JP2016513460A5 - - Google Patents
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- JP2016513460A5 JP2016513460A5 JP2016501596A JP2016501596A JP2016513460A5 JP 2016513460 A5 JP2016513460 A5 JP 2016513460A5 JP 2016501596 A JP2016501596 A JP 2016501596A JP 2016501596 A JP2016501596 A JP 2016501596A JP 2016513460 A5 JP2016513460 A5 JP 2016513460A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- hla
- cell according
- item
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims description 18
- 210000000822 natural killer cell Anatomy 0.000 claims description 17
- 108090000623 proteins and genes Proteins 0.000 claims description 12
- 102000004169 proteins and genes Human genes 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 6
- 208000009329 Graft vs Host Disease Diseases 0.000 claims description 4
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims description 4
- 230000006037 cell lysis Effects 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 208000024908 graft versus host disease Diseases 0.000 claims description 4
- 102100028970 HLA class I histocompatibility antigen, alpha chain E Human genes 0.000 claims description 2
- 102100028966 HLA class I histocompatibility antigen, alpha chain F Human genes 0.000 claims description 2
- 102100028967 HLA class I histocompatibility antigen, alpha chain G Human genes 0.000 claims description 2
- 108010024164 HLA-G Antigens Proteins 0.000 claims description 2
- 101000986085 Homo sapiens HLA class I histocompatibility antigen, alpha chain E Proteins 0.000 claims description 2
- 101000986080 Homo sapiens HLA class I histocompatibility antigen, alpha chain F Proteins 0.000 claims description 2
- 101710185494 Zinc finger protein Proteins 0.000 claims description 2
- 102100023597 Zinc finger protein 816 Human genes 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims description 2
- 102000036639 antigens Human genes 0.000 claims description 2
- 108091007433 antigens Proteins 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 238000010362 genome editing Methods 0.000 claims description 2
- 210000000265 leukocyte Anatomy 0.000 claims description 2
- 230000001404 mediated effect Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361777627P | 2013-03-12 | 2013-03-12 | |
| US61/777,627 | 2013-03-12 | ||
| PCT/US2014/024660 WO2014165177A1 (en) | 2013-03-12 | 2014-03-12 | Methods and compositions for modification of hla |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016513460A JP2016513460A (ja) | 2016-05-16 |
| JP2016513460A5 true JP2016513460A5 (enExample) | 2017-02-09 |
| JP6433480B2 JP6433480B2 (ja) | 2018-12-05 |
Family
ID=51659088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501596A Active JP6433480B2 (ja) | 2013-03-12 | 2014-03-12 | Ｈｌａを修飾するための方法および組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20150037304A1 (enExample) |
| EP (1) | EP2970886B1 (enExample) |
| JP (1) | JP6433480B2 (enExample) |
| CN (1) | CN105283539A (enExample) |
| AU (3) | AU2014248605B2 (enExample) |
| CA (1) | CA2904210C (enExample) |
| HK (1) | HK1217968A1 (enExample) |
| IL (1) | IL241112B (enExample) |
| WO (1) | WO2014165177A1 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2853829C (en) | 2011-07-22 | 2023-09-26 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US10391126B2 (en) | 2011-11-18 | 2019-08-27 | Board Of Regents, The University Of Texas System | CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA |
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US9458450B2 (en) | 2012-03-15 | 2016-10-04 | Flodesign Sonics, Inc. | Acoustophoretic separation technology using multi-dimensional standing waves |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9340800B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | Extended DNA-sensing GRNAS |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| EP3066201B1 (en) | 2013-11-07 | 2018-03-07 | Editas Medicine, Inc. | Crispr-related methods and compositions with governing grnas |
| US9840699B2 (en) | 2013-12-12 | 2017-12-12 | President And Fellows Of Harvard College | Methods for nucleic acid editing |
| WO2015105955A1 (en) | 2014-01-08 | 2015-07-16 | Flodesign Sonics, Inc. | Acoustophoresis device with dual acoustophoretic chamber |
| US20170044500A1 (en) * | 2014-04-24 | 2017-02-16 | Board Of Regents, The University Of Texas System | Application of induced pluripotent stem cells to generate adoptive cell therapy products |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| EP3194578B1 (en) | 2014-08-06 | 2021-03-10 | College of Medicine Pochon Cha University Industry-Academic Cooperation Foundation | Immune-compatible cells created by nuclease-mediated editing of genes encoding hla |
| BR112017008693A2 (pt) * | 2014-10-31 | 2018-02-27 | The Trustees Of The University Of Pennsylvania | célula t modificada, métodos para gerar uma célula t modificada, para tratar uma doença ou condição, para estimular uma resposta imune mediada por célula t e para terapia de transferência de célula adotiva, uso de uma célula t modificada, e, composição. |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| KR102796744B1 (ko) * | 2015-06-09 | 2025-04-15 | 에디타스 메디신, 인코포레이티드 | 이식의 개선을 위한 crispr/cas-관련 방법 및 조성물 |
| US11474085B2 (en) | 2015-07-28 | 2022-10-18 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| US11459540B2 (en) | 2015-07-28 | 2022-10-04 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| CN105112370B (zh) * | 2015-08-25 | 2019-02-05 | 杭州优善生物科技有限公司 | 一种体外刺激外周血γδT细胞高效增殖的方法及其应用 |
| IL294014B2 (en) | 2015-10-23 | 2024-07-01 | Harvard College | Nucleobase editors and uses thereof |
| NZ782858A (en) | 2015-12-04 | 2025-08-29 | Novartis Ag | Compositions and methods for immunooncology |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| US11085035B2 (en) | 2016-05-03 | 2021-08-10 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
| AU2017306676B2 (en) | 2016-08-03 | 2024-02-22 | President And Fellows Of Harvard College | Adenosine nucleobase editors and uses thereof |
| EP3497214B1 (en) | 2016-08-09 | 2023-06-28 | President and Fellows of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| WO2018071868A1 (en) | 2016-10-14 | 2018-04-19 | President And Fellows Of Harvard College | Aav delivery of nucleobase editors |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| WO2018165631A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Cancer vaccine |
| WO2018165629A1 (en) | 2017-03-10 | 2018-09-13 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| JP2020513832A (ja) | 2017-03-22 | 2020-05-21 | ノバルティス アーゲー | 免疫腫瘍学のための組成物および方法 |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| JP6647240B2 (ja) | 2017-05-12 | 2020-02-14 | 米満 吉和 | 高活性ｎｋ細胞、およびその利用 |
| AU2018292181B2 (en) | 2017-06-30 | 2025-04-10 | Cellectis | Cellular immunotherapy for repetitive administration |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
| WO2019079347A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | USES OF BASIC EDITORS ADENOSINE |
| KR20220066413A (ko) | 2017-12-14 | 2022-05-24 | 프로디자인 소닉스, 인크. | 음향 트랜스듀서 구동기 및 제어기 |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| JP7385281B2 (ja) * | 2018-02-16 | 2023-11-22 | 国立大学法人京都大学 | 低抗原性細胞の製造方法 |
| EP3797160A1 (en) | 2018-05-23 | 2021-03-31 | The Broad Institute Inc. | Base editors and uses thereof |
| WO2020014261A1 (en) | 2018-07-09 | 2020-01-16 | The Broad Institute, Inc. | Rna programmable epigenetic rna modifiers and uses thereof |
| US11016874B2 (en) | 2018-09-19 | 2021-05-25 | International Business Machines Corporation | Updating taint tags based on runtime behavior profiles |
| US10883084B2 (en) | 2018-10-05 | 2021-01-05 | Xenotherapeutics, Inc. | Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non-human) donor and methods and products relating to same |
| EP3860336A1 (en) | 2018-10-05 | 2021-08-11 | Xenotherapeutics, Inc. | Xenotransplantation products and methods |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| WO2020097188A1 (en) * | 2018-11-06 | 2020-05-14 | Sangamo Therapeutics, Inc. | Identification of molecules for inhibition of nk-mediated cell killing |
| JP2022513490A (ja) * | 2018-12-16 | 2022-02-08 | フィジーン、エルエルシー | 遺伝子編集線維芽細胞の治療的使用 |
| WO2020154500A1 (en) | 2019-01-23 | 2020-07-30 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| BR112021018607A2 (pt) | 2019-03-19 | 2021-11-23 | Massachusetts Inst Technology | Métodos e composições para editar sequências de nucleotídeos |
| EP3956349A1 (en) | 2019-04-17 | 2022-02-23 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| JP2020108405A (ja) * | 2020-04-03 | 2020-07-16 | 米満 吉和 | 高活性ｎｋ細胞、およびその利用 |
| AU2021267940A1 (en) | 2020-05-08 | 2022-12-08 | President And Fellows Of Harvard College | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| AU2023402360A1 (en) * | 2022-11-28 | 2025-05-01 | Invectys, Inc. | Humanized anti-hla-g chimeric antigen receptors and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9725764D0 (en) * | 1997-12-04 | 1998-02-04 | Isis Innovation | HLA-E binding |
| CA2755192C (en) * | 2009-03-20 | 2018-09-11 | Sangamo Biosciences, Inc. | Modification of cxcr4 using engineered zinc finger proteins |
| EP2596011B1 (en) * | 2010-07-21 | 2018-10-03 | Sangamo Therapeutics, Inc. | Methods and compositions for modification of a hla locus |
| US10391126B2 (en) * | 2011-11-18 | 2019-08-27 | Board Of Regents, The University Of Texas System | CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA |
-
2014
- 2014-03-12 EP EP14779898.7A patent/EP2970886B1/en active Active
- 2014-03-12 US US14/206,706 patent/US20150037304A1/en not_active Abandoned
- 2014-03-12 WO PCT/US2014/024660 patent/WO2014165177A1/en not_active Ceased
- 2014-03-12 AU AU2014248605A patent/AU2014248605B2/en not_active Ceased
- 2014-03-12 CN CN201480025999.3A patent/CN105283539A/zh active Pending
- 2014-03-12 HK HK16105965.2A patent/HK1217968A1/zh unknown
- 2014-03-12 JP JP2016501596A patent/JP6433480B2/ja active Active
- 2014-03-12 CA CA2904210A patent/CA2904210C/en active Active
-
2015
- 2015-09-03 IL IL241112A patent/IL241112B/en active IP Right Grant
-
2017
- 2017-04-18 US US15/490,601 patent/US20170216358A1/en not_active Abandoned
-
2020
- 2020-06-08 AU AU2020203765A patent/AU2020203765A1/en not_active Abandoned
-
2021
- 2021-07-22 US US17/383,265 patent/US20220202858A1/en not_active Abandoned
-
2022
- 2022-08-04 AU AU2022211891A patent/AU2022211891A1/en not_active Abandoned
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