JP6381557B2 - 肺線維症、肝線維症、皮膚線維症、及び心線維症の治療のための置換芳香族化合物 - Google Patents

肺線維症、肝線維症、皮膚線維症、及び心線維症の治療のための置換芳香族化合物 Download PDF

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JP6381557B2
JP6381557B2 JP2015561850A JP2015561850A JP6381557B2 JP 6381557 B2 JP6381557 B2 JP 6381557B2 JP 2015561850 A JP2015561850 A JP 2015561850A JP 2015561850 A JP2015561850 A JP 2015561850A JP 6381557 B2 JP6381557 B2 JP 6381557B2
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compound
fibrosis
composition
pulmonary fibrosis
disease
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JP2016510769A (ja
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リヌ・ギャニオン
ピエール・ローラン
ブリジット・グルー
リリアンヌ・ゲールツ
フランソワ・サラ−ブルネ
マルタン・ルデュック
ショーン・アボット
ブーロ・ザシャリエ
ジャン−フランソワ・ビアンヴヌ
ヴァレリー・ペロン
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Liminal Biosciences Ltd
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Prometic Pharma SMT Ltd
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JP2015561850A 2013-03-15 2014-03-14 肺線維症、肝線維症、皮膚線維症、及び心線維症の治療のための置換芳香族化合物 Expired - Fee Related JP6381557B2 (ja)

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US201361798427P 2013-03-15 2013-03-15
US61/798,427 2013-03-15
PCT/CA2014/000237 WO2014138907A1 (en) 2013-03-15 2014-03-14 Substituted aromatic compounds for the treatment of pulmonary fibrosis, liver fibrosis, skin fibrosis and cardiac fibrosis

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JP2016510769A JP2016510769A (ja) 2016-04-11
JP2016510769A5 JP2016510769A5 (https=) 2017-04-13
JP6381557B2 true JP6381557B2 (ja) 2018-08-29

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KR (1) KR102303493B1 (https=)
CN (1) CN105143170B (https=)
AR (1) AR095427A1 (https=)
AU (1) AU2014231649C1 (https=)
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TW (2) TWI742541B (https=)
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Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2649156T3 (es) 2013-01-14 2018-01-10 Incyte Holdings Corporation Compuestos bicíclicos de carboxamida aromática útiles como inhibidores de quinasas Pim
PE20191245A1 (es) 2013-01-15 2019-09-18 Incyte Holdings Corp Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de quinasa pim
TWI742541B (zh) * 2013-03-15 2021-10-11 英商邊緣生物科技有限公司 用於治療肺纖維化、肝纖維化、皮膚纖維化及心臟纖維化之經取代之芳族化合物
EA201690458A1 (ru) 2013-08-23 2016-07-29 Инсайт Корпорейшн Фуро- и тиенопиридинкарбоксамиды, используемые в качестве ингибиторов pim-киназы
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
US9822124B2 (en) 2014-07-14 2017-11-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors
BR112017007426A2 (pt) * 2014-10-10 2018-01-16 Prometic Pharma Smt Limited compostos aromáticos substituídos e composições farmacêuticas para prevenir e tratar osteoporose
KR20170072352A (ko) * 2014-11-12 2017-06-26 프로메틱 파마 에스엠티 리미티드 조직 자가-회복 및 재생을 위한 치환된 방향족 화합물 및 약제학적 조성물
MA41120A (fr) * 2014-12-02 2017-10-10 Afimmune Ltd Compositions comprenant le 15-hepe et méthodes de traitement ou de prévention de la fibrose à l'aide de celles-ci
MA47141A (fr) 2015-05-13 2019-11-06 Ds Biopharma Ltd Compositions comprenant du15-oxo-epa ou du 15-oxo-dgla et leurs procédés de préparation et d'utilisation
WO2016196244A1 (en) 2015-05-29 2016-12-08 Incyte Corporation Pyridineamine compounds useful as pim kinase inhibitors
US10046007B2 (en) * 2015-06-24 2018-08-14 Prescient Pharma, Llc Compositions and methods for treatment of short telomere disorders
TWI734699B (zh) 2015-09-09 2021-08-01 美商英塞特公司 Pim激酶抑制劑之鹽
US9920032B2 (en) 2015-10-02 2018-03-20 Incyte Corporation Heterocyclic compounds useful as pim kinase inhibitors
IL243707A0 (en) 2016-01-20 2016-05-01 Galmed Res And Dev Ltd Treatment to regulate the microbiota in the intestine
US11197870B2 (en) 2016-11-10 2021-12-14 Galmed Research And Development Ltd Treatment for hepatic fibrosis
RU2020119415A (ru) * 2017-11-15 2021-12-16 Галапагос Нв Соединения и их фармацевтические композиции для применения при лечении фиброзных заболеваний
WO2019113487A1 (en) 2017-12-08 2019-06-13 Incyte Corporation Low dose combination therapy for treatment of myeloproliferative neoplasms
US20210205253A1 (en) * 2018-05-31 2021-07-08 The Asan Foundation Use Of Stearic Acid For Preventing Or Treating Pulmonary Fibrosis
US11820834B2 (en) 2018-07-10 2023-11-21 Novmetapharma Co., Ltd. Polymorphic forms of Cyclo (-His-Pro) and methods of use to treat kidney disease
SG11202103011YA (en) 2018-10-11 2021-04-29 Basf As Aromatic compounds and pharmaceutical uses thereof
EP3890717A4 (en) * 2018-12-05 2022-08-24 Liminal Biosciences Limited USE OF SODIUM 2-(3-PENTYLPHENYL)ACETATE IN THE TREATMENT OF ALSTRÖM SYNDROME
EP3908668A4 (en) 2019-01-11 2022-11-09 University of Virginia Patent Foundation COMPOSITIONS AND METHODS FOR PREDICTING THE DECREASE IN LUNG FUNCTION IN IDIOPATHIC LUNG FIBROSIS
WO2020181163A1 (en) * 2019-03-06 2020-09-10 Tobira Therapeutics, Inc. Lipid-based formulation of cenicriviroc
KR102133151B1 (ko) 2019-03-28 2020-07-13 주식회사 노브메타파마 Chp(사이클로-히스프로)를 포함하는 복막 섬유증의 예방, 개선 또는 치료용 조성물
WO2021015218A1 (ja) * 2019-07-24 2021-01-28 国立大学法人九州大学 転写関連因子を標的とする線維化疾患の予防または治療
CN112441916A (zh) * 2019-08-29 2021-03-05 广东药科大学 新型苯乙酸衍生物、其制备方法及其作为药物的用途
US20240043372A1 (en) * 2020-10-06 2024-02-08 Pharmaceutique Ingenew Inc. Substituted aromatic compounds and pharmaceutical compositions thereof
US12053467B2 (en) * 2020-12-18 2024-08-06 NovMeta Pharma Co., Ltd. Method of treating fibrosis

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20012434A1 (it) 2001-11-20 2003-05-20 Dompe Spa Acidi 2-aril-propionici e composizioni farmaceutiche che li contengono
CA2761061A1 (en) * 2009-05-04 2010-11-11 Prometic Biosciences Inc. Salts of 3-pentylphenylacetic acid and pharmaceutical uses thereof
EA022445B1 (ru) * 2009-05-04 2016-01-29 Прометик Байосайенсиз Инк. Замещенные ароматические соединения, композиции на их основе и их фармацевтические применения
CN105997967B (zh) 2010-10-27 2019-08-23 普罗米蒂克医药Smt有限公司 用于治疗癌症的化合物和组合物
CN102070433B (zh) * 2010-12-27 2013-03-27 桂林师范高等专科学校 芳香基乙酸类衍生物的制备方法
TWI742541B (zh) * 2013-03-15 2021-10-11 英商邊緣生物科技有限公司 用於治療肺纖維化、肝纖維化、皮膚纖維化及心臟纖維化之經取代之芳族化合物
TWI689490B (zh) * 2013-03-15 2020-04-01 英商邊緣生物科技有限公司 用於治療纖維化之經取代之芳族化合物及相關方法
KR20170072352A (ko) * 2014-11-12 2017-06-26 프로메틱 파마 에스엠티 리미티드 조직 자가-회복 및 재생을 위한 치환된 방향족 화합물 및 약제학적 조성물

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US10450258B2 (en) 2019-10-22
BR112015023129A2 (pt) 2017-07-18
EP2970088B1 (en) 2020-01-01
IL241164B (en) 2020-11-30
EA031511B1 (ru) 2019-01-31
CN105143170A (zh) 2015-12-09
PL2970088T3 (pl) 2020-11-02
AU2014231649B2 (en) 2018-01-04
SG11201507274PA (en) 2015-10-29
CA2905633C (en) 2021-12-28
US9884802B2 (en) 2018-02-06
CN105143170B (zh) 2019-11-08
AU2014231649A1 (en) 2015-10-22
US20180134649A1 (en) 2018-05-17
AU2014231649C1 (en) 2018-08-23
DK2970088T3 (da) 2020-03-30
US20160023983A1 (en) 2016-01-28
CA2905633A1 (en) 2014-09-18
NZ712745A (en) 2020-06-26
CL2015002725A1 (es) 2016-04-15
IL241164A0 (en) 2015-11-30
EA201591774A1 (ru) 2015-12-30
MX375261B (es) 2025-03-06
UY35401A (es) 2014-10-31
US20200017432A1 (en) 2020-01-16
AR095427A1 (es) 2015-10-14
ES2780825T3 (es) 2020-08-27
US11267779B2 (en) 2022-03-08
KR20160040452A (ko) 2016-04-14
MX2015012886A (es) 2016-04-04
PH12015502012A1 (en) 2016-01-11
WO2014138907A1 (en) 2014-09-18
MY194727A (en) 2022-12-15
KR102303493B1 (ko) 2021-09-16
TWI689489B (zh) 2020-04-01
TW201441185A (zh) 2014-11-01
PT2970088T (pt) 2020-03-27
TW202045469A (zh) 2020-12-16
EP2970088A1 (en) 2016-01-20
JP2016510769A (ja) 2016-04-11
TWI742541B (zh) 2021-10-11
EP2970088A4 (en) 2016-10-19
ZA201507062B (en) 2017-04-26

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