JP6450371B2 - T細胞受容体α遺伝子を開裂するLAGLIDADGホーミングエンドヌクレアーゼおよびその用途 - Google Patents
T細胞受容体α遺伝子を開裂するLAGLIDADGホーミングエンドヌクレアーゼおよびその用途 Download PDFInfo
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- JP6450371B2 JP6450371B2 JP2016516173A JP2016516173A JP6450371B2 JP 6450371 B2 JP6450371 B2 JP 6450371B2 JP 2016516173 A JP2016516173 A JP 2016516173A JP 2016516173 A JP2016516173 A JP 2016516173A JP 6450371 B2 JP6450371 B2 JP 6450371B2
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201370303 | 2013-05-31 | ||
| DKPA201370303 | 2013-05-31 | ||
| PCT/EP2014/061189 WO2014191527A1 (en) | 2013-05-31 | 2014-05-28 | A laglidadg homing endonuclease cleaving the t cell receptor alpha gene and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016520320A JP2016520320A (ja) | 2016-07-14 |
| JP2016520320A5 JP2016520320A5 (OSRAM) | 2017-07-06 |
| JP6450371B2 true JP6450371B2 (ja) | 2019-01-09 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016516173A Active JP6450371B2 (ja) | 2013-05-31 | 2014-05-28 | T細胞受容体α遺伝子を開裂するLAGLIDADGホーミングエンドヌクレアーゼおよびその用途 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10000746B2 (OSRAM) |
| EP (1) | EP3004338B1 (OSRAM) |
| JP (1) | JP6450371B2 (OSRAM) |
| AU (1) | AU2014273091B2 (OSRAM) |
| CA (1) | CA2913872C (OSRAM) |
| DK (1) | DK3004338T3 (OSRAM) |
| ES (1) | ES2716867T3 (OSRAM) |
| WO (1) | WO2014191527A1 (OSRAM) |
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| JP6261500B2 (ja) | 2011-07-22 | 2018-01-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヌクレアーゼ切断特異性の評価および改善 |
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| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
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| BR112019011277A2 (pt) | 2016-12-02 | 2019-10-22 | University Of Southern California | polinucleotídeo, sistema de expressão recombinante, vetor, polipeptídeo, célula recombinante, polipeptídeo de receptor imune sintético isolado ou heterodímero de polipeptídeo, célula efetora imune ou célula-tronco, população de células imunes ou efetoras, métodos de fabricação de uma célula efetora imune que expressa sir, de geração de uma população de células modificadas por rna, de fornecimento de imunidade antidoença e de tratamento ou prevenção de uma doença, composição, uso ou método, kit, e, sequência de aminoácidos. |
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Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8956828B2 (en) * | 2009-11-10 | 2015-02-17 | Sangamo Biosciences, Inc. | Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases |
| US20140148361A1 (en) | 2010-06-07 | 2014-05-29 | Barry L. Stoddard | Generation and Expression of Engineered I-ONUI Endonuclease and Its Homologues and Uses Thereof |
| JP5996630B2 (ja) * | 2011-04-05 | 2016-09-21 | セレクティスCellectis | コンパクトtale−ヌクレアーゼを作製する方法及びその使用 |
| WO2013009525A1 (en) * | 2011-07-08 | 2013-01-17 | Cellectis S.A. | Method for increasing the efficiency of double-strand break-induced mutagenssis |
| US20130210151A1 (en) * | 2011-11-07 | 2013-08-15 | University Of Western Ontario | Endonuclease for genome editing |
-
2014
- 2014-05-28 US US14/891,216 patent/US10000746B2/en active Active
- 2014-05-28 JP JP2016516173A patent/JP6450371B2/ja active Active
- 2014-05-28 DK DK14728899.7T patent/DK3004338T3/en active
- 2014-05-28 CA CA2913872A patent/CA2913872C/en active Active
- 2014-05-28 ES ES14728899T patent/ES2716867T3/es active Active
- 2014-05-28 AU AU2014273091A patent/AU2014273091B2/en active Active
- 2014-05-28 WO PCT/EP2014/061189 patent/WO2014191527A1/en not_active Ceased
- 2014-05-28 EP EP14728899.7A patent/EP3004338B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3004338A1 (en) | 2016-04-13 |
| US10000746B2 (en) | 2018-06-19 |
| US20160130569A1 (en) | 2016-05-12 |
| CA2913872C (en) | 2022-01-18 |
| CA2913872A1 (en) | 2014-12-04 |
| ES2716867T3 (es) | 2019-06-17 |
| HK1223394A1 (en) | 2017-07-28 |
| JP2016520320A (ja) | 2016-07-14 |
| AU2014273091A1 (en) | 2015-12-03 |
| AU2014273091B2 (en) | 2019-12-12 |
| EP3004338B1 (en) | 2019-01-02 |
| DK3004338T3 (en) | 2019-04-08 |
| WO2014191527A1 (en) | 2014-12-04 |
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