JP6488320B2 - 糖尿病などの疾患の治療用のピロリジンｇｐｒ４０モジュレータ - Google Patents

糖尿病などの疾患の治療用のピロリジンｇｐｒ４０モジュレータ Download PDF

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JP6488320B2
JP6488320B2 JP2016566729A JP2016566729A JP6488320B2 JP 6488320 B2 JP6488320 B2 JP 6488320B2 JP 2016566729 A JP2016566729 A JP 2016566729A JP 2016566729 A JP2016566729 A JP 2016566729A JP 6488320 B2 JP6488320 B2 JP 6488320B2
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JP2017514865A5 (OSRAM
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チョンチン・スン
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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  • Health & Medical Sciences (AREA)
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  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
JP2016566729A 2014-05-07 2015-05-06 糖尿病などの疾患の治療用のピロリジンｇｐｒ４０モジュレータ Expired - Fee Related JP6488320B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461989560P 2014-05-07 2014-05-07
US61/989,560 2014-05-07
PCT/US2015/029422 WO2015171733A1 (en) 2014-05-07 2015-05-06 Pyrrolidine gpr40 modulators for the treatment of diseases such as diabetes

Publications (3)

Publication Number Publication Date
JP2017514865A JP2017514865A (ja) 2017-06-08
JP2017514865A5 JP2017514865A5 (OSRAM) 2018-06-14
JP6488320B2 true JP6488320B2 (ja) 2019-03-20

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ID=53181360

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JP2016566729A Expired - Fee Related JP6488320B2 (ja) 2014-05-07 2015-05-06 糖尿病などの疾患の治療用のピロリジンｇｐｒ４０モジュレータ

Country Status (14)

Country Link
US (1) US10017497B2 (OSRAM)
EP (1) EP3140297B1 (OSRAM)
JP (1) JP6488320B2 (OSRAM)
KR (1) KR20170002543A (OSRAM)
CN (1) CN106458987B (OSRAM)
AU (1) AU2015256038B2 (OSRAM)
BR (1) BR112016025188A2 (OSRAM)
CA (1) CA2948175A1 (OSRAM)
EA (1) EA032290B1 (OSRAM)
ES (1) ES2671402T3 (OSRAM)
IL (1) IL248670B (OSRAM)
MX (1) MX2016014118A (OSRAM)
SG (1) SG11201609167RA (OSRAM)
WO (1) WO2015171733A1 (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR102018007822A2 (pt) 2017-04-20 2018-11-06 Gilead Sciences, Inc. composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição
KR102708681B1 (ko) 2018-02-13 2024-09-26 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
EP4600247A3 (en) 2018-04-19 2025-11-19 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
UA126421C2 (uk) 2018-07-13 2022-09-28 Гіліад Сайєнсіз, Інк. Інгібітори pd-1/pd-l1
US11236085B2 (en) 2018-10-24 2022-02-01 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614492A (en) 1986-05-05 1997-03-25 The General Hospital Corporation Insulinotropic hormone GLP-1 (7-36) and uses thereof
US6995183B2 (en) 2003-08-01 2006-02-07 Bristol Myers Squibb Company Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
CN102639495A (zh) * 2009-10-06 2012-08-15 百时美施贵宝公司 吡咯烷gpr40调节剂
JP5864177B2 (ja) 2011-09-15 2016-02-17 船井電機株式会社 プロジェクタおよびプロジェクタシステム
KR20150082618A (ko) * 2012-11-16 2015-07-15 브리스톨-마이어스 스큅 컴퍼니 디히드로피라졸 gpr40 조절제
US9656963B2 (en) * 2012-11-16 2017-05-23 Bristol-Myers Squibb Company Dihydropyrazole GPR40 modulators
HUE032401T2 (en) * 2012-11-16 2017-09-28 Bristol Myers Squibb Co Dihydropyrazole GPR40 modulators
BR112015010649A2 (pt) * 2012-11-16 2017-07-11 Bristol Myers Squibb Co moduladores de gpr40 à base de pirrolidina
TR201809633T4 (tr) * 2014-05-07 2018-07-23 Bristol Myers Squibb Co Diyabet gibi hastalıkların tedavisine yönelik pirolidin GPR40 modülatörleri.

Also Published As

Publication number Publication date
EP3140297A1 (en) 2017-03-15
EA032290B1 (ru) 2019-05-31
CA2948175A1 (en) 2015-11-12
CN106458987A (zh) 2017-02-22
AU2015256038A1 (en) 2016-12-22
IL248670A0 (en) 2017-01-31
KR20170002543A (ko) 2017-01-06
ES2671402T3 (es) 2018-06-06
IL248670B (en) 2019-09-26
SG11201609167RA (en) 2016-12-29
EP3140297B1 (en) 2018-04-11
US20170217930A1 (en) 2017-08-03
JP2017514865A (ja) 2017-06-08
EA201692216A1 (ru) 2017-04-28
AU2015256038B2 (en) 2019-07-11
BR112016025188A2 (pt) 2017-08-15
WO2015171733A1 (en) 2015-11-12
MX2016014118A (es) 2017-02-09
US10017497B2 (en) 2018-07-10
CN106458987B (zh) 2019-09-24

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