JP2014527826A5 - - Google Patents
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- Publication number
- JP2014527826A5 JP2014527826A5 JP2014531243A JP2014531243A JP2014527826A5 JP 2014527826 A5 JP2014527826 A5 JP 2014527826A5 JP 2014531243 A JP2014531243 A JP 2014531243A JP 2014531243 A JP2014531243 A JP 2014531243A JP 2014527826 A5 JP2014527826 A5 JP 2014527826A5
- Authority
- JP
- Japan
- Prior art keywords
- lab
- bifidobacteria
- ptcc
- trehalose
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000186000 Bifidobacterium Species 0.000 claims 26
- 108090000623 proteins and genes Proteins 0.000 claims 20
- 238000000034 method Methods 0.000 claims 9
- 241000894006 Bacteria Species 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 7
- 239000002778 food additive Substances 0.000 claims 7
- 235000013373 food additive Nutrition 0.000 claims 7
- 239000007858 starting material Substances 0.000 claims 7
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 6
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 6
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 6
- 239000006041 probiotic Substances 0.000 claims 5
- 230000000529 probiotic effect Effects 0.000 claims 5
- 235000018291 probiotics Nutrition 0.000 claims 5
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 4
- 101000662918 Lactococcus lactis subsp. lactis (strain IL1403) Trehalose 6-phosphate phosphorylase Proteins 0.000 claims 4
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 4
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims 4
- 239000008103 glucose Substances 0.000 claims 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 4
- 239000000463 material Substances 0.000 claims 4
- 239000000758 substrate Substances 0.000 claims 4
- 108020003272 trehalose-phosphatase Proteins 0.000 claims 4
- 239000001963 growth medium Substances 0.000 claims 3
- 238000002156 mixing Methods 0.000 claims 3
- 101150089952 trePP gene Proteins 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 238000004108 freeze drying Methods 0.000 claims 2
- 238000007710 freezing Methods 0.000 claims 2
- 230000008014 freezing Effects 0.000 claims 2
- 235000014655 lactic acid Nutrition 0.000 claims 2
- 239000004310 lactic acid Substances 0.000 claims 2
- 239000002609 medium Substances 0.000 claims 2
- 101150095512 otsB gene Proteins 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000192125 Firmicutes Species 0.000 claims 1
- 241000186660 Lactobacillus Species 0.000 claims 1
- 241000194036 Lactococcus Species 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 239000003833 bile salt Substances 0.000 claims 1
- 229940093761 bile salts Drugs 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 230000003204 osmotic effect Effects 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11182643 | 2011-09-23 | ||
| EP11182643.4 | 2011-09-23 | ||
| PCT/EP2012/068634 WO2013041673A1 (en) | 2011-09-23 | 2012-09-21 | Modified gram positive bacteria and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017195120A Division JP6669703B2 (ja) | 2011-09-23 | 2017-10-05 | 改変されたグラム陽性菌及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014527826A JP2014527826A (ja) | 2014-10-23 |
| JP2014527826A5 true JP2014527826A5 (enExample) | 2015-12-03 |
| JP6329903B2 JP6329903B2 (ja) | 2018-05-23 |
Family
ID=47040665
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014531243A Active JP6329903B2 (ja) | 2011-09-23 | 2012-09-21 | 改変されたグラム陽性菌及びその使用 |
| JP2017195120A Expired - Fee Related JP6669703B2 (ja) | 2011-09-23 | 2017-10-05 | 改変されたグラム陽性菌及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017195120A Expired - Fee Related JP6669703B2 (ja) | 2011-09-23 | 2017-10-05 | 改変されたグラム陽性菌及びその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US9347036B2 (enExample) |
| EP (2) | EP3382006B1 (enExample) |
| JP (2) | JP6329903B2 (enExample) |
| KR (1) | KR102028771B1 (enExample) |
| CN (1) | CN103917639B (enExample) |
| AU (2) | AU2012311479B2 (enExample) |
| BR (1) | BR112014006883A8 (enExample) |
| CA (2) | CA2848471C (enExample) |
| DK (1) | DK2758513T3 (enExample) |
| ES (1) | ES2676270T3 (enExample) |
| HU (1) | HUE038336T2 (enExample) |
| RU (1) | RU2653757C2 (enExample) |
| WO (1) | WO2013041673A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2758512B1 (en) | 2011-09-23 | 2018-05-09 | Intrexon Actobiotics NV | Modified gram positive bacteria and uses thereof |
| BR112014006883A8 (pt) * | 2011-09-23 | 2018-06-26 | Actogenix Nv | bactéria gram-positiva não patogênica carecendo de atividade do componente llc do sistema pts celobiose específico (ptcc), medicamento, aditivo alimentar, composição probiótica, ou cultura iniciadora, produto alimentar e métodos |
| CA2971520C (en) | 2014-12-23 | 2024-04-09 | Ilya Pharma Ab | Methods for wound healing |
| EP3402499B1 (en) * | 2016-01-14 | 2021-07-21 | Intrexon Actobiotics NV | Compositions and methods for the treatment of type 1 diabetes |
| CN109843320A (zh) | 2016-09-02 | 2019-06-04 | 英特瑞克斯顿阿克图比奥帝克斯有限公司 | 稳定表达il-10和胰岛素的遗传修饰的细菌 |
| RU2762940C2 (ru) * | 2016-09-13 | 2021-12-24 | Интрексон Актобиотикс Н.В. | Мукоадгезивный микроорганизм |
| IT201600122724A1 (it) * | 2016-12-02 | 2018-06-02 | Sofar Spa | Exopolysaccharides and uses thereof |
| EP3863655A4 (en) * | 2018-10-09 | 2021-12-29 | Second Genome, Inc. | Lactococcus lactis expression system for delivering proteins efficacious for the treatment of epithelial barrier function disorders |
| CN114854807B (zh) * | 2022-05-23 | 2024-05-17 | 中国科学院微生物研究所 | 一种生产海藻糖六磷酸的方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9006400D0 (en) | 1990-03-22 | 1990-05-23 | Ciba Geigy Ag | Bacterial vectors |
| US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| IT1270123B (it) | 1994-10-05 | 1997-04-28 | Dompe Spa | Composizioni farmaceutiche contenenti microorganismi ingegnerizzati e loro uso per terapia |
| GB9521568D0 (en) | 1995-10-20 | 1995-12-20 | Lynxvale Ltd | Delivery of biologically active polypeptides |
| US6033376A (en) | 1998-09-30 | 2000-03-07 | Allergan Sales, Inc. | Wound shaper sleeve |
| DE69914932T2 (de) | 1998-10-20 | 2004-12-09 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Verwendung eines zytokine-produzierenden lactococcus stammes zur behandlung von kolitis |
| AU781679B2 (en) | 1999-07-05 | 2005-06-09 | Intrexon Actobiotics Nv | Delivery of trefoil peptides |
| AT407730B (de) | 2000-01-14 | 2001-05-25 | Hoerbiger Hydraulik | Betätigungsanordnung für schwenkbare teile an fahrzeugen |
| GB0013810D0 (en) | 2000-06-06 | 2000-07-26 | Celltech Chiroscience Ltd | Biological products |
| JP4347575B2 (ja) | 2001-05-03 | 2009-10-21 | アクトジェニックス・エヌブイ | 自己自制ラクトコッカス（Ｌｏｃｔｏｃｏｃｃｕｓ）株 |
| WO2004046346A2 (en) | 2002-11-15 | 2004-06-03 | Vib Vzw | Self-containing lactobacillus strain |
| AU2005215858B2 (en) | 2004-02-24 | 2010-07-15 | Chr. Hansen A/S | Frozen lactic acid bacteria culture of individual pellets |
| CA2567106A1 (en) | 2004-05-18 | 2005-11-24 | Vib Vzw | Self-containing lactobacillus strain |
| WO2006018446A2 (en) | 2004-08-20 | 2006-02-23 | Actogenix Nv | Method to improve lactococcus preservation |
| ES2626610T3 (es) | 2005-08-30 | 2017-07-25 | Intrexon Actobiotics Nv | Bacterias de ácido láctico productoras del anti-TNF alfa para el tratamiento de la enfermedad inflamatoria intestinal |
| ES2405552T3 (es) | 2005-11-29 | 2013-05-31 | Actogenix N.V. | Inducción de tolerancia mucosa a antiantígenos de células beta de islotes pancreáticos |
| RU2008147398A (ru) | 2006-05-02 | 2010-06-10 | Актогеникс Н.В. (Be) | Доставка пептидов, связанных с ожирением, через кишечник посредством микроорганизмов |
| CA2672229A1 (en) | 2006-12-14 | 2008-06-19 | Actogenix N.V. | Delivery of binding molecules to induce immunomodulation |
| EP3124614B1 (en) | 2007-01-12 | 2022-06-08 | Intrexon Actobiotics NV | Lactococcus promoters and uses thereof |
| EP2774621B1 (en) | 2007-01-25 | 2018-01-24 | Intrexon Actobiotics NV | Treatment of immune disease by mucosal delivery of antigens |
| EP2344626B1 (en) | 2008-09-29 | 2017-03-29 | Intrexon Actobiotics NV | Reduced colonization of microbes at the mucosa |
| RU2393214C1 (ru) * | 2009-01-29 | 2010-06-27 | Общество с ограниченной ответственностью "ИнноПроб"(ООО"ИнноПроб") | Иммунобиологическое противоаллергическое средство (варианты), штамм lactobacillus acidophilus nkjc, штамм lactobacillus acidophilus jch, штамм lactobacillus acidophilus kaa |
| WO2010124855A1 (en) | 2009-04-30 | 2010-11-04 | Actogenix Nv | Cryoprotectants for freeze drying of lactic acid bacteria |
| EP2758512B1 (en) * | 2011-09-23 | 2018-05-09 | Intrexon Actobiotics NV | Modified gram positive bacteria and uses thereof |
| BR112014006883A8 (pt) * | 2011-09-23 | 2018-06-26 | Actogenix Nv | bactéria gram-positiva não patogênica carecendo de atividade do componente llc do sistema pts celobiose específico (ptcc), medicamento, aditivo alimentar, composição probiótica, ou cultura iniciadora, produto alimentar e métodos |
-
2012
- 2012-09-21 BR BR112014006883A patent/BR112014006883A8/pt not_active Application Discontinuation
- 2012-09-21 US US14/346,488 patent/US9347036B2/en active Active
- 2012-09-21 AU AU2012311479A patent/AU2012311479B2/en not_active Ceased
- 2012-09-21 EP EP18172371.9A patent/EP3382006B1/en active Active
- 2012-09-21 CA CA2848471A patent/CA2848471C/en active Active
- 2012-09-21 HU HUE12773253A patent/HUE038336T2/hu unknown
- 2012-09-21 DK DK12773253.5T patent/DK2758513T3/en active
- 2012-09-21 CN CN201280053876.1A patent/CN103917639B/zh not_active Expired - Fee Related
- 2012-09-21 RU RU2014116230A patent/RU2653757C2/ru active
- 2012-09-21 JP JP2014531243A patent/JP6329903B2/ja active Active
- 2012-09-21 KR KR1020147010661A patent/KR102028771B1/ko not_active Expired - Fee Related
- 2012-09-21 ES ES12773253.5T patent/ES2676270T3/es active Active
- 2012-09-21 CA CA3131722A patent/CA3131722A1/en not_active Abandoned
- 2012-09-21 WO PCT/EP2012/068634 patent/WO2013041673A1/en not_active Ceased
- 2012-09-21 EP EP12773253.5A patent/EP2758513B1/en active Active
-
2016
- 2016-01-21 US US15/003,426 patent/US9982228B2/en active Active
-
2017
- 2017-10-05 JP JP2017195120A patent/JP6669703B2/ja not_active Expired - Fee Related
- 2017-11-29 AU AU2017268593A patent/AU2017268593B9/en not_active Ceased
-
2018
- 2018-04-23 US US15/959,705 patent/US10519418B2/en active Active
-
2019
- 2019-12-13 US US16/713,737 patent/US10793825B2/en active Active
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