JP6488320B2 - 糖尿病などの疾患の治療用のピロリジンｇｐｒ４０モジュレータ - Google Patents

糖尿病などの疾患の治療用のピロリジンｇｐｒ４０モジュレータ Download PDF

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JP6488320B2
JP6488320B2 JP2016566729A JP2016566729A JP6488320B2 JP 6488320 B2 JP6488320 B2 JP 6488320B2 JP 2016566729 A JP2016566729 A JP 2016566729A JP 2016566729 A JP2016566729 A JP 2016566729A JP 6488320 B2 JP6488320 B2 JP 6488320B2
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JP2017514865A5 (enExample
JP2017514865A (ja
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チョンチン・スン
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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  • Health & Medical Sciences (AREA)
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  • Diabetes (AREA)
  • Cardiology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Child & Adolescent Psychology (AREA)
JP2016566729A 2014-05-07 2015-05-06 糖尿病などの疾患の治療用のピロリジンｇｐｒ４０モジュレータ Expired - Fee Related JP6488320B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461989560P 2014-05-07 2014-05-07
US61/989,560 2014-05-07
PCT/US2015/029422 WO2015171733A1 (en) 2014-05-07 2015-05-06 Pyrrolidine gpr40 modulators for the treatment of diseases such as diabetes

Publications (3)

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JP2017514865A JP2017514865A (ja) 2017-06-08
JP2017514865A5 JP2017514865A5 (enExample) 2018-06-14
JP6488320B2 true JP6488320B2 (ja) 2019-03-20

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JP2016566729A Expired - Fee Related JP6488320B2 (ja) 2014-05-07 2015-05-06 糖尿病などの疾患の治療用のピロリジンｇｐｒ４０モジュレータ

Country Status (14)

Country Link
US (1) US10017497B2 (enExample)
EP (1) EP3140297B1 (enExample)
JP (1) JP6488320B2 (enExample)
KR (1) KR20170002543A (enExample)
CN (1) CN106458987B (enExample)
AU (1) AU2015256038B2 (enExample)
BR (1) BR112016025188A2 (enExample)
CA (1) CA2948175A1 (enExample)
EA (1) EA032290B1 (enExample)
ES (1) ES2671402T3 (enExample)
IL (1) IL248670B (enExample)
MX (1) MX2016014118A (enExample)
SG (1) SG11201609167RA (enExample)
WO (1) WO2015171733A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR102018007822A2 (pt) 2017-04-20 2018-11-06 Gilead Sciences, Inc. composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição
CR20200347A (es) 2018-02-13 2020-09-23 Gilead Sciences Inc Inhibidores pd-1/pd-l1
TWI712412B (zh) 2018-04-19 2020-12-11 美商基利科學股份有限公司 Pd‐1/pd‐l1抑制劑
SG11202012425QA (en) 2018-07-13 2021-01-28 Gilead Sciences Inc Pd-1/pd-l1 inhibitors
WO2020086556A1 (en) 2018-10-24 2020-04-30 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614492A (en) 1986-05-05 1997-03-25 The General Hospital Corporation Insulinotropic hormone GLP-1 (7-36) and uses thereof
US6995183B2 (en) 2003-08-01 2006-02-07 Bristol Myers Squibb Company Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
CN102639495A (zh) * 2009-10-06 2012-08-15 百时美施贵宝公司 吡咯烷gpr40调节剂
JP5864177B2 (ja) 2011-09-15 2016-02-17 船井電機株式会社 プロジェクタおよびプロジェクタシステム
RS55363B1 (sr) * 2012-11-16 2017-03-31 Bristol Myers Squibb Co Dihidropirazolni gpr40 modulatori
SG11201503562PA (en) * 2012-11-16 2015-06-29 Bristol Myers Squibb Co Dihydropyrazole gpr40 modulators
SG11201503556PA (en) * 2012-11-16 2015-06-29 Bristol Myers Squibb Co Dihydropyrazole gpr40 modulators
CA2891569A1 (en) * 2012-11-16 2014-05-22 Bristol-Myers Squibb Company Pyrrolidine gpr40 modulators
EP3140296B1 (en) * 2014-05-07 2018-04-11 Bristol-Myers Squibb Company Pyrrolidine gpr40 modulators for the treatment of diseases such as diabetes

Also Published As

Publication number Publication date
EA201692216A1 (ru) 2017-04-28
US20170217930A1 (en) 2017-08-03
AU2015256038B2 (en) 2019-07-11
AU2015256038A1 (en) 2016-12-22
ES2671402T3 (es) 2018-06-06
WO2015171733A1 (en) 2015-11-12
IL248670A0 (en) 2017-01-31
SG11201609167RA (en) 2016-12-29
CN106458987A (zh) 2017-02-22
CN106458987B (zh) 2019-09-24
EA032290B1 (ru) 2019-05-31
JP2017514865A (ja) 2017-06-08
IL248670B (en) 2019-09-26
CA2948175A1 (en) 2015-11-12
EP3140297B1 (en) 2018-04-11
BR112016025188A2 (pt) 2017-08-15
US10017497B2 (en) 2018-07-10
MX2016014118A (es) 2017-02-09
EP3140297A1 (en) 2017-03-15
KR20170002543A (ko) 2017-01-06

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