JP6407285B2 - ＲＯＲγ調節因子 - Google Patents
ＲＯＲγ調節因子 Download PDFInfo
- Publication number
- JP6407285B2 JP6407285B2 JP2016540455A JP2016540455A JP6407285B2 JP 6407285 B2 JP6407285 B2 JP 6407285B2 JP 2016540455 A JP2016540455 A JP 2016540455A JP 2016540455 A JP2016540455 A JP 2016540455A JP 6407285 B2 JP6407285 B2 JP 6407285B2
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- bicyclic
- monocyclic
- membered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC1C=CC*1(C)C Chemical compound CC1C=CC*1(C)C 0.000 description 11
- FZMPLKVGINKUJZ-UHFFFAOYSA-N Cc(cc1)cc(F)c1F Chemical compound Cc(cc1)cc(F)c1F FZMPLKVGINKUJZ-UHFFFAOYSA-N 0.000 description 2
- VCZNNAKNUVJVGX-UHFFFAOYSA-N Cc(cc1)ccc1C#N Chemical compound Cc(cc1)ccc1C#N VCZNNAKNUVJVGX-UHFFFAOYSA-N 0.000 description 2
- NPDACUSDTOMAMK-UHFFFAOYSA-N Cc(cc1)ccc1Cl Chemical compound Cc(cc1)ccc1Cl NPDACUSDTOMAMK-UHFFFAOYSA-N 0.000 description 2
- WRWPPGUCZBJXKX-UHFFFAOYSA-N Cc(cc1)ccc1F Chemical compound Cc(cc1)ccc1F WRWPPGUCZBJXKX-UHFFFAOYSA-N 0.000 description 2
- CHLICZRVGGXEOD-UHFFFAOYSA-N Cc(cc1)ccc1OC Chemical compound Cc(cc1)ccc1OC CHLICZRVGGXEOD-UHFFFAOYSA-N 0.000 description 2
- VXLYOURCUVQYLN-UHFFFAOYSA-N Cc(cc1)cnc1Cl Chemical compound Cc(cc1)cnc1Cl VXLYOURCUVQYLN-UHFFFAOYSA-N 0.000 description 2
- WWYQUVRQRXJULJ-UHFFFAOYSA-N Cc1cc(OCCN2C)c2nc1 Chemical compound Cc1cc(OCCN2C)c2nc1 WWYQUVRQRXJULJ-UHFFFAOYSA-N 0.000 description 2
- YKIVWXBPOOHWHJ-UHFFFAOYSA-N O=C(Nc1c(C2)cccc1)N2S Chemical compound O=C(Nc1c(C2)cccc1)N2S YKIVWXBPOOHWHJ-UHFFFAOYSA-N 0.000 description 2
- UASPUKAUCYOONN-UHFFFAOYSA-N CC(C)(C)OC(N1c2ccccc2CCC1O)=O Chemical compound CC(C)(C)OC(N1c2ccccc2CCC1O)=O UASPUKAUCYOONN-UHFFFAOYSA-N 0.000 description 1
- XPXWAMCRUWVOFQ-UHFFFAOYSA-N CC(C)(CNC(Cc1cc(F)ccc1S(N1c2ccc(C(C(F)(F)F)(C(F)(F)F)O)cc2CCC1)(=O)=O)=O)N Chemical compound CC(C)(CNC(Cc1cc(F)ccc1S(N1c2ccc(C(C(F)(F)F)(C(F)(F)F)O)cc2CCC1)(=O)=O)=O)N XPXWAMCRUWVOFQ-UHFFFAOYSA-N 0.000 description 1
- BMPNKLCPHIYLRR-HXBUSHRASA-N CC(CC1)(CN1C(C[C@H](CCc1cc(C(C(F)(F)F)(C(F)(F)F)O)ccc11)N1S(c(cc1)ccc1F)(=O)=O)=O)O Chemical compound CC(CC1)(CN1C(C[C@H](CCc1cc(C(C(F)(F)F)(C(F)(F)F)O)ccc11)N1S(c(cc1)ccc1F)(=O)=O)=O)O BMPNKLCPHIYLRR-HXBUSHRASA-N 0.000 description 1
- VLCLQKKUIXVTTE-UHFFFAOYSA-N CC(CN(Cc1ccccc1)Cc1ccccc1)(C(N1CF)=O)NC1=O Chemical compound CC(CN(Cc1ccccc1)Cc1ccccc1)(C(N1CF)=O)NC1=O VLCLQKKUIXVTTE-UHFFFAOYSA-N 0.000 description 1
- DSCWHNKZIWFACR-UHFFFAOYSA-N CN(C1)CNC1=O Chemical compound CN(C1)CNC1=O DSCWHNKZIWFACR-UHFFFAOYSA-N 0.000 description 1
- BXPUSDJPGORRAZ-UHFFFAOYSA-N CN(CC1)CCC1(c1ccccc1N1)OC1=O Chemical compound CN(CC1)CCC1(c1ccccc1N1)OC1=O BXPUSDJPGORRAZ-UHFFFAOYSA-N 0.000 description 1
- YLBQJBFSUOBZMA-SFHVURJKSA-N NC([C@H](CC(C1)(F)F)N1C(Cc1cc(F)ccc1S(N1c2ccc(C(C(F)(F)F)(C(F)(F)F)O)cc2CCC1)(=O)=O)=O)=O Chemical compound NC([C@H](CC(C1)(F)F)N1C(Cc1cc(F)ccc1S(N1c2ccc(C(C(F)(F)F)(C(F)(F)F)O)cc2CCC1)(=O)=O)=O)=O YLBQJBFSUOBZMA-SFHVURJKSA-N 0.000 description 1
- WOOJYBRETVZTMI-ROUUACIJSA-N N[C@@H](CC1)CN1C(C[C@H](CCc1cc(C(C(F)(F)F)(C(F)(F)F)O)ccc11)N1S(c(cc1)ccc1F)(=O)=O)=O Chemical compound N[C@@H](CC1)CN1C(C[C@H](CCc1cc(C(C(F)(F)F)(C(F)(F)F)O)ccc11)N1S(c(cc1)ccc1F)(=O)=O)=O WOOJYBRETVZTMI-ROUUACIJSA-N 0.000 description 1
- SZSDNGOPLYKUQL-UHFFFAOYSA-N OC(C(F)(F)F)(C(F)(F)F)c(cc1)cc(CCC2C(O)=O)c1N2S(c(cc1)ccc1F)(=O)=O Chemical compound OC(C(F)(F)F)(C(F)(F)F)c(cc1)cc(CCC2C(O)=O)c1N2S(c(cc1)ccc1F)(=O)=O SZSDNGOPLYKUQL-UHFFFAOYSA-N 0.000 description 1
- SLNICQZZTIMVDU-NVHKAFQKSA-N OC(C(F)(F)F)(C(F)(F)F)c(cc1CC[C@H]2CC(N(CC3)CC3(C(N3)=O)NC3=O)=O)ccc1N2S(c(cc1)ccc1F)(=O)=O Chemical compound OC(C(F)(F)F)(C(F)(F)F)c(cc1CC[C@H]2CC(N(CC3)CC3(C(N3)=O)NC3=O)=O)ccc1N2S(c(cc1)ccc1F)(=O)=O SLNICQZZTIMVDU-NVHKAFQKSA-N 0.000 description 1
- NULKBXRLIDQIMK-CGAIIQECSA-N OC(C(F)(F)F)(C(F)(F)F)c(cc1CC[C@H]2CC(N(CC3)CC3NC(c3ccccc3)=O)=O)ccc1N2S(c(cc1)ccc1F)(=O)=O Chemical compound OC(C(F)(F)F)(C(F)(F)F)c(cc1CC[C@H]2CC(N(CC3)CC3NC(c3ccccc3)=O)=O)ccc1N2S(c(cc1)ccc1F)(=O)=O NULKBXRLIDQIMK-CGAIIQECSA-N 0.000 description 1
- LEZVJLHMDYPHQY-HNNXBMFYSA-N OC(C(F)(F)F)(C(F)(F)F)c(cc1CC[C@H]2CC(NCC(O)=O)=O)ccc1N2S(c(cc1)ccc1F)(=O)=O Chemical compound OC(C(F)(F)F)(C(F)(F)F)c(cc1CC[C@H]2CC(NCC(O)=O)=O)ccc1N2S(c(cc1)ccc1F)(=O)=O LEZVJLHMDYPHQY-HNNXBMFYSA-N 0.000 description 1
- HODWZBJHXZYQBH-KRWDZBQOSA-N OC(C1)CN1C(CNC(C[C@H](CCc1cc(C(C(F)(F)F)(C(F)(F)F)O)ccc11)N1S(c(cc1)ccc1F)(=O)=O)=O)=O Chemical compound OC(C1)CN1C(CNC(C[C@H](CCc1cc(C(C(F)(F)F)(C(F)(F)F)O)ccc11)N1S(c(cc1)ccc1F)(=O)=O)=O)=O HODWZBJHXZYQBH-KRWDZBQOSA-N 0.000 description 1
- BLBDURVDDQPEOM-INIZCTEOSA-N OC(C1)CN1C(C[C@H](CCc1c2ccc(C(C(F)(F)F)(C(F)(F)F)O)c1)N2S(c(cc1)ccc1F)(=O)=O)=O Chemical compound OC(C1)CN1C(C[C@H](CCc1c2ccc(C(C(F)(F)F)(C(F)(F)F)O)c1)N2S(c(cc1)ccc1F)(=O)=O)=O BLBDURVDDQPEOM-INIZCTEOSA-N 0.000 description 1
- GSTDINZZKFXQTI-ROUUACIJSA-N O[C@@H](CC1)CN1C(C[C@H](CCc1cc(C(C(F)(F)F)(C(F)(F)F)O)ccc11)N1S(c(cc1)ccc1F)(=O)=O)=O Chemical compound O[C@@H](CC1)CN1C(C[C@H](CCc1cc(C(C(F)(F)F)(C(F)(F)F)O)ccc11)N1S(c(cc1)ccc1F)(=O)=O)=O GSTDINZZKFXQTI-ROUUACIJSA-N 0.000 description 1
- XSDFTPCIEJPJPU-UHFFFAOYSA-N SN1CC2OC2C1 Chemical compound SN1CC2OC2C1 XSDFTPCIEJPJPU-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Quinoline Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361875220P | 2013-09-09 | 2013-09-09 | |
| US61/875,220 | 2013-09-09 | ||
| PCT/US2014/054489 WO2015035278A1 (en) | 2013-09-09 | 2014-09-08 | RORγ MODULATORS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016532715A JP2016532715A (ja) | 2016-10-20 |
| JP2016532715A5 JP2016532715A5 (enExample) | 2017-10-19 |
| JP6407285B2 true JP6407285B2 (ja) | 2018-10-17 |
Family
ID=51541401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016540455A Expired - Fee Related JP6407285B2 (ja) | 2013-09-09 | 2014-09-08 | ＲＯＲγ調節因子 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9663469B2 (enExample) |
| EP (1) | EP3044219A1 (enExample) |
| JP (1) | JP6407285B2 (enExample) |
| CN (1) | CN105705501B (enExample) |
| WO (1) | WO2015035278A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105705501B (zh) | 2013-09-09 | 2019-04-19 | 百时美施贵宝公司 | RORγ调节剂 |
| JP6397488B2 (ja) | 2013-09-20 | 2018-09-26 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ＲＯＲγ調節因子 |
| WO2015103508A1 (en) | 2014-01-06 | 2015-07-09 | Bristol-Myers Squibb Company | CARBOCYCLIC SULFONE RORγ MODULATORS |
| US9708253B2 (en) | 2014-01-06 | 2017-07-18 | Bristol-Myers Squibb Company | Cyclohexyl sulfone RORγ modulators |
| CN106061956B (zh) | 2014-01-06 | 2021-03-12 | 百时美施贵宝公司 | 作为RORγ调节剂的杂环砜 |
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| ITMI20012060A1 (it) | 2001-10-05 | 2003-04-05 | Recordati Chem Pharm | Nuovi eterocilcli n-acilati |
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| JP6063870B2 (ja) * | 2010-11-08 | 2017-01-18 | ライセラ・コーポレイション | ＲＯＲγ活性の阻害用のＮ−スルホニル化テトラヒドロキノリンおよび関連二環化合物および病気の治療 |
| WO2013064231A1 (en) * | 2011-10-31 | 2013-05-10 | Phenex Pharmaceuticals Ag | SEVEN-MEMBERED SULFONAMIDES AS MODULATORS OF RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORγ, NR1F3) |
| SG11201502369XA (en) * | 2012-10-16 | 2015-05-28 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of ror-gamma-t |
| US10035790B2 (en) | 2012-10-19 | 2018-07-31 | Exelixis, Inc. | RORγ modulators |
| CN105705501B (zh) | 2013-09-09 | 2019-04-19 | 百时美施贵宝公司 | RORγ调节剂 |
| JP6397488B2 (ja) | 2013-09-20 | 2018-09-26 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ＲＯＲγ調節因子 |
| WO2015103508A1 (en) | 2014-01-06 | 2015-07-09 | Bristol-Myers Squibb Company | CARBOCYCLIC SULFONE RORγ MODULATORS |
| US9708253B2 (en) | 2014-01-06 | 2017-07-18 | Bristol-Myers Squibb Company | Cyclohexyl sulfone RORγ modulators |
| CN106061956B (zh) | 2014-01-06 | 2021-03-12 | 百时美施贵宝公司 | 作为RORγ调节剂的杂环砜 |
| CN106061971B (zh) | 2014-01-06 | 2019-03-12 | 百时美施贵宝公司 | 吡咯烷基砜衍生物及其作为RORγ调节剂的用途 |
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| CN105705501A (zh) | 2016-06-22 |
| EP3044219A1 (en) | 2016-07-20 |
| WO2015035278A1 (en) | 2015-03-12 |
| CN105705501B (zh) | 2019-04-19 |
| US9663469B2 (en) | 2017-05-30 |
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