JP6389270B2 - 凝縮した霜から発生させた氷晶の、圧力差による分布を用いた凍結乾燥サイクルの凍結ステップにおける制御された核形成 - Google Patents
凝縮した霜から発生させた氷晶の、圧力差による分布を用いた凍結乾燥サイクルの凍結ステップにおける制御された核形成 Download PDFInfo
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- JP6389270B2 JP6389270B2 JP2016557074A JP2016557074A JP6389270B2 JP 6389270 B2 JP6389270 B2 JP 6389270B2 JP 2016557074 A JP2016557074 A JP 2016557074A JP 2016557074 A JP2016557074 A JP 2016557074A JP 6389270 B2 JP6389270 B2 JP 6389270B2
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- 238000010899 nucleation Methods 0.000 title claims description 54
- 230000006911 nucleation Effects 0.000 title claims description 47
- 239000013078 crystal Substances 0.000 title claims description 36
- 238000007710 freezing Methods 0.000 title description 10
- 230000008014 freezing Effects 0.000 title description 10
- 238000004108 freeze drying Methods 0.000 title description 7
- 238000009826 distribution Methods 0.000 title description 3
- 238000009833 condensation Methods 0.000 claims description 56
- 230000005494 condensation Effects 0.000 claims description 56
- 238000000034 method Methods 0.000 claims description 50
- 238000004519 manufacturing process Methods 0.000 claims description 32
- 239000007789 gas Substances 0.000 claims description 28
- 238000009423 ventilation Methods 0.000 claims description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 7
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- 238000009827 uniform distribution Methods 0.000 claims description 3
- 229910052786 argon Inorganic materials 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims 2
- 239000000047 product Substances 0.000 description 11
- 230000008569 process Effects 0.000 description 10
- 239000003595 mist Substances 0.000 description 9
- 230000015572 biosynthetic process Effects 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 230000006910 ice nucleation Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000012792 lyophilization process Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002667 nucleating agent Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000009777 vacuum freeze-drying Methods 0.000 description 1
Images
Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
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- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Drying Of Solid Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/205,802 | 2014-03-12 | ||
| US14/205,802 US9435586B2 (en) | 2012-08-13 | 2014-03-12 | Controlled nucleation during freezing step of freeze drying cycle using pressure differential ice crystals distribution from condensed frost |
| PCT/US2014/056192 WO2015138005A1 (en) | 2014-03-12 | 2014-09-18 | Controlled nucleation during freezing step of freeze drying cycle using pressure differential ice crystals distribution from condensed frost |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017508126A JP2017508126A (ja) | 2017-03-23 |
| JP6389270B2 true JP6389270B2 (ja) | 2018-09-12 |
Family
ID=54072247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016557074A Active JP6389270B2 (ja) | 2014-03-12 | 2014-09-18 | 凝縮した霜から発生させた氷晶の、圧力差による分布を用いた凍結乾燥サイクルの凍結ステップにおける制御された核形成 |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP3640573B1 (zh) |
| JP (1) | JP6389270B2 (zh) |
| CN (2) | CN110108097A (zh) |
| ES (1) | ES2799600T3 (zh) |
| WO (1) | WO2015138005A1 (zh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110108097A (zh) * | 2014-03-12 | 2019-08-09 | 米尔洛克科技公司 | 在冻干循环的冷冻过程中利用来自冷凝霜的压差冰晶分布的受控成核 |
| ES2774058T3 (es) | 2017-04-21 | 2020-07-16 | Gea Lyophil Gmbh | Un liofilizador y un método para inducir la nucleación en los productos |
| WO2022175999A1 (ja) * | 2021-02-16 | 2022-08-25 | 株式会社アルバック | 凍結乾燥装置、および凍結乾燥方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4350568A (en) * | 1981-04-15 | 1982-09-21 | Dalupan Romulo V | High efficiency water distillation apparatus |
| EP1563237A2 (en) * | 2002-11-21 | 2005-08-17 | Transform Pharmaceuticals, Inc. | Freeze-drying microscope stage apparatus and process of using the same |
| CN101379356B (zh) * | 2006-02-10 | 2013-07-17 | 普莱克斯技术有限公司 | 诱导材料成核的方法 |
| US8240065B2 (en) * | 2007-02-05 | 2012-08-14 | Praxair Technology, Inc. | Freeze-dryer and method of controlling the same |
| US20110179667A1 (en) * | 2009-09-17 | 2011-07-28 | Lee Ron C | Freeze drying system |
| US8549768B2 (en) * | 2011-03-11 | 2013-10-08 | Linde Aktiengesellschaft | Methods for freeze drying |
| US8839528B2 (en) * | 2011-04-29 | 2014-09-23 | Millrock Technology, Inc. | Controlled nucleation during freezing step of freeze drying cycle using pressure differential ice fog distribution |
| US8875413B2 (en) * | 2012-08-13 | 2014-11-04 | Millrock Technology, Inc. | Controlled nucleation during freezing step of freeze drying cycle using pressure differential ice crystals distribution from condensed frost |
| CN110108097A (zh) * | 2014-03-12 | 2019-08-09 | 米尔洛克科技公司 | 在冻干循环的冷冻过程中利用来自冷凝霜的压差冰晶分布的受控成核 |
-
2014
- 2014-09-18 CN CN201910394343.3A patent/CN110108097A/zh active Pending
- 2014-09-18 EP EP19214972.2A patent/EP3640573B1/en active Active
- 2014-09-18 CN CN201480076298.2A patent/CN106255860B/zh active Active
- 2014-09-18 ES ES14885084T patent/ES2799600T3/es active Active
- 2014-09-18 EP EP14885084.5A patent/EP3117165B1/en active Active
- 2014-09-18 JP JP2016557074A patent/JP6389270B2/ja active Active
- 2014-09-18 WO PCT/US2014/056192 patent/WO2015138005A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| ES2799600T3 (es) | 2020-12-18 |
| EP3117165A4 (en) | 2017-11-22 |
| EP3640573A1 (en) | 2020-04-22 |
| EP3117165A1 (en) | 2017-01-18 |
| EP3117165B1 (en) | 2020-03-25 |
| EP3640573B1 (en) | 2024-05-22 |
| CN106255860A (zh) | 2016-12-21 |
| CN106255860B (zh) | 2019-06-18 |
| WO2015138005A1 (en) | 2015-09-17 |
| CN110108097A (zh) | 2019-08-09 |
| JP2017508126A (ja) | 2017-03-23 |
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