JP2016513460A5 - - Google Patents
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- JP2016513460A5 JP2016513460A5 JP2016501596A JP2016501596A JP2016513460A5 JP 2016513460 A5 JP2016513460 A5 JP 2016513460A5 JP 2016501596 A JP2016501596 A JP 2016501596A JP 2016501596 A JP2016501596 A JP 2016501596A JP 2016513460 A5 JP2016513460 A5 JP 2016513460A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- hla
- cell according
- item
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims description 18
- 210000000822 natural killer cell Anatomy 0.000 claims description 17
- 108090000623 proteins and genes Proteins 0.000 claims description 12
- 102000004169 proteins and genes Human genes 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 6
- 208000009329 Graft vs Host Disease Diseases 0.000 claims description 4
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims description 4
- 230000006037 cell lysis Effects 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 208000024908 graft versus host disease Diseases 0.000 claims description 4
- 102100028970 HLA class I histocompatibility antigen, alpha chain E Human genes 0.000 claims description 2
- 102100028966 HLA class I histocompatibility antigen, alpha chain F Human genes 0.000 claims description 2
- 102100028967 HLA class I histocompatibility antigen, alpha chain G Human genes 0.000 claims description 2
- 108010024164 HLA-G Antigens Proteins 0.000 claims description 2
- 101000986085 Homo sapiens HLA class I histocompatibility antigen, alpha chain E Proteins 0.000 claims description 2
- 101000986080 Homo sapiens HLA class I histocompatibility antigen, alpha chain F Proteins 0.000 claims description 2
- 101710185494 Zinc finger protein Proteins 0.000 claims description 2
- 102100023597 Zinc finger protein 816 Human genes 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims description 2
- 102000036639 antigens Human genes 0.000 claims description 2
- 108091007433 antigens Proteins 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 238000010362 genome editing Methods 0.000 claims description 2
- 210000000265 leukocyte Anatomy 0.000 claims description 2
- 230000001404 mediated effect Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361777627P | 2013-03-12 | 2013-03-12 | |
| US61/777,627 | 2013-03-12 | ||
| PCT/US2014/024660 WO2014165177A1 (en) | 2013-03-12 | 2014-03-12 | Methods and compositions for modification of hla |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016513460A JP2016513460A (ja) | 2016-05-16 |
| JP2016513460A5 true JP2016513460A5 (enExample) | 2017-02-09 |
| JP6433480B2 JP6433480B2 (ja) | 2018-12-05 |
Family
ID=51659088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501596A Active JP6433480B2 (ja) | 2013-03-12 | 2014-03-12 | Ｈｌａを修飾するための方法および組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20150037304A1 (enExample) |
| EP (1) | EP2970886B1 (enExample) |
| JP (1) | JP6433480B2 (enExample) |
| CN (1) | CN105283539A (enExample) |
| AU (3) | AU2014248605B2 (enExample) |
| CA (1) | CA2904210C (enExample) |
| HK (1) | HK1217968A1 (enExample) |
| IL (1) | IL241112B (enExample) |
| WO (1) | WO2014165177A1 (enExample) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| WO2013074916A1 (en) | 2011-11-18 | 2013-05-23 | Board Of Regents, The University Of Texas System | Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla |
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US9458450B2 (en) | 2012-03-15 | 2016-10-04 | Flodesign Sonics, Inc. | Acoustophoretic separation technology using multi-dimensional standing waves |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| KR20230054509A (ko) | 2013-11-07 | 2023-04-24 | 에디타스 메디신, 인코포레이티드 | 지배적인 gRNA를 이용하는 CRISPR-관련 방법 및 조성물 |
| US11053481B2 (en) | 2013-12-12 | 2021-07-06 | President And Fellows Of Harvard College | Fusions of Cas9 domains and nucleic acid-editing domains |
| CA2935960C (en) | 2014-01-08 | 2023-01-10 | Bart Lipkens | Acoustophoresis device with dual acoustophoretic chamber |
| CA2945393C (en) * | 2014-04-24 | 2021-03-23 | Board Of Regents, The University Of Texas System | Application of induced pluripotent stem cells to generate adoptive cell therapy products |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| CN106536721B (zh) | 2014-08-06 | 2020-12-04 | 车医科学大学校产学协力团 | 核酸酶介导的编辑编码hla的基因所产生的免疫相容性细胞 |
| EP4427809A3 (en) * | 2014-10-31 | 2024-12-04 | The Trustees of The University of Pennsylvania | Altering gene expression in car-t cells and uses thereof |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| WO2016201047A1 (en) * | 2015-06-09 | 2016-12-15 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for improving transplantation |
| US11459540B2 (en) | 2015-07-28 | 2022-10-04 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| US11474085B2 (en) | 2015-07-28 | 2022-10-18 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| CN105112370B (zh) * | 2015-08-25 | 2019-02-05 | 杭州优善生物科技有限公司 | 一种体外刺激外周血γδT细胞高效增殖的方法及其应用 |
| US12043852B2 (en) | 2015-10-23 | 2024-07-23 | President And Fellows Of Harvard College | Evolved Cas9 proteins for gene editing |
| JP2018536436A (ja) | 2015-12-04 | 2018-12-13 | ノバルティス アーゲー | 免疫腫瘍学のための組成物および方法 |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| US11085035B2 (en) | 2016-05-03 | 2021-08-10 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
| KR20250103795A (ko) | 2016-08-03 | 2025-07-07 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| CN109804066A (zh) | 2016-08-09 | 2019-05-24 | 哈佛大学的校长及成员们 | 可编程cas9-重组酶融合蛋白及其用途 |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| AU2017342543B2 (en) | 2016-10-14 | 2024-06-27 | President And Fellows Of Harvard College | AAV delivery of nucleobase editors |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| EP3592381A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine |
| KR20190127797A (ko) | 2017-03-10 | 2019-11-13 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 시토신에서 구아닌으로의 염기 편집제 |
| MX2019011272A (es) | 2017-03-22 | 2019-10-24 | Novartis Ag | Composiciones y metodos para inmunooncologia. |
| CA3057192A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| JP6647240B2 (ja) | 2017-05-12 | 2020-02-14 | 米満 吉和 | 高活性ｎｋ細胞、およびその利用 |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| JP2020530277A (ja) * | 2017-06-30 | 2020-10-22 | セレクティスＣｅｌｌｅｃｔｉｓ | 反復投与のための細胞免疫療法 |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| WO2019139645A2 (en) | 2017-08-30 | 2019-07-18 | President And Fellows Of Harvard College | High efficiency base editors comprising gam |
| CA3082251A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
| KR20220066413A (ko) | 2017-12-14 | 2022-05-24 | 프로디자인 소닉스, 인크. | 음향 트랜스듀서 구동기 및 제어기 |
| EP3724214A4 (en) | 2017-12-15 | 2021-09-01 | The Broad Institute Inc. | SYSTEMS AND METHODS FOR PREDICTING REPAIR RESULTS IN GENETIC ENGINEERING |
| KR102761346B1 (ko) * | 2018-02-16 | 2025-01-31 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 저항원성 세포의 제조 방법 |
| WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| US11016874B2 (en) | 2018-09-19 | 2021-05-25 | International Business Machines Corporation | Updating taint tags based on runtime behavior profiles |
| US10799614B2 (en) | 2018-10-05 | 2020-10-13 | Xenotherapeutics, Inc. | Xenotransplantation products and methods |
| US10883084B2 (en) | 2018-10-05 | 2021-01-05 | Xenotherapeutics, Inc. | Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non-human) donor and methods and products relating to same |
| US12281338B2 (en) | 2018-10-29 | 2025-04-22 | The Broad Institute, Inc. | Nucleobase editors comprising GeoCas9 and uses thereof |
| WO2020097188A1 (en) * | 2018-11-06 | 2020-05-14 | Sangamo Therapeutics, Inc. | Identification of molecules for inhibition of nk-mediated cell killing |
| JP2022513490A (ja) * | 2018-12-16 | 2022-02-08 | フィジーン、エルエルシー | 遺伝子編集線維芽細胞の治療的使用 |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| DE112020001306T5 (de) | 2019-03-19 | 2022-01-27 | Massachusetts Institute Of Technology | Verfahren und zusammensetzungen zur editierung von nukleotidsequenzen |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| JP2020108405A (ja) * | 2020-04-03 | 2020-07-16 | 米満 吉和 | 高活性ｎｋ細胞、およびその利用 |
| JP2023525304A (ja) | 2020-05-08 | 2023-06-15 | ザ ブロード インスティテュート，インコーポレーテッド | 標的二本鎖ヌクレオチド配列の両鎖同時編集のための方法および組成物 |
| KR20250139268A (ko) * | 2022-11-28 | 2025-09-23 | 인벡티스, 인크. | 인간화 항-hla-g 키메라 항원 수용체 및 이의 용도 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9725764D0 (en) * | 1997-12-04 | 1998-02-04 | Isis Innovation | HLA-E binding |
| CA2755192C (en) * | 2009-03-20 | 2018-09-11 | Sangamo Biosciences, Inc. | Modification of cxcr4 using engineered zinc finger proteins |
| CA2805442C (en) * | 2010-07-21 | 2020-05-12 | Sangamo Biosciences, Inc. | Methods and compositions for modification of an hla locus |
| WO2013074916A1 (en) * | 2011-11-18 | 2013-05-23 | Board Of Regents, The University Of Texas System | Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla |
-
2014
- 2014-03-12 EP EP14779898.7A patent/EP2970886B1/en active Active
- 2014-03-12 CA CA2904210A patent/CA2904210C/en active Active
- 2014-03-12 WO PCT/US2014/024660 patent/WO2014165177A1/en not_active Ceased
- 2014-03-12 AU AU2014248605A patent/AU2014248605B2/en not_active Ceased
- 2014-03-12 CN CN201480025999.3A patent/CN105283539A/zh active Pending
- 2014-03-12 JP JP2016501596A patent/JP6433480B2/ja active Active
- 2014-03-12 US US14/206,706 patent/US20150037304A1/en not_active Abandoned
- 2014-03-12 HK HK16105965.2A patent/HK1217968A1/zh unknown
-
2015
- 2015-09-03 IL IL241112A patent/IL241112B/en active IP Right Grant
-
2017
- 2017-04-18 US US15/490,601 patent/US20170216358A1/en not_active Abandoned
-
2020
- 2020-06-08 AU AU2020203765A patent/AU2020203765A1/en not_active Abandoned
-
2021
- 2021-07-22 US US17/383,265 patent/US20220202858A1/en not_active Abandoned
-
2022
- 2022-08-04 AU AU2022211891A patent/AU2022211891A1/en not_active Abandoned
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