JP6352269B2 - オフターゲットプロファイルの改善されたオリゴマー - Google Patents

オフターゲットプロファイルの改善されたオリゴマー Download PDF

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JP6352269B2
JP6352269B2 JP2015533454A JP2015533454A JP6352269B2 JP 6352269 B2 JP6352269 B2 JP 6352269B2 JP 2015533454 A JP2015533454 A JP 2015533454A JP 2015533454 A JP2015533454 A JP 2015533454A JP 6352269 B2 JP6352269 B2 JP 6352269B2
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JP2016513950A (ja
JP2016513950A5 (OSRAM
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メラー、トーライフ
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MIRRX THERAPEUTICS AS
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/53—Methods for regulating/modulating their activity reducing unwanted side-effects

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
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  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2015533454A 2012-09-26 2013-09-26 オフターゲットプロファイルの改善されたオリゴマー Active JP6352269B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261705668P 2012-09-26 2012-09-26
US61/705,668 2012-09-26
DKPA201200587 2012-09-26
DKPA201200587 2012-09-26
PCT/DK2013/050308 WO2014048441A1 (en) 2012-09-26 2013-09-26 Oligomers with improved off-target profile

Publications (3)

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JP2016513950A JP2016513950A (ja) 2016-05-19
JP2016513950A5 JP2016513950A5 (OSRAM) 2017-06-22
JP6352269B2 true JP6352269B2 (ja) 2018-07-04

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JP2015533454A Active JP6352269B2 (ja) 2012-09-26 2013-09-26 オフターゲットプロファイルの改善されたオリゴマー

Country Status (7)

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US (1) US9725721B2 (OSRAM)
EP (1) EP2900822B1 (OSRAM)
JP (1) JP6352269B2 (OSRAM)
CN (1) CN104955950B (OSRAM)
AU (1) AU2013324716B2 (OSRAM)
CA (1) CA2886116C (OSRAM)
WO (1) WO2014048441A1 (OSRAM)

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CN103620035B (zh) 2011-04-25 2021-04-23 赛诺菲 用于调节mir-21活性的微rna化合物以及方法
BR112014026639A8 (pt) 2012-04-25 2018-01-16 Regulus Therapeutics Inc compostos , métodos de inibição da atividade de mir-21 , método para diminuir a expressão de colágeno , método para tratar , prevenir ou atrasar o início de uma doença , método de tratamento de um distúrbio fibroproliferativo e usos de um composto.
US9879255B2 (en) 2012-10-02 2018-01-30 University Of Newcastle Upon Tyne Modulation of RNA activity and vascular permeability
UA116639C2 (uk) 2012-10-09 2018-04-25 Рег'Юлес Терап'Ютікс Інк. Способи лікування синдрому альпорта
NZ630890A (en) 2013-05-01 2017-09-29 Regulus Therapeutics Inc Microrna compounds and methods for modulating mir-122
EP3060664B1 (en) 2013-10-25 2021-07-07 Sanofi Microrna compounds and methods for modulating mir-21 activity
CN113151468B (zh) 2014-06-13 2024-11-26 东丽株式会社 乳癌的检测试剂盒或装置以及检测方法
KR20250030013A (ko) * 2014-06-13 2025-03-05 도레이 카부시키가이샤 대장암의 검출 키트 또는 디바이스 및 검출 방법
RU2017101023A (ru) * 2014-06-16 2018-07-16 Торэй Индастриз, Инк. Набор или устройство для обнаружения рака желудка и способ обнаружения
RU2017101174A (ru) 2014-06-18 2018-07-18 Торэй Индастриз, Инк. Набор или устройство для обнаружения рака печени и способ обнаружения
JP6385732B2 (ja) * 2014-06-27 2018-09-05 国立大学法人北海道大学 免疫応答制御剤
JP2017523790A (ja) 2014-08-07 2017-08-24 レグルス セラピューティクス インコーポレイテッド 代謝障害のためのマイクロｒｎａの標的化
CN107075578B (zh) * 2014-09-16 2021-06-01 东丽株式会社 miRNA表达量的比较分析方法和装置
WO2016115609A1 (en) * 2015-01-20 2016-07-28 Katholieke Universiteit Leuven Colon cancer
RU2686313C2 (ru) 2015-02-25 2019-04-25 Байонир Корпорейшн Фармацевтическая композиция для лечения рака, содержащая микроРНК в качестве активного ингредиента
CN104826133B (zh) * 2015-05-01 2020-11-24 北京博奥医学检验所有限公司 一种与肺腺癌有关的miRNA及其药物组合物
CN107058472B (zh) * 2016-11-03 2020-10-27 中国人民解放军陆军军医大学 一种通过四种血浆microRNA联合诊断急性高山病的诊断试剂盒
CN107058474B (zh) * 2016-11-03 2020-09-01 中国人民解放军陆军军医大学 一种通过血浆microRNA-3591-3p诊断急性高山病的诊断试剂盒
CN107058475B (zh) * 2016-11-03 2020-10-27 中国人民解放军陆军军医大学 一种联合miR-676、miR-181b和miR-193b诊断急性高山病的试剂盒
CN107058471B (zh) * 2016-11-03 2020-09-01 中国人民解放军陆军军医大学 一种通过四种microRNA生物标志物联合预测急性高山病发病风险的试剂盒
CN107058470B (zh) * 2016-11-03 2020-09-01 中国人民解放军陆军军医大学 一种通过联合miR-136和miR-4791预测急性高山病发病风险的诊断试剂盒
CN107058473B (zh) * 2016-11-03 2020-10-27 中国人民解放军陆军军医大学 一种联合miR-676、miR-181b和miR-3591诊断急性高山病的试剂盒
CN108251422A (zh) * 2016-12-29 2018-07-06 昆山彭济凯丰生物科技有限公司 通过miR-6069进行抗癌的方法和药物及其应用
CN108295260A (zh) * 2017-01-13 2018-07-20 彭长庚 通过miR-1915-3p进行抗癌的方法和药物及其应用
CN108295086B (zh) * 2017-01-13 2021-11-02 昆山彭济凯丰生物科技有限公司 通过miR-4418进行抗癌的方法和药物及其应用
CN108310381A (zh) * 2017-01-16 2018-07-24 昆山彭济凯丰生物科技有限公司 通过miR-6511b-3p进行抗癌的方法和药物及其应用
CN107502609A (zh) * 2017-09-08 2017-12-22 中国科学院深圳先进技术研究院 一种靶向cJun信号通路的miRNA及其制备方法和应用
KR102070969B1 (ko) * 2018-04-10 2020-01-29 한국한의학연구원 통증 판별용 마커
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CN109468375B (zh) * 2018-12-28 2021-05-14 固安博健生物技术有限公司 分子标志物在骨质疏松症中的应用
CN113993588B (zh) * 2019-06-05 2024-03-01 癌症干细胞科技公司 癌治疗剂
CN111073973A (zh) * 2019-12-10 2020-04-28 石河子大学 一种用于早期诊断2型糖尿病的microRNA序列及其应用
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WO2014048441A1 (en) 2014-04-03
EP2900822A1 (en) 2015-08-05
JP2016513950A (ja) 2016-05-19
US9725721B2 (en) 2017-08-08
EP2900822B1 (en) 2021-11-24
EP2900822A4 (en) 2016-05-25
CA2886116C (en) 2022-06-07
CN104955950B (zh) 2019-04-26
CA2886116A1 (en) 2014-04-03
AU2013324716B2 (en) 2019-06-13
US20160145620A1 (en) 2016-05-26
AU2013324716A1 (en) 2015-04-09
CN104955950A (zh) 2015-09-30

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