HUE038336T2 - Módosított gram-pozitív baktériumok és alkalmazásaik - Google Patents

Módosított gram-pozitív baktériumok és alkalmazásaik

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Publication number
HUE038336T2
HUE038336T2 HUE12773253A HUE12773253A HUE038336T2 HU E038336 T2 HUE038336 T2 HU E038336T2 HU E12773253 A HUE12773253 A HU E12773253A HU E12773253 A HUE12773253 A HU E12773253A HU E038336 T2 HUE038336 T2 HU E038336T2
Authority
HU
Hungary
Prior art keywords
positive bacteria
gram positive
modified gram
modified
bacteria
Prior art date
Application number
HUE12773253A
Other languages
English (en)
Hungarian (hu)
Inventor
Lothar Steidler
Huynegem Karolien Van
Klaas Vandenbroucke
Original Assignee
Intrexon Actobiotics Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intrexon Actobiotics Nv filed Critical Intrexon Actobiotics Nv
Publication of HUE038336T2 publication Critical patent/HUE038336T2/hu

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    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
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    • A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
    • A23C9/1234—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt characterised by using a Lactobacillus sp. other than Lactobacillus Bulgaricus, including Bificlobacterium sp.
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HUE12773253A 2011-09-23 2012-09-21 Módosított gram-pozitív baktériumok és alkalmazásaik HUE038336T2 (hu)

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Application Number Priority Date Filing Date Title
EP11182643 2011-09-23

Publications (1)

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HUE038336T2 true HUE038336T2 (hu) 2018-10-29

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EP (2) EP3382006B1 (enExample)
JP (2) JP6329903B2 (enExample)
KR (1) KR102028771B1 (enExample)
CN (1) CN103917639B (enExample)
AU (2) AU2012311479B2 (enExample)
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CA (2) CA2848471C (enExample)
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ES (1) ES2676270T3 (enExample)
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Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103917639B (zh) * 2011-09-23 2017-09-26 英特瑞克斯顿阿克图比奥帝克斯有限公司 经修饰的革兰氏阳性细菌及其用途
HUE038830T2 (hu) 2011-09-23 2018-11-28 Intrexon Actobiotics Nv Módosított gram-pozitív baktériumok és alkalmazásaik
EP3237622B1 (en) 2014-12-23 2021-02-24 Ilya Pharma AB Methods for wound healing
JP7292877B2 (ja) 2016-01-14 2023-06-19 イントレクソン・アクトバイオテイクス・エヌブイ １型糖尿病を処置するための組成物および方法
US10858663B2 (en) 2016-09-02 2020-12-08 Intrexon Actobiotics N.V. Genetically modified bacteria stably expressing IL-10 and insulin
KR102469701B1 (ko) * 2016-09-13 2022-11-22 인트랙슨 액토바이오틱스 엔.브이. 점막부착성 미생물
IT201600122724A1 (it) * 2016-12-02 2018-06-02 Sofar Spa Exopolysaccharides and uses thereof
CN120463807A (zh) 2018-03-22 2025-08-12 表面肿瘤学有限责任公司 抗il-27抗体及其用途
WO2020077010A1 (en) * 2018-10-09 2020-04-16 Second Genome, Inc. Lactococcus lactis expression system for delivering proteins efficacious for the treatment of epithelial barrier function disorders
CN114854807B (zh) * 2022-05-23 2024-05-17 中国科学院微生物研究所 一种生产海藻糖六磷酸的方法
CN121204013B (zh) * 2025-11-04 2026-06-09 大连理工大学 一种海藻糖-6-磷酸磷酸化酶及其突变体与应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9006400D0 (en) 1990-03-22 1990-05-23 Ciba Geigy Ag Bacterial vectors
US6277969B1 (en) 1991-03-18 2001-08-21 New York University Anti-TNF antibodies and peptides of human tumor necrosis factor
IT1270123B (it) 1994-10-05 1997-04-28 Dompe Spa Composizioni farmaceutiche contenenti microorganismi ingegnerizzati e loro uso per terapia
GB9521568D0 (en) 1995-10-20 1995-12-20 Lynxvale Ltd Delivery of biologically active polypeptides
US6033376A (en) 1998-09-30 2000-03-07 Allergan Sales, Inc. Wound shaper sleeve
EP1123314B1 (en) 1998-10-20 2004-02-18 Vlaams Interuniversitair Instituut voor Biotechnologie vzw. Use of a cytokine-producing lactococcus strain to treat colitis
ES2272311T3 (es) 1999-07-05 2007-05-01 Vlaams Interuniversitair Instituut Voor Biotechnologie Suministro de peptidos trebol.
AT407730B (de) 2000-01-14 2001-05-25 Hoerbiger Hydraulik Betätigungsanordnung für schwenkbare teile an fahrzeugen
GB0013810D0 (en) 2000-06-06 2000-07-26 Celltech Chiroscience Ltd Biological products
CA2446776C (en) 2001-05-03 2011-07-12 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Self-containing lactococcus strain
AU2003298291A1 (en) 2002-11-15 2004-06-15 Universiteit Gent Self-containing lactobacillus strain
PL1720974T5 (pl) 2004-02-24 2023-09-18 Chr. Hansen A/S Zamrożona kultura bakterii kwasu mlekowego w oddzielnych peletkach
CA2567106A1 (en) 2004-05-18 2005-11-24 Vib Vzw Self-containing lactobacillus strain
WO2006018446A2 (en) 2004-08-20 2006-02-23 Actogenix Nv Method to improve lactococcus preservation
JP5049973B2 (ja) 2005-08-30 2012-10-17 アクトジェニックス・エヌブイ 慢性全腸炎の治療のための、抗−ＴＮＦα産生乳酸菌
DK2119450T3 (da) 2005-11-29 2013-05-06 Actogenix Nv Induktion af mucosal tolerance over for pankreatisk ø-beta-celle-autoantigener
EP3255149A3 (en) 2006-05-02 2018-04-18 Intrexon Actobiotics NV Microbial intestinal delivery of obesity related peptides
CA2672229A1 (en) 2006-12-14 2008-06-19 Actogenix N.V. Delivery of binding molecules to induce immunomodulation
CN101605900B (zh) 2007-01-12 2014-04-23 阿克图杰尼斯公司 乳球菌启动子和其用途
BRPI0807857A2 (pt) 2007-01-25 2014-05-27 Actogenix Nv Tratamento de doença imune por meio de distribuição através da mucosa de antígenos.
JP2012504116A (ja) 2008-09-29 2012-02-16 アクトジェニックス・エヌブイ 粘膜での微生物のコロニー形成の低減
RU2393214C1 (ru) * 2009-01-29 2010-06-27 Общество с ограниченной ответственностью "ИнноПроб"(ООО"ИнноПроб") Иммунобиологическое противоаллергическое средство (варианты), штамм lactobacillus acidophilus nkjc, штамм lactobacillus acidophilus jch, штамм lactobacillus acidophilus kaa
ES2425385T3 (es) 2009-04-30 2013-10-15 Actogenix N.V. Crioprotectores para la liofilización de las bacterias de ácido láctico
HUE038830T2 (hu) * 2011-09-23 2018-11-28 Intrexon Actobiotics Nv Módosított gram-pozitív baktériumok és alkalmazásaik
CN103917639B (zh) * 2011-09-23 2017-09-26 英特瑞克斯顿阿克图比奥帝克斯有限公司 经修饰的革兰氏阳性细菌及其用途

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