JP6401171B2 - 貧血の治療に使用するためのバイオマーカー - Google Patents

貧血の治療に使用するためのバイオマーカー Download PDF

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JP6401171B2
JP6401171B2 JP2015539750A JP2015539750A JP6401171B2 JP 6401171 B2 JP6401171 B2 JP 6401171B2 JP 2015539750 A JP2015539750 A JP 2015539750A JP 2015539750 A JP2015539750 A JP 2015539750A JP 6401171 B2 JP6401171 B2 JP 6401171B2
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gdf11
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activin
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JP2016500698A (ja
JP2016500698A5 (enExample
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スング ビクトリア
スング ビクトリア
チョプラ ラジェシュ
チョプラ ラジェシュ
ヘルミネ オリビエル
ヘルミネ オリビエル
クルズ モウラ イバン
クルズ モウラ イバン
ドウシオト ミチャエル
ドウシオト ミチャエル
トロバトイ マシエル トヒアゴ
トロバトイ マシエル トヒアゴ
フリコト アウレリエ
フリコト アウレリエ
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Celgene Corp
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Celgene Corp
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
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  • Microbiology (AREA)
  • Biotechnology (AREA)
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  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
JP2015539750A 2012-10-24 2013-10-23 貧血の治療に使用するためのバイオマーカー Active JP6401171B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261718126P 2012-10-24 2012-10-24
US61/718,126 2012-10-24
PCT/US2013/066350 WO2014066486A2 (en) 2012-10-24 2013-10-23 Biomarker for use in treating anemia

Related Child Applications (1)

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JP2018131226A Division JP2018184428A (ja) 2012-10-24 2018-07-11 貧血の治療に使用するためのバイオマーカー

Publications (3)

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JP2016500698A JP2016500698A (ja) 2016-01-14
JP2016500698A5 JP2016500698A5 (enExample) 2016-12-08
JP6401171B2 true JP6401171B2 (ja) 2018-10-03

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JP2015539750A Active JP6401171B2 (ja) 2012-10-24 2013-10-23 貧血の治療に使用するためのバイオマーカー
JP2018131226A Pending JP2018184428A (ja) 2012-10-24 2018-07-11 貧血の治療に使用するためのバイオマーカー
JP2020108569A Active JP7146850B2 (ja) 2012-10-24 2020-06-24 貧血の治療に使用するためのバイオマーカー

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JP2018131226A Pending JP2018184428A (ja) 2012-10-24 2018-07-11 貧血の治療に使用するためのバイオマーカー
JP2020108569A Active JP7146850B2 (ja) 2012-10-24 2020-06-24 貧血の治療に使用するためのバイオマーカー

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US (2) US20150276766A1 (enExample)
EP (2) EP2912462B1 (enExample)
JP (3) JP6401171B2 (enExample)
CN (2) CN104968801B (enExample)
AU (3) AU2013334659B2 (enExample)
CA (1) CA2889209C (enExample)
ES (2) ES2753811T3 (enExample)
IL (3) IL267663B (enExample)
SA (1) SA515360337B1 (enExample)
WO (1) WO2014066486A2 (enExample)

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TW201919685A (zh) 2008-08-14 2019-06-01 美商艾瑟勒朗法瑪公司 使用ｇｄｆ阱以增加紅血球水平
US8216997B2 (en) 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
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CN104968801A (zh) 2015-10-07
IL290653B2 (en) 2025-05-01
JP7146850B2 (ja) 2022-10-04
CN113604550A (zh) 2021-11-05
ES2753811T3 (es) 2020-04-14
JP2018184428A (ja) 2018-11-22
WO2014066486A3 (en) 2015-07-16
US20190049469A1 (en) 2019-02-14
AU2013334659B2 (en) 2019-07-11
IL290653A (en) 2022-04-01
AU2021236465A1 (en) 2021-10-21
EP2912462A4 (en) 2016-06-15
ES3031001T3 (en) 2025-07-03
WO2014066486A2 (en) 2014-05-01
CN104968801B (zh) 2021-06-15
IL290653B1 (en) 2025-01-01
JP2020183389A (ja) 2020-11-12
IL238414B (en) 2019-07-31
EP3608419B1 (en) 2025-03-26
IL267663B (en) 2022-09-01
EP3608419A1 (en) 2020-02-12
IL238414A0 (en) 2015-06-30
HK1213948A1 (en) 2016-07-15
IL267663A (en) 2019-08-29
EP2912462A2 (en) 2015-09-02
CA2889209A1 (en) 2014-05-01
JP2016500698A (ja) 2016-01-14
US20150276766A1 (en) 2015-10-01
AU2019204098B2 (en) 2021-07-22
EP2912462B1 (en) 2019-08-07
AU2021236465B2 (en) 2024-06-13
SA515360337B1 (ar) 2019-09-12
AU2013334659A1 (en) 2015-05-14
AU2019204098A1 (en) 2019-07-04
CA2889209C (en) 2023-08-22

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