JP6478182B2 - Dry fermented plant extract prepared from a plant containing mineral and method for producing the same - Google Patents

Description

  The present invention relates to a dry fermented plant extract prepared from a plant containing a mineral having high storage stability and a method for producing the same.

  Cycloallyin ((3R, 5S) -5-methyl-3-thiomorpholinecarboxylic acid 1-oxide) is included in onion (+)-S- (1-propenyl) -L-cysteine sulfoxide (PeCSO) Is a component produced when heated under the inert conditions of the enzyme alliinase using PeCSO as a substrate. Cycloallyin has useful physiological effects such as a blood glucose and blood lipid lowering action (Patent Document 1), a thrombolytic action (Non-Patent Document 1), and a liver neutral lipid secretion inhibiting action (Non-Patent Document 2). The function is known.

  The present applicant has so far pulverized onion which has been heat-treated to inactivate the enzyme, and the pulverized product is treated with a cation exchanger, or is mixed with yeast and subjected to fermentation using a saccharide as a substrate. Thus, it is possible to obtain an onion extract having a high cycloaliin content and a brown reaction and flavor deterioration being suppressed, and the onion extract is used as a dry powder etc. in combination with excipients, carriers, etc. It has been reported that it can be prepared into processed foods in the form of granules, tablets, soft capsules, etc. (Patent Document 2)

JP-A-5-194237 JP 2013-132279 A

"Antiplatelet factor contained in spices" Kawaguro Goro Journal of Japanese Society of Food Industry Vol. 38, no. 5,445-453, 1991 Newly found regulators of lipoprotein synthesis "Yanada Yanara Chemistry and Biology Vol. 37, no. 8,502-503, 1999

  The present applicant, for the purpose of developing a product that enables easy intake of cycloaliin, was tableted using a dried onion extract containing cycloaliin produced by a method including the above fermentation step. And tried to produce tablets.

  However, even when the tablets are stored airtight in a dry state, the tablets are moistened, swelled and disintegrated, and the tablets are sticky to each other and discolored. It has been found that it has a problem that it is low and the commercial value is remarkably lowered.

  Then, an object of this invention is to provide the dry fermented plant extract with high storage stability which does not produce said problem, and its manufacturing method.

  As a result of earnest research to solve the problem, the present inventors have found that the above problem is a dry fermented extract obtained by fermenting a pulverized plant with a relatively high content of minerals such as onions. Compared to the case of tablets containing dry extract, which is obtained without fermentation from the pulverized plant with relatively high mineral content, compared with the occurrence of the tablets that contain remarkably, the content of minerals is compared. In tablets containing dried fermented extract obtained by fermenting a pulverized plant pulverized product, it has become clear that the above-mentioned problems do not occur or become apparent. From these findings, the present inventors have found that such a problem is that in the fermentation process, a bicarbonate produced by a reaction between a mineral derived from a pulverized plant and a bicarbonate ion generated by fermentation is present in the fermentation product. It was discovered that this bicarbonate was generated by decomposition during the preservation process to produce water and carbon dioxide.

  Therefore, the present inventors can promote the decomposition of the bicarbonate in advance and reduce the amount of the mixture in the dry fermented extract, thereby obtaining a dry fermented plant extract having high storage stability that does not cause the above problems. As a result, the present invention has been completed.

That is, the present invention has the following features.
[1] Dryness prepared from a plant containing minerals, characterized in that the difference between the moisture content measured by the heat drying method and the moisture content measured by the Karl Fischer method is less than 4.0% by weight. Fermented plant extract.
[2] The dry fermented plant extract according to [1], wherein the amount of carbon dioxide generated after storage is less than 4.0 ml per gram.
[3] The dry fermented plant extract according to [1] or [2], wherein the plant is an onion.
[4] A step of pulverizing a plant containing minerals to obtain a pulverized product, a step of mixing the obtained pulverized product and yeast and performing fermentation to obtain a fermented product, and an obtained fermented product by a heat drying method A method for producing a dry fermented plant extract, comprising a step of drying so that a difference between a measured moisture content and a moisture content measured by the Karl Fischer method is less than 4.0% by weight.
[5] The method of [4], wherein the plant is an onion.
[6] A step of pulverizing a plant containing minerals to obtain a pulverized product, a step of mixing the obtained pulverized product and yeast and performing fermentation to obtain a fermented product, and measuring the obtained fermented product by a heat drying method Drying to obtain a dry fermented plant extract, and a dry fermented plant extract obtained by drying so that the difference between the water content measured by the Karl Fischer method is less than 4.0% by weight The manufacturing method of the composition containing the dry fermented plant extract including the process of mixing with another raw material.
[7] The method of [6], wherein the plant is an onion.

  ADVANTAGE OF THE INVENTION According to this invention, a dry fermented plant extract with high storage stability and its manufacturing method can be provided. In addition, according to the present invention, it is possible to provide a dry fermented onion extract having a high cycloaliin content and high storage stability, and a method for producing the same. Moreover, compositions, such as a foodstuff and a pharmaceutical containing these dry fermented plant extracts, can be provided.

Before storage of the tablets of Example 1 ′, Comparative Example 1 ′ and Comparative Example 2 ′ produced from each dry fermented onion extract of Example 1, Comparative Example 1 and Comparative Example 2, and each dry fermented onion extract It is a photograph figure which shows each state after preserve | saving for 3 days at 60 degreeC.

  The dried fermented plant extract of the present invention includes, for example, a step of pulverizing a plant to obtain a pulverized product, a step of mixing the obtained pulverized product and yeast and performing fermentation to obtain a fermented product, and an obtained fermented product. And a step of drying such that the difference between the moisture content measured by the heat drying method and the moisture content measured by the Karl Fischer method is less than 4.0% by weight.

In the present invention, the “plant” is not particularly limited, but a plant having a high content of minerals is preferable. When a fermented product is produced by pulverizing a plant with a high content of minerals and mixing it with yeast to produce a fermented product, the minerals contained in the plant react with the bicarbonate ions generated during the fermentation process to produce bicarbonate. Salt is included in the fermentation. Since this bicarbonate decomposes over time to produce water and carbon dioxide, the fermented product and products containing the same are wetted during storage to cause swelling, discoloration, etc., resulting in low storage stability. Can occur. Examples of the “mineral” include those belonging to alkali metals and alkaline earth metals, as long as they react with hydrogen carbonate ions to form a hydrogen carbonate salt. For example, sodium, potassium, calcium, magnesium, zinc, Iron etc. are mentioned. When a plant contains sodium, sodium hydrogen carbonate produced in the fermentation process is mixed in the fermented product, which decomposes during storage as shown in the following formula to produce water and carbon dioxide.
2NaHCO ₃ → Na ₂ CO ₃ + CO ₂ + H ₂ O

  The plant contains at least 0.1 wt%, preferably at least 0.2 wt%, more preferably at least 0.4 wt% (based on dry weight). When the amount of minerals contained in the plant is low, the above problem does not become apparent in the first place because a large amount of bicarbonate is not contained in the fermented product.

Examples of the “plant” in the present invention include onion, garlic, rakkyo and the like, preferably onion.
The “plant” may be subjected to heat treatment for enzyme deactivation. For the heat treatment, a known method used for enzyme deactivation can be used. For example, microwave heating, boiling, steam heating, or the like can be used. The heat treatment is performed to such an extent that the target enzyme activity is substantially lost, preferably about 0.5% or less of the enzyme activity when not heated. For example, heating with a microwave oven can be performed by heating a plant (300 g) in a 500 W microwave oven for approximately 7.5 to 10 minutes. The heating by boiling can be performed, for example, by putting a plant into an appropriate amount of hot water of 90 ° C. or higher and heating for about 30 to 240 minutes. Heating with steam can be performed, for example, by putting an appropriate amount of water in a commercially available steamer, putting the plant into the steam generated by heating, and heating for about 30 to 240 minutes.

  For example, when the plant is an onion, an enzyme such as alliinase can be inactivated by heat treatment before crushing, whereby (+)-S- (1-propenyl) -L- contained in the onion. Cycloarin, which is known to have many useful physiological functions, can be produced from cysteine sulfoxide (PeCSO) (Japanese Patent Laid-Open No. 2013-132279).

  The plant can be pulverized using a mixer, a comitrol, a micromeister, a press, or the like. In order to elute useful components in the plant from the inside of the cell to the outside, it is preferable to grind with a suitable extraction solvent. The extraction solvent is not particularly limited as long as the target useful component can be extracted. For example, water, alcohol (methanol, ethanol, propanol, butanol, etc.), acetone, acetonitrile, methyl acetate, hexane, and A combination thereof may be mentioned. Preferably, water, ethanol, hydrous ethanol or the like can be used.

  The pulverized plant consists of a liquid part from which useful components are eluted and a solid part such as a cell wall. Then, you may isolate | separate (squeeze out) a liquid component from a ground material as needed. The solid-liquid separation can be performed by a usual method such as centrifugation or filtration (for example, diatomaceous earth filtration). In addition, a solid-liquid separation process can also be performed simultaneously with a grinding | pulverization process, such as pressing. Moreover, you may refine | purify or roughly refine | purify the useful component made into the objective from a ground material as needed. For purification of the useful component or rough purification, for example, a known technique using column chromatography can be used.

  Next, the pulverized plant is mixed with yeast to obtain a fermented product. Fermentation is performed using sugars present in the pulverized plant as a substrate to obtain a fermented product. By fermenting the pulverized plant, the sugars present in the pulverized product can be reduced. By reducing saccharides such as fructose present in the pulverized product, discoloration and off-taste of the product caused by the presence of the saccharide can be reduced, and a fermented product containing a lot of useful components and the like can be obtained.

  Examples of “yeast” that can be used in the present invention include Saccharomyces cerevisiae and S. cerevisiae. pombe or the like can be used.

  Fermentation conditions are not particularly limited, but typically under suitable stirring conditions, the Bx sugar content is less than half compared to that before fermentation, for example, 2.5 or less when Bx of the solution before fermentation is 5.0. It is preferable to carry out the fermentation. However, this is not absolute because it depends on the concentration of fructose or other sugars in the pre-fermentation solution.

  The obtained fermented product may be subjected to solid-liquid separation and liquid components may be separated and collected as necessary. The solid-liquid separation can be performed by a usual method such as centrifugation or filtration (for example, diatomaceous earth filtration). Moreover, you may refine | purify or roughly refine | purify the useful component made into the objective from fermented material as needed. A known technique using column chromatography can be used for purification or rough purification of useful components.

  Next, the obtained fermented product is subjected to a drying treatment to obtain a dry fermented plant extract. The drying process may be any method including heat treatment, and examples include spray drying, hot air drying, and drum drying. Preferably, the drying process is spray drying.

  The drying treatment is a condition that the difference between the moisture content measured by the heat drying method and the moisture content measured by the Karl Fischer method is less than 4.0% by weight for the dried fermented plant extract after the treatment. Good. As conditions for such drying treatment, in the case of spray drying, the exhaust temperature of the spray drying means is higher than 85 ° C, preferably 90 ° C or higher, more preferably 95 ° C or higher, More preferably, it can be performed at a temperature of 100 ° C. or higher. By setting the temperature of the drying treatment to the above temperature, the decomposition of bicarbonate contained in the fermented product is promoted, and the amount of bicarbonate mixed in the dried fermented plant extract, which is the product, is reduced and stable storage is achieved. A highly fermented dry fermented plant extract and a solid composition using the same can be obtained. On the other hand, when the temperature of the drying treatment is 85 ° C. or lower, the amount of bicarbonate mixed in the dried fermented plant extract as a product cannot be sufficiently reduced, and the mixed bicarbonate is aged over time. Since the amount of carbon dioxide and the amount of water generated by chemical decomposition also increase, problems such as wetting and discoloration during storage may occur. In addition, the conditions in the case of using another drying method can be suitably set so that it may become the moisture content which the dry fermented plant extract after a process calculates | requires.

  Although the upper limit of the temperature of the drying process in spray drying is not specifically limited, It can be 110 degrees C or less. If the temperature of the drying treatment exceeds 110 ° C., the fermented product may hatch, and the operability of the fermented product may be reduced.

  In the dried fermented plant extract of the present invention, the difference between the water content measured by the heat drying method and the water content measured by the Karl Fischer method is less than 4.0% by weight, preferably 3.7% by weight or less. More preferably, the content is 3.0% by weight or less. That is, bicarbonate is less than 4.0% by weight, preferably 3.7% by weight or less, more preferably in terms of the amount of water generated by decomposition of bicarbonate (based on the weight of the dried fermented plant extract). Is contained in an amount of 3.0% by weight or less. A dry fermented plant extract containing an amount of bicarbonate out of the above-specified range of water content, which is 4.0% by weight or more in terms of the amount of water generated by the decomposition of bicarbonate, is incorporated into the dry fermented plant extract. The amount of hydrogen carbonate mixed in is not sufficiently reduced, resulting in problems such as wetness and discoloration during storage, and storage stability is lowered.

  Here, the grounds for the amount of water determined by the following formula defined in the present invention to be the amount of water generated by the decomposition of the bicarbonate contained in the dry fermented plant extract will be described.

[formula]
Water content (% by weight) generated by decomposition of bicarbonate =
Moisture content (wt%) measured by heat drying method-Moisture content (wt%) measured by Karl Fischer method
* In the formula, each water content is based on the weight of the dried fermented plant extract.

  The heat drying method includes a step of removing moisture in the sample by heating the sample to the boiling point or higher of water, and the amount of moisture derived from the sample can be obtained based on the weight difference of the sample before and after the heat treatment. . In the present invention, for example, a dry fermented plant extract (3.0 g) is heat-treated at 105 ° C. under normal pressure for 16 hours, so that the moisture content derived from the dry fermented plant extract is based on the weight difference between the samples before and after the heat treatment. Can be requested. The amount of water determined by the heat drying method includes the amount of water contained in the dry fermented plant extract and the amount of water generated by the decomposition of the bicarbonate contained in the dry fermented plant extract.

  The Karl Fischer method can determine the amount of water in a sample by utilizing the fact that water reacts selectively and quantitatively with iodine and sulfur dioxide in the presence of pyridine and lower alcohol. The moisture content is measured by dissolving iodine in a moisture measurement reagent in advance and measuring the moisture content based on the amount used for the titration of the moisture measurement reagent to react with the water in the sample (capacity). Titration method) or iodide ions are dissolved in a water measurement reagent, and the amount of electricity required for electrolysis is determined based on the fact that iodine generated by electrolysis reacts with water in the sample. A method (coulometric titration method) for conversion (10.71 coulombs = 1 mg of water) can be used. In the present invention, the water content can be determined using a coulometric titration method. The amount of water determined by the Karl Fischer method includes the amount of water contained in the dry fermented plant extract, and does not include the amount of water generated by decomposition of the bicarbonate contained in the dry fermented plant extract.

  Therefore, by subtracting the amount of water measured by the Karl Fischer method from the amount of water measured by the heat drying method, the amount of water generated by the decomposition of the bicarbonate mixed in the dried fermented plant extract can be obtained.

  In addition, the dried fermented plant extract of the present invention has an expansion rate after storage of less than 150%, preferably 105% or less of the original volume after being subjected to the drying treatment. The expansion of the dry fermented plant extract is caused by water absorption caused by the decomposition of the bicarbonate mixed in the dry fermented plant extract. The dry fermented plant extract whose expansion rate after storage is 150% or more of the original volume is not sufficiently reduced in the amount of bicarbonate mixed in the dry fermented plant extract, and may cause the above problem. is there. In the present invention, the expansion rate can be determined from the volume before and after storage by measuring the volume of the dried fermented plant extract before and after storage at 60 ° C. for 3 days. For example, a dry fermented plant extract is filled in a 2 ml Eppendorf tube, and the expansion to the upper part before and after storage is read on a scale (calculation is performed in the examples and comparative examples).

  Furthermore, in the dry fermented plant extract of the present invention, the amount of carbon dioxide generated after storage is less than about 4 mL, preferably less than about 1 mL, more preferably about 0.5 mL or less, more preferably less than 1 mL per 1 g of the dry fermented plant extract. It is about 0.1 mL or less (measured value at 25 ° C.). The generation of carbon dioxide is caused by the decomposition of bicarbonate mixed in the dry fermented plant extract, and the dry fermented plant extract in which the generated amount of carbon dioxide is about 4 mL or more per 1 g of the dry fermented plant extract is dry fermented. The amount of bicarbonate contained in the plant extract is not sufficiently reduced, which may cause the above problem. In the present invention, the amount of carbon dioxide generated can be determined by collecting the gas generated during storage for 3 days at 60 ° C. by water replacement.

  The dry fermented plant extract specified by the above water content and / or specified by the expansion rate and / or the amount of carbon dioxide generated is reduced in the amount of mixed bicarbonate, wet / water absorption Problems such as swelling and stickiness due to the occurrence of carbon dioxide, generation of carbon dioxide, and discoloration are suppressed or do not occur, resulting in high storage stability.

  In one embodiment, the step of heat-treating the onion to deactivate the enzyme, the step of pulverizing the onion after enzyme inactivation to obtain a pulverized product, the step of mixing the pulverized product with yeast to obtain a fermented product, and By the method including the step of drying the fermented product at a temperature higher than 85 ° C., a dry fermented onion extract containing cycloaryin as a useful component and having high storage stability can be obtained.

  The dried fermented plant extract of the present invention can be used as it is, and other raw materials acceptable in the final form such as foods and pharmaceuticals, for example, excipients, binders, disintegrants, sweeteners, Vitamins, minerals, antioxidants, pigments, fragrances, preservatives, preservatives, fungicides, etc. are mixed with one or more raw materials and mixed to form a composition, preferably a solid composition can do. Although it does not specifically limit as a solid composition, It can be set as forms, such as a granule, a pill, a tablet, a powder agent, and a chewable tablet.

  The solid composition containing the dried fermented plant extract of the present invention can be produced using a general technique. For example, the dried fermented plant extract of the present invention is mixed with one or more of the above components to produce a solid composition. Process one or a combination of granulation (spray granulation, extrusion granulation, agitation granulation, fluidized bed granulation, rolling granulation, compression granulation, etc.), sizing, compression molding, tableting, etc. Can be manufactured.

  The dry fermented plant extract and the solid composition containing the same of the present invention can be used as a food composition or a pharmaceutical composition intended to ingest useful components contained in the dry fermented plant extract.

  The dried fermented plant extract of the present invention and a solid composition containing the same can be stored in a container or bag used as a container or bag for food or medicine, for example, paper, plastic, glass, metal Containers and bags. The solid composition of the present invention can be packaged for each oral intake. The means for storing the composition in a container or bag is arbitrary. The dried fermented plant extract and the solid composition are appropriately stored in a dry state.

  By including the dried fermented plant extract of the present invention, the solid composition of the present invention has problems such as swelling and stickiness due to wet / water absorption, generation of carbon dioxide, discoloration, and the like caused by the dried fermented plant extract. It is not or does not become apparent, and has high storage stability.

  EXAMPLES Hereinafter, the present invention will be described more specifically with reference to examples. However, the scope of the present invention is not limited to the scope of the examples.

[I. Production of dry fermented onion extract-including sugar removal step by yeast fermentation]
Example 1
Ten onions (north maple 2000 with a mineral content of about 0.4% by weight) were peeled and divided into four equal parts vertically with a knife. The weight of the 1/4 cut onion was 3525 g.

  A 1/4 cut onion was put into 6000 g of hot water that had been adjusted to 95 ° C. in advance, and was allowed to stand for 60 minutes while adjusting to 95 ° C. to inactivate enzymes such as alliinase and to produce cycloaliin. . Next, the onion was crushed with hot water using a household mixer and centrifuged using a centrifuge, and the supernatant was collected. The obtained supernatant liquid had a weight of 8521 g, a cycloaryin concentration of 0.72 mg / g, and a sugar content of Bx4.2.

Saccharomyces cerevisiae was added to this supernatant so as to be 1% (approximately 8.5 × 10 ¹¹ cells) and cultured at 30 ° C. for 3 days.

  After completion of the culture, the culture solution was centrifuged with a centrifuge, and the supernatant was collected. The obtained supernatant liquid had a weight of 8172 g, a cycloaryin concentration of 0.70 mg / g, and a sugar content of Bx0.8.

  The supernatant was powdered by spray drying (spray dryer) at 95 ° C. (exhaust temperature) to obtain 63.4 g of dried fermented onion extract (powder). The obtained dried fermented onion extract contained 5.61 g of cycloaliin (concentration was about 8.82 wt%), and the fructose content was 0 wt%.

(Examples 2-5, Comparative Examples 1-2)
For Examples 2-5 and Comparative Examples 1-2, dry fermented onion extract was obtained in the same manner as in Example 1 except that the temperature conditions for spray drying were changed to the conditions shown in Table 1, respectively. The cycloaliin content and fructose content in the dry fermented onion extract obtained in each case were similar to the dry fermented onion extract of Example 1 above.

[Method of evaluation]
About the dry fermented onion extract obtained in Examples 1-5 and Comparative Examples 1-2, each moisture content was measured. Moreover, each was put into the sealing packaging material, and it preserve | saved at 60 degreeC for 3 days, and measured each carbon dioxide gas generation amount and expansion coefficient. Further, the appearance properties after each storage were examined. The moisture content, carbon dioxide generation amount, expansion rate, and appearance properties after storage were measured by the following methods, respectively.

(Measurement of water content)
(1) Heat drying method Each dried fermented onion extract (3.0 g) obtained by spray drying is subjected to heat drying treatment at 105 ° C for 16 hours under normal pressure. From the weight difference before and after heating, the dried fermented onion The sum of the amount of moisture contained in the extract and the amount of moisture derived from the decomposition of bicarbonate was determined. The amount of water is expressed as a relative value with the weight of the dried fermented onion extract before heating as 100% by weight.

(2) Karl Fischer method Each dry fermented onion extract obtained by spray drying was subjected to coulometric titration to determine the amount of water contained in the dry fermented onion extract. The amount of water is expressed as a relative value with the weight of the dried fermented onion extract as 100% by weight.

(3) Moisture amount derived from decomposition of bicarbonate The amount of moisture derived from decomposition of bicarbonate was determined by subtracting the amount of moisture determined by the Karl Fischer method from the amount of moisture determined by the heat drying method. .

(Measurement method of carbon dioxide generation amount)
The gas generated in the sealed packaging after storage was collected by replacing with water, and the generated amount was measured at 25 ° C.

(Expansion coefficient measurement method)
The volume of the dried fermented onion extract before and after storage was measured to determine the expansion rate before and after storage.

(Appearance after storage)
The appearance properties of the dried fermented onion extract after storage were evaluated by visual comparison with those before storage.

  Table 1 shows the moisture content, carbon dioxide generation amount, expansion rate, and appearance properties after storage of each dried fermented onion extract. Moreover, the external appearance photograph before and behind the preservation | save of the dry fermented onion extract of Example 1 and Comparative Examples 1-2 is shown in FIG.

  In Example 5, hatching of the raw material was slightly observed during the drying, and the yield of the dried fermented onion extract tended to decrease.

[II. Production of tablets using dry fermented onion extract]
(Example 1 ')
Using the dried fermented onion extract (1 g each) obtained in Example 1, 3 g of tablets were produced by a conventional method and stored in a sealed container. It should be noted that the tablet does not contain components other than the dry fermented onion extract that change the water content of the tablet when stored airtight in a dry state.

(Examples 2 ′ to 5 ′, Comparative Examples 1 ′ to 2 ′)
About Example 2'-5 'and Comparative Example 1'-2', respectively, except changing dry fermented onion extract into the said Examples 2-5 and Comparative Examples 1-2, respectively, it carries out similarly to the said Example 1 '. Tablets were manufactured.
Any dry fermented onion extract could be tableted well, and the appearance after each tableting was the same as the tablet of Example 1 ′.

[Method of evaluation]
For the tablets of Examples 1 ′ to 5 ′ and Comparative Examples 1 ′ to 2 ′, each was placed in a sealed packaging material and stored at 60 ° C. for 3 days, and the appearance properties after each storage, that is, the degree of expansion, and The presence or absence of adhesion between tablets was evaluated.

(result)
The appearance properties of each tablet after storage are shown in Table 2. Moreover, the external appearance photograph before and behind the preservation | save of the tablet of Example 1 'and Comparative Examples 1'-2' is shown in FIG.

  From the above results, when the difference between the moisture content measured by the heat drying method of the dry fermented onion extract and the moisture content measured by the Karl Fischer method is less than 4.0% by weight, the dry fermented onion extract It was also confirmed that the storage stability of the tablets was increased.

Claims (2)

A step of pulverizing plant bulbs selected from onion, garlic, and raccoon containing minerals to obtain a pulverized product, a step of mixing the obtained pulverized product and yeast and performing fermentation to obtain a fermented product, and and the fermented product, at 90 ° C. or higher, heat drying method and the moisture content measured by the difference spray drying such that less than 4.0 wt% of the measured water content with the Karl Fischer method The manufacturing method of a dry fermented plant extract including the process to do. A step of obtaining a pulverized product by pulverizing a bulb of a plant selected from onion, garlic and rakkyo containing minerals, a step of obtaining a fermented product by performing fermentation by mixing the obtained pulverized product and yeast, and obtained the fermented product, at 90 ° C. or higher, and the water content measured by the heat drying method, spray drying so that the difference between the measured water content by the Karl Fischer method is less than 4.0 wt% The manufacturing method of the composition containing a dry fermented plant extract including the process of obtaining a dry fermented plant extract, and the process of mixing the obtained dry fermented plant extract with another raw material.

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