CN106539075A - A kind of preparation method of efficient absorption sea cucumber nutrient buccal tablet - Google Patents
A kind of preparation method of efficient absorption sea cucumber nutrient buccal tablet Download PDFInfo
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- CN106539075A CN106539075A CN201610566115.6A CN201610566115A CN106539075A CN 106539075 A CN106539075 A CN 106539075A CN 201610566115 A CN201610566115 A CN 201610566115A CN 106539075 A CN106539075 A CN 106539075A
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- Prior art keywords
- stichopus japonicuss
- sea cucumber
- buccal tablet
- stichopus
- japonicuss
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- 241000251511 Holothuroidea Species 0.000 title claims abstract description 47
- 235000015097 nutrients Nutrition 0.000 title claims abstract description 35
- 229940046011 buccal tablet Drugs 0.000 title claims abstract description 29
- 239000006189 buccal tablet Substances 0.000 title claims abstract description 29
- 238000010521 absorption reaction Methods 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 241000965254 Apostichopus japonicus Species 0.000 claims abstract description 94
- 230000000694 effects Effects 0.000 claims abstract description 10
- 238000000605 extraction Methods 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 7
- 238000000108 ultra-filtration Methods 0.000 claims abstract description 5
- 239000000843 powder Substances 0.000 claims description 35
- 238000001035 drying Methods 0.000 claims description 28
- 239000007788 liquid Substances 0.000 claims description 24
- 210000001835 viscera Anatomy 0.000 claims description 24
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 102000004190 Enzymes Human genes 0.000 claims description 15
- 108090000790 Enzymes Proteins 0.000 claims description 15
- 229940088598 enzyme Drugs 0.000 claims description 15
- 239000010410 layer Substances 0.000 claims description 12
- 239000002893 slag Substances 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 11
- 238000004108 freeze drying Methods 0.000 claims description 11
- 230000000050 nutritive effect Effects 0.000 claims description 11
- 239000011241 protective layer Substances 0.000 claims description 10
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 9
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims description 9
- 238000004140 cleaning Methods 0.000 claims description 9
- 239000012153 distilled water Substances 0.000 claims description 9
- 235000013372 meat Nutrition 0.000 claims description 9
- 229910052757 nitrogen Inorganic materials 0.000 claims description 9
- 238000005119 centrifugation Methods 0.000 claims description 8
- 238000000855 fermentation Methods 0.000 claims description 7
- 230000004151 fermentation Effects 0.000 claims description 7
- 235000016709 nutrition Nutrition 0.000 claims description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 6
- 239000004365 Protease Substances 0.000 claims description 6
- 229930006000 Sucrose Natural products 0.000 claims description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 6
- 238000007792 addition Methods 0.000 claims description 6
- 235000013361 beverage Nutrition 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 230000035764 nutrition Effects 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 239000005720 sucrose Substances 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 4
- 238000007710 freezing Methods 0.000 claims description 4
- 230000008014 freezing Effects 0.000 claims description 4
- 241000233866 Fungi Species 0.000 claims description 3
- 240000001046 Lactobacillus acidophilus Species 0.000 claims description 3
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 claims description 3
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 3
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 3
- 108090000526 Papain Proteins 0.000 claims description 3
- 108091005804 Peptidases Proteins 0.000 claims description 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 3
- 239000001569 carbon dioxide Substances 0.000 claims description 3
- 230000006837 decompression Effects 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 3
- 235000008434 ginseng Nutrition 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 3
- 235000008935 nutritious Nutrition 0.000 claims description 3
- 229940055729 papain Drugs 0.000 claims description 3
- 235000019834 papain Nutrition 0.000 claims description 3
- 235000019419 proteases Nutrition 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 238000000926 separation method Methods 0.000 claims description 3
- 239000002002 slurry Substances 0.000 claims description 3
- 238000003815 supercritical carbon dioxide extraction Methods 0.000 claims description 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 3
- 235000010447 xylitol Nutrition 0.000 claims description 3
- 239000000811 xylitol Substances 0.000 claims description 3
- 229960002675 xylitol Drugs 0.000 claims description 3
- 244000131316 Panax pseudoginseng Species 0.000 claims 1
- 230000008859 change Effects 0.000 abstract description 2
- 238000010579 first pass effect Methods 0.000 abstract description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 2
- 239000004615 ingredient Substances 0.000 abstract description 2
- 210000004185 liver Anatomy 0.000 abstract description 2
- 210000004877 mucosa Anatomy 0.000 abstract description 2
- 230000008569 process Effects 0.000 abstract description 2
- 230000009286 beneficial effect Effects 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 3
- 229910052720 vanadium Inorganic materials 0.000 description 3
- QXNWZXMBUKUYMD-ITUXNECMSA-N 4-keto-beta-carotene Chemical compound CC=1C(=O)CCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C QXNWZXMBUKUYMD-ITUXNECMSA-N 0.000 description 2
- 241000208340 Araliaceae Species 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- FDSDTBUPSURDBL-LOFNIBRQSA-N canthaxanthin Chemical compound CC=1C(=O)CCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)CCC1(C)C FDSDTBUPSURDBL-LOFNIBRQSA-N 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
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- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- DMASLKHVQRHNES-UPOGUZCLSA-N (3R)-beta,beta-caroten-3-ol Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C DMASLKHVQRHNES-UPOGUZCLSA-N 0.000 description 1
- 241000256844 Apis mellifera Species 0.000 description 1
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- 239000004475 Arginine Substances 0.000 description 1
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 description 1
- 239000004212 Cryptoxanthin Substances 0.000 description 1
- 206010018473 Glycosuria Diseases 0.000 description 1
- 229930188089 Holothurin Natural products 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- OOUTWVMJGMVRQF-DOYZGLONSA-N Phoenicoxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)C(=O)C(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)C(=O)CCC2(C)C OOUTWVMJGMVRQF-DOYZGLONSA-N 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
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- 229940121375 antifungal agent Drugs 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 235000013793 astaxanthin Nutrition 0.000 description 1
- 239000001168 astaxanthin Substances 0.000 description 1
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 description 1
- 229940022405 astaxanthin Drugs 0.000 description 1
- 235000002360 beta-cryptoxanthin Nutrition 0.000 description 1
- DMASLKHVQRHNES-ITUXNECMSA-N beta-cryptoxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)CCCC2(C)C DMASLKHVQRHNES-ITUXNECMSA-N 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 235000012682 canthaxanthin Nutrition 0.000 description 1
- 239000001659 canthaxanthin Substances 0.000 description 1
- 229940008033 canthaxanthin Drugs 0.000 description 1
- 230000023852 carbohydrate metabolic process Effects 0.000 description 1
- 235000021256 carbohydrate metabolism Nutrition 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000003153 cholinolytic effect Effects 0.000 description 1
- 235000019244 cryptoxanthin Nutrition 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000006932 echinenone Nutrition 0.000 description 1
- YXPMCBGFLULSGQ-YHEDCBSUSA-N echinenone Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCC(=O)C1(C)C)C=CC=C(/C)C=CC2=C(C)CCCC2(C)C YXPMCBGFLULSGQ-YHEDCBSUSA-N 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 230000003394 haemopoietic effect Effects 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 235000001497 healthy food Nutrition 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- MAWWITJOQDJRJF-ADBICINLSA-M holothurin Chemical compound [Na+].O[C@@H]1[C@@H](OC)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O[C@H]3[C@@H](OC[C@H]([C@@H]3O)OS([O-])(=O)=O)O[C@@H]3C([C@H]4[C@](C=5[C@H]([C@@]6(CC[C@]7(O)[C@](C)([C@H]8OC(C)(C)CC8)OC(=O)[C@@]76[C@@H](O)C=5)C)CC4)(C)CC3)(C)C)O[C@@H]2C)O)O[C@H](C)[C@H]1O MAWWITJOQDJRJF-ADBICINLSA-M 0.000 description 1
- 229930186900 holotoxin Natural products 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 235000021049 nutrient content Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 230000004223 radioprotective effect Effects 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a kind of preparation method of efficient absorption sea cucumber nutrient buccal tablet, the technical problem to be solved is：A kind of efficient absorption sea cucumber nutrient buccal tablet is prepared, the comprehensive utilization ratio of Stichopus japonicuss is improved, while improving the assimilation effect of human body.It is an advantage of the invention that：Show Stichopus japonicuss farthest to comprehensively utilize, change traditional sea cucumber processing process；Sea cucumber nutrient value is remained at utmost, by the extraction processes such as enzymolysis, ultrafiltration membrance filter of fermenting, Stichopus japonicuss are made by buccal, the new paragon of mucosa absorption in mouth, guarantee essential ingredient release and maximize with absorbing, active component is directly entered human circulation, first pass effect without gastrointestinal tract and liver, absorbs and maximizes.
Description
Technical field
The present invention relates to health food processing method, in particular, is to be related to a kind of efficient absorption sea cucumber nutrient buccal tablet
Preparation method.
Background technology
Stichopus japonicuss be it is a kind of be beneficial to healthy food, containing various biological regulation materials, such as antitumorigenic substance, anti-dynamic
The Multiple components such as arteries and veins hardening, antiinflammatory, enhance immunity.
In recent years, as Chinese Stichopus japonicuss industry is developed rapidly, market and cultivation scale constantly expand, corresponding problem
It is that Stichopus japonicuss comprehensive utilization degree is low, Holothurian machining is only limited to wall of sea cucumber Stichopus japonicus, the leftover bits and pieces Intestinum Stichopi japonici in the course of processing is adding
Because of its a large amount of silt of carrying during work, often it is taken as garbage to abandon, is sufficiently developed, causes resource wave
Take and environmental pollution, therefore in order to open up Stichopus japonicuss comprehensive processing and utilization, meet market demand, increase economic well-being of workers and staff, need searching badly
A kind of method processing and utilization Intestinum Stichopi japonici of high efficiency low cost.Modern nutriology analytical proof, Intestinum Stichopi japonici are not only contained with wall of sea cucumber Stichopus japonicus
Same abundant active substance, and many precious nutrient contents are higher, such as polysaccharide, vanadium, nucleic acid, arginine etc.；Intestinum Stichopi japonici is also
Containing extremely abundant pigment (bata-carotene, echinenone, astaxanthin, cryptoxanthin, canthaxanthin and some unknown pigments),
The compositions such as Radix Morinae Bulleyanae lipid, Radix Morinae Bulleyanae Saponin, selenium, zinc, ferrum.
The pigment of Stichopus japonicuss enteral, itself can not synthesize in animal body, with non-oxidizability, can remove internal freedom
Base, slow down aging.In Intestinum Stichopi japonici, the content of vanadium is 3-4 times of wall of sea cucumber Stichopus japonicus, and vanadium can maintain the normal carbohydrate metabolism of body, have
Diabetes are prevented and treated effect, stimulates the hemopoietic function of body, promote the hematopoietic potential of skeleton.The nutritional labeling of Intestinum Stichopi japonici is very rich
Richness, especially holotoxin, are also referred to as holothurin by some, and it can be with antitumor, radioprotective, antifungal, anti-cell poison
Property, cholinolytic effect, the growth and transfer of being capable of anticancer, affect neural traffic, to aplastic anemia, glycosuria
Disease, gastric ulcer etc. have good effect.Stichopus japonicus polysaccharide also has several functions activity, serves important in the vital movement of body
Effect.As can be seen here, Intestinum Stichopi japonici has very high using value.
The content of the invention
The present invention is directed to the deficiencies in the prior art, and provides a kind of preparation method of efficient absorption sea cucumber nutrient buccal tablet.This
Inventing technical problem to be solved is：A kind of efficient absorption sea cucumber nutrient buccal tablet is prepared, the comprehensive utilization ratio of Stichopus japonicuss is improved, together
The assimilation effect of Shi Tigao human bodies.
A kind of preparation method of efficient absorption sea cucumber nutrient buccal tablet of the present invention, comprises the following steps：
A () is clean by cleaning sea cucumber, take out internal calcium carbonate, the Stichopus japonicuss internal organs for cleaning up are separated with meat wall；
(b) take Stichopus japonicuss meat wall add distilled water heating 1-2 hours, keeping temperature 75-100 DEG C be put into vacuum equipment keep-
0.04MPa, is reduced pressure -0.01MPa per hour using gradient decompression method, after being depressurized to -0.08MPa, takes out internal organs and meat wall is twisted
Broken and grinding slurry, below 3 μm of defibrination fineness, obtains Stichopus japonicuss virgin pulp liquid；Stichopus japonicuss virgin pulp liquid is put in filter centrifugal, using super
Stichopus japonicuss virgin pulp liquid is separated into Stichopus japonicuss slag and Stichopus japonicuss filtrate by filter membrane；
C () takes the 95% ethanol mixing and stirring of concentration that Stichopus japonicuss filtrate adds 1-2 times, place 12 hours, using centrifugation
Filter 3000rpm centrifugation 10-15 minutes, will be placed in thermostatic drying chamber, be kept for 60-75 DEG C, after alcohol taste, adopt
Liquid nitrogen carries out very fast pre-freeze；Then it will be vacuum dried during freeze drying equipment will be put into, below -20 DEG C, control -
0.08MPa；Keep vacuum 1-3 hour；Then on an hourly basis 3.5-4.5 DEG C of cascade raising temperature heat drying 10～12 when；It has been dried
Stichopus japonicuss dry powder is obtained after finishing；
D () takes Stichopus japonicuss slag and adds DDW, add concentration for the sucrose water of 2-5%, sucrose water after stirring
1: 3～5 are deployed into by weight with Stichopus japonicuss slag solution, add the compound ferment powder of Stichopus japonicuss slag 4-8% weight, 35-45 DEG C of sealing to keep away
Light ferments 3-4 days；Using Stichopus japonicuss fermentation liquid is obtained after high temperature moment enzyme denaturing after filtering to take out debris, then Stichopus japonicuss fermentation liquid is put into
Freeze drying equipment is dried freezing, and the Stichopus japonicuss yeast powder of 200-300 mesh is then ground into by Lowtemperaturepulverizer；
E the Stichopus japonicuss internal organs for cleaning up addition distilled water is ground into Stichopus japonicuss internal organs serosity by (), keep 34.5 DEG C of additions
The compound enzyme of 8ml/g stirs, and digests 35 minutes；Stichopus japonicuss internal organs serosity after enzymolysis heats 100-115 DEG C, keeps 10-20
Minute, carry out enzyme denaturing；；Add 1-2 times of 95% ethanol mixing and stirring of concentration, filter centrifugal 3000rpm centrifugations
10-15 minutes, be put in thermostatic drying chamber, keep 60 DEG C, without alcohol taste after, very fast pre-freeze is carried out using liquid nitrogen；Then it is put into cold
Freeze in drying equipment and be vacuum dried, below -20 DEG C, control -0.08MPa；Keep vacuum 1-3 hour；Then by per little
When 3.5-4.5 DEG C of cascade raising temperature heat drying 10～12 when；Drying obtains Stichopus japonicuss internal organs dry powder after finishing, and uses supercritical carbon dioxide
Extraction equipment carries out extracting Stichopus japonicuss bata-carotene；
F () takes Stichopus japonicuss dry powder, Stichopus japonicuss yeast powder, Stichopus japonicuss internal organs dry powder respectively according to the ratio that weight compares 1: 2: 0.5, plus steam
Distilled water is modulated into nutritive sea cucumber beverage, adds activated carbon, is separated using 5000D ultrafiltration membrance filters, and after separation, nutritive sea cucumber beverage is adopted
Liquid nitrogen carries out very fast pre-freeze；Then it will be vacuum dried during freeze drying equipment will be put into, below -20 DEG C, control -
0.08MPa；Keep vacuum 1-3 hour；Then on an hourly basis 3.5-4.5 DEG C of cascade raising temperature heat drying 10～12 when, it is dry
Sea cucumber nutrient powder, obtains final product sea cucumber nutrient buccal tablet by sea cucumber nutrient powder tabletted.
The outer layer of sea cucumber nutrient buccal tablet described in step (f) arranges nutritious protective layer.
The nutrition protective layer raw material is prepared by the raw materials in, 15～25 parts of Herba Menthae, 10～20 parts of Fructus Crataegi, honeybee
10～20 parts of honey, 2～8 parts of starch, 15～50 parts of xylitol, 1～10 part of Stichopus japonicuss bata-carotene, are put into pulverizer and are crushed to 300
Mesh～400 mesh, adds water and makes nutritive layer serosity, and drying had both obtained nutrition protective layer
The nutritive layer serosity uniformly brushes the outer layer in sea cucumber nutrient buccal tablet, and drying vacuum is aluminum-plastic packaged.
Compound enzyme described in step (e) is black fermented preparation fungi protease and papain, and the two enzyme activity proportioning is 1: 3～1:
5。
The compound ferment powder is bacillus acidophilus, saccharomyces cerevisiae.
The condition that Stichopus japonicuss bata-carotene is extracted described in step (e) is that Stichopus japonicuss internal organs dry powder amount is 200-500g, extraction kettle
Pressure 25MPa, extraction kettle temperature room temperature to 35-45 DEG C, carbon dioxide flow 25L/h, extraction time 3-4h.
The invention has the beneficial effects as follows：1st, present invention control processing step realizes Stichopus japonicuss and farthest comprehensively utilizes,
Change traditional sea cucumber processing process；Sea cucumber nutrient value is remained at utmost, by enzymolysis, the ultrafiltration membrance filter etc. of fermenting
Extraction process, makes Stichopus japonicuss by buccal, the new paragon of mucosa absorption in mouth, it is ensured that essential ingredient discharges and maximizes with absorbing, living
Property composition be directly entered human circulation, the first pass effect without gastrointestinal tract and liver, absorb maximize.Sea prepared by the inventive method
Ginseng buccal tablet, chilled vacuum drying, in cellular, specific surface area is strong so as to adsorption greatly, can quickly by oral cavity for Stichopus japonicuss structure
Solution absorption.
Specific embodiment
With reference to embodiment, the invention will be further described.
Embodiment one
A kind of preparation method of efficient absorption sea cucumber nutrient buccal tablet, comprises the following steps：
A () is clean by cleaning sea cucumber, take out internal calcium carbonate, the Stichopus japonicuss internal organs for cleaning up are separated with meat wall；
(b) take Stichopus japonicuss meat wall add distilled water heat 1 hour, 100 DEG C of keeping temperature be put into vacuum equipment keep-
0.04MPa, is reduced pressure -0.01MPa per hour using gradient decompression method, after being depressurized to -0.08MPa, takes out internal organs and meat wall is twisted
Broken and grinding slurry, below 3 μm of defibrination fineness, obtains Stichopus japonicuss virgin pulp liquid；Stichopus japonicuss virgin pulp liquid is put in filter centrifugal, using super
Stichopus japonicuss virgin pulp liquid is separated into Stichopus japonicuss slag and Stichopus japonicuss filtrate by filter membrane；
C () takes the 95% ethanol mixing and stirring of concentration that Stichopus japonicuss filtrate adds 1-2 times, place 12 hours, using centrifugation
Filter 3000rpm centrifugation 10-15 minutes, will be placed in thermostatic drying chamber, keep 75 DEG C, without alcohol taste after, using liquid
Nitrogen carries out very fast pre-freeze；Then it will be vacuum dried during freeze drying equipment will be put into, below -20 DEG C, control -0.08MPa；
Keep vacuum 3 hours；Then on an hourly basis 4.5 DEG C of cascade raising temperature heat dryings 12 when；Drying obtains Stichopus japonicuss dry powder after finishing；
(d) take Stichopus japonicuss slag add DDW, after stirring add concentration be 5% sucrose water, sucrose water and
Stichopus japonicuss slag solution is deployed into 1: 5 by weight, adds the compound ferment powder of 8% weight of Stichopus japonicuss slag, 45 DEG C of sealing lucifuge fermentation 3-4
My god；Using Stichopus japonicuss fermentation liquid is obtained after high temperature moment enzyme denaturing after filtering to take out debris, Stichopus japonicuss fermentation liquid is put into into lyophilization then
Equipment is dried freezing, and the Stichopus japonicuss yeast powder of 300 mesh is then ground into by Lowtemperaturepulverizer；
E the Stichopus japonicuss internal organs for cleaning up addition distilled water is ground into Stichopus japonicuss internal organs serosity by (), keep 34.5 DEG C of additions
The compound enzyme of 8ml/g stirs, and digests 35 minutes；Stichopus japonicuss internal organs serosity after enzymolysis heats 115 DEG C, is kept for 20 minutes, is entered
Row enzyme denaturing；1-2 times of 95% ethanol mixing and stirring of concentration, filter centrifugal 3000rpm centrifugations 15 minutes is added to put
To in thermostatic drying chamber, keep 60 DEG C, without alcohol taste after, very fast pre-freeze is carried out using liquid nitrogen；Then it is put in freeze drying equipment
It is vacuum dried, below -20 DEG C, control -0.08MPa；Keep vacuum 1-3 hour；Then on an hourly basis 4.5 DEG C rise step by step
When temperature heating makes to be dried 12；Drying obtains Stichopus japonicuss internal organs dry powder after finishing, and is carried out extracting sea with supercritical carbon dioxide extraction apparatus
Ginseng bata-carotene；
F () takes Stichopus japonicuss dry powder, Stichopus japonicuss yeast powder, Stichopus japonicuss internal organs dry powder respectively according to the ratio that weight compares 1: 2: 0.5, plus steam
Distilled water is modulated into nutritive sea cucumber beverage, adds activated carbon, is separated using 5000D ultrafiltration membrance filters, and after separation, nutritive sea cucumber beverage is adopted
Liquid nitrogen carries out very fast pre-freeze；Then it will be vacuum dried during freeze drying equipment will be put into, below -20 DEG C, control -
0.08MPa；Keep vacuum 1 hour；Then on an hourly basis 3.5 DEG C of cascade raising temperature heat dryings 10 when, dry sea cucumber nutrient powder,
Sea cucumber nutrient buccal tablet is obtained final product by sea cucumber nutrient powder tabletted.The very fast lyophilisation of sea cucumber nutrient powder is in -0.08MPa shapes
Under state, moisture directly greatly shortens drying time to gaseous state from solid state transformed, makes sea cucumber nutrient buccal tablet have spongy porous
The effect for being beneficial to assimilate, while preservative need not be added, extend the shelf life with sterilization sterilizing.
The outer layer of sea cucumber nutrient buccal tablet described in step (f) arranges nutritious protective layer.
The nutrition protective layer raw material is prepared by the raw materials in, 15 parts of Herba Menthae, 10 parts of Fructus Crataegi, 10 parts of Mel,
2 parts of starch, 15 parts of xylitol, 1 part of Stichopus japonicuss bata-carotene, are put into pulverizer and are crushed to 300 mesh, add water and make nutritive layer serosity,
Drying had both obtained nutrition protective layer.Nutrition protective layer can improve the mouthfeel of Stichopus japonicuss buccal tablet while protecting Stichopus japonicuss buccal tablet to reduce oxidation.
The nutritive layer serosity uniformly brushes the outer layer in sea cucumber nutrient buccal tablet, and drying vacuum is aluminum-plastic packaged.
Compound enzyme described in step (e) is black fermented preparation fungi protease and papain, and the two enzyme activity proportioning is 1: 3.
The compound ferment powder is bacillus acidophilus, saccharomyces cerevisiae.
The condition that Stichopus japonicuss bata-carotene is extracted described in step (e) is that Stichopus japonicuss internal organs dry powder amount is 200-500g, extraction kettle
Pressure 25MPa, extraction kettle temperature room temperature to 35-45 DEG C, carbon dioxide flow 25L/h, extraction time 3-4h.
Embodiments of the invention are the foregoing is only, the scope of the claims of the present invention is not thereby limited, it is every using this
Equivalent structure or equivalent flow conversion that bright description is made, or directly or indirectly it is used in other related technology necks
Domain, is included within the scope of the present invention.
Claims (7)
1. a kind of preparation method of efficient absorption sea cucumber nutrient buccal tablet, it is characterised in that comprise the following steps：
A () is clean by cleaning sea cucumber, take out internal calcium carbonate, the Stichopus japonicuss internal organs for cleaning up are separated with meat wall；
(b) take Stichopus japonicuss meat wall add distilled water heating 1-2 hours, keeping temperature 75-100 DEG C be put into vacuum equipment keep-
0.04MPa, is reduced pressure -0.01MPa per hour using gradient decompression method, after being depressurized to -0.08MPa, takes out internal organs and meat wall is twisted
Broken and grinding slurry, below 3 μm of defibrination fineness, obtains Stichopus japonicuss virgin pulp liquid；Stichopus japonicuss virgin pulp liquid is put in filter centrifugal, using super
Stichopus japonicuss virgin pulp liquid is separated into Stichopus japonicuss slag and Stichopus japonicuss filtrate by filter membrane；
C () takes the 95% ethanol mixing and stirring of concentration that Stichopus japonicuss filtrate adds 1-2 times, place 12 hours, using centrifugal filtration
Machine 3000rpm centrifugation 10-15 minutes, will be placed in thermostatic drying chamber, keep 60-75 DEG C, without alcohol taste after, using liquid nitrogen
Carry out very fast pre-freeze；Then it will be vacuum dried during freeze drying equipment will be put into, below -20 DEG C, control -0.08MPa；Protect
Hold vacuum 1-3 hour；Then on an hourly basis 3.5-4.5 DEG C of cascade raising temperature heat drying 10～12 when；Drying obtains Stichopus japonicuss after finishing
Dry powder；
D () takes Stichopus japonicuss slag and adds DDW, add concentration for the sucrose water of 2-5%, sucrose water and sea after stirring
Ginseng slag solution is deployed into 1: 3～5 by weight, adds the compound ferment powder of Stichopus japonicuss slag 4-8% weight, 35-45 DEG C of sealing lucifuge to send out
Ferment 3-4 days；Using Stichopus japonicuss fermentation liquid is obtained after high temperature moment enzyme denaturing after filtering to take out debris, Stichopus japonicuss fermentation liquid is put into into freezing then
Drying equipment is dried freezing, and the Stichopus japonicuss yeast powder of 200-300 mesh is then ground into by Lowtemperaturepulverizer；
E the Stichopus japonicuss internal organs for cleaning up addition distilled water is ground into Stichopus japonicuss internal organs serosity by (), keep 34.5 DEG C of addition 8ml/g's
Compound enzyme stirs, and digests 35 minutes；Stichopus japonicuss internal organs serosity after enzymolysis heats 100-115 DEG C, is kept for 10-20 minutes, is entered
Row enzyme denaturing；；1-2 times of 95% ethanol mixing and stirring of concentration, filter centrifugal 3000rpm centrifugations 10-15 is added to divide
Clock, is put in thermostatic drying chamber, keep 60 DEG C, without alcohol taste after, very fast pre-freeze is carried out using liquid nitrogen；Then it is put into lyophilization to set
It is vacuum dried in standby, below -20 DEG C, control -0.08MPa；Keep vacuum 1-3 hour；Then 3.5-4.5 on an hourly basis
During DEG C cascade raising temperature heat drying 10～12；Drying obtains Stichopus japonicuss internal organs dry powder after finishing, and uses supercritical carbon dioxide extraction apparatus
Carry out extracting Stichopus japonicuss bata-carotene；
F () takes Stichopus japonicuss dry powder, Stichopus japonicuss yeast powder, Stichopus japonicuss internal organs dry powder, plus distilled water respectively according to the ratio that weight compares 1: 2: 0.5
Nutritive sea cucumber beverage is modulated into, activated carbon is added, is separated using 5000D ultrafiltration membrance filters, nutritive sea cucumber beverage adopts liquid nitrogen after separation
Carry out very fast pre-freeze；Then it will be vacuum dried during freeze drying equipment will be put into, below -20 DEG C, control -0.08MPa：Protect
Hold vacuum 1-3 hour；Then on an hourly basis 3.5-4.5 DEG C of cascade raising temperature heat drying 10～12 when, dry sea cucumber nutrient powder,
Sea cucumber nutrient buccal tablet is obtained final product by sea cucumber nutrient powder tabletted.
2. a kind of preparation method of efficient absorption sea cucumber nutrient buccal tablet according to claim 1, it is characterised in that step
F the outer layer of sea cucumber nutrient buccal tablet described in () arranges nutritious protective layer.
3. a kind of preparation method of efficient absorption sea cucumber nutrient buccal tablet according to claim 2, it is characterised in that the battalion
Foster protective layer raw material is prepared by the raw materials in, 15～25 parts of Herba Menthae, 10～20 parts of Fructus Crataegi, 10～20 parts of Mel, shallow lake
2～8 parts of powder, 15～50 parts of xylitol, 1～10 part of Stichopus japonicuss bata-carotene, are put into pulverizer and are crushed to 300 mesh～400 mesh, add water
Nutritive layer serosity is made, drying had both obtained nutrition protective layer.
4. a kind of preparation method of efficient absorption sea cucumber nutrient buccal tablet according to claim 3, it is characterised in that the battalion
Foster layer serosity uniformly brushes the outer layer in sea cucumber nutrient buccal tablet, and drying vacuum is aluminum-plastic packaged.
5. a kind of preparation method of efficient absorption sea cucumber nutrient buccal tablet according to claim 1, it is characterised in that step
E compound enzyme described in () is black fermented preparation fungi protease and papain, the two enzyme activity proportioning is 1: 3～1: 5.
6. the preparation method of a kind of efficient absorption sea cucumber nutrient buccal tablet according to claim 1, it is characterised in that described multiple
It is bacillus acidophilus, saccharomyces cerevisiae to close ferment powder.
7. a kind of preparation method of efficient absorption sea cucumber nutrient buccal tablet according to claim 1, it is characterised in that step
E it is 200-500g, extraction kettle pressure 25MPa that the condition that Stichopus japonicuss bata-carotene is extracted described in () is Stichopus japonicuss internal organs dry powder amount, is extracted
Kettle temperature degree room temperature is taken to 35-45 DEG C, carbon dioxide flow 25L/h, extraction time 3-4h.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112293728A (en) * | 2020-07-13 | 2021-02-02 | 丽江美之源食品有限公司 | Fructus phyllanthi probiotic buccal tablet |
| CN112385798A (en) * | 2020-11-22 | 2021-02-23 | 福建御蓝记水产食品有限公司 | Sea cucumber chewable tablet and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104432214A (en) * | 2013-09-24 | 2015-03-25 | 修运庆 | Sea cucumber buccal tablets |
| CN105325801A (en) * | 2014-08-15 | 2016-02-17 | 中国海洋大学 | Preparation method of sea cucumber intestinal peptide |
| CN105614750A (en) * | 2016-03-11 | 2016-06-01 | 淮海工学院 | Making method of sea cucumber oral administration stock solution and sea cucumber buccal tablets |
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2016
- 2016-07-18 CN CN201610566115.6A patent/CN106539075A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104432214A (en) * | 2013-09-24 | 2015-03-25 | 修运庆 | Sea cucumber buccal tablets |
| CN105325801A (en) * | 2014-08-15 | 2016-02-17 | 中国海洋大学 | Preparation method of sea cucumber intestinal peptide |
| CN105614750A (en) * | 2016-03-11 | 2016-06-01 | 淮海工学院 | Making method of sea cucumber oral administration stock solution and sea cucumber buccal tablets |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112293728A (en) * | 2020-07-13 | 2021-02-02 | 丽江美之源食品有限公司 | Fructus phyllanthi probiotic buccal tablet |
| CN112385798A (en) * | 2020-11-22 | 2021-02-23 | 福建御蓝记水产食品有限公司 | Sea cucumber chewable tablet and preparation method thereof |
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