JP6411998B2 - 抗トランスグルタミナーゼ２抗体 - Google Patents

抗トランスグルタミナーゼ２抗体 Download PDF

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Publication number
JP6411998B2
JP6411998B2 JP2015513275A JP2015513275A JP6411998B2 JP 6411998 B2 JP6411998 B2 JP 6411998B2 JP 2015513275 A JP2015513275 A JP 2015513275A JP 2015513275 A JP2015513275 A JP 2015513275A JP 6411998 B2 JP6411998 B2 JP 6411998B2
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Japan
Prior art keywords
antibody
antigen
binding fragment
chain variable
human
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Japanese (ja)
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JP2015519897A5 (enExample
JP2015519897A (ja
Inventor
ジョンソン、ティム
ワトソン、フィル
マシューズ、デイヴィッド
ブラウン、アレックス
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Medical Research Council Technology
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1075—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being against an enzyme
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
JP2015513275A 2012-05-24 2013-05-24 抗トランスグルタミナーゼ２抗体 Active JP6411998B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1209096.5 2012-05-24
GBGB1209096.5A GB201209096D0 (en) 2012-05-24 2012-05-24 Compounds
PCT/GB2013/051373 WO2013175229A1 (en) 2012-05-24 2013-05-24 Anti -transglutaminase 2 antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018104139A Division JP2018166510A (ja) 2012-05-24 2018-05-30 抗トランスグルタミナーゼ２抗体

Publications (3)

Publication Number Publication Date
JP2015519897A JP2015519897A (ja) 2015-07-16
JP2015519897A5 JP2015519897A5 (enExample) 2016-06-30
JP6411998B2 true JP6411998B2 (ja) 2018-10-24

Family

ID=46546551

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015513275A Active JP6411998B2 (ja) 2012-05-24 2013-05-24 抗トランスグルタミナーゼ２抗体
JP2018104139A Pending JP2018166510A (ja) 2012-05-24 2018-05-30 抗トランスグルタミナーゼ２抗体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018104139A Pending JP2018166510A (ja) 2012-05-24 2018-05-30 抗トランスグルタミナーゼ２抗体

Country Status (39)

Country Link
US (3) US10005846B2 (enExample)
EP (2) EP2855530B1 (enExample)
JP (2) JP6411998B2 (enExample)
KR (1) KR102091223B1 (enExample)
CN (1) CN104321346B (enExample)
AU (1) AU2013265025B2 (enExample)
BR (1) BR112014029089B1 (enExample)
CA (1) CA2874488C (enExample)
CL (1) CL2014003125A1 (enExample)
CO (1) CO7151528A2 (enExample)
CY (2) CY1121932T1 (enExample)
DK (2) DK2855530T3 (enExample)
EA (1) EA036810B1 (enExample)
EC (1) ECSP14030942A (enExample)
ES (2) ES2835383T3 (enExample)
GB (1) GB201209096D0 (enExample)
HR (2) HRP20191293T1 (enExample)
HU (2) HUE045539T2 (enExample)
IL (1) IL235369B (enExample)
IN (1) IN2014MN02231A (enExample)
LT (2) LT2855530T (enExample)
MA (1) MA37670B1 (enExample)
ME (1) ME03393B (enExample)
MX (1) MX367517B (enExample)
MY (1) MY185966A (enExample)
NZ (1) NZ701424A (enExample)
PE (1) PE20150346A1 (enExample)
PH (1) PH12014502582A1 (enExample)
PL (2) PL2855530T3 (enExample)
PT (2) PT2855530T (enExample)
RS (2) RS61286B1 (enExample)
SG (1) SG11201407053YA (enExample)
SI (2) SI2855530T1 (enExample)
SM (2) SMT202100014T1 (enExample)
TN (1) TN2014000458A1 (enExample)
TR (1) TR201906781T4 (enExample)
UA (1) UA117657C2 (enExample)
WO (1) WO2013175229A1 (enExample)
ZA (1) ZA201408213B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110055235A (zh) * 2019-05-14 2019-07-26 深圳市亚辉龙生物科技股份有限公司 用于转谷氨酰胺酶抗体检测的抗原及其制备方法、试剂盒及检测方法
FR3117599B1 (fr) * 2020-12-16 2024-11-29 Oreal Méthode de pronostic et/ou de diagnostic d’un état pelliculaire du cuir chevelu
GB202115121D0 (en) 2021-10-21 2021-12-08 Ucb Biopharma Sprl Formulations
GB202115127D0 (en) 2021-10-21 2021-12-08 Ucb Biopharma Sprl Formulations
GB202116665D0 (en) 2021-11-18 2022-01-05 UCB Biopharma SRL Method for the treatment of a scleroderma disease
MX2024006093A (es) 2021-11-18 2024-05-30 UCB Biopharma SRL Metodo para el tratamiento de la enfermedad pulmonar intersticial cronica progresiva.
GB202118010D0 (en) 2021-12-13 2022-01-26 UCB Biopharma SRL Method for detecting and/or quantifying crosslinks formed by transglutaminases
CN116515786B (zh) * 2023-04-26 2024-05-28 广东医科大学 一种人tgm3乙酰化多肽、抗原、抗体及其制备方法和应用
WO2025153465A1 (en) 2024-01-15 2025-07-24 UCB Biopharma SRL Method for the treatment of fibrotic-related disorder associated to ibd

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4912120A (en) 1986-03-14 1990-03-27 Syntex (U.S.A.) Inc. 3,5-substituted 4,5-dihydroisoxazoles as transglutaminase inhibitors
AU1268192A (en) 1991-01-04 1992-08-17 Board Of Regents, The University Of Texas System Cloning and expression of tissue transglutaminases
WO1998004245A1 (en) 1996-07-25 1998-02-05 The Victoria University Of Manchester Use of transglutaminase modulators to promote wound healing
GB0103024D0 (en) * 2001-02-07 2001-03-21 Rsr Ltd Assay for Autoantibodies to tissue transglutaminase
WO2004069175A2 (en) 2003-02-02 2004-08-19 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services METHODS AND COMPOSITIONS FOR THE TREATMENT OF PARKINSON’S DISEASE AND OTHER α-SYNUCLEINOPATHIES
GB0314262D0 (en) 2003-06-19 2003-07-23 Univ Nottingham Trent Novel compounds and methods of using the same
WO2006100679A2 (en) 2005-03-22 2006-09-28 Quark Pharmaceuticals, Inc. Recombinant antibodies against human type ii transglutaminase and uses thereof
US8299040B2 (en) 2006-10-18 2012-10-30 Board Of Regents, The University Of Texas System Methods for treating cancer targeting transglutaminase
EP2281003B1 (en) * 2008-04-24 2017-08-02 Gene Techno Science Co., Ltd. Humanized antibodies specific for amino acid sequence rgd of an extracellular matrix protein and the uses thereof
CA2755786A1 (en) 2009-03-19 2010-09-23 Tristan Croll Targets for growth factor signalling and methods of therapy
HU0900199D0 (en) * 2009-04-01 2009-06-29 Debreceni Egyetem Diagnosis of gluten-induced autoimmune diseases
HU0900195D0 (en) * 2009-04-01 2009-06-29 Debreceni Egyetem Diagnosis and treatment of gluten-induced autoimmune diseases
EP2579861A2 (en) 2010-06-02 2013-04-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Transglutaminase 2 inhibitors for use in the prevention or treatment of rapidly progressive glomerulonephritis
GB2490655A (en) 2011-04-28 2012-11-14 Univ Aston Modulators of tissue transglutaminase

Also Published As

Publication number Publication date
EA036810B1 (ru) 2020-12-23
SMT202100014T1 (it) 2021-03-15
SI2855530T1 (sl) 2019-08-30
PT3521315T (pt) 2020-10-29
LT2855530T (lt) 2019-07-25
TN2014000458A1 (en) 2016-03-30
CY1121932T1 (el) 2020-10-14
DK2855530T3 (da) 2019-06-24
ES2835383T3 (es) 2021-06-22
UA117657C2 (uk) 2018-09-10
NZ701424A (en) 2016-08-26
PT2855530T (pt) 2019-07-08
IL235369A0 (en) 2014-12-31
JP2018166510A (ja) 2018-11-01
US20150218289A1 (en) 2015-08-06
IN2014MN02231A (enExample) 2015-07-24
DK3521315T3 (da) 2020-11-09
PH12014502582B1 (en) 2015-01-21
ZA201408213B (en) 2020-02-26
AU2013265025A1 (en) 2014-12-04
BR112014029089A2 (pt) 2019-06-25
HRP20191293T1 (hr) 2019-10-18
SMT201900407T1 (it) 2019-09-09
PL3521315T3 (pl) 2021-08-23
MA37670A1 (fr) 2016-05-31
SG11201407053YA (en) 2014-12-30
CY1123926T1 (el) 2022-05-27
CO7151528A2 (es) 2014-12-29
EP2855530B1 (en) 2019-05-01
PL2855530T3 (pl) 2019-10-31
CA2874488C (en) 2021-09-07
MA37670B1 (fr) 2019-12-31
EP3521315B1 (en) 2020-10-14
MY185966A (en) 2021-06-14
TR201906781T4 (tr) 2019-05-21
RS61286B1 (sr) 2021-02-26
EA201492162A1 (ru) 2015-03-31
BR112014029089B1 (pt) 2023-04-25
CL2014003125A1 (es) 2015-08-21
JP2015519897A (ja) 2015-07-16
KR20150013340A (ko) 2015-02-04
ES2728856T3 (es) 2019-10-29
US11718686B2 (en) 2023-08-08
US20180355060A1 (en) 2018-12-13
US20210101999A1 (en) 2021-04-08
AU2013265025B2 (en) 2018-04-26
CN104321346A (zh) 2015-01-28
CA2874488A1 (en) 2013-11-28
PH12014502582A1 (en) 2015-01-21
US10005846B2 (en) 2018-06-26
MX2014014264A (es) 2015-05-15
ME03393B (me) 2020-01-20
HUE045539T2 (hu) 2019-12-30
GB201209096D0 (en) 2012-07-04
EP3521315A1 (en) 2019-08-07
PE20150346A1 (es) 2015-03-05
RS59135B1 (sr) 2019-09-30
SI3521315T1 (sl) 2020-12-31
HK1203974A1 (en) 2015-11-06
LT3521315T (lt) 2020-12-28
HRP20202059T1 (hr) 2021-02-19
US10961319B2 (en) 2021-03-30
HUE052490T2 (hu) 2021-04-28
IL235369B (en) 2019-05-30
EP2855530A1 (en) 2015-04-08
WO2013175229A1 (en) 2013-11-28
CN104321346B (zh) 2018-12-07
KR102091223B1 (ko) 2020-03-20
ECSP14030942A (es) 2015-09-30
MX367517B (es) 2019-08-26

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