JP6397488B2 - ＲＯＲγ調節因子 - Google Patents
ＲＯＲγ調節因子 Download PDFInfo
- Publication number
- JP6397488B2 JP6397488B2 JP2016515522A JP2016515522A JP6397488B2 JP 6397488 B2 JP6397488 B2 JP 6397488B2 JP 2016515522 A JP2016515522 A JP 2016515522A JP 2016515522 A JP2016515522 A JP 2016515522A JP 6397488 B2 JP6397488 B2 JP 6397488B2
- Authority
- JP
- Japan
- Prior art keywords
- tetrahydroquinolin
- sulfonyl
- fluorophenyl
- hexafluoro
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *[C@@](C(F)(F)F)(c(cc1)cc(CC[C@@]2CC(O)=O)c1N2S(c(cc1)ccc1F)(=O)=O)O Chemical compound *[C@@](C(F)(F)F)(c(cc1)cc(CC[C@@]2CC(O)=O)c1N2S(c(cc1)ccc1F)(=O)=O)O 0.000 description 1
- QBLZQBOPZUOSEP-INIZCTEOSA-N CC(C)(C(NNC(C[C@H](CCc1cc(C(C(F)(F)F)(C(F)(F)F)O)ccc11)N1S(c(cc1)ccc1F)(=O)=O)=O)=O)O Chemical compound CC(C)(C(NNC(C[C@H](CCc1cc(C(C(F)(F)F)(C(F)(F)F)O)ccc11)N1S(c(cc1)ccc1F)(=O)=O)=O)=O)O QBLZQBOPZUOSEP-INIZCTEOSA-N 0.000 description 1
- BZJZPVQQQMJXRF-KRWDZBQOSA-N CN(C)C(Cc1nnc(C[C@H](CCc2cc(C(C(F)(F)F)(C(F)(F)F)O)ccc22)N2S(c(cc2)ccc2F)(=O)=O)[o]1)=O Chemical compound CN(C)C(Cc1nnc(C[C@H](CCc2cc(C(C(F)(F)F)(C(F)(F)F)O)ccc22)N2S(c(cc2)ccc2F)(=O)=O)[o]1)=O BZJZPVQQQMJXRF-KRWDZBQOSA-N 0.000 description 1
- CZCQPGVHVPRQGT-INIZCTEOSA-N N#CCc1nnc(C[C@H](CCc2cc(C(C(F)(F)F)(C(F)(F)F)O)ccc22)N2S(c(cc2)ccc2F)(=O)=O)[o]1 Chemical compound N#CCc1nnc(C[C@H](CCc2cc(C(C(F)(F)F)(C(F)(F)F)O)ccc22)N2S(c(cc2)ccc2F)(=O)=O)[o]1 CZCQPGVHVPRQGT-INIZCTEOSA-N 0.000 description 1
- QIOFTFKSLWHSSG-UHFFFAOYSA-N O=C(CC1Nc2ccccc2CC1)OCc1ccccc1 Chemical compound O=C(CC1Nc2ccccc2CC1)OCc1ccccc1 QIOFTFKSLWHSSG-UHFFFAOYSA-N 0.000 description 1
- UWAVEZLBRVSMCA-UHFFFAOYSA-N OC(C(F)(F)F)(C(F)(F)F)c(cc1CCC2)ccc1N2S(c(c(CC(NCC(CN1)OC1=O)=O)c1)ccc1F)(=O)=O Chemical compound OC(C(F)(F)F)(C(F)(F)F)c(cc1CCC2)ccc1N2S(c(c(CC(NCC(CN1)OC1=O)=O)c1)ccc1F)(=O)=O UWAVEZLBRVSMCA-UHFFFAOYSA-N 0.000 description 1
- UXZRPPYGZFZIEB-AWEZNQCLSA-N OC(C(F)(F)F)(C(F)(F)F)c(cc1CC[C@H]2CC(O)=O)ccc1N2S(c(cc1)ccc1F)(=O)=O Chemical compound OC(C(F)(F)F)(C(F)(F)F)c(cc1CC[C@H]2CC(O)=O)ccc1N2S(c(cc1)ccc1F)(=O)=O UXZRPPYGZFZIEB-AWEZNQCLSA-N 0.000 description 1
- HBNJOSMGIAZNMX-XJDOXCRVSA-N OCC(C[n]1nccc1C[C@H](CCc1cc(C(C(F)(F)F)(C(F)(F)F)O)ccc11)N1S(c(cc1)ccc1F)(=O)=O)O Chemical compound OCC(C[n]1nccc1C[C@H](CCc1cc(C(C(F)(F)F)(C(F)(F)F)O)ccc11)N1S(c(cc1)ccc1F)(=O)=O)O HBNJOSMGIAZNMX-XJDOXCRVSA-N 0.000 description 1
- YYGNTJLVXLCHGQ-BHWOMJMDSA-N OCC(Cc1nnc(C[C@H](CCc2cc(C(C(F)(F)F)(C(F)(F)F)O)ccc22)N2S(c(cc2)ccc2F)(=O)=O)[o]1)O Chemical compound OCC(Cc1nnc(C[C@H](CCc2cc(C(C(F)(F)F)(C(F)(F)F)O)ccc22)N2S(c(cc2)ccc2F)(=O)=O)[o]1)O YYGNTJLVXLCHGQ-BHWOMJMDSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361880391P | 2013-09-20 | 2013-09-20 | |
| US61/880,391 | 2013-09-20 | ||
| PCT/US2014/056197 WO2015042212A1 (en) | 2013-09-20 | 2014-09-18 | RORγ MODULATORS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016530213A JP2016530213A (ja) | 2016-09-29 |
| JP2016530213A5 JP2016530213A5 (enExample) | 2017-10-26 |
| JP6397488B2 true JP6397488B2 (ja) | 2018-09-26 |
Family
ID=51726859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016515522A Expired - Fee Related JP6397488B2 (ja) | 2013-09-20 | 2014-09-18 | ＲＯＲγ調節因子 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9725443B2 (enExample) |
| EP (1) | EP3046906B1 (enExample) |
| JP (1) | JP6397488B2 (enExample) |
| CN (1) | CN105555768B (enExample) |
| WO (1) | WO2015042212A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015035278A1 (en) | 2013-09-09 | 2015-03-12 | Bristol-Myers Squibb Company | RORγ MODULATORS |
| WO2015042212A1 (en) | 2013-09-20 | 2015-03-26 | Bristol-Myers Squibb Company | RORγ MODULATORS |
| CN105829316B (zh) * | 2013-12-19 | 2019-01-08 | 默克专利股份公司 | 作为RORγ抑制剂的四氢-四唑并[1，5-a]吡嗪 |
| EP3092215B1 (en) | 2014-01-06 | 2018-10-17 | Bristol-Myers Squibb Company | Cyclohexyl sulfone ror gamma modulators |
| JP6476205B2 (ja) | 2014-01-06 | 2019-02-27 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ＲＯＲγ修飾因子としてのヘテロ環式スルホン |
| WO2015103508A1 (en) | 2014-01-06 | 2015-07-09 | Bristol-Myers Squibb Company | CARBOCYCLIC SULFONE RORγ MODULATORS |
| WO2016069978A1 (en) | 2014-10-30 | 2016-05-06 | Janssen Pharmaceutica Nv | AMIDE SUBSTITUTED THIAZOLES AS MODULATORS OF RORγT |
| US9861618B2 (en) | 2014-10-30 | 2018-01-09 | Janssen Pharmaceutica Nv | Thiazoles as modulators of RORγt |
| TWI705057B (zh) | 2014-10-30 | 2020-09-21 | 比利時商健生藥品公司 | 用作ＲＯＲγｔ調節劑之三氟甲基醇 |
| CN107709295B (zh) * | 2015-05-07 | 2021-05-04 | 百时美施贵宝公司 | 作为RORγ调节剂的三环砜类 |
| TW201803869A (zh) | 2016-04-27 | 2018-02-01 | 健生藥品公司 | 作為ＲＯＲγＴ調節劑之６－胺基吡啶－３－基噻唑 |
| WO2017213210A1 (ja) * | 2016-06-10 | 2017-12-14 | 武田薬品工業株式会社 | 複素環化合物 |
| WO2018071620A1 (en) * | 2016-10-13 | 2018-04-19 | Bristol-Myers Squibb Company | Heterocyclic sulfones as ror gamma modulators |
| CN112566901A (zh) | 2018-06-18 | 2021-03-26 | 詹森药业有限公司 | 作为RORγt的调节剂的苯基取代的吡唑类 |
| US10975057B2 (en) | 2018-06-18 | 2021-04-13 | Janssen Pharmaceutica Nv | 6-aminopyridin-3-yl pyrazoles as modulators of RORgT |
| US11034658B2 (en) | 2018-06-18 | 2021-06-15 | Janssen Pharmaceutica Nv | Pyridinyl pyrazoles as modulators of RORγT |
| CN112334450A (zh) | 2018-06-18 | 2021-02-05 | 詹森药业有限公司 | 作为RORγt的调节剂的苯基和吡啶基取代的咪唑 |
| CN111635373B (zh) * | 2019-03-01 | 2022-07-12 | 山东轩竹医药科技有限公司 | 多环磺酰胺类RORγ调节剂 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20012060A1 (it) | 2001-10-05 | 2003-04-05 | Recordati Chem Pharm | Nuovi eterocilcli n-acilati |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| EP2368886A1 (en) * | 2010-03-01 | 2011-09-28 | Phenex Pharmaceuticals AG | Novel compounds for modulation of orphan nuclear receptor RAR-related orphan receptor-gamma (ROR gamma, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune desease |
| JP6063870B2 (ja) * | 2010-11-08 | 2017-01-18 | ライセラ・コーポレイション | ＲＯＲγ活性の阻害用のＮ−スルホニル化テトラヒドロキノリンおよび関連二環化合物および病気の治療 |
| WO2013064231A1 (en) * | 2011-10-31 | 2013-05-10 | Phenex Pharmaceuticals Ag | SEVEN-MEMBERED SULFONAMIDES AS MODULATORS OF RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORγ, NR1F3) |
| WO2014062938A1 (en) | 2012-10-19 | 2014-04-24 | Bristol-Myers Squibb Company | Rory modulators |
| WO2015035278A1 (en) | 2013-09-09 | 2015-03-12 | Bristol-Myers Squibb Company | RORγ MODULATORS |
| WO2015042212A1 (en) | 2013-09-20 | 2015-03-26 | Bristol-Myers Squibb Company | RORγ MODULATORS |
| KR101544975B1 (ko) * | 2013-09-30 | 2015-08-18 | 주식회사 플라즈마트 | 임피던스 매칭 방법 및 임피던스 매칭 시스템 |
| ES2669208T3 (es) | 2014-01-06 | 2018-05-24 | Bristol-Myers Squibb Company | Derivados de pirrolidinilsulfona y su uso como moduladores de ROR gamma |
| JP6476205B2 (ja) | 2014-01-06 | 2019-02-27 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ＲＯＲγ修飾因子としてのヘテロ環式スルホン |
| WO2015103508A1 (en) | 2014-01-06 | 2015-07-09 | Bristol-Myers Squibb Company | CARBOCYCLIC SULFONE RORγ MODULATORS |
| EP3092215B1 (en) | 2014-01-06 | 2018-10-17 | Bristol-Myers Squibb Company | Cyclohexyl sulfone ror gamma modulators |
-
2014
- 2014-09-18 WO PCT/US2014/056197 patent/WO2015042212A1/en not_active Ceased
- 2014-09-18 JP JP2016515522A patent/JP6397488B2/ja not_active Expired - Fee Related
- 2014-09-18 CN CN201480051836.2A patent/CN105555768B/zh not_active Expired - Fee Related
- 2014-09-18 US US15/022,673 patent/US9725443B2/en active Active
- 2014-09-18 EP EP14784387.4A patent/EP3046906B1/en not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| CN105555768A (zh) | 2016-05-04 |
| US20160229844A1 (en) | 2016-08-11 |
| EP3046906B1 (en) | 2017-08-16 |
| US9725443B2 (en) | 2017-08-08 |
| JP2016530213A (ja) | 2016-09-29 |
| WO2015042212A1 (en) | 2015-03-26 |
| CN105555768B (zh) | 2018-10-16 |
| EP3046906A1 (en) | 2016-07-27 |
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