JP6392202B2 - 脳損傷または神経変性のバイオマーカーとしてのシトルリン化脳および神経タンパク質 - Google Patents

脳損傷または神経変性のバイオマーカーとしてのシトルリン化脳および神経タンパク質 Download PDF

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JP6392202B2
JP6392202B2 JP2015500570A JP2015500570A JP6392202B2 JP 6392202 B2 JP6392202 B2 JP 6392202B2 JP 2015500570 A JP2015500570 A JP 2015500570A JP 2015500570 A JP2015500570 A JP 2015500570A JP 6392202 B2 JP6392202 B2 JP 6392202B2
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citrullinated
protein
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brain injury
amino acid
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JP2015513370A (ja
JP2015513370A5 (enExample
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エイク ジェニファー イー ヴァン
エイク ジェニファー イー ヴァン
アレン デイル エヴェレット
アレン デイル エヴェレット
ツァイチェン ジン
ツァイチェン ジン
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Johns Hopkins University
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/0077—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction specific reactions other than fragmentation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/18—Post-translational modifications [PTMs] in chemical analysis of biological material citrullination
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Urology & Nephrology (AREA)
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  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
JP2015500570A 2012-03-13 2013-03-13 脳損傷または神経変性のバイオマーカーとしてのシトルリン化脳および神経タンパク質 Active JP6392202B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261610034P 2012-03-13 2012-03-13
US61/610,034 2012-03-13
PCT/US2013/031012 WO2013138509A1 (en) 2012-03-13 2013-03-13 Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration

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JP2015513370A JP2015513370A (ja) 2015-05-11
JP2015513370A5 JP2015513370A5 (enExample) 2016-05-12
JP6392202B2 true JP6392202B2 (ja) 2018-09-19

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US (4) US9709573B2 (enExample)
EP (1) EP2825893A4 (enExample)
JP (1) JP6392202B2 (enExample)
HK (1) HK1206425A1 (enExample)
WO (1) WO2013138509A1 (enExample)

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US20190310265A1 (en) 2019-10-10
EP2825893A4 (en) 2016-03-16
US12007395B2 (en) 2024-06-11
JP2015513370A (ja) 2015-05-11
US9709573B2 (en) 2017-07-18
EP2825893A1 (en) 2015-01-21
US10365288B2 (en) 2019-07-30
HK1206425A1 (en) 2016-01-08
WO2013138509A1 (en) 2013-09-19
US20150031048A1 (en) 2015-01-29
US20250085292A1 (en) 2025-03-13
US20170370943A1 (en) 2017-12-28

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