JP6373805B2 - Ophthalmic solution with contact lens - Google Patents

Description

  The present invention relates to a contact lens mounting liquid for improving fatigue eyes and / or blurring eyes. More specifically, the present invention relates to a contact lens mounting liquid that is applied to a contact lens and improves fatigue and / or blurred eyes by wearing the lens. The present invention also relates to an ophthalmic solution with a contact lens for improving fatigue eyes and / or blurring eyes that can be used for both wearing and eye drops.

In recent years, there are an increasing number of people complaining of eye strain as lifestyle changes, and there are a wide range of countermeasures such as eye drops and internal medicines, products that give warmth and coolness, and massage machines around the eyes. The product is being developed.
Causes of eye fatigue include eye overuse and mental tension such as reading, gazing work, and observation work. In recent years, VDT (Visual Display Terminal) has been increasing rapidly with the spread of personal computers. ) Eye fatigue due to work is very high. Patients who complain of eye fatigue generally have symptoms such as pain in the back of the eye, blurred vision, dry eyes, stiff shoulders, head weight, etc. When eye fatigue is severe, nausea and nausea may occur. is there. It has been pointed out that these symptoms are caused by the ciliary muscles becoming excessively tensioned due to long-term gaze work and the like, and the function of eye regulation being lowered.

  In addition, wearing contact lenses often promotes and worsens eye fatigue, and eye fatigue is listed as the main complaint of contact lens wearers. Of these, many complain of eye fatigue due to VDT work while wearing contact lenses.

Conventional ophthalmic solutions for improving eye fatigue mainly contain neostigmine methylsulfate, vitamin B ₂ , vitamin B ₆ , and panthenol. Has been. Furthermore, eye drops for improving eye strain (Patent Document 1) containing taurine and menthol, eye drops for improving eye strain (Patent Document 2) consisting of taurine, menthol, neostigmine methyl sulfate, vitamin E acetate, and caffeine. Eye drops for eye strain formulated as an active ingredient (Patent Document 3) and the like are disclosed.
However, the above-mentioned components may be adsorbed to the contact lens depending on the type of the component, and may affect the specifications and shape of the contact lens size, base curve, etc., so it is not always safe for contact lens wearers. In addition, there were problems such as an insufficient effect of improving fatigue eyes.

  In addition, with regard to blurred vision, many people complain of symptoms related to aging, conjunctivitis, contact lens wearing, eyes, etc. in addition to eye fatigue. Conventionally, for example, ingestion of foods such as blueberries, surgical operations, eye drops, and the like have been used for such complaints. In addition, as an ophthalmic composition for improving blurred vision, for example, use of an eye mask or an ointment containing proanthocyanidins (Patent Document 4) is known.

  However, especially if the patient who complains of blurred vision is a contact lens wearer, using eye drops or the above-mentioned ointments while wearing the contact lens may adsorb to the contact lens or contact lens standards depending on the type of component. There is a problem that it is not always safe and the effect of improving the blurred eye is not sufficient.

  On the other hand, the contact lens mounting liquid has been used for the purpose of reducing the feeling of foreign matter and making the contact lens easier to wear (easy to wear) when wearing the contact lens when getting up. It has not been used in applications for improving and / or improving blurred vision.

Japanese Patent Laid-Open No. 9-40549 Japanese Patent Laid-Open No. 9-143064 Japanese Unexamined Patent Publication No. 2000-247885 JP 2004-277350 A

  An object of the present invention is to provide an ophthalmic composition that can be safely used by a contact lens wearer and that has an excellent fatigue eye improvement effect and / or blurred eye improvement effect.

The present inventors have conducted research to develop a composition for improving fatigue eyes and / or blurring eyes that can be used safely by contact lens wearers and has an excellent effect. It has been found that when the composition contained is in the form of a contact lens mounting solution, it is surprisingly possible to effectively improve fatigue and / or blurred vision. As described above, conventionally, wearing of a contact lens is usually supposed to promote or worsen fatigued eyes and / or blurred eyes. Therefore, wearing of contact lenses can improve fatigued eyes and / or blurred eyes. The above finding that it is possible is totally unexpected.
Specifically, the present inventors provide (A) a contact lens mounting liquid containing, as an essential component, one or more selected from the group consisting of a cellulose-based polymer compound, a vinyl-based polymer compound, and dextran. The present invention was completed by finding that the above problems were solved and an excellent fatigue eye improvement effect and / or haze improvement effect was exhibited.

That is, this invention is the invention hung up below.
(1) (A) A contact lens mounting liquid for improving fatigue eyes and / or blurring eyes, comprising at least one selected from the group consisting of a cellulose polymer compound, a vinyl polymer compound, and dextran.
(2) The contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to (1), wherein the component (A) is contained in a ratio of 0.0001 to 25 (w / v)%.
(3) The contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to (1) or (2), further comprising (B) amino acids.
(4) The component (B) is at least one selected from the group consisting of chondroitin sulfate, hyaluronic acid, aspartic acid, aminoethylsulfonic acid, epsilon aminocaproic acid, and salts thereof, according to (3) Contact lens mounting liquid for improving fatigue eyes and / or blurring eyes.
(5) Contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to (3) or (4), wherein component (B) is contained at a ratio of 0.0001 to 10 (w / v)%. .
(6) The contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to any one of (1) to (5), further comprising (C) a terpenoid.
(7) The contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to (6), wherein the terpenoid is menthol.
(8) The contact lens for improving fatigue eyes and / or blurring eyes according to (6) or (7), wherein the component (C) is contained at a ratio of 0.0001 to 0.1 (w / v)%. Wearing fluid.
(9) The contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to any one of (1) to (8), which further contains a nonionic surfactant as component (D).
(10) The component (D) is at least one selected from the group consisting of polyoxyethylene sorbitan fatty acid esters, polyoxyethylene hydrogenated castor oils, and polyoxyethylene polyoxypropylene copolymers, (9) The contact lens mounting liquid for improving fatigue eyes and / or improving blurred vision described in 1.
(11) The contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to (9) or (10), wherein the component (D) is polysorbate 80.
(12) The contact for improving fatigue eyes and / or the blurring eye improvement according to any one of (9) to (11), wherein the component (D) is contained at a ratio of 0.001 to 5 (w / v)%. Lens mounting fluid.
(13) The contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to any one of (1) to (12), wherein the contact lenses are soft contact lenses.
(14) The contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to (13), wherein the soft contact lenses are in principle soft contact lenses of soft contact lens classification group IV.
(15) The contact lens mounting solution for improving fatigue eyes and / or blurring eyes according to (13), wherein the soft contact lens is a soft contact lens made of a silicone hydrogel material.
(16) (A) A contact lens wearing ophthalmic solution for improving fatigue eyes and / or blurring eyes comprising at least one selected from the group consisting of a cellulose polymer compound, a vinyl polymer compound and dextran.
(17) The contact lens wearing ophthalmic solution for improving fatigue eyes and / or blurring eyes according to (16), wherein the component (A) is contained in a ratio of 0.0001 to 25 (w / v)%.
(18) The contact lens wearing ophthalmic solution for improving fatigue eyes and / or blurring eyes according to (16) or (17), further comprising (B) an amino acid.
(19) The component (B) is at least one selected from the group consisting of chondroitin sulfate, hyaluronic acid, aspartic acid, aminoethylsulfonic acid, epsilon aminocaproic acid, and salts thereof. Eye drops with contact lenses for improving fatigue and / or blurring eyes.
(20) Contact lens wearing eye drop for improving fatigue eye and / or blur eye improvement according to (18) or (19), containing component (B) at a ratio of 0.0001 to 10 (w / v)% liquid.
(21) The ophthalmic solution with a contact lens for improving fatigue eyes and / or blurring eyes according to any one of (16) to (20), further comprising (C) a terpenoid.
(22) The contact lens wearing ophthalmic solution for improving fatigue eyes and / or blurring eyes according to (21), wherein the terpenoid is menthol.
(23) The contact lens for improving fatigue eyes and / or blurring eyes according to (21) or (22), wherein the component (C) is contained in a ratio of 0.0001 to 0.1 (w / v)%. Wearing eye drops.
(24) The contact lens wearing ophthalmic solution for improving fatigue eyes and / or blurring eyes according to any one of (16) to (23), further comprising a nonionic surfactant as component (D).
(25) The component (D) is at least one selected from the group consisting of polyoxyethylene sorbitan fatty acid esters, polyoxyethylene hydrogenated castor oils, and polyoxyethylene polyoxypropylene copolymers, (24) An ophthalmic solution with a contact lens for improving fatigue eyes and / or blurring eyes described in 1.
(26) The contact lens wearing ophthalmic solution for improving fatigue eyes and / or blurring eyes according to (24) or (25), wherein the component (D) is polysorbate 80.
(27) The contact for improving fatigue eyes and / or the blurring eye improvement according to any one of (24) to (26), wherein the component (D) is contained at a ratio of 0.001 to 5 (w / v)%. Lens ophthalmic solution.
(28) The contact lens wearing ophthalmic solution for improving fatigue eyes and / or blurring eyes according to any one of (16) to (27), wherein the contact lens is a soft contact lens.
(29) The ophthalmic solution with a contact lens for improving fatigue eyes and / or blurring eyes according to (28), wherein the soft contact lenses are in principle soft contact lenses of soft contact lens classification group IV.
(30) The ophthalmic solution with a contact lens for improving fatigue eyes and / or blurring eyes according to (28), wherein the soft contact lenses are soft contact lenses made of a silicone hydrogel material.

  According to the contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to the present invention, the effect of fatigue eyes and / or blurring eyes can be obtained by directly dropping the product onto the contact lenses and mounting the contact lenses. Can be reduced / improved. Therefore, according to the contact lens mounting liquid of the present invention, it is possible to treat fatigue eye symptoms and / or blurred eye symptoms not only for users of contact lenses but also for non-users by using in combination with contact lenses. Is possible. In addition, the contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to the present invention may be used as a mounting ophthalmic solution for both wearing a contact lens and instilling while wearing a contact lens. A more excellent fatigue eye improvement effect and / or blurred eye improvement effect can be exhibited.

It is a figure which shows the flicker value improvement rate (average value) as described in Experimental example 1. FIG. It is a figure which shows the flicker value improvement rate (average value) as described in Experimental example 2. FIG. It is a figure which shows the fatigue-eye improvement index | exponent (total) as described in Experimental example 4. FIG. It is a figure which shows the blurring eye improvement index | exponent (total) as described in Experimental example 4. FIG.

Hereinafter, the present invention will be described in detail.
In this specification, the expression “wearing” represents an action (operation) of “contacting” a contact lens, and the expression “wearing” represents a state where the contact lens is “on the cornea”. A “contact lens wearer” represents a person who uses a contact lens on a daily basis or on an occasional basis (occasionally).
In the present specification, the notation “%” means w / v%, that is, the weight g of each component (solute) dissolved in 100 mL of a solution unless otherwise specified.

  Further, the term “contact lens” is used to include all types of contact lenses such as hard, oxygen-permeable hard, and soft unless otherwise specified.

  In addition, in this specification, “Soft contact lens classification” means “Pharmaceutical Examination No. 645 dated March 31, 1999, Ministry of Health, Labor and Welfare (Ministry of Health, Labor and Welfare)” This is a SCL classification based on “How to classify soft contact lenses” defined in “Handling of materials to be attached when applying for approval of manufacture (import) of disinfectant for medical use”. As a common property, the water content is 50% or more and the mole% of the monomer having an anion among the constituent monomers of the raw material polymer is 1% or more. This classification follows the classification method for soft contact lenses performed by the FDA (Food and Drug Administration). Further, "in principle" means that a soft contact lens that can be understood by those skilled in the art as being equivalent to those belonging to the classification in terms of materials, functions, and the like is included.

  A silicone hydrogel contact lens is a silicone-containing material (for example, TRIS or TRIS derivative that is a polymer of silicone and acrylate) and a hydrophilic monomer (for example, hydroxyethyl methacrylate, dimethylacrylamide, etc.). Contact lenses using a polymerized material, and names of materials based on USAN (United State Adopted Name) include, for example, Lotrafilcon A, Lotrafilcon B, Balafilcon A, Galifilcon A, and Senofilcon A.

  The contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to the present invention contains (A) one or more selected from the group consisting of a cellulose polymer compound, a vinyl polymer compound, and dextran. To improve fatigue and / or blurred vision. The fatigue eye improving effect and / or blurred eye improving effect of these components (A) is not known.

The contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to the present invention is one or more selected from the group consisting of cellulose polymer compounds, vinyl polymer compounds and dextran (hereinafter simply referred to as (A)). It may be described as an ingredient).
Cellulosic polymer compound is a cellulose polymer compound obtained by replacing the hydroxyl group of cellulose with other functional groups, which can impart viscosity to aqueous compositions and is applicable to contact lenses Possible compounds can be used. Examples of the functional group that substitutes the hydroxyl group of cellulose include a methoxy group, an ethoxy group, a hydroxymethoxy group, a hydroxyethoxy group, a hydroxypropoxy group, a carboxymethoxy group, and a carboxyethoxy group. Examples of the cellulose polymer compound include methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, and salts thereof. Here, the salt is preferably a pharmacologically acceptable salt, more preferably an alkali metal salt, and particularly preferably a sodium salt or a potassium salt. The cellulose polymer used in the present invention is not limited in the degree of substitution and the molecular weight of the substituent. For example, the weight average molecular weight is 50,000 to 1,000,000, preferably 10,000 to 500,000, and more preferably 10,000. About 100,000 can be used. Moreover, a commercially available thing can be used for these cellulose polymer compounds, and you may use it combining 1 type (s) or 2 or more types of these compounds. Among these, from the viewpoint of further enhancing the effects of the present invention, it is preferably at least one selected from the group consisting of methylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, and salts thereof. More preferred are hydroxypropyl methylcellulose, hydroxyethylcellulose, sodium carboxymethylcellulose, and particularly preferred are hydroxypropylmethylcellulose and hydroxyethylcellulose.

  The content of the cellulosic polymer compound in the contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to the present invention is not limited because it varies depending on the type and molecular weight of the compound, but improves fatigue eyes. These compounds are generally in a total amount of 0.0001 to 25%, preferably 0.001 to 10%, more preferably 0.001 to 7% based on the total amount of the contact lens mounting solution for use and / or blurring improvement. More preferably, it is 0.005 to 5%, particularly preferably 0.01 to 2%, and still more preferably 0.2 to 2%.

  As the vinyl polymer compound, a compound that can impart viscosity to the aqueous composition and can be applied to contact lenses can be used. Examples of the vinyl polymer compound include a vinyl alcohol polymer such as polyvinyl alcohol (completely or partially saponified product), a vinyl pyrrolidone polymer such as polyvinyl pyrrolidone, a carboxy vinyl polymer, and the like. The molecular weight of the vinyl polymer used in the present invention is not limited, but for example, a weight average molecular weight of 50,000 to 1,000,000, preferably 10,000 to 500,000, more preferably about 10,000 to 400,000 Can be used. These vinyl polymer compounds may be commercially available, or one or more of these compounds may be used in combination. Of these, polyvinyl pyrrolidone K25, polyvinyl pyrrolidone K30, polyvinyl pyrrolidone K90, polyvinyl alcohol (partially saponified product), and carboxyvinyl polymer are preferable from the viewpoint of further enhancing the effects of the present invention, and polyvinyl alcohol (partial) is more preferable. Saponified product) and carboxyvinyl polymer, particularly preferably polyvinyl alcohol (partially saponified product).

  The content of the vinyl polymer compound in the contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to the present invention is not limited because it varies depending on the type and molecular weight of the compound, but improves fatigue eyes. These compounds are generally in a total amount of 0.001 to 25%, preferably 0.001 to 10%, more preferably 0.005 to 5%, based on the total amount of the contact lens mounting liquid for use and / or blurring improvement. More preferably, it is 0.01 to 5%, and particularly preferably 0.1 to 3%.

  Dextran is a water-soluble polymer compound obtained by partially hydrolyzing a polysaccharide produced by certain lactic acid bacteria using sucrose as a raw material. Dextran having a weight average molecular weight of 50,000 to 1,000,000, preferably 10,000 to 500,000, more preferably about 10,000 to 100,000 can be used. Moreover, these dextrans can use a commercially available thing, and can be used 1 type or in combination of 2 or more types. Of these, dextran, dextran 70, dextran 40, and particularly preferably dextran 70 are preferred from the viewpoint of further enhancing the effects of the present invention.

  The content of dextran in the contact lens mounting liquid for improving fatigue eyes and / or blurring eyes in the present invention is the total amount of the contact lens mounting liquid for improving fatigue eyes and / or blurring eyes. Usually 0.001 to 25%, preferably 0.001 to 10%, more preferably 0.01 to 10%, still more preferably 0.01 to 5%, particularly preferably 0.01 to 1%, still more preferably. Is 0.01 to 0.1%.

(A) component in this invention can also be used 1 type or in combination of 2 or more types. From the viewpoint of further enhancing the effects of the present invention, the preferred component (A) is a cellulose-based polymer compound, among which hydroxypropylmethylcellulose and hydroxyethylcellulose are particularly preferable.
The content of the component (A) in the contact lens mounting liquid for improving fatigue eyes and / or blurring eyes in the present invention is generally 0.0001 to 25% of the total amount of the contact lens mounting liquid. The content is preferably 0.001 to 10%, more preferably 0.005 to 10%, still more preferably 0.01 to 7%, and particularly preferably 0.01 to 5%.

The contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to the present invention may further contain amino acids (hereinafter sometimes simply referred to as component (B)) as necessary.
The amino acid used in the present invention includes an amino acid or a salt thereof, and an amino acid analog, and means a compound having an amino group and a carboxyl group or a sulfone group in the molecule or a derivative thereof. Specific examples include amino acids or salts thereof, mucopolysaccharides or derivatives thereof, or salts thereof.

  For example, among amino acids, examples of amino acids or salts thereof include monoamino monocarboxylic acids such as glycine, alanine, aminobutyric acid, aminovaleric acid, and aminocaproic acid; monoaminodicarboxylic acids such as aspartic acid and glutamic acid; Diaminomonocarboxylic acids such as arginine and lysine or salts thereof; derivatives such as aminoethylsulfonic acid (taurine) or salts thereof; Among amino acids, mucopolysaccharide or a derivative thereof or a salt thereof is, for example, an acidic mucopolysaccharide, a derivative such as chondroitin sulfate or hyaluronic acid, or a salt thereof. Specific examples include glycine, alanine, γ-aminobutyric acid, γ-aminovaleric acid, epsilon aminocaproic acid, aspartic acid, glutamic acid, arginine, aminoethylsulfonic acid, chondroitin sulfate, hyaluronic acid, and salts thereof. Amino acid salts or mucopolysaccharide salts include pharmaceutically, pharmacologically or physiologically acceptable salts. Such salts include salts with organic acids [for example, monocarboxylates (acetate, trifluoroacetate, butyrate, palmitate, stearate, etc.), polyvalent carboxylate (fumarate , Maleate, etc.), oxycarboxylate (lactate, tartrate, citrate, succinate, malonate, etc.), organic sulfonate (methanesulfonate, toluenesulfonate, tosylate) Etc.], salts with inorganic acids (eg, hydrochloride, sulfate, nitrate, hydrobromide, phosphate, etc.), salts with organic bases (eg, methylamine, triethylamine, triethanolamine, Salts with organic amines such as morpholine, piperazine, pyrrolidine, tripyridine, picoline, etc.), salts with inorganic bases [eg ammonium salts; alkali metals (sodium, potassium) Etc.), alkaline earth metal (calcium, magnesium etc.), etc. and salts with metals such as aluminum] can be exemplified, it is appropriately selected depending on the compound. For example, in the case of monoaminodicarboxylic acid, a salt with an inorganic base is preferable, and an alkali metal salt or an alkaline earth metal salt is particularly preferable.

  Preferred amino acids are glycine, alanine, γ-aminobutyric acid, γ-aminovaleric acid, epsilon aminocaproic acid, sodium aspartate, potassium aspartate, magnesium aspartate, calcium aspartate, magnesium L-aspartate (equivalent) Mixture), glutamic acid, glutamic acid hydrochloride, magnesium glutamate, aminoethylsulfonic acid, sodium chondroitin sulfate, sodium hyaluronate and the like. More preferred are epsilon aminocaproic acid, potassium aspartate, magnesium aspartate, magnesium / potassium L-aspartate (a mixture of equal amounts), aminoethylsulfonic acid, sodium chondroitin sulfate, and sodium hyaluronate. The amino acids of the present invention may be any of D form, L form, and DL form. The amino acids of the present invention can be used alone or in combination of two or more.

  The content of amino acids in the contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to the present invention is not limited because it varies depending on the type and molecular weight of the compound. Or the total amount of these compounds is usually 0.0001 to 10%, preferably 0.001 to 10%, more preferably 0.005 to 8%, and still more preferably based on the total amount of the contact lens mounting solution for improving blurred vision. Is 0.02 to 5% by weight, particularly preferably 0.05 to 2%, and still more preferably 0.2 to 2%.

The contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to the present invention may further contain a terpenoid (hereinafter sometimes simply referred to as component (C)) as necessary.
Examples of terpenoids used in the contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to the present invention include menthol (l-menthol, dl-menthol, etc.), menthone, camphor (d-camphor, dl-camphor, etc.). , Borneol (d-borneol, dl-borneol, etc.), geraniol, cineol, citral, linalool, anethole, limonene, eugenol and the like. These may be d-form, l-form or dl-form, but from the viewpoint of further enhancing the effects of the present invention, l-menthol, d-camphor, dl-camphor, d-borneol, dl-borneol, geraniol are used. It is preferable. Of these, l-menthol, d-camphor, dl-camphor and geraniol are preferable, and l-menthol is more preferable. The terpenoid can also be used in the state of being contained in essential oil, and preferred essential oils are mint oil, peppermint oil, eucalyptus oil, bergamot oil, fennel oil, cinnamon oil, rose oil and the like. These terpenoids can be used alone or in combination of two or more.

From the viewpoint of further enhancing the effects of the present invention, the terpenoid content in the contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to the present invention is a contact lens for improving fatigue eyes and / or blurring eyes. These are generally preferably 0.0001 to 0.1% of the total amount of the mounting liquid. More preferably, it is 0.0001-0.07%, More preferably, it is 0.0005-0.05%, Especially preferably, it is 0.0005-0.02%, More preferably, it is 0.002- 0.01%.
In addition, when using the essential oil containing a terpenoid as (C) component, the mixture ratio of the said essential oil is set so that the terpenoid content in the essential oil mix | blended may satisfy | fill the said ratio.

The contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to the present invention contains an appropriate nonionic surfactant (hereinafter sometimes simply referred to as component (D)) as necessary. be able to.
As the nonionic surfactant used in the present invention, those that can be used by those skilled in the art for ophthalmic compositions for contact lenses can be used. For example, polyoxyethylene-poly (polyoxamer 407, poloxamer 235, poloxamer 188) can be used. Oxypropylene block copolymer (hereinafter also referred to as polyoxyethylene polyoxypropylene copolymer); POE-POP block copolymer adduct of ethylenediamine such as poloxamine; monolauric acid POE (20) sorbitan (polysorbate 20), monooleic acid POE sorbitan fatty acid esters such as POE (20) sorbitan (polysorbate 80), POE sorbitan monostearate (polysorbate 60), POE sorbitan tristearate (polysorbate 65); POE cured castor oils such as OE cured castor oil 5, POE cured castor oil 10, POE cured castor oil 20, POE cured castor oil 40, POE cured castor oil 50, POE cured castor oil 60, POE cured castor oil 100; (9) POE alkyl ethers such as lauryl ether; POE (20) POP (4) POE / POP alkyl ethers such as cetyl ether; POE (10) POE alkyl phenyl ethers such as nonyl phenyl ether. POE represents polyoxyethylene, POP represents polyoxypropylene, and the numbers in parentheses indicate the number of moles added.
Among these, polyoxyethylene-polyoxypropylene block copolymers, POE sorbitan fatty acid esters or POE hydrogenated castor oil are preferable, and poloxamer 407, polysorbate 80, and POE hydrogenated castor oil 60 are particularly preferable.

  The content of the nonionic surfactant in the contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to the present invention varies depending on the type of the surfactant, etc., and thus cannot be generally specified. And / or the total amount of the contact lens mounting liquid for improving blurred vision, these are the total amount, usually 0.001 to 5%, preferably 0.001 to 1.5%, more preferably 0.001 to 1%, More preferably, it is 0.005 to 0.5%, and particularly preferably 0.05 to 0.3%.

  It is preferable that a suitable buffering agent is blended in the contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to the present invention. Examples of the buffer used in the present invention include borate buffer, phosphate buffer, carbonate buffer, citrate buffer, acetate buffer, HEPES buffer, and MOPS buffer. More specifically, boric acid, sodium borate, potassium tetraborate, borax, potassium metaborate, phosphoric acid, sodium hydrogen phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, carbonic acid, sodium hydrogen carbonate, Examples thereof include compounds such as sodium carbonate, citric acid, sodium citrate, potassium citrate, acetic acid, sodium acetate, HEPES, and MOPS, hydrates thereof, and combinations of two or more compounds selected from these groups.

  Preferred buffering agents are borate buffer, phosphate buffer, carbonate buffer and citrate buffer. Particularly preferred buffering agents are borate buffers or phosphate buffers. Particularly preferred buffering agents include, more specifically, boric acid buffers such as boric acid, borate salts such as alkali metal borate salts and alkaline earth metal borate salts, and combinations of boric acid and borate salts. In particular, boric acid and borax are preferable, and phosphate buffering agents include phosphoric acid, phosphates such as alkali metal phosphates and alkaline earth metal phosphates, hydrates thereof, phosphoric acid and The combination with a phosphate is mentioned, Especially sodium hydrogenphosphate, sodium dihydrogenphosphate, and those hydrates are preferable.

  In the present invention, the content of the buffering agent in the contact lens mounting liquid for improving fatigue eyes and / or blurring eyes varies depending on the type of the buffering agent and the like, and thus cannot be specified unconditionally, but for improving fatigue eyes and / or blurring eyes. These are total amounts with respect to the total amount of the contact lens mounting solution for improvement, and are usually 0.001 to 5%, preferably 0.001 to 3%, more preferably 0.005 to 2%, and still more preferably 0.005. 1.5%.

In the contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to the present invention, it is preferable to add an appropriate inorganic salt as required. Examples of inorganic salts include potassium chloride, sodium chloride, sodium hydrogen carbonate, and sodium carbonate, and these may be used alone or in combination.
The content of inorganic salts in the contact lens mounting liquid for improving fatigue eyes and / or blurring eyes in the present invention varies depending on the types of inorganic salts and the like, and thus cannot be specified unconditionally, but for improving fatigue eyes and / or blurring eyes. These are generally used in an amount of 0.001 to 5%, preferably 0.01 to 1.5%, more preferably 0.1 to 0.7% of the total amount of the contact lens mounting solution for improvement.

  The contact lens mounting liquid for improving fatigue eyes and / or blurring eyes of the present invention preferably contains an appropriate ethylenediamineacetic acid derivative or a salt thereof as necessary. Examples of such ethylenediamineacetic acid derivatives or salts thereof include edetic acid (ethylenediaminetetraacetic acid, EDTA), ethylenediaminediacetic acid (EDDA), diethylenetriaminepentaacetic acid (DTPA), and N- (2-hydroxyethyl) ethylenediaminetriacetic acid (HEDTA). Or the salt etc. can illustrate. Salts of ethylenediamineacetic acid derivatives include pharmacologically or physiologically acceptable salts such as salts with alkali metals (sodium, potassium, etc.) and salts with alkaline earth metals (calcium, etc.). . Among these, ethylenediaminetetraacetic acid or a salt thereof is preferable, such as ethylenediaminetetraacetic acid calcium disodium, ethylenediaminetetraacetic acid disodium, ethylenediaminetetraacetic acid disodium dihydrate (hereinafter also referred to as sodium edetate). Particularly preferred is disodium ethylenediaminetetraacetate dihydrate. These can be used alone or in combination of two or more.

  The content of the ethylenediamineacetic acid derivative or its salt in the contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to the present invention varies depending on the molecular weight or the type and cannot be generally specified. These are the total amount, preferably 0.0001 to 1%, more preferably 0.0005 to 0.5%, and still more preferably 0.001 to 0.3%, with respect to the total amount of the contact lens mounting solution for improving blurred vision. Especially preferably, it is 0.001 to 0.05%.

Further, in order to further exert the effect of the present invention, it is more preferable to blend an ethylenediamineacetic acid derivative or a salt thereof, a nonionic surfactant, an inorganic salt, and a buffering agent in combination.
The content of the ethylenediamineacetic acid derivative or a salt thereof, a nonionic surfactant, an inorganic salt, and a buffering agent in the contact lens mounting liquid for improving fatigue eyes and / or blurring in the present invention is determined by the amount of the contact lens mounting liquid. These are the total amount with respect to the total amount, preferably 0.01 to 5%, particularly preferably 0.05 to 3%.

  The contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to the present invention is particularly suitable for use in soft contact lenses among contact lenses. Since the soft contact lens has a large area and covers the surface of the cornea more widely, the effect of the contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to the present invention can be exhibited more effectively. it can. Among them, the soft contact lens of the soft contact lens classification group IV and the soft contact lens made of a silicone hydrogel material exhibit more remarkable effects, and can be used more suitably for these contact lenses.

  In addition, the contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to the present invention contains various components and additives according to conventional methods in accordance with the usage and form within a range not impairing the effects of the invention. You may select suitably and may contain 1 type or more. As those components or additives, for example, carriers (water, aqueous solvents, aqueous or oily bases, etc.) commonly used in the preparation of semi-solids and liquids, sugars, sugar alcohols, surfactants, Various additives such as preservatives, bactericides or antibacterial agents, pH adjusters, isotonic agents, stabilizers and the like can be mentioned.

Although the typical component used for the contact lens mounting liquid for a fatigue eye improvement and / or a blurry eye improvement of this invention is illustrated below, it is not limited to these.
Sugars: for example, glucose, cyclodextrin and the like.
Sugar alcohols: For example, xylitol, sorbitol, mannitol and the like.
Surfactant: For example, in addition to the above-mentioned nonionic surfactants, glycine type amphoteric surfactants such as alkyldiaminoethylglycine; alkyl quaternary ammonium salts (specifically, benzalkonium chloride, benzethonium chloride, etc.) Cationic surfactant etc.) etc.

  Preservatives, bactericides or antibacterial agents: for example, alkyldiaminoethylglycine hydrochloride, sodium benzoate, ethanol, benzalkonium chloride, benzethonium chloride, chlorhexidine gluconate, chlorobutanol, sorbic acid, potassium sorbate, sodium dehydroacetate, paraoxy Methyl benzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate, oxyquinoline sulfate, phenethyl alcohol, benzyl alcohol, biguanide compounds (specifically, polyhexamethylene biguanide or its hydrochloride), polydronium chloride , Glow Kill (trade name made by Rhodia).

pH adjuster: For example, hydrochloric acid, boric acid, epsilon-aminocaproic acid, acetic acid, sodium hydroxide, sodium hydrogen carbonate, sodium carbonate, borax, triethanolamine, monoethanolamine and the like.
Isotonizing agents: for example, sodium bisulfite, sodium sulfite, magnesium chloride, potassium acetate, sodium acetate, sodium thiosulfate, magnesium sulfate, glycerin, propylene glycol and the like.

Stabilizer: Dibutylhydroxytoluene, trometamol, sodium formaldehyde sulfoxylate (Longalite), tocopherol, sodium pyrosulfite, monoethanolamine, aluminum monostearate, etc.

  Note that the contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to the present invention comprises a decongestant component, an eye muscle modulator component, an anti-inflammatory component or an astringent component, and an antihistamine that are usually used in ophthalmic compositions. It is desirable not to include as much of the medicinal ingredients and vitamins as possible. These components, when used as a contact lens mounting solution, adsorb to the contact lens, change the standard and shape of the contact lens size and base curve, and color the contact lens depending on the formulation concentration and prescription. There may be problems such as. As a result, the effects of the present invention may not be fully exhibited. Examples of such components include the following components.

Decongestant: For example, α-adrenergic agonists, specifically epinephrine, epinephrine hydrochloride, ephedrine hydrochloride, oxymetazoline hydrochloride, tetrahydrozoline hydrochloride, naphazoline hydrochloride, phenylephrine hydrochloride, methylephedrine hydrochloride, epinephrine hydrogen tartrate, naphazoline nitrate.
Eye muscle modulator component: For example, cholinesterase inhibitor having an active center similar to acetylcholine, specifically, neostigmine methyl sulfate, tropicamide, atropine sulfate helenien, and the like.

Anti-inflammatory component or astringent component: for example, indomethacin, silver nitrate, pranoprofen, dipotassium glycyrrhizinate, berberine chloride, berberine sulfate and the like.
Antihistamine component: For example, diphenhydramine hydrochloride and the like.

  Vitamins: For example, flavin adenine dinucleotide sodium.

  The contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to the present invention can be initially set to an appropriate viscosity in order to obtain a desired effect, and the set viscosity can be stably maintained over a long period of time. When setting the viscosity of the contact lens mounting liquid, it is preferable to design the liquid at 20 ° C. while maintaining the viscosity at 1.1 mPa · s or more, usually 1.1 to 300 mPa · s, preferably 1.3 to It can be designed to 100 mPa · s, particularly preferably 1.5 to 80 mPa · s.

  Viscosity is measured by a method using a cone-and-plate rotational viscometer (general test method, 45. Viscosity measuring method, second method rotational viscometer method described in the 14th revised Japanese pharmacy method, “(3) conical According to the method described in the section of “Plate Rotational Viscometer”, specifically, it can be measured using a commercially available cone-plate rotational viscometer and an appropriately selected rotor. For example, using a commercially available E-type viscometer [manufactured by TOKIMED, sold by Toki Sangyo (Japan)] and a suitably selected rotor, petroleum carbonization specified by JIS Z8809 for each sample measurement By adjusting hydrogen oil (Newtonian fluid) as a calibration standard solution, the viscosity at 20 ° C. can be measured. Specifically, the viscosity measurement method described in JP-A-2006-348055 is followed (measurement conditions are described later).

  The contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to the present invention is used by adjusting to an osmotic pressure within a range acceptable for a living body, if necessary. The osmotic pressure is usually 0.3 to 4.1, preferably 0.4 to 4.1, preferably 0.3 to 2.1, particularly preferably 0.5 to 1 as the osmotic pressure ratio with respect to physiological saline. .4. The measurement method of the osmotic pressure ratio refers to the 15th revised Japanese Pharmacopoeia general test method osmotic pressure measurement method.

  The contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to the present invention is used after adjusting to a pH within a range applicable to a living body, if necessary. The pH is usually from 4.0 to 9.0, preferably from 5.0 to 8.5, particularly preferably from 5.5 to 8.5. Adjustment of pH can be performed using the said buffer, a pH adjuster, etc.

  The contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to the present invention can be produced by a known method, and if necessary, a filtration sterilization treatment step, a filling step into a container, and the like can be added.

  As a method for using the contact lens mounting liquid for improving fatigue eyes and / or blurring eyes according to the present invention, the contact lens mounting liquid for improving fatigue eyes and / or the blurring eyes at the time of mounting the contact lens (immediately before mounting). Is directly dropped onto the contact lens, and both sides or one side of the contact lens are wetted with an appropriate amount (for example, preferably 1 to 3 drops at a time), and then used by attaching the contact lens.

  Furthermore, after wearing a contact lens by the method of use as described above, an appropriate amount (for example, preferably 1 to 3 drops) of the contact lens mounting solution for improving fatigue eyes and / or blurring eyes is applied. When used, the effects of the invention can be exhibited more remarkably. As described above, an ophthalmic composition having both a function as a contact lens mounting liquid and a function as an eye drop that can be instilled while wearing a contact lens is referred to as a “contact lens mounting eye drop” in this specification. May be described. That is, the present invention includes eye drops for wearing contact lenses for improving fatigue and / or blurring eyes. In addition, in the contact lens mounting ophthalmic solution, the type and concentration (mixing ratio) of the components to be used, the type of contact lens that can be applied, and the like are the same as those in the contact lens mounting solution for improving fatigue eyes and / or blurring eyes. It is.

  The present invention also includes the following method for preparing a contact lens for improving fatigue eyes and / or blurring eyes. That is, the contact lens mounting solution for improving the fatigue eye according to the present invention is directly dropped onto the contact lens, and both sides or one surface of the contact lens is wetted with an appropriate amount (for example, preferably 1 to 2 drops at a time), thereby causing fatigue eyes. The contact lens for improving the fatigue eye and / or the blurring eye exhibiting an excellent effect on the improvement and / or the blurring eye is prepared. Fatigue eyes and / or blurred eyes can be improved by wearing or wearing the contact lenses in a usual manner. After the contact lens is mounted on the eye, the contact lens mounting liquid for improving the fatigue eye and / or the blurred eye according to the present invention is instilled, whereby the contact lens for improving the fatigue eye and / or the blurred eye is improved. The effect is further enhanced.

Hereinafter, the present invention will be described in detail based on Examples and Comparative Examples, but the present invention is not limited to these Examples.
In addition, the viscosity of each Example and Comparative Example is appropriately measured using a TVE-20L type viscometer cone plate type (manufactured by TOKIMEC, Toki Sangyo (Japan)), which is a type of E-type viscometer. Under the conditions, it can be carried out according to the viscosity measuring method described in JP-A-2006-348055. Preferred measurement conditions are as follows.
Rotor used: Standard rotor (1 ° 34 ', R = 2.4Dm)
Rotational speed: 100 rpm (In addition, since the allowable range of the rotational speed varies depending on the viscosity, it is measured at the highest rotational speed among the rotational speeds that can be measured according to each prescription.)
Sample volume: 1 ml
Measurement temperature: 20 ° C
Time: The viscosity after 3 minutes is taken as the measured value.
In the examples, the “contact lens mounting liquid for improving fatigue eyes and / or blurring eyes” of the present invention is simply abbreviated as “contact lens mounting liquid”.

Experimental Example 1 Evaluation Test 1 for Fatigue Eye Improvement Effect 1
Using contact lens mounting liquids of the compositions shown in Table 1 (Examples 1, 2-1, 2-2, Comparative Example 1), the fatigue eye improving effect was evaluated.

Specifically, contact lenses are worn more than 5 days a week, and five subjects who are likely to feel tired eyes perform 1 VDT work (character entry work while looking at a personal computer screen) while wearing contact lenses. The eye was strained by performing for hours.
Next, the flicker value (pre-dose flicker value) was measured with the contact lens worn.
Next, the contact lenses for both eyes are once removed, and the contact lens mounting solution of Example 1 is dropped directly on the concave surface of the contact lens (inner side, the surface in contact with the cornea), one drop for each lens. The flicker value (post-dose flicker value) was measured again after wearing on the eye.
Next, sufficient time was taken and the post-administration flicker values were also measured for Examples 2-1 and 2-2 and Comparative Example 1 in the same procedure as Example 1.
The contact lenses worn by the subjects are (1) Soft contact lens classification group I manufactured by Bosch Lom, (2) Soft contact lens classification group IV manufactured by Johnson & Johnson, and (3) Material manufactured by Ciba Vision: Lotrafilcon A ( Silicone hydrogel material) Soft contact lens classification group I.

The flicker value is a critical frequency at which blinking cannot be identified by the naked eye when the blinking frequency of the blinking light is gradually increased. Using the flicker value as an index, it is possible to measure eye fatigue and deterioration of perceptual function. That is, improvement of the flicker value is an index of improvement of eye fatigue (particularly eye fatigue caused by physical and mental fatigue accompanied by a decrease in perceptual function) and eye strain.
In this test, the flicker value was measured with the following apparatus and conditions.
Device name: Rugken digital flicker value measuring instrument RDF-1 (manufactured by Shibata Kagaku Co., Ltd.)
Illuminance: Set to the illuminance that is easy for the measurer to see Distance: Set to the position where the measurer is easy to see (the position where the letter “K” is most clearly visible) SCAN knob (initial flicker frequency to be lowered): 60 Hz
MANU-AUTO: set to AUTO From the measured flicker value, the fatigue eye improvement rate (flicker value improvement rate) was determined by the following equation (1).

  The average of the results of 5 subjects is shown in FIG. As a result, in the average values of the five subjects, the prescriptions of Examples 1, 2-1, and 2-2 showed an improvement in the flicker value improvement rate. Among them, (2) Johnson & Johnson soft contact lens classification group IV, (3) Cibavision material: Lotrafilcon A (silicone hydrogel material) contact lens users, especially the improvement in flicker value improvement was remarkable . On the other hand, in the case of the formulation of Comparative Example 1, the flicker value improvement rate was less than 1%. In this field, it is generally considered that the presence / absence of an effect (clear change) is determined based on a flicker value improvement rate of about 3%. From the above results, the contact lens mounting liquid of the present invention is excellent in fatigue eye improving effect (particularly eye fatigue resulting from general fatigue) and eye strain improving effect. As a result, it was confirmed that the utility is high.

Experimental Example 2 Evaluation Test 2 for Fatigue Eye Improvement Effect 2
The fatigue eye improvement effect of the contact lens mounting liquid having the composition of Example 2-1 shown in Table 1 was evaluated by the following method.
Specifically, four subjects who wear contact lenses for 5 days or more per week and feel tired eyes wear the contact lenses for 8 hours or more throughout the day, and then the flicker value when the contact lenses are worn (Pre-dose flicker value) was measured. The contact lenses used by the test subjects were (1) Soft contact lens classification group I manufactured by Bausch & Lom, (2) Soft contact lens classification group IV manufactured by Johnson & Johnson, and (3) Material manufactured by Ciba Vision: Lotrafilcon A ( Silicone hydrogel material) Soft contact lens classification group I. Next, using the contact lens mounting solution of Example 2-1, after wearing a contact lens, one eye drop was applied to both eyes, and the flicker value (flicker value after administration) was measured again (Test 1). Further, 30 minutes after Test 1, the contact lens mounting solution of Example 2-1 was again instilled into both eyes, and the flicker value (flicker value after administration) was measured (Test 2).

Next, after allowing sufficient time and measuring the flicker value before the test in the same procedure as described above, the contact lenses for both eyes were once removed, and the contact lens mounting liquid of Example 2-1 was directly applied to the concave surface (inside of the contact lens). , One drop per one lens was dropped on the surface in contact with the cornea), the contact lens was attached to both eyes again, and the flicker value (flicker value after administration) was measured again (Test 3). Further, 30 minutes after Test 3, one drop of the contact lens mounting solution of Example 2-1 was applied to both eyes, and the flicker value (flicker value after administration) was measured (Test 4).
Note that the measurement equipment and measurement conditions were the same as in Experimental Example 1.
From the measured flicker value, the flicker value improvement rate was determined by the above-described equation (1).

The average of the results of 4 subjects is shown in FIG. As a result, in all of the four subjects, in Trial 3 and Trial 4, a significant increase in the flicker value improvement rate was seen as compared to before administration. In particular, in Test 4, since a far superior flicker value improvement rate was obtained as compared with Test 3, Example 2-1 was further applied after attaching a contact lens using Example 2-1. It became clear that even higher effects were achieved by instillation. In particular, (2) Johnson & Johnson soft contact lens classification group IV, (3) Ciba Vision material: Lotrafilcon A (silicone hydrogel material) contact lens users, especially the increase in flicker value improvement rate is remarkable there were.
On the other hand, in Test 1 and Test 2, the flicker value improvement rate was hardly increased compared with that before administration. From the above results, the contact lens mounting liquid of the present invention is more effective in improving fatigue eyes, improving eyestrain, or improving physical and mental fatigue than when the same prescription is used only as an ophthalmic solution. It was confirmed that it is highly useful as a contact lens mounting liquid for improving fatigue eyes.

具体的には、コンタクトレンズを週５日以上装用しており、かすみ目を感じ易い４名の被験者に対して、コンタクトレンズを装用した状態でＶＤＴ作業（パソコン画面を見ながらの文字入力作業）を１時間実施して、被験者の目に負荷をかけた状態でのかすみ目度を測定した（投与前かすみ目度）。
次いで、一旦両眼のコンタクトレンズを外し、実施例１のコンタクトレンズ装着液を直接コンタクトレンズの凹面（内側、角膜と接触する面）に片方のレンズにつき１滴ずつ滴下し、再びコンタクトレンズを両眼に装着し、かすみ目度（投与後かすみ目度）を測定した。さらにその３０分後に、再度実施例１の装着液を両眼に１滴ずつ点眼した後にかすみ目度（投与後かすみ目度）を測定した。 Experimental Example 3 Evaluation Test for Haze Improvement Effect The haze improvement effect of the contact lens mounting liquid having the composition shown in Table 2 was evaluated by the following method.

Specifically, VDT work for 4 subjects who are wearing contact lenses for 5 days or more per week and are likely to feel blurred eyes while wearing contact lenses. Was carried out for 1 hour, and the degree of haze when the subject's eyes were loaded was measured (the haze degree before administration).
Next, the contact lenses for both eyes are once removed, and the contact lens mounting solution of Example 1 is dropped directly on the concave surface of the contact lens (inner side, the surface in contact with the cornea), one drop for each lens. It was attached to the eye and the degree of haze (the haze after administration) was measured. Furthermore, 30 minutes after that, the drop of the mounting solution of Example 1 was again applied to both eyes, and the degree of haze (haze after administration) was measured.

  The contact lenses used by the test subjects were (1) Soft contact lens classification group I manufactured by Bausch & Lom, (2) Soft contact lens classification group IV manufactured by Johnson & Johnson, and (3) Material manufactured by Ciba Vision: Lotrafilcon A ( Silicone hydrogel material) Soft contact lens classification group I.

The haze degree was measured according to the following procedure. In a visual acuity tester (CV-500: manufactured by Tome Co., Ltd. for 5 m), the subject's normal corrected visual acuity (before VDT work) with the contact lens worn is sandwiched between three steps higher visual acuity Up to 25 indicators {Landolt ring (3 rows, 5 rows, 15 in total) and Hiragana (2 rows, 5 rows, 10 in total)} were observed in order from a distance of 5 meters for each left and right eye {for example, In the case of a subject whose normal corrected visual acuity is 1.0, 5 rows drawn in the 1.2, 1.0, 0.9, 0.8, 0.7 stage of the visual acuity tester, a total of 25 The indicators (Landolt ring and Hiragana) were observed}. For each of the 25 indices, if the outline could be recognized, it was judged as “good”, and if it was not recognized, it was judged as “poor”. Then, the blur improvement degree was calculated | required by the following formula 2.

実施例１及び実施例２−１では、かすみ目改善度の顕著な増大が見られた。またいずれの実施例においても、装着のみを行った後よりも、装着後にさらに点眼を行った後の方がかすみ目改善度が優れていた。この結果は、実施例１もしくは２−１の組成物を用いてコンタクトレンズを装着した後、同一処方の組成物を点眼液として使用することによって、より一層高いかすみ目改善効果が奏される事を示している。尚、中でも（２）ジョンソン＆ジョンソン社製ソフトコンタクトレンズ分類グループＩＶ、（３）チバビジョン社製素材：ＬｏｔｒａｆｉｌｃｏｎＡ（シリコーンハイドロゲル素材）のコンタクトレンズ使用者において、かすみ目改善度の増大が顕著であった。
これに対し、比較例１の処方では、装着後、装着＋点眼後のいずれの場合にも、かすみ目改善度の増大は殆ど認められなかった。以上の結果から、本発明のコンタクトレンズ装着液は、かすみ目に対して顕著な改善効果を有することが明らかである。また、この試験により、本発明のコンタクトレンズ装着液は、かすみ目改善用コンタクトレンズ装着液として有用性が高いことが確認された。またさらに、この試験により、本発明のコンタクトレンズ装着液は、視力増強効果、ピント調節能改善効果にも顕著に優れている事が判明した。 Table 3 shows the average of the results of 4 subjects.

In Example 1 and Example 2-1, a significant increase in the degree of blurring was observed. In any of the examples, the degree of improvement in blurred vision was better after further instillation after wearing than when only wearing. This result shows that, after the contact lens is mounted using the composition of Example 1 or 2-1, the use of the composition of the same prescription as an ophthalmic solution has an even higher effect of improving blurred vision. Is shown. Of these, (2) Johnson &Johnson's soft contact lens classification group IV, (3) Ciba Vision's material: Lotrafilcon A (silicone hydrogel material) contact lens users, the increase in blurring improvement was remarkable. It was.
On the other hand, in the prescription of Comparative Example 1, almost no increase in the degree of improvement in blurred vision was observed in either case after wearing or after wearing + instillation. From the above results, it is clear that the contact lens mounting liquid of the present invention has a remarkable improvement effect on blurred eyes. Moreover, it was confirmed by this test that the contact lens mounting liquid of the present invention is highly useful as a blurring contact lens mounting liquid. Furthermore, this test revealed that the contact lens mounting liquid of the present invention is remarkably excellent in visual acuity enhancement effect and focus adjustment ability improvement effect.

Experimental Example 4 Evaluation of Effectiveness (Changes in Subjective Symptoms) Regarding Improvement of Fatigue Eyes or Blurred Eyes Effectiveness of contact lens mounting liquids having the composition shown in Table 4 was evaluated by 4 subjects.

Specifically, for four subjects wearing contact lenses for 5 days or more per week, contact lenses were mounted using the contact lens mounting solutions of Example 2-2 and Comparative Example 1, and compared with before use. The effectiveness of fatigue eye improvement or haze improvement was evaluated.
Regarding the evaluation items of the feeling of effectiveness for tired eyes, 7 items according to the criteria of Table 5 were (1) the head was surely crushed, (2) the eyes were tired, and (3) the body became soft. A stage evaluation (−3 to +3) was performed, and the total score was calculated as a fatigue eye improvement index. In addition, for the evaluation items of the sense of effectiveness for blurred eyes, the same seven-point evaluation was performed for three items: (1) moistened eyes, (2) clear vision, and (3) overall brighter appearance. The total score was calculated as a blur improvement index. Furthermore, the sum of the fatigue improvement index of 4 people or the sum of the blur improvement index was calculated.

The results are shown in FIGS. From the result of FIG. 3, when Example 2-2 and the test solution of Comparative Example 1 were compared, Example 2-2 exhibited a far superior fatigue eye improvement index. When Example 2-2 was compared with the test solution of Comparative Example 1, it was confirmed that Example 2-2 exhibited a much better haze improvement index.
Moreover, when Example 2-1 and Example 2-3 were similarly compared with the test solution of Comparative Example 1, it was far superior to Comparative Example 1 as in Example 2-2. It was confirmed that the tired eye improvement index and the haze improvement index were exhibited.
From this result, the fatigue eye improvement effect and the blurred eye improvement effect by the contact lens mounting liquid of the present invention were also confirmed in terms of effectiveness.

Example 3-46
A contact lens mounting solution (Example 3-46) of the present invention was prepared according to the formulations shown in Tables 6 to 13. In Tables 6 to 13, the unit of each compounding component is g / 100 mL. All of these Examples showed the same effects of the invention as in Examples 1, 2-1, 2-2, and 2-3 in the tests of Experimental Examples 1 to 4.

１）ヒドロキシプロピルメチルセルロース商品名：６５ＳＨ−４０００ 信越化学工業株式会社
２）商品名： ＣＦ−Ｖ 住友精化株式会社
３）商品名： ＡＧガムＭ 第一工業製薬株式会社
４）商品名： ＳＭ８０００ 信越化学工業株式会社 Formulation Example 1-20
With the prescriptions shown in Table 14 to Table 17, contact eye drop ophthalmic solutions (Prescription Examples 1-20) were prepared. In Tables 14 to 17, the unit of each blending component is g / 100 mL.

1) Hydroxypropyl methylcellulose Product name: 65SH-4000 Shin-Etsu Chemical Co., Ltd. 2) Product name: CF-V Sumitomo Seika Co., Ltd. 3) Product name: AG Gum M Daiichi Kogyo Seiyaku Co., Ltd. 4) Product name: SM8000 Shin-Etsu Chemical Industry Co., Ltd.

１）ヒドロキシプロピルメチルセルロース商品名：６５ＳＨ−４０００ 信越化学工業株式会社
２）商品名： ＣＦ−Ｖ 住友精化株式会社
３）商品名： ＡＧガムＭ 第一工業製薬株式会社
４）商品名： ＳＭ８０００ 信越化学工業株式会社

1) Hydroxypropyl methylcellulose Product name: 65SH-4000 Shin-Etsu Chemical Co., Ltd. 2) Product name: CF-V Sumitomo Seika Co., Ltd. 3) Product name: AG Gum M Daiichi Kogyo Seiyaku Co., Ltd. 4) Product name: SM8000 Shin-Etsu Chemical Industry Co., Ltd.

Claims (5)

(A) one or more selected from the group consisting of a cellulose-based polymer compound, a vinyl-based polymer compound, and dextran;
(B) Chondroitin sulfate San及 beauty least one selected from the group consisting of a salt and,
(C) a contact lens wearing ophthalmic solution containing a terpenoid ,
Used for both applications contact lens wetting solution and eye drops in contact lenses at the same composition, the contact lens eye drops (provided that polyoxyethylene sorbitan fatty acid esters, polyoxyethylene hardened castor oils and poly Excluding those containing one or more selected from the group consisting of oxyethylene polyoxypropylene copolymers and those containing trimethoprim and benzyl alcohol).   The contact lens-attached ophthalmic solution according to claim 1, which contains the component (A) at a ratio of 0.0001 to 25 (w / v)%. The contact lens wearing ophthalmic solution according to claim 1 or 2, comprising at least one selected from the group consisting of chondroitin sulfate and a salt thereof in a ratio of 0.0001 to 10 (w / v)%. The contact lens wearing ophthalmic solution according to any one of claims 1 to 3 , comprising (C) a terpenoid in a proportion of 0.0001 to 0.1 (w / v)%. The contact lens wearing eye drop according to any one of claims 1 to 4 , comprising at least one selected from the group consisting of an ethylenediamineacetic acid derivative and a salt thereof, a nonionic surfactant, an inorganic salt, and a buffering agent. liquid.

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