014145257A2 (https=)

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EP4218829A3 (en) * 2013-03-15 2023-08-16 The Board of Trustees of the Leland Stanford Junior University Activity-based probe compounds, compositions, and methods of use
PT3204352T (pt) 2014-10-06 2020-09-23 Cortexyme Inc Inibidores de lisina-gingipaína
US10570173B2 (en) 2015-01-22 2020-02-25 The Board Of Trustees Of The Leland Stanford Junior University Protease-activated contrast agents for in vivo imaging
CA3004095A1 (en) 2015-11-09 2017-05-18 Cortexyme, Inc. Inhibitors of arginine gingipain
ES2992410T3 (es) 2016-09-16 2024-12-12 Lighthouse Pharmaceuticals Inc Inhibidores cetónicos de la lisina gingipaína
US11506662B2 (en) 2016-10-11 2022-11-22 The Regents Of The University Of California Detection, identification, and purification of degradative and non-degradative enzymes in biological samples
JP6984909B2 (ja) * 2016-12-23 2021-12-22 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 活性ベースのプローブ化合物、組成物、および使用方法
KR102669535B1 (ko) * 2017-03-30 2024-05-24 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 생체 내 이미징을 위한 프로테아제 활성화 조영제
WO2018200498A1 (en) * 2017-04-24 2018-11-01 Georgetown University Compositions and methods for analyzing cysteine
EP3717019A4 (en) * 2017-11-28 2021-09-22 Board of Regents of the University of Nebraska RADIOPHARMACEUTICALS AND METHOD OF USE THEREOF
US12486293B2 (en) 2018-07-30 2025-12-02 Georgetown University Chirality sensing with molecular click chemistry probes
WO2020056012A1 (en) 2018-09-11 2020-03-19 Georgetown University Quantitative auxiliary-free chirality sensing with a metal probe
CN113195641B (zh) * 2018-12-20 2024-09-03 武田药品工业株式会社 用作半胱氨酸蛋白酶的探针的氧化锍叶立德衍生物
JP2022515728A (ja) * 2018-12-20 2022-02-22 武田薬品工業株式会社 好中球エラスターゼの新規な活性ベースのプローブおよびその使用

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US4172896A (en) 1978-06-05 1979-10-30 Dainippon Pharmaceutical Co., Ltd. Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same
US5055451A (en) 1986-12-22 1991-10-08 Syntex Inc. Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors
GB9217295D0 (en) 1992-08-14 1992-09-30 Wellcome Found Controlled released tablets
GB9315856D0 (en) 1993-07-30 1993-09-15 Wellcome Found Stabilized pharmaceutical
US5541231A (en) 1993-07-30 1996-07-30 Glaxo Wellcome Inc. Stabilized Pharmaceutical
US5358970A (en) 1993-08-12 1994-10-25 Burroughs Wellcome Co. Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
WO1996041638A1 (en) 1995-06-13 1996-12-27 Sanofi Winthrop, Inc. Calpain inhibitors for the treatment of neurodegenerative diseases
US5989823A (en) 1998-09-18 1999-11-23 Nexstar Pharmaceuticals, Inc. Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction
AU2483599A (en) 1998-01-29 1999-08-16 Sepracor, Inc. Pharmaceutical uses of optically pure (-)-bupropion
US6197750B1 (en) 1998-07-02 2001-03-06 Idun Pharmaceuticals, Inc. C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US6544951B2 (en) 1998-07-02 2003-04-08 Idun Pharmaceuticals, Inc. C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
WO2000064988A1 (en) 1999-04-23 2000-11-02 Molecular Probes, Inc. Xanthene dyes and their application as luminescence quenching compounds
US7019129B1 (en) 2000-05-09 2006-03-28 Biosearch Technologies, Inc. Dark quenchers for donor-acceptor energy transfer
US20020052323A1 (en) * 2000-08-30 2002-05-02 Jinhai Wang Quinoline-(C=O)-(multiple amino acids)-leaving group compounds for pharmaceutical compositions and reagents
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US20050014160A1 (en) 2003-07-18 2005-01-20 Sriram Kumaraswamy Assays for protease enzyme activity
US8968700B2 (en) 2005-08-11 2015-03-03 The Board Of Trustees Of The Leland Stanford Junior University Imaging of protease activity in live cells using activity based probes
US8343458B2 (en) * 2008-04-03 2013-01-01 The Board Of Trustees Of The Leland Stanford Junior University Probes for in vivo targeting of active cysteine proteases
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EP4218829A3 (en) * 2013-03-15 2023-08-16 The Board of Trustees of the Leland Stanford Junior University Activity-based probe compounds, compositions, and methods of use
JP6984909B2 (ja) * 2016-12-23 2021-12-22 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 活性ベースのプローブ化合物、組成物、および使用方法

Also Published As

Publication number Publication date
US10829477B2 (en) 2020-11-10
WO2014145257A3 (en) 2014-12-31
KR102279618B1 (ko) 2021-07-20
ES2938225T3 (es) 2023-04-05
US20190270722A1 (en) 2019-09-05
US20160039792A1 (en) 2016-02-11
US11655236B2 (en) 2023-05-23
JP7689753B2 (ja) 2025-06-09
JP2023085423A (ja) 2023-06-20
EP2971065A4 (en) 2016-12-21
KR20150129004A (ko) 2015-11-18
CN120132004A (zh) 2025-06-13
JP2025124721A (ja) 2025-08-26
CN105431546A (zh) 2016-03-23
EP4218829A2 (en) 2023-08-02
US10100037B2 (en) 2018-10-16
EP2971065A2 (en) 2016-01-20
JP2019081791A (ja) 2019-05-30
JP2021059606A (ja) 2021-04-15
US20210284626A1 (en) 2021-09-16
US20230391750A1 (en) 2023-12-07
WO2014145257A2 (en) 2014-09-18
EP2971065B1 (en) 2022-12-14
JP2016518341A (ja) 2016-06-23
EP4218829A3 (en) 2023-08-16

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