JP6366709B2 - アザインドール化合物、その合成、および同化合物の使用方法 - Google Patents

アザインドール化合物、その合成、および同化合物の使用方法 Download PDF

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JP6366709B2
JP6366709B2 JP2016526988A JP2016526988A JP6366709B2 JP 6366709 B2 JP6366709 B2 JP 6366709B2 JP 2016526988 A JP2016526988 A JP 2016526988A JP 2016526988 A JP2016526988 A JP 2016526988A JP 6366709 B2 JP6366709 B2 JP 6366709B2
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methyl
hydrogen
mmol
added
pyridine
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Japanese (ja)
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JP2016530242A (ja
JP2016530242A5 (https=
Inventor
プラビン・エス・シルデ
マルティ・エヌ・ナイク
ビカス・ナラヤン・シンデ
シャフル・ハミード・ペール・モハメド
モナリサ・チャテルジ
ラダ・ケイ・シャンディル
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Foundation For Neglected Disease Research
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Foundation For Neglected Disease Research
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2016526988A 2013-07-17 2014-07-10 アザインドール化合物、その合成、および同化合物の使用方法 Active JP6366709B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN3196CH2013 2013-07-17
IN3196/CHE/2013 2013-07-17
PCT/US2014/046100 WO2015009525A1 (en) 2013-07-17 2014-07-10 Azaindole compounds, synthesis thereof, and methods of using the same

Publications (3)

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JP2016530242A JP2016530242A (ja) 2016-09-29
JP2016530242A5 JP2016530242A5 (https=) 2017-08-17
JP6366709B2 true JP6366709B2 (ja) 2018-08-01

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JP2016526988A Active JP6366709B2 (ja) 2013-07-17 2014-07-10 アザインドール化合物、その合成、および同化合物の使用方法

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US (1) US9163020B2 (https=)
EP (1) EP3021947B1 (https=)
JP (1) JP6366709B2 (https=)
KR (1) KR102301753B1 (https=)
CN (1) CN105636646B (https=)
AU (1) AU2014290598B2 (https=)
CA (1) CA2918487C (https=)
EA (1) EA028611B1 (https=)
ES (1) ES2644025T3 (https=)
WO (1) WO2015009525A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201512197A (zh) * 2013-08-30 2015-04-01 Hoffmann La Roche 吡咯并吡啶或吡唑并吡啶衍生物
GB201317363D0 (en) * 2013-10-01 2013-11-13 Eisai Ltd Novel compounds
ES2997871T3 (en) 2017-12-06 2025-02-18 Prollergy Corp Composition and method for reducing allergic response
RU2702224C2 (ru) * 2018-03-29 2019-10-07 Общество С Ограниченной Ответственностью "Мт-Медикалс" Производные фенил формамидина, обладающие антимикобактериальной активностью
WO2019239382A1 (en) 2018-06-15 2019-12-19 Cadila Healthcare Limited Condensed azaheteroaryl compounds having antibacterial activity against tuberculosis bacteria
WO2020188405A1 (en) * 2019-03-20 2020-09-24 Foundation For Neglected Disease Research Benzimidazoles derivatives as anti-tuberculosis agents
CN111393435A (zh) * 2020-03-16 2020-07-10 青岛吉澳医药科技有限公司 氮杂吲哚酰胺类化合物及其制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1532980A1 (en) * 2003-11-24 2005-05-25 Novo Nordisk A/S N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes
CA2691512A1 (en) * 2007-08-10 2009-02-19 H. Lundbeck A/S Heteroaryl amide analogues
CA2793086C (en) * 2010-03-18 2018-08-21 Institut Pasteur Korea Substituted imidazo[1,2-a]pyridine compounds and their use in the treatment of bacterial infections

Also Published As

Publication number Publication date
US9163020B2 (en) 2015-10-20
EP3021947A1 (en) 2016-05-25
US20150025087A1 (en) 2015-01-22
KR20160058757A (ko) 2016-05-25
AU2014290598A1 (en) 2016-02-11
JP2016530242A (ja) 2016-09-29
EP3021947B1 (en) 2017-08-23
WO2015009525A1 (en) 2015-01-22
KR102301753B1 (ko) 2021-09-15
CA2918487C (en) 2021-08-03
CN105636646A (zh) 2016-06-01
ES2644025T3 (es) 2017-11-27
EA028611B1 (ru) 2017-12-29
CA2918487A1 (en) 2015-01-22
CN105636646B (zh) 2017-12-19
EA201690227A1 (ru) 2016-07-29
BR112016000712A2 (pt) 2022-03-22
AU2014290598B2 (en) 2018-11-08

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