JP6433480B2 - Ｈｌａを修飾するための方法および組成物 - Google Patents

Ｈｌａを修飾するための方法および組成物 Download PDF

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Publication number
JP6433480B2
JP6433480B2 JP2016501596A JP2016501596A JP6433480B2 JP 6433480 B2 JP6433480 B2 JP 6433480B2 JP 2016501596 A JP2016501596 A JP 2016501596A JP 2016501596 A JP2016501596 A JP 2016501596A JP 6433480 B2 JP6433480 B2 JP 6433480B2
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hla
cells
cell
gene
protein
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JP2016513460A (ja
JP2016513460A5 (enExample
Inventor
フィリップ ディー． グレゴリー，
フィリップ ディー． グレゴリー，
ローレンス ジェイ．エヌ． クーパー，
ローレンス ジェイ．エヌ． クーパー，
宏基 鳥飼
宏基 鳥飼
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Sangamo Therapeutics Inc
University of Texas System
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Sangamo Therapeutics Inc
University of Texas System
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/50—Cellular immunotherapy characterised by the use of allogeneic cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
JP2016501596A 2013-03-12 2014-03-12 Ｈｌａを修飾するための方法および組成物 Active JP6433480B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361777627P 2013-03-12 2013-03-12
US61/777,627 2013-03-12
PCT/US2014/024660 WO2014165177A1 (en) 2013-03-12 2014-03-12 Methods and compositions for modification of hla

Publications (3)

Publication Number Publication Date
JP2016513460A JP2016513460A (ja) 2016-05-16
JP2016513460A5 JP2016513460A5 (enExample) 2017-02-09
JP6433480B2 true JP6433480B2 (ja) 2018-12-05

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JP2016501596A Active JP6433480B2 (ja) 2013-03-12 2014-03-12 Ｈｌａを修飾するための方法および組成物

Country Status (9)

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US (3) US20150037304A1 (enExample)
EP (1) EP2970886B1 (enExample)
JP (1) JP6433480B2 (enExample)
CN (1) CN105283539A (enExample)
AU (3) AU2014248605B2 (enExample)
CA (1) CA2904210C (enExample)
HK (1) HK1217968A1 (enExample)
IL (1) IL241112B (enExample)
WO (1) WO2014165177A1 (enExample)

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CN109804066A (zh) 2016-08-09 2019-05-24 哈佛大学的校长及成员们 可编程cas9-重组酶融合蛋白及其用途
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Also Published As

Publication number Publication date
EP2970886A1 (en) 2016-01-20
HK1217968A1 (zh) 2017-01-27
JP2016513460A (ja) 2016-05-16
US20220202858A1 (en) 2022-06-30
CA2904210A1 (en) 2014-10-09
WO2014165177A1 (en) 2014-10-09
US20170216358A1 (en) 2017-08-03
EP2970886A4 (en) 2016-08-17
CN105283539A (zh) 2016-01-27
CA2904210C (en) 2022-07-19
AU2014248605A1 (en) 2015-09-24
AU2022211891A1 (en) 2022-09-01
AU2014248605B2 (en) 2020-05-28
IL241112B (en) 2021-02-28
EP2970886B1 (en) 2018-05-23
IL241112A0 (en) 2015-11-30
US20150037304A1 (en) 2015-02-05
AU2020203765A1 (en) 2020-06-25

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