JP6400672B2 - アルカフタジンの製造方法 - Google Patents
アルカフタジンの製造方法 Download PDFInfo
- Publication number
- JP6400672B2 JP6400672B2 JP2016504606A JP2016504606A JP6400672B2 JP 6400672 B2 JP6400672 B2 JP 6400672B2 JP 2016504606 A JP2016504606 A JP 2016504606A JP 2016504606 A JP2016504606 A JP 2016504606A JP 6400672 B2 JP6400672 B2 JP 6400672B2
- Authority
- JP
- Japan
- Prior art keywords
- acid
- formula
- compound
- salt
- addition salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- BYXWNFRPGUGFSI-UHFFFAOYSA-N CN(CC1)CCC1C(c1ncc[n]1CCc1ccccc1)=O Chemical compound CN(CC1)CCC1C(c1ncc[n]1CCc1ccccc1)=O BYXWNFRPGUGFSI-UHFFFAOYSA-N 0.000 description 2
- SSENHTOBLYRWKU-UHFFFAOYSA-N C(C[n]1cncc1)c1ccccc1 Chemical compound C(C[n]1cncc1)c1ccccc1 SSENHTOBLYRWKU-UHFFFAOYSA-N 0.000 description 1
- JWXOOQCMGJBSML-UHFFFAOYSA-N CCOC(C1CCN(C)CC1)=O Chemical compound CCOC(C1CCN(C)CC1)=O JWXOOQCMGJBSML-UHFFFAOYSA-N 0.000 description 1
- GKTUOCXSVQTQJF-UHFFFAOYSA-N CN(CC1)CCC1=C(c1ncc[n]1CC1)c2c1cccc2 Chemical compound CN(CC1)CCC1=C(c1ncc[n]1CC1)c2c1cccc2 GKTUOCXSVQTQJF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13160829 | 2013-03-25 | ||
| EP13160829.1 | 2013-03-25 | ||
| PCT/EP2014/055815 WO2014154620A1 (en) | 2013-03-25 | 2014-03-24 | Methods for the preparation of alcaftadine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016515555A JP2016515555A (ja) | 2016-05-30 |
| JP2016515555A5 JP2016515555A5 (enExample) | 2017-03-30 |
| JP6400672B2 true JP6400672B2 (ja) | 2018-10-03 |
Family
ID=47913271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016504606A Active JP6400672B2 (ja) | 2013-03-25 | 2014-03-24 | アルカフタジンの製造方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9682984B2 (enExample) |
| EP (1) | EP2978765B1 (enExample) |
| JP (1) | JP6400672B2 (enExample) |
| KR (1) | KR102204578B1 (enExample) |
| CA (1) | CA2907396C (enExample) |
| ES (1) | ES2680933T3 (enExample) |
| WO (1) | WO2014154620A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104860920B (zh) * | 2015-04-15 | 2017-08-25 | 武汉武药科技有限公司 | 一种阿卡他定中间体的制备方法 |
| CN104987337B (zh) * | 2015-07-28 | 2018-01-12 | 武汉武药科技有限公司 | 一种制备阿卡他定的氧化方法 |
| WO2018126229A2 (en) | 2016-12-30 | 2018-07-05 | Sutrovax, Inc. | Polypeptide-antigen conjugates with non-natural amino acids |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4070381A (en) * | 1972-07-12 | 1978-01-24 | Lever Brothers Company | Certain 2-(hydroxyalkyl)-2,5-dialkyl-4-hydroxy-4,5-dihydrofuran-3-ones and method for their preparation |
| IL101850A (en) * | 1991-06-13 | 1996-01-31 | Janssen Pharmaceutica Nv | 11-(4-Piperidinyl)-imidazo (2,1-b) (3) benzazepine derivatives their preparation and pharmaceutical compositions containing them |
| TW527186B (en) | 1996-03-19 | 2003-04-11 | Janssen Pharmaceutica Nv | Fused imidazole derivatives as multidrug resistance modulators |
| US20080139531A1 (en) | 2006-12-04 | 2008-06-12 | Alcon Manufacturing Ltd. | Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair |
| WO2014083571A1 (en) | 2012-11-29 | 2014-06-05 | Neuland Laboratories Limited | A process for the preparation of alcaftadine |
-
2014
- 2014-03-24 US US14/778,461 patent/US9682984B2/en active Active
- 2014-03-24 EP EP14712650.2A patent/EP2978765B1/en active Active
- 2014-03-24 ES ES14712650.2T patent/ES2680933T3/es active Active
- 2014-03-24 KR KR1020157030845A patent/KR102204578B1/ko active Active
- 2014-03-24 JP JP2016504606A patent/JP6400672B2/ja active Active
- 2014-03-24 WO PCT/EP2014/055815 patent/WO2014154620A1/en not_active Ceased
- 2014-03-24 CA CA2907396A patent/CA2907396C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2907396A1 (en) | 2014-10-02 |
| EP2978765B1 (en) | 2018-05-02 |
| KR20160018472A (ko) | 2016-02-17 |
| US9682984B2 (en) | 2017-06-20 |
| EP2978765A1 (en) | 2016-02-03 |
| US20160280709A1 (en) | 2016-09-29 |
| WO2014154620A1 (en) | 2014-10-02 |
| KR102204578B1 (ko) | 2021-01-20 |
| JP2016515555A (ja) | 2016-05-30 |
| CA2907396C (en) | 2021-11-02 |
| ES2680933T3 (es) | 2018-09-11 |
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