JP6329903B2 - 改変されたグラム陽性菌及びその使用 - Google Patents

改変されたグラム陽性菌及びその使用 Download PDF

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JP6329903B2
JP6329903B2 JP2014531243A JP2014531243A JP6329903B2 JP 6329903 B2 JP6329903 B2 JP 6329903B2 JP 2014531243 A JP2014531243 A JP 2014531243A JP 2014531243 A JP2014531243 A JP 2014531243A JP 6329903 B2 JP6329903 B2 JP 6329903B2
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lab
bifidobacteria
trehalose
lactic acid
ptcc
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JP2014527826A (ja
JP2014527826A5 (enExample
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ステイドラー,ローター
ヒュイネヘム,カロリアン ファン
ヒュイネヘム,カロリアン ファン
ファンデンブルック,クラース
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Intrexon Actobiotics NV
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JP2014531243A 2011-09-23 2012-09-21 改変されたグラム陽性菌及びその使用 Active JP6329903B2 (ja)

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EP11182643.4 2011-09-23
EP11182643 2011-09-23
PCT/EP2012/068634 WO2013041673A1 (en) 2011-09-23 2012-09-21 Modified gram positive bacteria and uses thereof

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JP2014527826A JP2014527826A (ja) 2014-10-23
JP2014527826A5 JP2014527826A5 (enExample) 2015-12-03
JP6329903B2 true JP6329903B2 (ja) 2018-05-23

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US (4) US9347036B2 (enExample)
EP (2) EP3382006B1 (enExample)
JP (2) JP6329903B2 (enExample)
KR (1) KR102028771B1 (enExample)
CN (1) CN103917639B (enExample)
AU (2) AU2012311479B2 (enExample)
BR (1) BR112014006883A8 (enExample)
CA (2) CA2848471C (enExample)
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HU (1) HUE038336T2 (enExample)
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WO (1) WO2013041673A1 (enExample)

Cited By (1)

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JP2018046827A (ja) * 2011-09-23 2018-03-29 イントレクソン・アクトバイオテイクス・エヌブイIntrexon Actobiotics NV 改変されたグラム陽性菌及びその使用

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HUE038830T2 (hu) 2011-09-23 2018-11-28 Intrexon Actobiotics Nv Módosított gram-pozitív baktériumok és alkalmazásaik
EP3237622B1 (en) 2014-12-23 2021-02-24 Ilya Pharma AB Methods for wound healing
JP7292877B2 (ja) 2016-01-14 2023-06-19 イントレクソン・アクトバイオテイクス・エヌブイ 1型糖尿病を処置するための組成物および方法
US10858663B2 (en) 2016-09-02 2020-12-08 Intrexon Actobiotics N.V. Genetically modified bacteria stably expressing IL-10 and insulin
KR102469701B1 (ko) * 2016-09-13 2022-11-22 인트랙슨 액토바이오틱스 엔.브이. 점막부착성 미생물
IT201600122724A1 (it) * 2016-12-02 2018-06-02 Sofar Spa Exopolysaccharides and uses thereof
CN120463807A (zh) 2018-03-22 2025-08-12 表面肿瘤学有限责任公司 抗il-27抗体及其用途
WO2020077010A1 (en) * 2018-10-09 2020-04-16 Second Genome, Inc. Lactococcus lactis expression system for delivering proteins efficacious for the treatment of epithelial barrier function disorders
CN114854807B (zh) * 2022-05-23 2024-05-17 中国科学院微生物研究所 一种生产海藻糖六磷酸的方法
CN121204013B (zh) * 2025-11-04 2026-06-09 大连理工大学 一种海藻糖-6-磷酸磷酸化酶及其突变体与应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9006400D0 (en) 1990-03-22 1990-05-23 Ciba Geigy Ag Bacterial vectors
US6277969B1 (en) 1991-03-18 2001-08-21 New York University Anti-TNF antibodies and peptides of human tumor necrosis factor
IT1270123B (it) 1994-10-05 1997-04-28 Dompe Spa Composizioni farmaceutiche contenenti microorganismi ingegnerizzati e loro uso per terapia
GB9521568D0 (en) 1995-10-20 1995-12-20 Lynxvale Ltd Delivery of biologically active polypeptides
US6033376A (en) 1998-09-30 2000-03-07 Allergan Sales, Inc. Wound shaper sleeve
EP1123314B1 (en) 1998-10-20 2004-02-18 Vlaams Interuniversitair Instituut voor Biotechnologie vzw. Use of a cytokine-producing lactococcus strain to treat colitis
ES2272311T3 (es) 1999-07-05 2007-05-01 Vlaams Interuniversitair Instituut Voor Biotechnologie Suministro de peptidos trebol.
AT407730B (de) 2000-01-14 2001-05-25 Hoerbiger Hydraulik Betätigungsanordnung für schwenkbare teile an fahrzeugen
GB0013810D0 (en) 2000-06-06 2000-07-26 Celltech Chiroscience Ltd Biological products
CA2446776C (en) 2001-05-03 2011-07-12 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Self-containing lactococcus strain
AU2003298291A1 (en) 2002-11-15 2004-06-15 Universiteit Gent Self-containing lactobacillus strain
PL1720974T5 (pl) 2004-02-24 2023-09-18 Chr. Hansen A/S Zamrożona kultura bakterii kwasu mlekowego w oddzielnych peletkach
CA2567106A1 (en) 2004-05-18 2005-11-24 Vib Vzw Self-containing lactobacillus strain
WO2006018446A2 (en) 2004-08-20 2006-02-23 Actogenix Nv Method to improve lactococcus preservation
JP5049973B2 (ja) 2005-08-30 2012-10-17 アクトジェニックス・エヌブイ 慢性全腸炎の治療のための、抗−TNFα産生乳酸菌
DK2119450T3 (da) 2005-11-29 2013-05-06 Actogenix Nv Induktion af mucosal tolerance over for pankreatisk ø-beta-celle-autoantigener
EP3255149A3 (en) 2006-05-02 2018-04-18 Intrexon Actobiotics NV Microbial intestinal delivery of obesity related peptides
CA2672229A1 (en) 2006-12-14 2008-06-19 Actogenix N.V. Delivery of binding molecules to induce immunomodulation
CN101605900B (zh) 2007-01-12 2014-04-23 阿克图杰尼斯公司 乳球菌启动子和其用途
BRPI0807857A2 (pt) 2007-01-25 2014-05-27 Actogenix Nv Tratamento de doença imune por meio de distribuição através da mucosa de antígenos.
JP2012504116A (ja) 2008-09-29 2012-02-16 アクトジェニックス・エヌブイ 粘膜での微生物のコロニー形成の低減
RU2393214C1 (ru) * 2009-01-29 2010-06-27 Общество с ограниченной ответственностью "ИнноПроб"(ООО"ИнноПроб") Иммунобиологическое противоаллергическое средство (варианты), штамм lactobacillus acidophilus nkjc, штамм lactobacillus acidophilus jch, штамм lactobacillus acidophilus kaa
ES2425385T3 (es) 2009-04-30 2013-10-15 Actogenix N.V. Crioprotectores para la liofilización de las bacterias de ácido láctico
HUE038830T2 (hu) * 2011-09-23 2018-11-28 Intrexon Actobiotics Nv Módosított gram-pozitív baktériumok és alkalmazásaik
CN103917639B (zh) * 2011-09-23 2017-09-26 英特瑞克斯顿阿克图比奥帝克斯有限公司 经修饰的革兰氏阳性细菌及其用途

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018046827A (ja) * 2011-09-23 2018-03-29 イントレクソン・アクトバイオテイクス・エヌブイIntrexon Actobiotics NV 改変されたグラム陽性菌及びその使用

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