JP6476205B2 - ＲＯＲγ修飾因子としてのヘテロ環式スルホン - Google Patents
ＲＯＲγ修飾因子としてのヘテロ環式スルホン Download PDFInfo
- Publication number
- JP6476205B2 JP6476205B2 JP2016562466A JP2016562466A JP6476205B2 JP 6476205 B2 JP6476205 B2 JP 6476205B2 JP 2016562466 A JP2016562466 A JP 2016562466A JP 2016562466 A JP2016562466 A JP 2016562466A JP 6476205 B2 JP6476205 B2 JP 6476205B2
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- phenyl
- cycloalkyl
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- XEZUHOPNAXUEBQ-UHFFFAOYSA-N C1=C[I]=NN=C1 Chemical compound C1=C[I]=NN=C1 XEZUHOPNAXUEBQ-UHFFFAOYSA-N 0.000 description 1
- XUJVCVLNDXVLPH-UHFFFAOYSA-N C=C(c1ccc(C(C(F)(F)F)(C(F)(F)F)OCc(c(F)ccc2)c2F)cc1)S(c(cc1)ccc1F)(=O)=O Chemical compound C=C(c1ccc(C(C(F)(F)F)(C(F)(F)F)OCc(c(F)ccc2)c2F)cc1)S(c(cc1)ccc1F)(=O)=O XUJVCVLNDXVLPH-UHFFFAOYSA-N 0.000 description 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N c1c[nH]c2c1cccc2 Chemical compound c1c[nH]c2c1cccc2 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461923904P | 2014-01-06 | 2014-01-06 | |
| US61/923,904 | 2014-01-06 | ||
| PCT/US2015/010090 WO2015103510A1 (en) | 2014-01-06 | 2015-01-05 | Heterocyclic sulfone as ror-gamma modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017501237A JP2017501237A (ja) | 2017-01-12 |
| JP2017501237A5 JP2017501237A5 (OSRAM) | 2018-01-25 |
| JP6476205B2 true JP6476205B2 (ja) | 2019-02-27 |
Family
ID=52392247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016562466A Expired - Fee Related JP6476205B2 (ja) | 2014-01-06 | 2015-01-05 | ＲＯＲγ修飾因子としてのヘテロ環式スルホン |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9637455B2 (OSRAM) |
| EP (1) | EP3092221B1 (OSRAM) |
| JP (1) | JP6476205B2 (OSRAM) |
| CN (1) | CN106061956B (OSRAM) |
| ES (1) | ES2705400T3 (OSRAM) |
| WO (1) | WO2015103510A1 (OSRAM) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105705501B (zh) | 2013-09-09 | 2019-04-19 | 百时美施贵宝公司 | RORγ调节剂 |
| CN105555768B (zh) | 2013-09-20 | 2018-10-16 | 百时美施贵宝公司 | RORγ调节剂 |
| EP3092221B1 (en) | 2014-01-06 | 2018-10-17 | Bristol-Myers Squibb Company | Heterocyclic sulfones as ror-gamma modulators |
| JP6530764B2 (ja) | 2014-01-06 | 2019-06-12 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ＲＯＲγ調節因子としてのピロリジニルスルホン誘導体およびその使用 |
| JP6548664B2 (ja) * | 2014-01-06 | 2019-07-24 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | シクロヘキシルスルホンＲＯＲγ調節因子 |
| ES2713681T3 (es) | 2014-01-06 | 2019-05-23 | Bristol Myers Squibb Co | Moduladores de ROR gamma de sulfona carbocíclica |
| PT3212642T (pt) | 2014-10-30 | 2019-12-19 | Janssen Pharmaceutica Nv | Tiazóis com amida substituída como moduladores de rorgammat |
| PT3212641T (pt) | 2014-10-30 | 2019-02-11 | Janssen Pharmaceutica Nv | Tiazoles como moduladores de rorãt |
| JOP20200117A1 (ar) | 2014-10-30 | 2017-06-16 | Janssen Pharmaceutica Nv | كحولات ثلاثي فلوروميثيل كمُعدلات للمستقبل النووي جاما تي المرتبط بحمض الريتيونَويك ROR?t |
| KR102114536B1 (ko) | 2015-05-07 | 2020-05-22 | 브리스톨-마이어스 스큅 컴퍼니 | RORγ 조정제로서의 트리시클릭 술폰 |
| TW201803869A (zh) | 2016-04-27 | 2018-02-01 | 健生藥品公司 | 作為ＲＯＲγＴ調節劑之６－胺基吡啶－３－基噻唑 |
| AR110152A1 (es) | 2016-11-09 | 2019-02-27 | Bristol Myers Squibb Co | SULFONAS TRICÍCLICAS COMO MODULADORES DE RORg |
| US11034658B2 (en) | 2018-06-18 | 2021-06-15 | Janssen Pharmaceutica Nv | Pyridinyl pyrazoles as modulators of RORγT |
| JP2021528398A (ja) | 2018-06-18 | 2021-10-21 | ヤンセン ファーマシューティカ エヌ．ベー． | ＲＯＲγＴのモジュレーターとしての６−アミノピリジン−３−イルピラゾール |
| WO2019243999A1 (en) | 2018-06-18 | 2019-12-26 | Janssen Pharmaceutica Nv | Phenyl substituted pyrazoles as modulators of roryt |
| JP2021527660A (ja) | 2018-06-18 | 2021-10-14 | ヤンセン ファーマシューティカ エヌ．ベー． | ＲＯＲγｔのモジュレータとしてのフェニル及びピリジニル置換イミダゾール |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE735866C (de) | 1941-01-17 | 1943-06-11 | Ig Farbenindustrie Ag | Verfahren zur Darstellung von Aminoalkylsulfonverbindungen |
| US2802013A (en) | 1954-02-12 | 1957-08-06 | Searle & Co | 2-(oxo and imino)-3-(phenyl and halophenyl)-tetrahydrofuransulfones and processes for the manufacture thereof |
| US3016403A (en) | 1955-07-29 | 1962-01-09 | Searle & Co | 1-aryl-3-hydroxypropyl sulfones and processes |
| US2812330A (en) * | 1956-05-02 | 1957-11-05 | Searle & Co | Sulfone derivatives of 2, 6-piperidinedione |
| GB0108591D0 (en) * | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
| JP4329905B2 (ja) * | 2001-12-27 | 2009-09-09 | 第一三共株式会社 | βアミロイド蛋白産生・分泌阻害剤 |
| WO2010019392A1 (en) * | 2008-08-13 | 2010-02-18 | Merck Sharp & Dohme Corp. | Purine derivatives for treatment of alzheimer's disease |
| US20130190356A1 (en) * | 2011-12-22 | 2013-07-25 | Genentech, Inc. | Benzyl sulfonamide derivatives as rorc modulators |
| AU2013259904A1 (en) * | 2012-05-08 | 2014-10-02 | Lycera Corporation | Bicyclic sulfone compounds for inhibition of RORy activity and the treatment of disease |
| WO2014028669A1 (en) * | 2012-08-15 | 2014-02-20 | Biogen Idec Ma Inc. | Novel compounds for modulation of ror-gamma activity |
| US10035790B2 (en) | 2012-10-19 | 2018-07-31 | Exelixis, Inc. | RORγ modulators |
| CN105705501B (zh) | 2013-09-09 | 2019-04-19 | 百时美施贵宝公司 | RORγ调节剂 |
| CN105555768B (zh) | 2013-09-20 | 2018-10-16 | 百时美施贵宝公司 | RORγ调节剂 |
| JP6548664B2 (ja) | 2014-01-06 | 2019-07-24 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | シクロヘキシルスルホンＲＯＲγ調節因子 |
| JP6530764B2 (ja) | 2014-01-06 | 2019-06-12 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ＲＯＲγ調節因子としてのピロリジニルスルホン誘導体およびその使用 |
| EP3092221B1 (en) | 2014-01-06 | 2018-10-17 | Bristol-Myers Squibb Company | Heterocyclic sulfones as ror-gamma modulators |
| ES2713681T3 (es) | 2014-01-06 | 2019-05-23 | Bristol Myers Squibb Co | Moduladores de ROR gamma de sulfona carbocíclica |
-
2015
- 2015-01-05 EP EP15700818.6A patent/EP3092221B1/en not_active Not-in-force
- 2015-01-05 WO PCT/US2015/010090 patent/WO2015103510A1/en not_active Ceased
- 2015-01-05 CN CN201580011973.8A patent/CN106061956B/zh not_active Expired - Fee Related
- 2015-01-05 ES ES15700818T patent/ES2705400T3/es active Active
- 2015-01-05 US US15/109,727 patent/US9637455B2/en active Active
- 2015-01-05 JP JP2016562466A patent/JP6476205B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US9637455B2 (en) | 2017-05-02 |
| JP2017501237A (ja) | 2017-01-12 |
| WO2015103510A1 (en) | 2015-07-09 |
| EP3092221A1 (en) | 2016-11-16 |
| CN106061956A (zh) | 2016-10-26 |
| ES2705400T3 (es) | 2019-03-25 |
| US20160326115A1 (en) | 2016-11-10 |
| CN106061956B (zh) | 2021-03-12 |
| EP3092221B1 (en) | 2018-10-17 |
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