CN106458987B - 用于治疗疾病诸如糖尿病的吡咯烷gpr40调节剂 - Google Patents

用于治疗疾病诸如糖尿病的吡咯烷gpr40调节剂 Download PDF

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CN106458987B
CN106458987B CN201580023783.8A CN201580023783A CN106458987B CN 106458987 B CN106458987 B CN 106458987B CN 201580023783 A CN201580023783 A CN 201580023783A CN 106458987 B CN106458987 B CN 106458987B
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CN106458987A (zh
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孙崇庆
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Cardiology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Child & Adolescent Psychology (AREA)
CN201580023783.8A 2014-05-07 2015-05-06 用于治疗疾病诸如糖尿病的吡咯烷gpr40调节剂 Expired - Fee Related CN106458987B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461989560P 2014-05-07 2014-05-07
US61/989,560 2014-05-07
PCT/US2015/029422 WO2015171733A1 (en) 2014-05-07 2015-05-06 Pyrrolidine gpr40 modulators for the treatment of diseases such as diabetes

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CN106458987A CN106458987A (zh) 2017-02-22
CN106458987B true CN106458987B (zh) 2019-09-24

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US (1) US10017497B2 (enExample)
EP (1) EP3140297B1 (enExample)
JP (1) JP6488320B2 (enExample)
KR (1) KR20170002543A (enExample)
CN (1) CN106458987B (enExample)
AU (1) AU2015256038B2 (enExample)
BR (1) BR112016025188A2 (enExample)
CA (1) CA2948175A1 (enExample)
EA (1) EA032290B1 (enExample)
ES (1) ES2671402T3 (enExample)
IL (1) IL248670B (enExample)
MX (1) MX2016014118A (enExample)
SG (1) SG11201609167RA (enExample)
WO (1) WO2015171733A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR102018007822A2 (pt) 2017-04-20 2018-11-06 Gilead Sciences, Inc. composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição
CR20200347A (es) 2018-02-13 2020-09-23 Gilead Sciences Inc Inhibidores pd-1/pd-l1
TWI712412B (zh) 2018-04-19 2020-12-11 美商基利科學股份有限公司 Pd‐1/pd‐l1抑制劑
SG11202012425QA (en) 2018-07-13 2021-01-28 Gilead Sciences Inc Pd-1/pd-l1 inhibitors
WO2020086556A1 (en) 2018-10-24 2020-04-30 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102639495A (zh) * 2009-10-06 2012-08-15 百时美施贵宝公司 吡咯烷gpr40调节剂
WO2014078609A1 (en) * 2012-11-16 2014-05-22 Bristol-Myers Squibb Company Pyrrolidine gpr40 modulators

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614492A (en) 1986-05-05 1997-03-25 The General Hospital Corporation Insulinotropic hormone GLP-1 (7-36) and uses thereof
US6995183B2 (en) 2003-08-01 2006-02-07 Bristol Myers Squibb Company Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
JP5864177B2 (ja) 2011-09-15 2016-02-17 船井電機株式会社 プロジェクタおよびプロジェクタシステム
RS55363B1 (sr) * 2012-11-16 2017-03-31 Bristol Myers Squibb Co Dihidropirazolni gpr40 modulatori
SG11201503562PA (en) * 2012-11-16 2015-06-29 Bristol Myers Squibb Co Dihydropyrazole gpr40 modulators
SG11201503556PA (en) * 2012-11-16 2015-06-29 Bristol Myers Squibb Co Dihydropyrazole gpr40 modulators
EP3140296B1 (en) * 2014-05-07 2018-04-11 Bristol-Myers Squibb Company Pyrrolidine gpr40 modulators for the treatment of diseases such as diabetes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102639495A (zh) * 2009-10-06 2012-08-15 百时美施贵宝公司 吡咯烷gpr40调节剂
WO2014078609A1 (en) * 2012-11-16 2014-05-22 Bristol-Myers Squibb Company Pyrrolidine gpr40 modulators

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Publication number Publication date
EA201692216A1 (ru) 2017-04-28
US20170217930A1 (en) 2017-08-03
AU2015256038B2 (en) 2019-07-11
AU2015256038A1 (en) 2016-12-22
JP6488320B2 (ja) 2019-03-20
ES2671402T3 (es) 2018-06-06
WO2015171733A1 (en) 2015-11-12
IL248670A0 (en) 2017-01-31
SG11201609167RA (en) 2016-12-29
CN106458987A (zh) 2017-02-22
EA032290B1 (ru) 2019-05-31
JP2017514865A (ja) 2017-06-08
IL248670B (en) 2019-09-26
CA2948175A1 (en) 2015-11-12
EP3140297B1 (en) 2018-04-11
BR112016025188A2 (pt) 2017-08-15
US10017497B2 (en) 2018-07-10
MX2016014118A (es) 2017-02-09
EP3140297A1 (en) 2017-03-15
KR20170002543A (ko) 2017-01-06

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