JP6339998B2 - 幹細胞よりナチュラルキラー細胞を発生させる方法 - Google Patents
幹細胞よりナチュラルキラー細胞を発生させる方法 Download PDFInfo
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- JP6339998B2 JP6339998B2 JP2015509079A JP2015509079A JP6339998B2 JP 6339998 B2 JP6339998 B2 JP 6339998B2 JP 2015509079 A JP2015509079 A JP 2015509079A JP 2015509079 A JP2015509079 A JP 2015509079A JP 6339998 B2 JP6339998 B2 JP 6339998B2
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- Animal Behavior & Ethology (AREA)
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- Organic Chemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Developmental Biology & Embryology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Reproductive Health (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
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- Gynecology & Obstetrics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261637592P | 2012-04-24 | 2012-04-24 | |
| US61/637,592 | 2012-04-24 | ||
| PCT/US2013/037782 WO2013163171A1 (en) | 2012-04-24 | 2013-04-23 | Method for developing natural killer cells from stem cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017115944A Division JP6529541B2 (ja) | 2012-04-24 | 2017-06-13 | 幹細胞よりナチュラルキラー細胞を発生させる方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015519890A JP2015519890A (ja) | 2015-07-16 |
| JP2015519890A5 JP2015519890A5 (OSRAM) | 2016-06-23 |
| JP6339998B2 true JP6339998B2 (ja) | 2018-06-06 |
Family
ID=48289670
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015509079A Active JP6339998B2 (ja) | 2012-04-24 | 2013-04-23 | 幹細胞よりナチュラルキラー細胞を発生させる方法 |
| JP2017115944A Active JP6529541B2 (ja) | 2012-04-24 | 2017-06-13 | 幹細胞よりナチュラルキラー細胞を発生させる方法 |
| JP2019091121A Pending JP2019122415A (ja) | 2012-04-24 | 2019-05-14 | 幹細胞よりナチュラルキラー細胞を発生させる方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017115944A Active JP6529541B2 (ja) | 2012-04-24 | 2017-06-13 | 幹細胞よりナチュラルキラー細胞を発生させる方法 |
| JP2019091121A Pending JP2019122415A (ja) | 2012-04-24 | 2019-05-14 | 幹細胞よりナチュラルキラー細胞を発生させる方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9260696B2 (OSRAM) |
| EP (2) | EP3567102A1 (OSRAM) |
| JP (3) | JP6339998B2 (OSRAM) |
| AU (3) | AU2013251785B2 (OSRAM) |
| WO (1) | WO2013163171A1 (OSRAM) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9260696B2 (en) * | 2012-04-24 | 2016-02-16 | Dan S. Kaufman | Method for developing natural killer cells from stem cells |
| WO2014165707A2 (en) | 2013-04-03 | 2014-10-09 | Memorial Sloan-Kettering Cancer Center | Effective generation of tumor-targeted t-cells derived from pluripotent stem cells |
| WO2016123100A1 (en) | 2015-01-26 | 2016-08-04 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| JP6773268B2 (ja) * | 2015-03-09 | 2020-10-21 | 学校法人慶應義塾 | 多能性幹細胞を所望の細胞型へ分化する方法 |
| CN105517672B (zh) * | 2015-05-26 | 2019-06-21 | 中国科学院广州生物医药与健康研究院 | 一种人原代细胞培养基及其应用 |
| PL412787A1 (pl) * | 2015-06-22 | 2017-01-02 | Magdalena Król | Oparty na makrofagach celowany system dostarczania związków związanych z ferrytyną |
| CN107850596B (zh) * | 2015-07-24 | 2020-12-04 | 先天制药公司 | 用于检测组织浸润nk细胞的方法 |
| ES2922475T3 (es) * | 2015-09-08 | 2022-09-15 | Sumitomo Pharma Co Ltd | Método para producir células epiteliales pigmentarias de la retina |
| CN108368520B (zh) | 2015-11-04 | 2023-01-17 | 菲特治疗公司 | 多能细胞的基因组工程改造 |
| WO2017078807A1 (en) | 2015-11-04 | 2017-05-11 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| CN105296428A (zh) * | 2015-12-03 | 2016-02-03 | 广州医科大学附属第三医院 | 一种提高诱导多能干细胞的体外分化造血效率的方法 |
| JP2019505498A (ja) | 2015-12-16 | 2019-02-28 | ザ・ウォルター・アンド・エリザ・ホール・インスティテュート・オブ・メディカル・リサーチ | Nk細胞におけるサイトカイン誘導性sh2タンパク質の阻害 |
| US20190161726A1 (en) * | 2016-07-29 | 2019-05-30 | Daikin Industries, Ltd. | Differentiated cell production method and culture bag used therefor |
| US20190194621A1 (en) * | 2016-09-08 | 2019-06-27 | Kyowa Hakko Bio Co., Ltd. | Medium for culturing stem cells, method for culturing stem cells, growth promoter for stem cells, and cell composition and method for producing same |
| JP7092281B2 (ja) * | 2017-02-07 | 2022-06-28 | エージェンシー フォー サイエンス,テクノロジー アンド リサーチ | 多能性幹細胞から模倣自然免疫細胞を生成する方法及びキット |
| US11696927B2 (en) * | 2017-02-28 | 2023-07-11 | University Of Central Florida Research Foundation, Inc. | PM21 particles to improve bone marrow homing of NK cells |
| CN110573610B (zh) | 2017-03-08 | 2025-01-28 | 住友制药株式会社 | 视网膜色素上皮细胞的制备方法 |
| US20200080058A1 (en) * | 2017-03-21 | 2020-03-12 | Etablissement Francais Du Sang | Methods of improving hematopoietic grafts |
| KR102167548B1 (ko) * | 2017-09-21 | 2020-10-19 | 한국생명공학연구원 | 자연살해세포의 제조방법 및 그의 용도 |
| JP7433230B2 (ja) | 2017-12-08 | 2024-02-19 | ジュノー セラピューティクス インコーポレイテッド | 細胞を培養するための無血清培地配合物およびその使用の方法 |
| AU2019215034C1 (en) | 2018-02-01 | 2022-01-06 | Nkmax Co., Ltd. | Method of producing natural killer cells and composition for treating cancer |
| WO2019165121A1 (en) | 2018-02-21 | 2019-08-29 | Board Of Regents, The University Of Texas System | Methods for activation and expansion of natural killer cells and uses therof |
| FI3755347T3 (fi) * | 2018-02-21 | 2025-07-29 | Univ Texas | Universaaleja antigeeniä esitteleviä soluja ja niiden käyttöjä |
| SG11202101204TA (en) | 2018-08-09 | 2021-03-30 | Juno Therapeutics Inc | Processes for generating engineered cells and compositions thereof |
| WO2020037303A1 (en) | 2018-08-16 | 2020-02-20 | The Regents Of The University Of California | Chemically and photochemically initiated cell membrane blebbing to induce cell vesicle production, modifications thereof, and uses thereof |
| RS65658B1 (sr) | 2018-08-27 | 2024-07-31 | Affimed Gmbh | Kriokonzervirane nk ćelije prethodno punjene konstruktom antitela |
| AU2019336221B2 (en) | 2018-09-07 | 2025-05-15 | Wisconsin Alumni Research Foundation | Generation of hematopoietic progenitor cells from human pluripotent stem cells |
| WO2020180744A1 (en) * | 2019-03-01 | 2020-09-10 | The Regents Of The University Of California | Natural killer cell induced cellular vesicles for cancer therapy |
| KR102298639B1 (ko) * | 2019-03-28 | 2021-09-07 | 한국생명공학연구원 | 면역세포의 제조방법 및 그의 용도 |
| RU2731293C1 (ru) | 2019-04-12 | 2020-09-01 | Игорь Петрович Белецкий | Способ получения генно-модифицированных линий клеток натуральных киллеров с нокаутированным геном PD-1 и повышенной экспрессией белков семейства Фактора Некроза Опухолей для иммунотерапии онкологических заболеваний |
| US20220154144A1 (en) * | 2019-04-26 | 2022-05-19 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Artificial antigen presenting cells comprising ligands for nkg2d for expanding immune cells for immunotherapy |
| WO2021096218A1 (ko) | 2019-11-13 | 2021-05-20 | 연세대학교 산학협력단 | 혈관 내피세포 순수 분리 방법, 혈관 내피세포 특성 유지 배지 및 이를 포함하는 배양 방법 |
| CN111235105B (zh) * | 2020-03-06 | 2021-08-10 | 安徽中盛溯源生物科技有限公司 | 一种从人多能干细胞分化为自然杀伤细胞的方法及应用 |
| CN116018148A (zh) * | 2020-03-11 | 2023-04-25 | 全国儿童医院研究所 | Nk细胞及其用于治疗微生物感染的用途 |
| US11547726B2 (en) | 2020-03-26 | 2023-01-10 | Honed Life Sciences, Llc | Enhancement of production of NK cells from stem cells |
| EP4170020A4 (en) | 2020-06-17 | 2025-01-22 | Kyoto University | IMMUNOCOMPETENT CELLS WITH CHIMERIC ANTIGEN RECEPTOR EXPRESSION |
| AU2021317752A1 (en) * | 2020-07-27 | 2023-03-02 | Stemcell Technologies Canada Inc. | Systems and methods for differentiating hematopoietic cells |
| US11459372B2 (en) | 2020-11-30 | 2022-10-04 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
| CN112608895B (zh) * | 2020-12-18 | 2024-02-27 | 深圳市济因生物科技有限公司 | 一种人多能干细胞分化的自然杀伤细胞及其制备方法与应用 |
| US11473060B2 (en) | 2020-12-30 | 2022-10-18 | Crispr Therapeutics Ag | Compositions and methods for differentiating stem cells into NK cells |
| EP4326852A4 (en) * | 2021-04-22 | 2025-04-23 | Artec Biotech, Inc. | Method for producing hematopoietic cells from stem cells using vascular organoids |
| WO2022269393A1 (en) | 2021-06-23 | 2022-12-29 | Crispr Therapeutics Ag | Engineered cells with improved protection from natural killer cell killing |
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| US20250000974A1 (en) * | 2021-10-27 | 2025-01-02 | The Regents Of The University Of California | Combination of human natural killer cells and macrophages for cancer therapy |
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