JP6404220B2 - テアニン誘導体とカルボン酸クマリン誘導体との縮合生成物、その中間体、調製方法、及びその使用 - Google Patents

テアニン誘導体とカルボン酸クマリン誘導体との縮合生成物、その中間体、調製方法、及びその使用 Download PDF

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JP6404220B2
JP6404220B2 JP2015533430A JP2015533430A JP6404220B2 JP 6404220 B2 JP6404220 B2 JP 6404220B2 JP 2015533430 A JP2015533430 A JP 2015533430A JP 2015533430 A JP2015533430 A JP 2015533430A JP 6404220 B2 JP6404220 B2 JP 6404220B2
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cancer
compound
pharmaceutical composition
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theanine
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JP2016500649A (ja
JP2016500649A5 (enExample
Inventor
グオイーン ジャン
グオイーン ジャン
イーン ジャン
イーン ジャン
ベンハオ ウー
ベンハオ ウー
グオホワ ジャン
グオホワ ジャン
Original Assignee
シャンドーン イーンドーン イーンハオ バイオテクノロジー，インコーポレイティド
シャンドーン イーンドーン イーンハオ バイオテクノロジー，インコーポレイティド
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Priority claimed from CN201210363378.9A external-priority patent/CN103690531A/zh
Priority claimed from CN201210363367.0A external-priority patent/CN103690529A/zh
Priority claimed from CN201210363369.XA external-priority patent/CN103690530A/zh
Priority claimed from CN201210363366.6A external-priority patent/CN103690528A/zh
Priority claimed from CN201210515826.2A external-priority patent/CN103845324A/zh
Priority claimed from CN201210515827.7A external-priority patent/CN103845325A/zh
Priority claimed from CN 201310030234 external-priority patent/CN103110621A/zh
Application filed by シャンドーン イーンドーン イーンハオ バイオテクノロジー，インコーポレイティド, シャンドーン イーンドーン イーンハオ バイオテクノロジー，インコーポレイティド filed Critical シャンドーン イーンドーン イーンハオ バイオテクノロジー，インコーポレイティド
Publication of JP2016500649A publication Critical patent/JP2016500649A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/12—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 3 and unsubstituted in position 7
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0039—Coumarin dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2015533430A 2012-09-27 2013-09-25 テアニン誘導体とカルボン酸クマリン誘導体との縮合生成物、その中間体、調製方法、及びその使用 Expired - Fee Related JP6404220B2 (ja)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
CN201210363378.9A CN103690531A (zh) 2012-09-27 2012-09-27 茶乙香酸等在制备具有预防和治疗癌症等疾病的产品中的应用
CN201210363366.6A CN103690528A (zh) 2012-09-27 2012-09-27 茶氨酸溴香酰胺在制备具有预防和治疗癌症等疾病的产品中的应用
CN201210363369.XA CN103690530A (zh) 2012-09-27 2012-09-27 茶氨酸氯香酰胺等在制备具有预防和治疗癌症等疾病的产品中的应用
CN201210363367.0 2012-09-27
CN201210363367.0A CN103690529A (zh) 2012-09-27 2012-09-27 茶甲香酸等在制备具有预防和治疗癌症等疾病的产品中的应用
CN201210363366.6 2012-09-27
CN201210363378.9 2012-09-27
CN201210363369.X 2012-09-27
CN201210515827.7 2012-12-06
CN201210515826.2 2012-12-06
CN201210515826.2A CN103845324A (zh) 2012-12-06 2012-12-06 茶氨酸氟香酰胺在制备具有预防和治疗癌症等疾病的产品中的应用
CN201210515827.7A CN103845325A (zh) 2012-12-06 2012-12-06 茶氨酸硝香酰胺在制备具有预防和治疗癌症等疾病的产品中的应用
CN201310030234.6 2013-01-28
CN 201310030234 CN103110621A (zh) 2013-01-28 2013-01-28 茶双氯香酰胺和茶双溴香酰胺等在制备具有预防和治疗癌症等疾病的产品中的应用
PCT/CN2013/084146 WO2014048313A1 (zh) 2012-09-27 2013-09-25 茶氨酸衍生物与羧酸香豆素衍生物的缩合产物及其中间体、其制备方法和用途

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JP2016500649A JP2016500649A (ja) 2016-01-14
JP2016500649A5 JP2016500649A5 (enExample) 2016-11-10
JP6404220B2 true JP6404220B2 (ja) 2018-10-10

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JP2015533430A Expired - Fee Related JP6404220B2 (ja) 2012-09-27 2013-09-25 テアニン誘導体とカルボン酸クマリン誘導体との縮合生成物、その中間体、調製方法、及びその使用

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US (1) US9518038B2 (enExample)
EP (1) EP2902388B1 (enExample)
JP (1) JP6404220B2 (enExample)
CN (1) CN104144919B (enExample)
WO (1) WO2014048313A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108069929B (zh) * 2016-11-18 2021-06-15 中国科学院大连化学物理研究所 3-取代香豆素类衍生物及应用和gpr35受体的激动剂
WO2020011607A1 (en) 2018-07-09 2020-01-16 Fondation Asile Des Aveugles Inhibition of prc2 subunits to treat eye disorders
EP4081209A4 (en) * 2019-12-24 2024-04-24 The Regents of the University of California Compositions and methods for treating cancer and improving epithelial homeostasis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4317774A (en) 1978-03-24 1982-03-02 American Cyanamid Company 6-[D-α-(Coumarin-3-carboxamido)arylacetamido]-penicillanic acids or salts
RU2009103623A (ru) 2006-07-04 2010-08-10 Унилевер Н.В. (NL) Производные теанина, их применение и способы их получения
BRPI0907162A2 (pt) * 2008-01-11 2015-07-07 Univ California Composto, composição farmacêutica e métodos para ativar procaspase executora 3, 6 e/ou 7 e para tratar um estado de doença em um mamífero
DE102008059578A1 (de) * 2008-11-28 2010-06-10 Merck Patent Gmbh Benzo-Naphtyridin Verbindungen
CN103110621A (zh) 2013-01-28 2013-05-22 烟台大学 茶双氯香酰胺和茶双溴香酰胺等在制备具有预防和治疗癌症等疾病的产品中的应用

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US9518038B2 (en) 2016-12-13
CN104144919B (zh) 2018-07-03
JP2016500649A (ja) 2016-01-14
EP2902388A4 (en) 2016-08-31
CN104144919A (zh) 2014-11-12
US20150239861A1 (en) 2015-08-27
WO2014048313A1 (zh) 2014-04-03
EP2902388A1 (en) 2015-08-05
EP2902388B1 (en) 2019-03-13

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