JP6441792B2 - Ｅｇｆｒに結合する抗原結合蛋白質 - Google Patents

Ｅｇｆｒに結合する抗原結合蛋白質 Download PDF

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Publication number
JP6441792B2
JP6441792B2 JP2015512727A JP2015512727A JP6441792B2 JP 6441792 B2 JP6441792 B2 JP 6441792B2 JP 2015512727 A JP2015512727 A JP 2015512727A JP 2015512727 A JP2015512727 A JP 2015512727A JP 6441792 B2 JP6441792 B2 JP 6441792B2
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JP
Japan
Prior art keywords
seq
sequence number
egfr
antibody
referred
Prior art date
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Expired - Fee Related
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JP2015512727A
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English (en)
Japanese (ja)
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JP2015518827A5 (OSRAM
JP2015518827A (ja
Inventor
ヘユー・ジョウ
ランディ・ギャストワート
バーバラ・エイ・スワンソン
ジョン・ディクソン・グレイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sorrento Therapeutics Inc
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Sorrento Therapeutics Inc
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2015512727A 2012-05-17 2013-05-13 Ｅｇｆｒに結合する抗原結合蛋白質 Expired - Fee Related JP6441792B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261648391P 2012-05-17 2012-05-17
US61/648,391 2012-05-17
PCT/US2013/040827 WO2013173255A2 (en) 2012-05-17 2013-05-13 Antigen binding proteins that bind egfr

Publications (3)

Publication Number Publication Date
JP2015518827A JP2015518827A (ja) 2015-07-06
JP2015518827A5 JP2015518827A5 (OSRAM) 2016-06-30
JP6441792B2 true JP6441792B2 (ja) 2018-12-19

Family

ID=49581478

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015512727A Expired - Fee Related JP6441792B2 (ja) 2012-05-17 2013-05-13 Ｅｇｆｒに結合する抗原結合蛋白質

Country Status (7)

Country Link
US (1) US9944707B2 (OSRAM)
EP (1) EP2850105A4 (OSRAM)
JP (1) JP6441792B2 (OSRAM)
CN (1) CN104918956A (OSRAM)
CA (1) CA2872018A1 (OSRAM)
HK (1) HK1208474A1 (OSRAM)
WO (1) WO2013173255A2 (OSRAM)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10100118B2 (en) 2015-04-08 2018-10-16 Sorrento Therapeutics, Inc. Antibody therapeutics that bind CD123
JP2018513856A (ja) * 2015-04-08 2018-05-31 ソレント・セラピューティクス・インコーポレイテッドＳｏｒｒｅｎｔｏ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． Ｃｄ１２３に結合する抗体治療剤
BR112018012352A2 (pt) * 2015-12-16 2018-12-11 Merck Sharp & Dohme Corp. anticorpos anti-lag3 e fragmentos de ligação ao antígeno
MA43660A (fr) 2016-01-22 2018-11-28 Adimab Llc Anticorps anti-facteur xi de coagulation
HUE058745T2 (hu) * 2016-04-27 2022-09-28 Green Cross Corp Hatóanyagként epidermális növekedési faktor receptorhoz specifikusan kötõdõ antitestet tartalmazó gyógyászati készítmény rák áttételének gátlására
TWI752964B (zh) 2016-06-14 2022-01-21 美商默沙東藥廠 抗凝血因子ｘｉ抗體
JP7302028B2 (ja) * 2019-06-04 2023-07-03 アカデミア シニカ 上皮成長因子受容体を標的とするリガンド、及び腫瘍を治療するための組成物
WO2021035096A1 (en) * 2019-08-20 2021-02-25 Kumquat Biosciences Inc. Compositions and methods for targeting cellular molecules
EP4347643A4 (en) * 2021-05-27 2025-09-17 Us Gov Veterans Affairs HUMAN MONOCLONAL ANTIBODIES SPECIFIC TO STREPTOLYSIN O AND METHODS OF USE
EP4473018A2 (en) * 2022-02-04 2024-12-11 Vivasor, Inc. Antigen binding proteins that bind b7-h3

Family Cites Families (22)

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PL181342B1 (pl) 1994-03-17 2001-07-31 Merck Patent Gmbh Jednolancuchowe anty-EGFR Fv i przeciwciala anty-EGFR, czasteczka DNA, sposoby wytwarzania jednolancuchowego przeciwciala anty-EGFR i przeciwciala anty-EGFR oraz kompozycja farmaceutyczna PL PL PL PL PL PL PL
ES2301183T3 (es) 1996-12-03 2008-06-16 Amgen Fremont Inc. Anticuerpo completamente humano que se une al receptor del egfr.
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
US20020173629A1 (en) * 1997-05-05 2002-11-21 Aya Jakobovits Human monoclonal antibodies to epidermal growth factor receptor
DE60042693D1 (de) 1999-08-27 2009-09-17 Genentech Inc Dosierung für die behandlung mit anti erbb2-antikörpern
US7595378B2 (en) 2001-06-13 2009-09-29 Genmab A/S Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
RU2335507C2 (ru) 2001-06-13 2008-10-10 Генмаб А/С Человеческие моноклональные антитела к рецептору эпидермального фактора роста (egfr), способ их получения и их использование, гибридома, трансфектома, трансгенное животное, экспрессионный вектор
RU2402569C2 (ru) 2004-03-19 2010-10-27 Имклоун Элэлси Человеческие антитела к рецептору эпидермального фактора роста
CN101233155B (zh) * 2004-03-19 2013-06-19 英克隆有限责任公司 人抗表皮生长因子受体抗体
WO2006082515A2 (en) * 2005-02-07 2006-08-10 Glycart Biotechnology Ag Antigen binding molecules that bind egfr, vectors encoding same, and uses thereof
US20060216288A1 (en) 2005-03-22 2006-09-28 Amgen Inc Combinations for the treatment of cancer
ATE461220T1 (de) * 2005-11-12 2010-04-15 Lilly Co Eli Anti-egfr-antikörper
WO2009012181A2 (en) 2007-07-13 2009-01-22 Ventana Medical Systems, Inc. Method of identifying diagnostic reagents
MX2011003133A (es) 2008-09-26 2011-04-21 Roche Glycart Ag Anticuerpos biespecificos anti-egfr/anti-igf-1r.
US20110287112A1 (en) 2009-01-30 2011-11-24 Ono Pharmaceutical Co., Ltd. Prostate cancer progression inhibitor and progression inhibition method
CA2754646A1 (en) 2009-03-31 2010-10-07 Roche Glycart Ag Treatment of cancer with a humanized anti-egfr igg1 antibody and irinotecan
US8658175B2 (en) 2009-10-28 2014-02-25 Abbvie Biotherapeutics Inc. Anti-EGFR antibodies and their uses
JP5818003B2 (ja) 2009-11-18 2015-11-18 国立大学法人東北大学 ヒト型化抗ｅｇｆｒ抗体可変領域の高機能性変異体
WO2011156617A2 (en) 2010-06-09 2011-12-15 Aveo Pharmaceuticals, Inc. Anti-egfr antibodies
EP2632490A4 (en) 2010-10-29 2014-10-22 Immunogen Inc NOVEL MOLECULES BINDING TO THE EGF RECEPTOR AND IMMUNOCONJUGATES THEREOF
US8691231B2 (en) 2011-06-03 2014-04-08 Merrimack Pharmaceuticals, Inc. Methods of treatment of tumors expressing predominantly high affinity EGFR ligands or tumors expressing predominantly low affinity EGFR ligands with monoclonal and oligoclonal anti-EGFR antibodies
TWI443108B (zh) 2011-12-28 2014-07-01 Ind Tech Res Inst 抗人類表皮生長因子受體抗體及其應用

Also Published As

Publication number Publication date
US9944707B2 (en) 2018-04-17
EP2850105A4 (en) 2016-03-16
WO2013173255A2 (en) 2013-11-21
JP2015518827A (ja) 2015-07-06
HK1208474A1 (en) 2016-03-04
CN104918956A (zh) 2015-09-16
CA2872018A1 (en) 2013-11-21
EP2850105A2 (en) 2015-03-25
US20130309233A1 (en) 2013-11-21

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