JP6357100B2 - ６−（ピペリジン−４−イルオキシ）−２ｈ−イソキノリン−１−オン塩酸塩の結晶性溶媒和物 - Google Patents

６−（ピペリジン−４−イルオキシ）−２ｈ−イソキノリン−１−オン塩酸塩の結晶性溶媒和物 Download PDF

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JP6357100B2
JP6357100B2 JP2014517674A JP2014517674A JP6357100B2 JP 6357100 B2 JP6357100 B2 JP 6357100B2 JP 2014517674 A JP2014517674 A JP 2014517674A JP 2014517674 A JP2014517674 A JP 2014517674A JP 6357100 B2 JP6357100 B2 JP 6357100B2
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polymorph
dihydrate
compound
yloxy
piperidin
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JP2014518235A (ja
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ノルベルト・ナーゲル
ブルーノ・バウムガルトナー
ハーラルト・ベルヒトールト
オリヴァー・プレッテンブルク
ディーター・カーデライト
マンディー・モーニッケ
ジーモン・ゲスラー
ヨアヒム・ティルナー
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Sanofi SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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JP2014517674A 2011-07-08 2012-06-27 ６−（ピペリジン−４−イルオキシ）−２ｈ−イソキノリン−１−オン塩酸塩の結晶性溶媒和物 Active JP6357100B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11305890.3 2011-07-08
EP11305890 2011-07-08
EP11306033.9 2011-12-29
EP11306033 2011-12-29
PCT/EP2012/062431 WO2013007518A1 (en) 2011-07-08 2012-06-27 Crystalline solvates of 6-(piperidin-4-yloxy)-2h-isoquinolin-1-one hydrochloride

Publications (2)

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JP2014518235A JP2014518235A (ja) 2014-07-28
JP6357100B2 true JP6357100B2 (ja) 2018-07-11

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JP2014517674A Active JP6357100B2 (ja) 2011-07-08 2012-06-27 ６−（ピペリジン−４−イルオキシ）−２ｈ−イソキノリン−１−オン塩酸塩の結晶性溶媒和物

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US (2) US8710078B2 (enExample)
EP (1) EP2729460B1 (enExample)
JP (1) JP6357100B2 (enExample)
KR (1) KR102013566B1 (enExample)
CN (1) CN103781778B (enExample)
AU (1) AU2012283276B2 (enExample)
CA (1) CA2843773C (enExample)
CO (1) CO6870040A2 (enExample)
CY (1) CY1118326T1 (enExample)
DK (1) DK2729460T3 (enExample)
ES (1) ES2568245T3 (enExample)
HR (1) HRP20160356T1 (enExample)
HU (1) HUE027309T2 (enExample)
IN (1) IN2014CN00817A (enExample)
MA (1) MA35340B1 (enExample)
PH (1) PH12014500289B1 (enExample)
PL (1) PL2729460T3 (enExample)
RU (1) RU2619129C2 (enExample)
SG (1) SG2014007520A (enExample)
SI (1) SI2729460T1 (enExample)
WO (1) WO2013007518A1 (enExample)
ZA (1) ZA201400941B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2729460T3 (en) * 2011-07-08 2016-04-18 Sanofi Sa Crystalline solvates of 6- (piperidin-4-yloxy) -2H-isoquinolin-1-one hydrochloride
KR20250036929A (ko) 2022-08-01 2025-03-14 발로 헬스, 인코포레이티드 6-치환된-1-(2h)-아이소퀴놀리논 및 중간체 화합물의 제조 방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL150524A0 (en) * 2000-01-07 2003-02-12 Transform Pharmaceuticals Inc High-throughput formation, identification, and analysis of diverse solid-forms
PT1910333E (pt) * 2005-07-26 2013-08-01 Sanofi Sa Derivados de isoquinolona substituída com piperidinilo como inibidores da rho-cinase
TW200738682A (en) 2005-12-08 2007-10-16 Organon Nv Isoquinoline derivatives
US7478743B2 (en) 2006-02-28 2009-01-20 Holley Jr John M Carton for tapered and cylindrical articles
JP5421783B2 (ja) * 2006-12-27 2014-02-19 サノフイ Ｒｈｏキナーゼ阻害剤としての置換イソキノロン及びイソキノリノン誘導体
ATE502027T1 (de) * 2006-12-27 2011-04-15 Sanofi Aventis Substituierte isochinoline und ihre verwendung als rho-kinase-inhibitoren
KR20100103646A (ko) * 2007-12-26 2010-09-27 사노피-아벤티스 ６­치환된­１­（２ｈ）­이소퀴놀리논의 제조 방법
DK2729460T3 (en) * 2011-07-08 2016-04-18 Sanofi Sa Crystalline solvates of 6- (piperidin-4-yloxy) -2H-isoquinolin-1-one hydrochloride

Also Published As

Publication number Publication date
WO2013007518A1 (en) 2013-01-17
PL2729460T3 (pl) 2016-07-29
CO6870040A2 (es) 2014-02-20
PH12014500289A1 (en) 2014-03-24
RU2014104358A (ru) 2015-08-20
MA35340B1 (fr) 2014-08-01
US20140221656A1 (en) 2014-08-07
AU2012283276A1 (en) 2014-02-27
CN103781778A (zh) 2014-05-07
CY1118326T1 (el) 2017-06-28
HK1192546A1 (zh) 2014-08-22
IN2014CN00817A (enExample) 2015-04-03
HUE027309T2 (en) 2016-10-28
CA2843773C (en) 2018-11-06
SI2729460T1 (sl) 2016-05-31
HRP20160356T1 (hr) 2016-05-06
SG2014007520A (en) 2014-07-30
CA2843773A1 (en) 2013-01-17
KR102013566B1 (ko) 2019-08-23
PH12014500289B1 (en) 2019-06-28
NZ620864A (en) 2015-08-28
US20130012444A1 (en) 2013-01-10
DK2729460T3 (en) 2016-04-18
AU2012283276B2 (en) 2014-07-24
KR20140045550A (ko) 2014-04-16
EP2729460A1 (en) 2014-05-14
RU2619129C2 (ru) 2017-05-12
CN103781778B (zh) 2015-10-07
JP2014518235A (ja) 2014-07-28
ES2568245T3 (es) 2016-04-28
US8710078B2 (en) 2014-04-29
EP2729460B1 (en) 2016-01-13
ZA201400941B (en) 2015-05-27

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